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Common nonsynonymous polymorphisms in the NOD2 gene are associated with resistance or susceptibility to tuberculosis disease in African Americans.

Authors: Austin, CM  Ma, X  Graviss, EA 
Citation: Austin CM, etal., J Infect Dis. 2008 Jun 15;197(12):1713-6.
Pubmed: (View Article at PubMed) PMID:18419343
DOI: Full-text: DOI:10.1086/588384

Pattern-recognition receptors (PRRs) play a key role in innate immunity against intracellular bacteria. NOD2 is one of the PRRs that contribute to the immune response to Mycobacterium tuberculosis infection. We sequenced coding regions of the NOD2 gene in 377 African Americans with tuberculosis (TB) disease and 187 ethnically matched control subjects. Three common nonsynonymous single-nucleotide polymorphisms--Pro268Ser, Arg702Trp, and Ala725Gly--demonstrated significant associations with TB disease. This finding may contribute to the future development of immunotherapy and immunoprophylaxis for TB disease.


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RGD Object Information
RGD ID: 5131510
Created: 2011-05-02
Species: All species
Last Modified: 2011-05-02
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.