NOD2 (nucleotide binding oligomerization domain containing 2) - Rat Genome Database

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Gene: NOD2 (nucleotide binding oligomerization domain containing 2) Canis lupus familiaris
Analyze
Symbol: NOD2
Name: nucleotide binding oligomerization domain containing 2
RGD ID: 12095632
Description: ENCODES a protein that exhibits muramyl dipeptide binding (ortholog); INVOLVED IN activation of immune response (ortholog); biosynthetic process of antibacterial peptides active against Gram-positive bacteria (ortholog); cellular response to organic cyclic compound (ortholog); PARTICIPATES IN NOD-like receptor signaling pathway; nuclear factor kappa B signaling pathway; ASSOCIATED WITH acne (ortholog); Acute Lung Injury (ortholog); allergic rhinitis (ortholog); FOUND IN cytosol (ortholog); extrinsic component of plasma membrane (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: nucleotide-binding oligomerization domain-containing protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1264,636,850 - 64,667,232 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl264,635,519 - 64,667,232 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha261,209,788 - 61,240,085 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0265,182,339 - 65,218,538 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl265,182,339 - 65,212,649 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1262,006,039 - 62,036,328 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0263,025,931 - 63,056,292 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0263,913,478 - 63,943,824 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acne  (ISO)
Acute Lung Injury  (ISO)
allergic rhinitis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
autoimmune disease  (ISO)
Bacteremia  (ISO)
bacterial infectious disease  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
Blau syndrome  (ISO)
breast cancer  (ISO)
bronchiolitis obliterans  (ISO)
Chediak-Higashi syndrome  (ISO)
Chromosome 16q12 Duplication Syndrome  (ISO)
chronic obstructive pulmonary disease  (ISO)
colitis  (ISO)
Colonic Neoplasms  (ISO)
colorectal adenocarcinoma  (ISO)
coronary artery disease  (ISO)
Crohn's disease  (ISO)
dermatitis  (ISO)
Experimental Arthritis  (ISO)
Experimental Colitis  (ISO)
familial Mediterranean fever  (ISO)
gastritis  (ISO)
gastrointestinal carcinoma  (ISO)
genetic disease  (ISO)
graft-versus-host disease  (ISO)
Granuloma  (ISO)
hidradenitis suppurativa  (ISO)
inflammatory bowel disease  (ISO)
inflammatory bowel disease 1  (ISO)
intestinal disease  (ISO)
larynx cancer  (ISO)
Legionnaires' disease  (ISO)
leprosy  (ISO)
lung cancer  (ISO)
Lyme disease  (ISO)
meningococcal meningitis  (ISO)
Metaplasia  (ISO)
middle cerebral artery infarction  (ISO)
nephronophthisis 14  (ISO)
Ocular Toxoplasmosis  (ISO)
ovarian cancer  (ISO)
pancreatitis  (ISO)
perinatal necrotizing enterocolitis  (ISO)
PFAPA syndrome  (ISO)
Pneumococcal Meningitis  (ISO)
psoriatic arthritis  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
pyoderma gangrenosum  (ISO)
relapsing-remitting multiple sclerosis  (ISO)
Reperfusion Injury  (ISO)
rhinitis  (ISO)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (ISO)
Splenomegaly  (ISO)
Staphylococcal Pneumonia  (ISO)
systemic lupus erythematosus  (ISO)
Townes-Brocks syndrome  (ISO)
transient cerebral ischemia  (ISO)
ulcerative colitis  (ISO)
uveitis  (ISO)
YAO SYNDROME  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of immune response  (IEA,ISO)
adaptive immune response  (IEA)
antibacterial innate immune response  (IEA)
autophagy  (IEA)
biosynthetic process of antibacterial peptides active against Gram-positive bacteria  (IEA,ISO)
cellular response to lipopolysaccharide  (IEA)
cellular response to muramyl dipeptide  (IEA)
cellular response to organic cyclic compound  (ISO)
cellular response to peptidoglycan  (IEA,ISO)
defense response to bacterium  (IEA)
defense response to Gram-positive bacterium  (IEA,ISO)
detection of bacterium  (IEA)
detection of muramyl dipeptide  (IEA,ISO)
ERK1 and ERK2 cascade  (IEA,ISO)
establishment of localization in cell  (IEA,ISO)
host-mediated regulation of intestinal microbiota composition  (IEA)
innate immune response  (IEA)
innate immune response in mucosa  (IEA,ISO)
intestinal stem cell homeostasis  (IEA)
intracellular signal transduction  (IEA)
JNK cascade  (IEA,ISO)
maintenance of gastrointestinal epithelium  (IEA)
MAPK cascade  (IEA,ISO)
negative regulation of inflammatory response to antigenic stimulus  (IEA,ISO)
negative regulation of interleukin-12 production  (IEA,ISO)
negative regulation of interleukin-18 production  (IEA,ISO)
negative regulation of interleukin-2 production  (IEA,ISO)
negative regulation of macrophage apoptotic process  (IEA)
negative regulation of macrophage cytokine production  (IEA,ISO)
negative regulation of NF-kappaB transcription factor activity  (ISO)
negative regulation of T cell mediated immunity  (IEA,ISO)
negative regulation of toll-like receptor 2 signaling pathway  (IEA,ISO)
negative regulation of tumor necrosis factor production  (IEA,ISO)
negative regulation of type II interferon production  (IEA,ISO)
nucleotide-binding oligomerization domain containing 2 signaling pathway  (IEA,ISO)
pattern recognition receptor signaling pathway  (IEA)
peptidyl-tyrosine phosphorylation  (ISO)
phagocytosis  (IEA,ISO)
positive regulation of antibacterial peptide biosynthetic process  (IEA,ISO)
positive regulation of autophagy  (IEA)
positive regulation of B cell activation  (IEA)
positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria  (IEA,ISO)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cytokine production involved in immune response  (IEA)
positive regulation of cytokine production involved in inflammatory response  (IEA)
positive regulation of dendritic cell antigen processing and presentation  (IEA)
positive regulation of dendritic cell cytokine production  (ISO)
positive regulation of epithelial cell proliferation  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of humoral immune response mediated by circulating immunoglobulin  (IEA,ISO)
positive regulation of innate immune response  (IEA,ISO)
positive regulation of interleukin-1 beta production  (IEA)
positive regulation of interleukin-10 production  (IEA,ISO)
positive regulation of interleukin-12 production  (IEA,ISO)
positive regulation of interleukin-17 production  (IEA)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of interleukin-8 production  (IEA)
positive regulation of JNK cascade  (IEA,ISO)
positive regulation of macrophage cytokine production  (IEA,ISO)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of mitophagy  (IEA)
positive regulation of monocyte chemotactic protein-1 production  (IEA)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of nitric-oxide synthase biosynthetic process  (IEA)
positive regulation of non-canonical NF-kappaB signal transduction  (IEA)
positive regulation of Notch signaling pathway  (IEA)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA,ISO)
positive regulation of phagocytosis  (IEA,ISO)
positive regulation of protein K63-linked ubiquitination  (IEA)
positive regulation of protein ubiquitination  (IEA)
positive regulation of stress-activated MAPK cascade  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of tumor necrosis factor production  (IEA,ISO)
positive regulation of type 2 immune response  (IEA)
positive regulation of xenophagy  (IEA,ISO)
regulation of apoptotic process  (IEA)
regulation of appetite  (IEA)
regulation of inflammatory response  (IEA,ISO)
regulation of neutrophil chemotaxis  (IEA,ISO)
response to endoplasmic reticulum stress  (IEA)
response to exogenous dsRNA  (IEA,ISO)
response to lipopolysaccharide  (IEA,ISO)
response to muramyl dipeptide  (IEA,ISO)
response to nutrient  (ISO)
response to peptidoglycan  (IEA,ISO)
stress-activated MAPK cascade  (IEA,ISO)
temperature homeostasis  (IEA)
toll-like receptor 2 signaling pathway  (IEA,ISO)
xenophagy  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:19604345   PMID:22301074   PMID:22321737   PMID:23600687   PMID:25017709   PMID:25746347   PMID:30947975  


Genomics

Comparative Map Data
NOD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1264,636,850 - 64,667,232 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl264,635,519 - 64,667,232 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha261,209,788 - 61,240,085 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0265,182,339 - 65,218,538 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl265,182,339 - 65,212,649 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1262,006,039 - 62,036,328 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0263,025,931 - 63,056,292 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0263,913,478 - 63,943,824 (-)NCBIUU_Cfam_GSD_1.0
NOD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381650,693,606 - 50,733,075 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1650,693,588 - 50,733,077 (+)EnsemblGRCh38hg38GRCh38
GRCh371650,727,517 - 50,766,986 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361649,288,551 - 49,324,488 (+)NCBINCBI36Build 36hg18NCBI36
Build 341649,288,550 - 49,324,488NCBI
Celera1635,246,377 - 35,282,313 (+)NCBICelera
Cytogenetic Map16q12.1NCBI
HuRef1636,618,016 - 36,653,950 (+)NCBIHuRef
CHM1_11652,138,579 - 52,174,513 (+)NCBICHM1_1
T2T-CHM13v2.01656,491,240 - 56,530,709 (+)NCBIT2T-CHM13v2.0
Nod2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39889,373,943 - 89,415,103 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl889,373,943 - 89,415,102 (+)EnsemblGRCm39 Ensembl
GRCm38888,647,315 - 88,688,474 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl888,647,315 - 88,688,474 (+)EnsemblGRCm38mm10GRCm38
MGSCv37891,171,246 - 91,212,373 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36891,537,452 - 91,578,579 (+)NCBIMGSCv36mm8
Celera892,927,621 - 92,968,882 (+)NCBICelera
Cytogenetic Map8C3NCBI
cM Map843.51NCBI
Nod2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81934,555,832 - 34,596,281 (-)NCBIGRCr8
mRatBN7.21918,382,369 - 18,422,817 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1918,382,439 - 18,417,177 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1920,062,002 - 20,096,735 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01925,256,605 - 25,291,343 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01928,214,380 - 28,249,133 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01919,342,061 - 19,389,366 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1919,332,594 - 19,377,492 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01930,375,065 - 30,409,527 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41919,662,337 - 19,697,341 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11919,670,606 - 19,715,845 (-)NCBI
Celera1918,269,940 - 18,304,004 (-)NCBICelera
Cytogenetic Map19p11NCBI
Nod2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554338,746,004 - 8,782,710 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554338,746,213 - 8,780,119 (+)NCBIChiLan1.0ChiLan1.0
NOD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21860,150,040 - 60,189,509 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11666,055,771 - 66,095,149 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01630,955,976 - 30,995,451 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11649,834,385 - 49,873,783 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1649,837,891 - 49,873,773 (+)Ensemblpanpan1.1panPan2
Nod2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934955,844,066 - 55,881,006 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364753,713,362 - 3,745,982 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364753,708,069 - 3,742,845 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl634,130,938 - 34,177,534 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1634,132,127 - 34,167,446 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NOD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1536,492,158 - 36,531,766 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl536,496,414 - 36,530,499 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604739,970,704 - 40,009,792 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nod2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247575,958,486 - 6,000,103 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247575,956,873 - 6,000,052 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NOD2
357 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001287039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005617571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038657812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038657813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038657814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038657815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038657816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038657817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JF681171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KX868105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KX868106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KX868107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCAFT00000015589   ⟹   ENSCAFP00000014425
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl264,636,850 - 64,667,232 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000062567   ⟹   ENSCAFP00000064029
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl264,635,519 - 64,667,232 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000070587   ⟹   ENSCAFP00000052322
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl264,635,519 - 64,667,232 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000071093   ⟹   ENSCAFP00000046476
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl264,636,850 - 64,667,232 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000072356   ⟹   ENSCAFP00000050978
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl264,635,519 - 64,667,232 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000077000   ⟹   ENSCAFP00000061928
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl264,635,519 - 64,667,232 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845006982   ⟹   ENSCAFP00845005569
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl265,182,339 - 65,212,649 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845007002   ⟹   ENSCAFP00845005585
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl265,182,339 - 65,212,649 (-)Ensembl
RefSeq Acc Id: NM_001287039   ⟹   NP_001273968
RefSeq Status: INFERRED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1264,636,850 - 64,667,232 (-)NCBI
Dog10K_Boxer_Tasha261,209,788 - 61,240,085 (-)NCBI
ROS_Cfam_1.0265,182,339 - 65,212,649 (-)NCBI
UMICH_Zoey_3.1262,006,039 - 62,036,328 (-)NCBI
UNSW_CanFamBas_1.0263,025,931 - 63,056,292 (-)NCBI
UU_Cfam_GSD_1.0263,913,478 - 63,943,824 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038657812   ⟹   XP_038513740
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0265,182,343 - 65,218,538 (-)NCBI
RefSeq Acc Id: XM_038657813   ⟹   XP_038513741
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0265,182,343 - 65,218,538 (-)NCBI
RefSeq Acc Id: XM_038657814   ⟹   XP_038513742
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0265,182,343 - 65,218,538 (-)NCBI
RefSeq Acc Id: XM_038657815   ⟹   XP_038513743
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0265,182,343 - 65,207,024 (-)NCBI
RefSeq Acc Id: XM_038657816   ⟹   XP_038513744
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0265,182,343 - 65,212,322 (-)NCBI
RefSeq Acc Id: XM_038657817   ⟹   XP_038513745
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0265,182,343 - 65,218,515 (-)NCBI
RefSeq Acc Id: NP_001273968   ⟸   NM_001287039
- UniProtKB: A0A8I3MJL0 (UniProtKB/TrEMBL),   A0A8I3MSY5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000014425   ⟸   ENSCAFT00000015589
Ensembl Acc Id: ENSCAFP00000052322   ⟸   ENSCAFT00000070587
Ensembl Acc Id: ENSCAFP00000061928   ⟸   ENSCAFT00000077000
Ensembl Acc Id: ENSCAFP00000064029   ⟸   ENSCAFT00000062567
Ensembl Acc Id: ENSCAFP00000050978   ⟸   ENSCAFT00000072356
Ensembl Acc Id: ENSCAFP00000046476   ⟸   ENSCAFT00000071093
RefSeq Acc Id: XP_038513742   ⟸   XM_038657814
- Peptide Label: isoform X3
- UniProtKB: A0A8I3MSY5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038513741   ⟸   XM_038657813
- Peptide Label: isoform X2
- UniProtKB: A0A8I3MSY5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038513740   ⟸   XM_038657812
- Peptide Label: isoform X1
- UniProtKB: A0A8I3MJL0 (UniProtKB/TrEMBL),   A0A8I3MSY5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038513745   ⟸   XM_038657817
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038513744   ⟸   XM_038657816
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038513743   ⟸   XM_038657815
- Peptide Label: isoform X4
Ensembl Acc Id: ENSCAFP00845005569   ⟸   ENSCAFT00845006982
Ensembl Acc Id: ENSCAFP00845005585   ⟸   ENSCAFT00845007002
Protein Domains
CARD   NACHT   NACHT LRR and PYD   NOD1/2 winged helix


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000009818 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030008448 UniProtKB/TrEMBL
  ENSCAFG00845003875 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000015589.5 UniProtKB/TrEMBL
  ENSCAFT00030015540.1 UniProtKB/TrEMBL
  ENSCAFT00030015624.1 UniProtKB/TrEMBL
  ENSCAFT00030015712.1 UniProtKB/TrEMBL
  ENSCAFT00845006982 ENTREZGENE
  ENSCAFT00845006982.1 UniProtKB/TrEMBL
  ENSCAFT00845007002.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro CARD UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  NACHT_NTPase UniProtKB/TrEMBL
  NLR UniProtKB/TrEMBL
  NLRP_HD2 UniProtKB/TrEMBL
  NLRP_innate_immun_reg UniProtKB/TrEMBL
  NOD2_WH UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report cfa:487286 UniProtKB/TrEMBL
NCBI Gene NOD2 ENTREZGENE
PANTHER NACHT, LRR AND CARD DOMAINS-CONTAINING UniProtKB/TrEMBL
  NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12 UniProtKB/TrEMBL
  NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 14 UniProtKB/TrEMBL
  NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2 UniProtKB/TrEMBL
Pfam CARD UniProtKB/TrEMBL
  LRR_6 UniProtKB/TrEMBL
  NACHT UniProtKB/TrEMBL
  NLRC4_HD2 UniProtKB/TrEMBL
  NOD2_WH UniProtKB/TrEMBL
PROSITE CARD UniProtKB/TrEMBL
  LRR UniProtKB/TrEMBL
  NACHT UniProtKB/TrEMBL
SMART LRR_RI UniProtKB/TrEMBL
Superfamily-SCOP RNI-like UniProtKB/TrEMBL
  SSF47986 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A1L6YTL6_CANLF UniProtKB/TrEMBL
  A0A1L6YTL9_CANLF UniProtKB/TrEMBL
  A0A1L6YTM1_CANLF UniProtKB/TrEMBL
  A0A8C0MLS9_CANLF UniProtKB/TrEMBL
  A0A8C0MPR7_CANLF UniProtKB/TrEMBL
  A0A8C0MS35_CANLF UniProtKB/TrEMBL
  A0A8I3MJL0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MSY5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SET9_CANLF UniProtKB/TrEMBL
  H6BA92_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:43878 ENTREZGENE