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Low prevalence of NOD2 SNPs in Behcet's disease suggests protective association in Caucasians.

Authors: Kappen, JH  Wallace, GR  Stolk, L  Rivadeneira, F  Uitterlinden, AG  Van Daele, PL  Laman, JD  Kuijpers, RW  Baarsma, GS  Stanford, MR  Fortune, F  Madanat, W  Van Hagen, PM  Van Laar, JA 
Citation: Kappen JH, etal., Rheumatology (Oxford). 2009 Nov;48(11):1375-7. doi: 10.1093/rheumatology/kep292. Epub 2009 Sep 11.
Pubmed: (View Article at PubMed) PMID:19748964
DOI: Full-text: DOI:10.1093/rheumatology/kep292

OBJECTIVE: It has been shown previously that three nucleotide-binding oligomerization domain containing 2 (NOD2) variants (Arg702Trp, Gly908Arg and Lue1007fs) are associated with Crohn's disease (CD), a disorder clinically resembling Behcet's disease (BD). We studied the frequency of these variants in BD patients. METHODS: DNA samples of 200 BD patients [59 Caucasians, 139 Middle Easterns (MEs) of Arab descent and 2 Asians] and 520 healthy controls (444 Caucasians and 76 MEs) were genotyped using a Taqman assay. RESULTS: Both the Arg702Trp and Leu1007fs (frameshift) variants were significantly less frequently present among BD patients compared with healthy controls (0.5 vs 5.8%; P < 1.10(-5) and 0.0 vs 1.8%; P < 0.007, respectively). In the Caucasian subpopulation, Arg702Trp was significantly less frequent in the BD group as compared with the controls (P = 0.04); whereas in the ME subpopulation, a trend was observed (P < 0.06). CONCLUSIONS: Of the three CD-associated single nucleotide polymorphisms, one of the variant NOD2 alleles, was found to be present significantly less in Caucasian BD patients.


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RGD Object Information
RGD ID: 8158059
Created: 2014-02-06
Species: All species
Last Modified: 2014-02-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.