RGD Reference Report - Association of c.802C>T polymorphism of NOD2/CARD15 gene with the chronic gastritis and predisposition to cancer in H. pylori infected patients. - Rat Genome Database

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Association of c.802C>T polymorphism of NOD2/CARD15 gene with the chronic gastritis and predisposition to cancer in H. pylori infected patients.

Authors: Hnatyszyn, A  Szalata, M  Stanczyk, J  Cichy, W  Slomski, R 
Citation: Hnatyszyn A, etal., Exp Mol Pathol. 2010 Jun;88(3):388-93. Epub 2010 Mar 15.
RGD ID: 5508759
Pubmed: PMID:20230816   (View Abstract at PubMed)
DOI: DOI:10.1016/j.yexmp.2010.03.003   (Journal Full-text)

This paper shows analysis of the association of the 802C>T polymorphism of the NOD2/CARD15 gene with the occurrence of the chronic inflammation of the gastric mucosa associated with the Helicobacter pylori infections, development of intestinal metaplasia and dysplasia and, in the result of this, gastric cancer. Genomic DNA samples were extracted from paraffin blocks of gastric mucosal biopsies and from peripheral blood. H. pylori infection was confirmed by histological analysis and urease test. Pyrosequencing of 802C>T polymorphism of the NOD2/CARD15 gene was performed for H. pylori infected patients (131) and population group (100). Analysis of the NOD2/CARD15 gene showed that frequency of the T allele was significantly higher (32.8%) in the group of patients in comparison with the population group (18.1%), with the relative risk of 1.8. In the patient group, the frequency of the CC genotype was 51.1%, CT 32.1% and TT 16.8% (relative risk: 0.7, 1.1 and 4.2, respectively), while in the population group it was 69.0%, 25.7% and 5.3% (relative risk: 1.0, 0.9 and 1.3, respectively). The increasing frequency of the T allele and CT and TT genotypes in the patients with increasingly deeper changes in the gastric mucosa becomes apparent. Our findings suggest that polymorphism 802C>T is associated with changes in gastric mucosa and plays a significant role in the initiation and the progression of carcinogenesis. The number of observed mutations in gastric mucosa correlated with severity of disease.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
NOD2Humangastritis  IAGP associated with Helicobacter Infections and DNA:SNP: :c.802C>T (human)RGD 
Nod2Ratgastritis  ISONOD2 (Homo sapiens)associated with Helicobacter Infections and DNA:SNP: :c.802C>T (human)RGD 
Nod2Mousegastritis  ISONOD2 (Homo sapiens)associated with Helicobacter Infections and DNA:SNP: :c.802C>T (human)RGD 
NOD2Humangastrointestinal carcinoma  IAGP associated with Helicobacter Infections and DNA:SNP: :c.802C>T (human)RGD 
Nod2Ratgastrointestinal carcinoma  ISONOD2 (Homo sapiens)associated with Helicobacter Infections and DNA:SNP: :c.802C>T (human)RGD 
Nod2Mousegastrointestinal carcinoma  ISONOD2 (Homo sapiens)associated with Helicobacter Infections and DNA:SNP: :c.802C>T (human)RGD 
NOD2HumanMetaplasia  IAGP associated with Helicobacter Infections and DNA:SNP: :c.802C>T (human)RGD 
Nod2RatMetaplasia  ISONOD2 (Homo sapiens)associated with Helicobacter Infections and DNA:SNP: :c.802C>T (human)RGD 
Nod2MouseMetaplasia  ISONOD2 (Homo sapiens)associated with Helicobacter Infections and DNA:SNP: :c.802C>T (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Nod2  (nucleotide-binding oligomerization domain containing 2)

Genes (Mus musculus)
Nod2  (nucleotide-binding oligomerization domain containing 2)

Genes (Homo sapiens)
NOD2  (nucleotide binding oligomerization domain containing 2)


Additional Information