RGD Reference Report - Viral infection augments Nod1/2 signaling to potentiate lethality associated with secondary bacterial infections. - Rat Genome Database

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Viral infection augments Nod1/2 signaling to potentiate lethality associated with secondary bacterial infections.

Authors: Kim, YG  Park, JH  Reimer, T  Baker, DP  Kawai, T  Kumar, H  Akira, S  Wobus, C  Nunez, G 
Citation: Kim YG, etal., Cell Host Microbe. 2011 Jun 16;9(6):496-507.
RGD ID: 5508748
Pubmed: PMID:21669398   (View Abstract at PubMed)
PMCID: PMC3125972   (View Article at PubMed Central)
DOI: DOI:10.1016/j.chom.2011.05.006   (Journal Full-text)

Secondary bacterial infection is a common sequela to viral infection and is associated with increased lethality and morbidity. However, the underlying mechanisms remain poorly understood. We show that the TLR3/MDA5 agonist poly I:C or viral infection dramatically augments signaling via the NLRs Nod1 and Nod2 and enhances the production of proinflammatory cytokines. Enhanced Nod1 and Nod2 signaling by poly I:C required the TLR3/MDA5 adaptors TRIF and IPS-1 and was mediated by type I IFNs. Mechanistically, poly I:C or IFN-beta induced the expression of Nod1, Nod2, and the Nod-signaling adaptor Rip2. Systemic administration of poly I:C or IFN-beta or infection with murine norovirus-1 promoted inflammation and lethality in mice superinfected with E. coli, which was independent of bacterial burden but attenuated in the absence of Nod1/Nod2 or Rip2. Thus, crosstalk between type I IFNs and Nod1/Nod2 signaling promotes bacterial recognition, but induces harmful effects in the virally infected host.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
NOD2Humanbacterial infectious disease  ISONod2 (Mus musculus)associated with Virus DiseasesRGD 
Nod2Ratbacterial infectious disease  ISONod2 (Mus musculus)associated with Virus DiseasesRGD 
Nod2Mousebacterial infectious disease  IMP associated with Virus DiseasesRGD 

Objects Annotated

Genes (Rattus norvegicus)
Nod2  (nucleotide-binding oligomerization domain containing 2)

Genes (Mus musculus)
Nod2  (nucleotide-binding oligomerization domain containing 2)

Genes (Homo sapiens)
NOD2  (nucleotide binding oligomerization domain containing 2)


Additional Information