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The 3020insC Allele of NOD2 Predisposes to Cancers of Multiple Organs.

Authors: Lubinski, J  Huzarski, T  Kurzawski, G  Suchy, J  Masojc, B  Mierzejewski, M  Lener, M  Domagala, W  Chosia, M  Teodorczyk, U  Medrek, K  Debniak, T  Zlowocka, E  Gronwald, J  Byrski, T  Grabowska, E  Nej, K  Szymanska, A  Szymanska, J  Matyjasik, J  Cybulski, C  Jakubowska, A  Gorski, B  Narod, SA 
Citation: Lubinski J, etal., Hered Cancer Clin Pract. 2005 Mar 15;3(2):59-63.
Pubmed: (View Article at PubMed) PMID:20223031
DOI: Full-text: DOI:10.1186/1897-4287-3-2-59

ABSTRACT: The NOD2 gene has been associated with susceptibility to Crohn's disease and individuals with Crohn's disease are at increased risk for cancer at a number of organ sites. We studied the association between the 3020insC allele of the NOD2 gene and cancer among 2604 cancer patients and 1910 controls from Poland. Patients were diagnosed with one of twelve types of cancer in the Szczecin region between 1994 and 2004. Significant associations were found for colon cancer (OR = 1.8; 95% CI 1.2 to 2.6), for lung cancer (OR = 1.7; 95% CI = 1.1 to 2.5) and for ovarian cancer (OR = 1.6; 95% CI 1.1 to 2.3). In addition, a significant association was found for early-onset laryngeal cancer (OR = 2.9; 95% CI 1.4 to 6.2) and for breast cancer in the presence of DCIS (OR = 2.1 95% CI = 1.2 to 3.6). The NOD2 3020insC allele is relatively common (in Poland 7.3% of individuals) and may be responsible for an important fraction of cancer cases. We estimate that the lifetime cancer risk among carriers of this allele is 30% higher than that of individuals with two wild-type alleles.


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RGD Object Information
RGD ID: 5131515
Created: 2011-05-02
Species: All species
Last Modified: 2011-05-02
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.