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Contribution of NOD2 to lung inflammation during Staphylococcus aureus-induced pneumonia.

Authors: Kapetanovic, R  Jouvion, G  Fitting, C  Parlato, M  Blanchet, C  Huerre, M  Cavaillon, JM  Adib-Conquy, M 
Citation: Kapetanovic R, etal., Microbes Infect. 2010 Sep;12(10):759-67. Epub 2010 May 21.
Pubmed: (View Article at PubMed) PMID:20493961
DOI: Full-text: DOI:10.1016/j.micinf.2010.05.003

Staphylococcus aureus is the most commonly found Gram-positive bacterium in patients admitted in intensive-care units, causing septicaemia or pneumonia. In this work, we investigated the role of NOD2 in S. aureus-induced pneumonia. We found that the absence of NOD2 affected weight loss and recovery speed. Nod2-/- mice showed a reduced lung inflammation in comparison to wild-type animals, with lower presence of cytokines in broncho-alveolar lavage fluids and reduced recruitment of neutrophils. Furthermore, histological analysis of the lungs revealed less severe lesions in Nod2-/- mice at day 2 and day 7 post-infection. In conclusion, we demonstrated that NOD2 is not a crucial receptor to fight S. aureus-induced pneumonia, but that it contributes to the inflammatory response in the lungs. Interestingly, the absence of NOD2 led to a lesser inflammation and was finally beneficial for the animal recovery.

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RGD ID: 5131444
Created: 2011-04-27
Species: All species
Last Modified: 2011-04-27
Status: ACTIVE



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