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Recipient NOD2/CARD15 variants: a novel independent risk factor for the development of bronchiolitis obliterans after allogeneic stem cell transplantation.

Authors: Hildebrandt, GC  Granell, M  Urbano-Ispizua, A  Wolff, D  Hertenstein, B  Greinix, HT  Brenmoehl, J  Schulz, C  Dickinson, AM  Hahn, J  Rogler, G  Andreesen, R  Holler, E 
Citation: Hildebrandt GC, etal., Biol Blood Marrow Transplant. 2008 Jan;14(1):67-74.
Pubmed: (View Article at PubMed) PMID:18158963
DOI: Full-text: DOI:10.1016/j.bbmt.2007.09.009

Bronchiolitis obliterans (BO) is a serious complication after allogeneic stem cell transplantation. We hypothesized that single nucleotide polymorphisms (SNPs) of the NOD2/CARD15 gene (=NOD2/CARD15 variants) contribute to changes in host defense and subsequent alloreaction, leading to BO. We analyzed 427 donor-recipient pairs for the association of NOD2/CARD15 variants (SNP8 [Arg702Trp], SNP12 [Gly908Arg], and SNP13 [Leu1007fsinsC]) with BO occurrence. Overall, 11 patients (2.6%) developed BO. The cumulative incidence of BO rose from 1.3% in donor-recipient pairs without mutation to 18.7% in pairs with donor or recipient NOD2/CARD15 variants (P < .001). Recipient NOD2/CARD15 variants alone led to BO in 22.3% (P < .001), whereas donor variants alone associated with BO in 13.2% (P = .04). Multivariate analysis proved recipient but not donor NOD2/CARD15 variants to be a novel independent risk factor for BO development, and NOD2/CARD15 typing may help identify patients at increased risk for BO.


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RGD Object Information
RGD ID: 5131450
Created: 2011-04-27
Species: All species
Last Modified: 2011-04-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.