RGD Reference Report - Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling. - Rat Genome Database

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Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling.

Authors: Klussmann, E  Edemir, B  Pepperle, B  Tamma, G  Henn, V  Klauschenz, E  Hundsrucker, C  Maric, K  Rosenthal, W 
Citation: Klussmann E, etal., FEBS Lett 2001 Nov 2;507(3):264-8.
RGD ID: 1299587
Pubmed: PMID:11696353   (View Abstract at PubMed)

In an attempt to isolate protein kinase A anchoring proteins (AKAPs) involved in vasopressin-mediated water reabsorbtion, the complete sequence of the human AKAP Ht31 was determined and a partial cDNA of its rat orthologue (Rt31) was cloned. The Ht31 cDNA includes the estrogen receptor cofactor Brx and the RhoA GDP/GTP exchange factor proto-lymphoid blast crisis (Lbc) sequences. The Ht31 gene was assigned to chromosome 15 (region q24-q25). It encodes Ht31 and the smaller splice variants Brx and proto-Lbc. A protein of the predicted size of Ht31 (309 kDa) was detected in human mammary carcinoma and HeLa cells. Anti-Ht31/Rt31 antibodies immunoprecipitated RhoA from primary cultured rat renal inner medullary collecting duct cells, indicating an interaction between the AKAP and RhoA in vivo. These results suggest that Ht31/Rt31 represent a new type of AKAP, containing both an anchoring and a catalytic domain, which appears to be capable of modulating the activity of an interacting partner. Ht31/Rt31 have the potential to integrate Rho and protein kinase A signaling pathways, and thus, are prime candidates to regulate vasopressin-mediated water reabsorbtion.




Molecular Function

  
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Evidence
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Original Reference(s)
RhoaRatprotein domain specific binding  IPIAkap13 (Rattus norvegicus) RGD 


Genes (Rattus norvegicus)
Rhoa  (ras homolog family member A)

Gene Akap13 A-kinase anchoring protein 13 Rattus norvegicus