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Association of a NOD2 gene polymorphism and T-helper 17 cells with presumed ocular toxoplasmosis.

Authors: Dutra, MS  Bela, SR  Peixoto-Rangel, AL  Fakiola, M  Cruz, AG  Gazzinelli, A  Quites, HF  Bahia-Oliveira, LM  Peixe, RG  Campos, WR  Higino-Rocha, AC  Miller, NE  Blackwell, JM  Antonelli, LR  Gazzinelli, RT 
Citation: Dutra MS, etal., J Infect Dis. 2013 Jan 1;207(1):152-63. doi: 10.1093/infdis/jis640. Epub 2012 Oct 24.
Pubmed: (View Article at PubMed) PMID:23100559
DOI: Full-text: DOI:10.1093/infdis/jis640

Retinochoroiditis manifests in patients infected with Toxoplasma gondii. Here, we assessed 30 sibships and 89 parent/case trios of presumed ocular toxoplasmosis (POT) to evaluate associations with polymorphisms in the NOD2 gene. Three haplotype-tagging single-nucleotide polymorphisms (tag-SNPs) within the NOD2 gene were genotyped. The family-based association test showed that the tag-SNP rs3135499 is associated with retinochoroiditis (P = .039). We then characterized the cellular immune response of 59 cases of POT and 4 cases of active ocular toxoplasmosis (AOT). We found no differences in levels of interferon gamma (IFN-gamma) and interleukin 2 produced by T-helper 1 cells when comparing patients with AOT or POT to asymptomatic individuals. Unexpectedly, we found an increased interleukin 17A (IL-17A) production in patients with POT or OAT. In patients with POT or AOT, the main cellular source of IL-17A was CD4(+)CD45RO(+)T-bet(-)IFN-gamma(-) T-helper 17 cells. Altogether, our results suggest that NOD2 influences the production of IL-17A by CD4(+) T lymphocytes and might contribute to the development of ocular toxoplasmosis.


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RGD Object Information
RGD ID: 8547527
Created: 2014-02-13
Species: All species
Last Modified: 2014-02-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.