NOD2 (nucleotide binding oligomerization domain containing 2) - Rat Genome Database

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Gene: NOD2 (nucleotide binding oligomerization domain containing 2) Canis lupus familiaris
Analyze
Symbol: NOD2
Name: nucleotide binding oligomerization domain containing 2
RGD ID: 12095632
Description: ENCODES a protein that exhibits muramyl dipeptide binding (ortholog); INVOLVED IN activation of immune response (ortholog); biosynthetic process of antibacterial peptides active against Gram-positive bacteria (ortholog); cellular response to peptidoglycan (ortholog); PARTICIPATES IN NOD-like receptor signaling pathway; nuclear factor kappa B signaling pathway; ASSOCIATED WITH acne (ortholog); Acute Lung Injury (ortholog); allergic rhinitis (ortholog); FOUND IN plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: nucleotide-binding oligomerization domain-containing protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1264,636,850 - 64,667,232 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl264,635,519 - 64,667,232 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha261,209,788 - 61,240,085 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0265,182,339 - 65,218,538 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl265,182,339 - 65,212,649 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1262,006,039 - 62,036,328 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0263,025,931 - 63,056,292 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0263,913,478 - 63,943,824 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 60 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NOD2DogAcute Lung Injury treatmentISONod2 (Rattus norvegicus)9068941associated with SepsisRGDPMID:22575870 and REF_RGD_ID:8547530
NOD2Dogallergic rhinitis  ISONOD2 (Homo sapiens)9068941mRNA:increased expression:nasal mucosa (human)RGDPMID:23858718 and REF_RGD_ID:8547523
NOD2Dogasthma susceptibilityISONOD2 (Homo sapiens)9068941DNA:polymorphisms:intron more ...RGDPMID:16008671 and REF_RGD_ID:5131477
NOD2Dogasthma  ISONod2 (Mus musculus)9068941 RGDPMID:21051079 and REF_RGD_ID:5508757
NOD2Dogatherosclerosis  ISONod2 (Mus musculus)9068941 RGDPMID:24324141 and REF_RGD_ID:8158039
NOD2Dogautoimmune disease  ISONOD2 (Homo sapiens)9068941associated with Common Variable Immunodeficiency and DNA:missense mutation: :p.G908R (human)RGDPMID:20646002 and REF_RGD_ID:5508739
NOD2DogBacteremia severityISONOD2 (Homo sapiens)9068941associated with Staphylococcal InfectionsRGDPMID:24086711 and REF_RGD_ID:13204726
NOD2Dogbacterial infectious disease  ISONod2 (Mus musculus)9068941associated with Virus DiseasesRGDPMID:21669398 and REF_RGD_ID:5508748
NOD2Dogbacterial pneumonia  ISONod2 (Mus musculus)9068941 RGDPMID:19360122 and REF_RGD_ID:5131449
NOD2DogBehcet's disease no_associationISONOD2 (Homo sapiens)9068941DNA:mutations:cds:p.G908R more ...RGDPMID:15515785 and REF_RGD_ID:13204711
NOD2DogBehcet's disease susceptibilityISONOD2 (Homo sapiens)9068941DNA:snp more ...RGDPMID:19748964 and REF_RGD_ID:8158059
NOD2DogBlau syndrome susceptibilityISONOD2 (Homo sapiens)9068941DNA:snp:cds:p.E383K (human)RGDPMID:15812565 and REF_RGD_ID:8547515
NOD2DogBlau syndrome susceptibilityISONOD2 (Homo sapiens)9068941DNA:snps:cds:p.R334Q more ...RGDPMID:11528384 and REF_RGD_ID:8158040
NOD2DogBlau syndrome susceptibilityISONOD2 (Homo sapiens)9068941DNA:snp:cds:p.E383G (human)RGDPMID:19116920 and REF_RGD_ID:8158051
NOD2DogBlau syndrome susceptibilityISONOD2 (Homo sapiens)9068941DNA:snps:cds:p.R587C more ...RGDPMID:19479837 and REF_RGD_ID:8547518
NOD2Dogbreast cancer susceptibilityISONOD2 (Homo sapiens)9068941DNA:insertion: : 3020_3021insC (human)RGDPMID:16267612 and REF_RGD_ID:5131514
NOD2Dogbronchiolitis obliterans  ISONOD2 (Homo sapiens)9068941 RGDPMID:18158963 and REF_RGD_ID:5131450
NOD2Dogchronic obstructive pulmonary disease severityISONOD2 (Homo sapiens)9068941DNA:SNP:intron: (rs1077861) (human)RGDPMID:21943069 and REF_RGD_ID:5508720
NOD2Dogcolitis  ISONod2 (Rattus norvegicus)9068941mRNA:increased expression:colonRGDPMID:16891783 and REF_RGD_ID:1600781
NOD2Dogcolitis  ISONod2 (Mus musculus)9068941 RGDPMID:20921147 more ...
1 to 20 of 60 rows
1 to 17 of 17 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NOD2DogBehcet's disease  ISONOD2 (Homo sapiens)8554872ClinVar Annotator: match by term: Behcet diseaseClinVarPMID:28492532
NOD2DogBlau syndrome  ISONOD2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11385576 more ...
NOD2DogChediak-Higashi syndrome  ISONOD2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11385576 more ...
NOD2DogChediak-Higashi syndrome  ISONOD2 (Homo sapiens)8554872ClinVar Annotator: match by term: Autoinflammatory syndromeClinVarPMID:11385576 more ...
NOD2DogChromosome 16q12 Duplication Syndrome  ISONOD2 (Homo sapiens)8554872ClinVar Annotator: match by term: Chromosome 16q12 duplication syndromeClinVarPMID:25741868
NOD2DogCrohn's disease  ISONOD2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11385576 more ...
NOD2Dogdilated cardiomyopathy 1G  ISONOD2 (Homo sapiens)8554872ClinVar Annotator: match by term: Dilated cardiomyopathy 1GClinVarPMID:25741868
NOD2Doggenetic disease  ISONOD2 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:16199547 more ...
NOD2Doginflammatory bowel disease  ISONOD2 (Homo sapiens)8554872ClinVar Annotator: match by term: Regional enteritisClinVarPMID:11385576 more ...
NOD2Doginflammatory bowel disease  ISONOD2 (Homo sapiens)8554872ClinVar Annotator: match by term: Regional enteritisClinVarPMID:11385576 more ...
NOD2Doginflammatory bowel disease 1  ISONOD2 (Homo sapiens)8554872ClinVar Annotator: match by term: Inflammatory bowel disease 1ClinVarPMID:11385576 more ...
NOD2Dogleprosy  ISONOD2 (Homo sapiens)8554872ClinVar Annotator: match by term: Leprosy more ...ClinVarPMID:25741868
NOD2Dognephronophthisis 14  ISONOD2 (Homo sapiens)8554872ClinVar Annotator: match by term: Nephronophthisis 14ClinVarPMID:12915476 more ...
NOD2DogNoonan syndrome 1  ISONOD2 (Homo sapiens)8554872ClinVar Annotator: match by term: Noonan syndrome 1ClinVarPMID:25741868
NOD2Dogpsoriatic arthritis  ISONOD2 (Homo sapiens)8554872ClinVar Annotator: match by term: Psoriatic arthritis and susceptibility toClinVarPMID:11385576 more ...
NOD2DogTownes-Brocks syndrome  ISONOD2 (Homo sapiens)8554872ClinVar Annotator: match by term: Townes syndromeClinVarPMID:12915476 more ...
NOD2DogYAO SYNDROME  ISONOD2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11385576 more ...
1 to 17 of 17 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NOD2Dogacne  ISONOD2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:27106250
NOD2Dogdermatitis  ISONOD2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:19467619
NOD2Doghidradenitis suppurativa  ISONOD2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:27106250
NOD2Dogpyoderma gangrenosum  ISONOD2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:27106250
NOD2Dogulcerative colitis  ISONOD2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:20452301
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NOD2DogBlau syndrome  ISONOD2 (Homo sapiens)7240710 OMIM 
NOD2DogCrohn's disease  ISONOD2 (Homo sapiens)7240710 OMIM 
NOD2DogYAO SYNDROME  ISONOD2 (Homo sapiens)7240710 OMIM 


Biological Process
1 to 20 of 126 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NOD2Dogactivation of immune response acts_upstream_of_or_withinISOMGI:35295949068941 PMID:15692051MGIPMID:15692051
NOD2Dogantibacterial innate immune response involved_inIEAUniProtKB:Q9HC29 and ensembl:ENSP00000495993150520179 EnsemblGO_REF:0000107
NOD2Dogbiosynthetic process of antibacterial peptides active against Gram-positive bacteria acts_upstream_ofISOMGI:35295949068941 PMID:15692051MGIPMID:15692051
NOD2Dogcanonical NF-kappaB signal transduction involved_inIEAUniProtKB:Q9HC29 and ensembl:ENSP00000495993150520179 EnsemblGO_REF:0000107
NOD2Dogcellular response to lipopolysaccharide involved_inIEAUniProtKB:Q9HC29 and ensembl:ENSP00000495993150520179 EnsemblGO_REF:0000107
NOD2Dogcellular response to muramyl dipeptide involved_inIEAUniProtKB:Q9HC29 and ensembl:ENSP00000495993150520179 EnsemblGO_REF:0000107
NOD2Dogcellular response to peptidoglycan  ISONod2 (Rattus norvegicus)9068941 RGDPMID:24169446 and REF_RGD_ID:13204728
NOD2Dogcellular response to peptidoglycan acts_upstream_of_or_withinISOMGI:26805819068941 PMID:16949315MGIPMID:16949315
NOD2Dogdefense response to bacterium involved_inIEAUniProtKB:Q9HC29 and ensembl:ENSP00000495993150520179 EnsemblGO_REF:0000107
NOD2Dogdefense response to bacterium involved_inIBAMGI:2429397 more ...150520179 GO_CentralGO_REF:0000033
NOD2Dogdefense response to Gram-positive bacterium acts_upstream_of_or_withinISOMGI:13418399068941 PMID:18261938MGIPMID:18261938
NOD2Dogdefense response to Gram-positive bacterium acts_upstream_of_or_withinISOMGI:35295949068941 PMID:15692051 more ...MGIPMID:15692051 more ...
NOD2Dogdetection of bacterium involved_inIEAUniProtKB:Q9HC29 and ensembl:ENSP00000495993150520179 EnsemblGO_REF:0000107
NOD2Dogdetection of muramyl dipeptide acts_upstream_of_or_withinISONOD2 (Homo sapiens)9068941 PMID:12527755MGIPMID:12527755
NOD2Dogdetection of muramyl dipeptide involved_inIEAUniProtKB:Q9HC29 and ensembl:ENSP00000495993150520179 EnsemblGO_REF:0000107
NOD2DogERK1 and ERK2 cascade acts_upstream_ofISONod2 (Mus musculus)9068941 PMID:18261938MGIPMID:18261938
NOD2Dogestablishment of localization in cell acts_upstream_ofISOMGI:35295949068941 PMID:19139201MGIPMID:19139201
NOD2Doghost-mediated regulation of intestinal microbiota composition involved_inISONod2 (Mus musculus)9068941 PMID:21421666 more ...UniProtPMID:21421666 more ...
NOD2Dogimmune system process involved_inIEAUniProtKB-KW:KW-0391150520179 UniProtGO_REF:0000043
NOD2Doginnate immune response involved_inIEAUniProtKB-KW:KW-0399150520179 UniProtGO_REF:0000043
1 to 20 of 126 rows

Cellular Component
1 to 19 of 19 rows

  
Object Symbol
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Evidence
With
Reference
Notes
Source
Original Reference(s)
NOD2Dogbasolateral plasma membrane located_inIEAUniProtKB:Q9HC29 and ensembl:ENSP00000495993150520179 EnsemblGO_REF:0000107
NOD2Dogbasolateral plasma membrane located_inIEAUniProtKB-SubCell:SL-0026150520179 UniProtGO_REF:0000044
NOD2Dogcell surface located_inIEAUniProtKB:Q9HC29 and ensembl:ENSP00000495993150520179 EnsemblGO_REF:0000107
NOD2Dogcytoplasm located_inIEAUniProtKB-KW:KW-0963150520179 UniProtGO_REF:0000043
NOD2Dogcytoplasm located_inIEAUniProtKB-SubCell:SL-0086150520179 UniProtGO_REF:0000044
NOD2Dogcytoplasm located_inIEAUniProtKB:Q9HC29 and ensembl:ENSP00000495993150520179 EnsemblGO_REF:0000107
NOD2Dogcytoskeleton located_inIEAUniProtKB:Q9HC29 and ensembl:ENSP00000495993150520179 EnsemblGO_REF:0000107
NOD2Dogcytosol located_inIEAUniProtKB:Q9HC29 and ensembl:ENSP00000495993150520179 EnsemblGO_REF:0000107
NOD2Dogcytosol is_active_inIBAPANTHER:PTN004670420 and UniProtKB:Q9HC29150520179 GO_CentralGO_REF:0000033
NOD2Dogextrinsic component of plasma membrane is_active_inIEAUniProtKB:Q9HC29 and ensembl:ENSP00000495993150520179 EnsemblGO_REF:0000107
NOD2DogGolgi apparatus located_inIEAUniProtKB:Q9HC29 and ensembl:ENSP00000495993150520179 EnsemblGO_REF:0000107
NOD2Dogmembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043
NOD2Dogphagocytic vesicle located_inIEAUniProtKB:Q9HC29 and ensembl:ENSP00000495993150520179 EnsemblGO_REF:0000107
NOD2Dogplasma membrane located_inIEAUniProtKB:Q9HC29 and ensembl:ENSP00000495993150520179 EnsemblGO_REF:0000107
NOD2Dogplasma membrane located_inIEAUniProtKB-SubCell:SL-0039150520179 UniProtGO_REF:0000044
NOD2Dogplasma membrane located_inIEAUniProtKB-KW:KW-1003150520179 UniProtGO_REF:0000043
NOD2Dogplasma membrane is_active_inISONOD2 (Homo sapiens)9068941 PMID:17355968UniProtPMID:17355968
NOD2Dogprotein-containing complex part_ofIEAUniProtKB:Q9HC29 and ensembl:ENSP00000495993150520179 EnsemblGO_REF:0000107
NOD2Dogvesicle located_inIEAUniProtKB:Q9HC29 and ensembl:ENSP00000495993150520179 EnsemblGO_REF:0000107
1 to 19 of 19 rows

Molecular Function
1 to 20 of 38 rows

  
Object Symbol
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Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
NOD2Dogactin binding enablesIEAUniProtKB:Q9HC29 and ensembl:ENSP00000495993150520179 EnsemblGO_REF:0000107
NOD2DogCARD domain binding enablesIEAUniProtKB:Q9HC29 and ensembl:ENSP00000495993150520179 EnsemblGO_REF:0000107
NOD2Dogenzyme binding enablesIEAUniProtKB:Q9HC29 and ensembl:ENSP00000495993150520179 EnsemblGO_REF:0000107
NOD2DogHsp70 protein binding enablesIEAUniProtKB:Q9HC29 and ensembl:ENSP00000495993150520179 EnsemblGO_REF:0000107
NOD2DogHsp90 protein binding enablesIEAUniProtKB:Q9HC29 and ensembl:ENSP00000495993150520179 EnsemblGO_REF:0000107
NOD2Dogmuramyl dipeptide binding  ISONod2 (Rattus norvegicus)9068941 RGDPMID:16973131 and REF_RGD_ID:1643119
NOD2Dogmuramyl dipeptide binding enablesIEAUniProtKB:Q9HC29 and ensembl:ENSP00000495993150520179 EnsemblGO_REF:0000107
NOD2Dogpattern recognition receptor activity enablesIEAUniProtKB:Q9HC29 and ensembl:ENSP00000495993150520179 EnsemblGO_REF:0000107
NOD2Dogpeptidoglycan binding enablesIEAUniProtKB:Q9HC29 and ensembl:ENSP00000495993150520179 EnsemblGO_REF:0000107
NOD2Dogprotein binding enablesISOUniProtKB:O603369068941 PMID:22700971UniProtPMID:22700971
NOD2Dogprotein binding enablesISOMGI:26856289068941 PMID:17187069MGIPMID:17187069
NOD2Dogprotein binding enablesISOUniProtKB:Q8IYM99068941 PMID:26836588IntActPMID:26836588
NOD2Dogprotein binding enablesISOUniProtKB:O43353 more ...9068941 PMID:27812135IntActPMID:27812135
NOD2Dogprotein binding enablesISOPR:Q3UZZ49068941 PMID:20534456MGIPMID:20534456
NOD2Dogprotein binding enablesISOUniProtKB:O43353 and UniProtKB:P143739068941 PMID:22829933IntActPMID:22829933
NOD2Dogprotein binding enablesISOUniProtKB:O433539068941 PMID:21931826IntActPMID:21931826
NOD2Dogprotein binding enablesISOUniProtKB:Q9NPP49068941 PMID:11472070UniProtPMID:11472070
NOD2Dogprotein binding enablesISOUniProtKB:P08670 more ...9068941 PMID:21699783IntActPMID:21699783
NOD2Dogprotein binding enablesISOUniProtKB:O43353 more ...9068941 PMID:19337385BHF-UCLPMID:19337385
NOD2Dogprotein binding enablesISOUniProtKB:O43353 more ...9068941 PMID:27812135UniProtPMID:27812135
1 to 20 of 38 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NOD2DogNOD-like receptor signaling pathway  ISONod2 (Rattus norvegicus)9068941 RGDPMID:16973131 and REF_RGD_ID:1643119

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NOD2Dognuclear factor kappa B signaling pathway   ISONOD2 (Homo sapiens)9068941 PIDPID:200031
PMID:19604345   PMID:22301074   PMID:22321737   PMID:23600687   PMID:25017709   PMID:25746347   PMID:30947975  



NOD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1264,636,850 - 64,667,232 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl264,635,519 - 64,667,232 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha261,209,788 - 61,240,085 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0265,182,339 - 65,218,538 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl265,182,339 - 65,212,649 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1262,006,039 - 62,036,328 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0263,025,931 - 63,056,292 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0263,913,478 - 63,943,824 (-)NCBIUU_Cfam_GSD_1.0
NOD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381650,693,606 - 50,733,075 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1650,693,588 - 50,733,077 (+)EnsemblGRCh38hg38GRCh38
GRCh371650,727,517 - 50,766,986 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361649,288,551 - 49,324,488 (+)NCBINCBI36Build 36hg18NCBI36
Build 341649,288,550 - 49,324,488NCBI
Celera1635,246,377 - 35,282,313 (+)NCBICelera
Cytogenetic Map16q12.1NCBI
HuRef1636,618,016 - 36,653,950 (+)NCBIHuRef
CHM1_11652,138,579 - 52,174,513 (+)NCBICHM1_1
T2T-CHM13v2.01656,491,240 - 56,530,709 (+)NCBIT2T-CHM13v2.0
Nod2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39889,373,943 - 89,415,103 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl889,373,943 - 89,415,102 (+)EnsemblGRCm39 Ensembl
GRCm38888,647,315 - 88,688,474 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl888,647,315 - 88,688,474 (+)EnsemblGRCm38mm10GRCm38
MGSCv37891,171,246 - 91,212,373 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36891,537,452 - 91,578,579 (+)NCBIMGSCv36mm8
Celera892,927,621 - 92,968,882 (+)NCBICelera
Cytogenetic Map8C3NCBI
cM Map843.51NCBI
Nod2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81934,555,832 - 34,596,281 (-)NCBIGRCr8
mRatBN7.21918,382,369 - 18,422,817 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1918,382,439 - 18,417,177 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1920,062,002 - 20,096,735 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01925,256,605 - 25,291,343 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01928,214,380 - 28,249,133 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01919,342,061 - 19,389,366 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1919,332,594 - 19,377,492 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01930,375,065 - 30,409,527 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41919,662,337 - 19,697,341 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11919,670,606 - 19,715,845 (-)NCBI
Celera1918,269,940 - 18,304,004 (-)NCBICelera
Cytogenetic Map19p11NCBI
Nod2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554338,746,004 - 8,782,710 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554338,746,213 - 8,780,119 (+)NCBIChiLan1.0ChiLan1.0
NOD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21860,150,040 - 60,189,509 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11666,055,771 - 66,095,149 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01630,955,976 - 30,995,451 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11649,834,385 - 49,873,783 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1649,837,891 - 49,873,773 (+)Ensemblpanpan1.1panPan2
Nod2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934955,844,066 - 55,881,006 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364753,713,362 - 3,745,982 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364753,708,069 - 3,742,845 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl634,130,938 - 34,177,534 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1634,132,127 - 34,167,446 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NOD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1536,492,158 - 36,531,766 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl536,496,414 - 36,530,499 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604739,970,704 - 40,009,792 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nod2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247575,958,486 - 6,000,103 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247575,956,873 - 6,000,052 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in NOD2
357 total Variants


Assembly: CanFam3.1
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
2 64647821 64647822 C T snv Basenji (BJ005) View more Information
2 64655175 64655176 C A snv Wolf (WO002_732) View more Information
2 64655353 64655354 G A snv Alaskan Malamute (AM007) View more Information
2 64655533 64655534 C T snv European Variation Archive Release 4, European Variation Archive Release 6, Australian Cattle dog (AC023), Yorkshire Terrier (YT003), Australian Cattle dog (AC046), American Staffordshire Terrier (AS006), Bearded Collie (BD036), Bearded Collie (BD085), Bearded Collie (BD089), Bearded Collie (BD091), Bearded Collie (BD093), Bearded Collie (BD098), Miniature Bullterrier (BT007), Bullterrier (BT012), Bullmastiff (BU002), Cairn Terrier (CE073), Chihuahua (CH019), Great Dane (DD116), Doberman Pinscher (DO159), Doberman Pinscher (DO242), Doberman Pinscher (DO263), German Shepherd/Mixed breed (DS032), French Bulldog (FB046), French Bulldog (FB065), Golden Retriever (GR1078), Greyhound (GY432), Heideterrier (HT001), Irish Terrier (IT0390), Irish Terrier (IT221), German Hunting Terrier (JT007), Jagdterrier (JT011), Kunming Dog (KM1), Kunming Dog (KM10), Kunming Dog (KM2), Kunming Dog (KM4), Kunming Dog (KM5), Kunming Dog (KM6), Kunming Dog (KM8), Kunming Dog (KM9), Labrador Retriever (LA1869), Labrador Retriever (LA2382), Chinese indigenous dogs (LJ1), Chinese indigenous dogs (LJ3), Chinese indigenous dogs (LJ4), Chinese indigenous dogs (LJ6), Chinese indigenous dogs (LJ8), Border Collie (LN47), Lagotto Romagnolo (LR1030), Lagotto Romagnolo (LR390), Lagotto Romagnolo (LR433), Lagotto Romagnolo (LR538), Lagotto Romagnolo (LR654), Malinois (MA0163), Malinois (MA142), Malinois (MA152), Malinois (MA324), Mixed Breed (MI016), Norwich Terrier (NW062), Norwich Terrier (NW152), Norwich Terrier (NW255), Spanish Wolf (SRS661495), Chinese Crested (SRS713815), Shetland Sheepdog (SRS932138), Border Terrier (SRS932144), Shetland Sheepdog (SS004), Tibetan Mastiff (TM8), West Highland White Terrier (WW174), West Highland White Terrier (WW361), West Highland White Terrier (WW362), West Highland White Terrier (WW363), West Highland White Terrier (WW364), West Highland White Terrier (WW558), West Highland White Terrier (WW64), Chinese indigenous dogs (YJ1), Chinese indigenous dogs (YJ4) View more Information
2 64656439 64656440 T G snv Eurasier (EU035) View more Information
2 64666878 64666879 C T snv Chinese indigenous dogs (YJ5) View more Information




adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10


1 to 17 of 17 rows
RefSeq Transcripts NM_001287039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005617571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038657812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038657813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038657814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038657815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038657816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038657817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JF681171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KX868105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KX868106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KX868107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 17 of 17 rows

Ensembl Acc Id: ENSCAFT00000015589   ⟹   ENSCAFP00000014425
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl264,636,850 - 64,667,232 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000062567   ⟹   ENSCAFP00000064029
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl264,635,519 - 64,667,232 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000070587   ⟹   ENSCAFP00000052322
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl264,635,519 - 64,667,232 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000071093   ⟹   ENSCAFP00000046476
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl264,636,850 - 64,667,232 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000072356   ⟹   ENSCAFP00000050978
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl264,635,519 - 64,667,232 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000077000   ⟹   ENSCAFP00000061928
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl264,635,519 - 64,667,232 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845006982   ⟹   ENSCAFP00845005569
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl265,182,339 - 65,212,649 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845007002   ⟹   ENSCAFP00845005585
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl265,182,339 - 65,212,649 (-)Ensembl
RefSeq Acc Id: NM_001287039   ⟹   NP_001273968
RefSeq Status: INFERRED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1264,636,850 - 64,667,232 (-)NCBI
Dog10K_Boxer_Tasha261,209,788 - 61,240,085 (-)NCBI
ROS_Cfam_1.0265,182,339 - 65,212,649 (-)NCBI
UMICH_Zoey_3.1262,006,039 - 62,036,328 (-)NCBI
UNSW_CanFamBas_1.0263,025,931 - 63,056,292 (-)NCBI
UU_Cfam_GSD_1.0263,913,478 - 63,943,824 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038657812   ⟹   XP_038513740
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0265,182,343 - 65,218,538 (-)NCBI
RefSeq Acc Id: XM_038657813   ⟹   XP_038513741
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0265,182,343 - 65,218,538 (-)NCBI
RefSeq Acc Id: XM_038657814   ⟹   XP_038513742
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0265,182,343 - 65,218,538 (-)NCBI
RefSeq Acc Id: XM_038657815   ⟹   XP_038513743
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0265,182,343 - 65,207,024 (-)NCBI
RefSeq Acc Id: XM_038657816   ⟹   XP_038513744
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0265,182,343 - 65,212,322 (-)NCBI
RefSeq Acc Id: XM_038657817   ⟹   XP_038513745
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0265,182,343 - 65,218,515 (-)NCBI
1 to 5 of 15 rows
1 to 5 of 15 rows
RefSeq Acc Id: NP_001273968   ⟸   NM_001287039
- UniProtKB: A0A8I3MJL0 (UniProtKB/TrEMBL),   A0A8I3MSY5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000014425   ⟸   ENSCAFT00000015589
Ensembl Acc Id: ENSCAFP00000052322   ⟸   ENSCAFT00000070587
Ensembl Acc Id: ENSCAFP00000061928   ⟸   ENSCAFT00000077000
Ensembl Acc Id: ENSCAFP00000064029   ⟸   ENSCAFT00000062567
CARD   NACHT   NACHT LRR and PYD   NOD1/2 winged helix



1 to 40 of 51 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCAFG00000009818 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030008448 UniProtKB/TrEMBL
  ENSCAFG00845003875 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000015589.5 UniProtKB/TrEMBL
  ENSCAFT00030015540.1 UniProtKB/TrEMBL
  ENSCAFT00030015624.1 UniProtKB/TrEMBL
  ENSCAFT00030015712.1 UniProtKB/TrEMBL
  ENSCAFT00845006982 ENTREZGENE
  ENSCAFT00845006982.1 UniProtKB/TrEMBL
  ENSCAFT00845007002.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro CARD UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  NACHT_NTPase UniProtKB/TrEMBL
  NLR UniProtKB/TrEMBL
  NLRP_HD2 UniProtKB/TrEMBL
  NLRP_innate_immun_reg UniProtKB/TrEMBL
  NOD2_WH UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report cfa:487286 UniProtKB/TrEMBL
NCBI Gene NOD2 ENTREZGENE
PANTHER NACHT, LRR AND CARD DOMAINS-CONTAINING UniProtKB/TrEMBL
  NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12 UniProtKB/TrEMBL
  NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 3 UniProtKB/TrEMBL
Pfam CARD UniProtKB/TrEMBL
  LRR_6 UniProtKB/TrEMBL
  NACHT UniProtKB/TrEMBL
  NLRC4_HD2 UniProtKB/TrEMBL
  NOD2_WH UniProtKB/TrEMBL
PROSITE CARD UniProtKB/TrEMBL
  LRR UniProtKB/TrEMBL
  NACHT UniProtKB/TrEMBL
SMART LRR_RI UniProtKB/TrEMBL
Superfamily-SCOP RNI-like UniProtKB/TrEMBL
  SSF47986 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
1 to 40 of 51 rows