PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: cholesterol biosynthetic pathway
Accession: PW:0000454
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Definition: Those metabolic reactions involved in the synthesis of cholesterol, an essential sterol component of mammalian cell membrane. Cholesterol is the precursor of all steroid hormones.
Synonyms: related_synonym: Cholesterol biosynthesis; cholesterol biosynthetic process
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Acat2
acetyl-CoA acetyltransferase 2
ISO
SMPDB RGD
PMID:16876788
SMP:00023, RGD:2316857
NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821
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Cyp51
cytochrome P450, family 51
ISO IDA
SMPDB RGD
PMID:16876788 PMID:12668600 PMID:7581240
SMP:00023, RGD:2316857 , RGD:2316868 , RGD:2316902
NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
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Dhcr24
24-dehydrocholesterol reductase
ISO
SMPDB RGD
PMID:16876788 PMID:12668600
SMP:00023, RGD:2316857 , RGD:2316868
NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137
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Dhcr7
7-dehydrocholesterol reductase
ISO IMP
RGD
PMID:16876788 PMID:12668600 PMID:9831636
RGD:2316857 , RGD:2316868 , RGD:2316918
NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
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Ebp
EBP, cholestenol delta-isomerase
ISO
SMPDB RGD
PMID:16876788 PMID:12668600
SMP:00023, RGD:2316857 , RGD:2316868
NCBI chr X:14,299,427...14,305,826
Ensembl chr X:14,299,448...14,305,826
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Fdft1
farnesyl diphosphate farnesyl transferase 1
IMP ISO
SMPDB RGD
PMID:16440058 PMID:16876788
SMP:00023, RGD:1626611 , RGD:2316857
NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
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Fdps
farnesyl diphosphate synthase
ISO
SMPDB RGD
PMID:16876788
SMP:00023, RGD:2316857
NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
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Ggps1
geranylgeranyl diphosphate synthase 1
ISO
SMPDB
SMP:00023
NCBI chr17:51,263,262...51,282,471
Ensembl chr17:51,263,263...51,276,220
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Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
ISO
SMPDB RGD
PMID:16876788
SMP:00023, RGD:2316857
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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Hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1
ISO
SMPDB RGD
PMID:16876788
SMP:00023, RGD:2316857
NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
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Hsd17b7
hydroxysteroid (17-beta) dehydrogenase 7
ISO
SMPDB
SMP:00023
NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017
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Idi1
isopentenyl-diphosphate delta isomerase 1
ISO
SMPDB RGD
PMID:16876788
SMP:00023, RGD:2316857
NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
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Lbr
lamin B receptor
ISO
RGD
PMID:16876788 PMID:12668600
RGD:2316857 , RGD:2316868
NCBI chr13:93,539,386...93,564,026
Ensembl chr13:93,538,920...93,564,017
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Lipa
lipase A, lysosomal acid type
ISO
SMPDB
SMP:00023
NCBI chr 1:232,024,351...232,057,735
Ensembl chr 1:232,024,356...232,057,633
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Lss
lanosterol synthase
IMP ISO IDA
SMPDB RGD
PMID:16440058 PMID:16876788 PMID:1429550
SMP:00023, RGD:1626611 , RGD:2316857 , RGD:2316919
NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
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Msmo1
methylsterol monooxygenase 1
ISO
SMPDB
SMP:00023
NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
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Mvd
mevalonate diphosphate decarboxylase
ISO
SMPDB RGD
PMID:16876788
SMP:00023, RGD:2316857
NCBI chr19:50,496,366...50,506,429
Ensembl chr19:50,496,367...50,507,971
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Mvk
mevalonate kinase
ISO
SMPDB RGD
PMID:16876788
SMP:00023, RGD:2316857
NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882
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Nsdhl
NAD(P) dependent steroid dehydrogenase-like
ISO
SMPDB RGD
PMID:16876788 PMID:12668600
SMP:00023, RGD:2316857 , RGD:2316868
NCBI chr X:150,775,034...150,807,161
Ensembl chr X:150,775,080...150,807,142
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Pmvk
phosphomevalonate kinase
ISO
SMPDB RGD
PMID:16876788
SMP:00023, RGD:2316857
NCBI chr 2:174,876,586...174,886,365
Ensembl chr 2:174,876,657...174,886,364
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Sc5d
sterol-C5-desaturase
ISO IDA
SMPDB RGD
PMID:16876788 PMID:12668600 PMID:7961720
SMP:00023, RGD:2316857 , RGD:2316868 , RGD:2316911
NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273
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Soat1
sterol O-acyltransferase 1
ISO
SMPDB
SMP:00023
NCBI chr13:68,552,274...68,597,529
Ensembl chr13:68,552,317...68,597,494
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Sqle
squalene epoxidase
ISO
SMPDB RGD
PMID:16876788
SMP:00023, RGD:2316857
NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618
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Tm7sf2
transmembrane 7 superfamily member 2
ISO
SMPDB
SMP:00023
NCBI chr 1:203,355,930...203,360,287
Ensembl chr 1:203,355,931...203,360,270
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