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Association of CARD15 polymorphisms with atopy-related traits in a population-based cohort of Caucasian adults.

Authors: Weidinger, S  Klopp, N  Rummler, L  Wagenpfeil, S  Baurecht, HJ  Gauger, A  Darsow, U  Jakob, T  Novak, N  Schafer, T  Heinrich, J  Behrendt, H  Wichmann, HE  Ring, J  Illig, T  Illig, T 
Citation: Weidinger S, etal., Clin Exp Allergy. 2005 Jul;35(7):866-72.
Pubmed: (View Article at PubMed) PMID:16008671
DOI: Full-text: DOI:10.1111/j.1365-2222.2005.02269.x

BACKGROUND: Influences of microbial pathogens are crucial for the maturation of the immune system. Caspase-recruitment domain containing protein 15 (CARD15) is a cytosolic receptor involved in bacterial recognition by antigen-presenting cells. CARD15 polymorphisms have been associated with Crohn's disease. Recently, associations with atopic phenotypes have been reported in children. OBJECTIVE: Within a large population of German adults (n=1875), we evaluated eight CARD15 polymorphisms for associations with atopic phenotypes. METHODS: Subjects were phenotyped by standardized questionnaires and interviews as well as total and allergen-specific IgE measurements. Genotyping was performed using matrix-assisted laser desorption ionization--time of flight mass spectrometry. Haplotypes were estimated using the SAS/Genetics module. RESULTS: Subjects with a T allele at rs1077861 had a decreased risk of developing asthma (odds ratio OR=0.648, P=0.013), whereas the presence of an A allele at rs3135500 was significantly associated with an increased risk (OR=1.374, P=0.023). In addition, a CARD15 haplotype revealed to be protective against the development of asthma (OR=0.326, P=0.003). Subjects with an A allele at position rs5743266 or a T allele at rs2066842 had a significantly decreased risk of developing allergic rhinoconjunctivitis with ORs of 0.820 (P=0.049) and 0.801 (P=0.025). Polymorphism rs2066845 showed a significant association with increased total serum IgE (OR=2.155, P=0.006). CONCLUSION: Genetic variants of CARD15 that might result in inappropriate immunomodulation are not only associated with autoimmune diseases but also with atopic disorders.


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RGD Object Information
RGD ID: 5131477
Created: 2011-04-29
Species: All species
Last Modified: 2011-04-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.