RGD Reference Report - Distribution and expression of RhoA in rat retina after optic nerve injury. - Rat Genome Database

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Distribution and expression of RhoA in rat retina after optic nerve injury.

Authors: Wang, YH  Wang, Y  Wang, DW  Wu, N  Liu, DN  Yin, ZQ 
Citation: Wang YH, etal., Ophthalmic Res. 2007;39(3):174-8. Epub 2007 May 25.
RGD ID: 1642826
Pubmed: PMID:17534117   (View Abstract at PubMed)
DOI: DOI:10.1159/000103237   (Journal Full-text)

BACKGROUND: RhoA is a small guanosine triphosphatase which participates in signaling pathways of axonal repellents or inhibitors. However, the distribution and expression of RhoA in the rat retina after optic nerve injury has not been elucidated yet. OBJECTIVES: To study the distribution and expression of RhoA in the rat retina after optic nerve injury. METHODS: Immunohistochemistry was used to determine the distribution of RhoA in rat retina after optic nerve injury. The expression of RhoA was analyzed by Western blot. RESULTS: In normal retina and the retina 1 day after optic nerve injury, RhoA was distributed in the retinal ganglion cell (RGC) layer. Three days after optic nerve injury, it existed in RGCs and the inner plexiform layer. However, 7 days after surgery its immunoreactivity was abundant not only in the RGC and inner plexiform layers but also in the inner nuclear and outer plexiform layers. Western blot analysis showed that the expression of RhoA increased significantly in the retina after optic nerve injury in comparison with normal retina. CONCLUSION: These results indicate that the distribution and expression of RhoA were extended and enhanced after optic nerve injury, and that RhoA plays an important role in optic nerve regeneration.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
RHOAHumanOptic Nerve Injuries  ISORhoa (Rattus norvegicus)protein:increased expression and altered localization:retinaRGD 
RhoaRatOptic Nerve Injuries  IEP protein:increased expression and altered localization:retinaRGD 
RhoaMouseOptic Nerve Injuries  ISORhoa (Rattus norvegicus)protein:increased expression and altered localization:retinaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Rhoa  (ras homolog family member A)

Genes (Mus musculus)
Rhoa  (ras homolog family member A)

Genes (Homo sapiens)
RHOA  (ras homolog family member A)


Additional Information