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ONTOLOGY REPORT - ANNOTATIONS

Term:pyroptotic inflammatory response
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Accession:GO:0070269 term browser browse the term
Definition:A gasdermin-dependent inflammatory response that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18. Gasdermins are activated by caspase-1 or caspase-4/11, or by certain granzymes. In some, but not all cells, it can lead to pyroptotic programmed cell death.
Synonyms:broad_synonym: pyroptosis


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pyroptotic inflammatory response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aim2 absent in melanoma 2 involved_in ISO (PMID:19158675), (PMID:19158676)
(MGI:3839523|PMID:19158676), (MGI:5807418|PMID:27846608), (MGI:6101070|PMID:29033131), (MGI:6445914|PMID:32350463), (MGI:6713897|PMID:34006824)		 RGD PMID:19158675 PMID:19158676 PMID:27846608 PMID:29033131 PMID:32350463 More... MGI:3839523 MGI:5807418 MGI:6101070 MGI:6445914 MGI:6713897 NCBI chr13:85,865,206...85,906,996
Ensembl chr13:85,866,284...85,906,975 		JBrowse link
G Apip APAF1 interacting protein involved_in ISO (PMID:24367089) RGD PMID:24367089 NCBI chr 3:89,431,964...89,458,000
Ensembl chr 3:89,432,037...89,458,340 		JBrowse link
G Casp1 caspase 1 involved_in
acts_upstream_of_or_within		 ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:32109412), (PMID:32553275)
(MGI:6716955|PMID:21147462)
MGI:2158744 (PMID:22002608)		 UniProt
Ensembl
RGD		 PMID:21147462 PMID:22002608 PMID:32109412 PMID:32553275 GO_REF:0000024 GO_REF:0000107 MGI:6716955 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 involved_in ISO (PMID:36426955) RGD PMID:36426955 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp4 caspase 4 involved_in
acts_upstream_of_or_within		 ISO (MGI:5468357|PMID:23348507), (MGI:6201935|PMID:30135078), (MGI:6467703|PMID:32109412), (MGI:6865810|PMID:34671164), (MGI:7432483|PMID:30589883)
MGI:5468949 (PMID:22002608)
(PMID:31268602), (PMID:32109412), (PMID:34671164)		 RGD PMID:22002608 PMID:23348507 PMID:30135078 PMID:30589883 PMID:31268602 More... MGI:5468357 MGI:6201935 MGI:6467703 MGI:6865810 MGI:7432483 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Casp6 caspase 6 involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:32298652)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:32298652 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Casp8 caspase 8 involved_in ISS
ISO		 GO_REF:0000024
(MGI:6270017|PMID:30361383), (MGI:6401035|PMID:31748744)		 UniProt
RGD		 PMID:30361383 PMID:31748744 GO_REF:0000024 MGI:6270017 MGI:6401035 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Dhx9 DExH-box helicase 9 involved_in ISO (MGI:5908739|PMID:28636595) RGD PMID:28636595 MGI:5908739 NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069 		JBrowse link
G Dpp9 dipeptidyl peptidase 9 acts_upstream_of_negative_effect ISO (PMID:33731929), (PMID:34019797) RGD PMID:33731929 PMID:34019797 NCBI chr 9:1,011,347...1,046,337
Ensembl chr 9:1,011,351...1,046,541 		JBrowse link
G Gsdma gasdermin A involved_in ISO
IBA		 (PMID:35110732), (PMID:35545676)
GO_REF:0000033		 RGD
GO_Central		 PMID:35110732 PMID:35545676 GO_REF:0000033 NCBI chr10:83,614,336...83,639,543
Ensembl chr10:83,627,051...83,639,543 		JBrowse link
G Gsdmc gasdermin C involved_in ISO
IBA		 (PMID:32929201), (PMID:34012073)
GO_REF:0000033		 RGD
GO_Central		 PMID:32929201 PMID:34012073 GO_REF:0000033 NCBI chr 7:95,594,015...95,606,106
Ensembl chr 7:95,594,015...95,611,344 		JBrowse link
G Gsdmd gasdermin D involved_in ISO
IBA		 (MGI:5751630|PMID:26611636), (MGI:6467699|PMID:29576317), (MGI:6467703|PMID:32109412), (MGI:6467707|PMID:32553275), (MGI:6467712|PMID:32820063), (PMID:27383986), (PMID:35705808)
GO_REF:0000033
(PMID:32109412), (PMID:33883744)
(PMID:28392147), (PMID:30361383)
(PMID:36227980)		 RGD
GO_Central		 PMID:26611636 PMID:27383986 PMID:28392147 PMID:29576317 PMID:30361383 More... GO_REF:0000033 MGI:5751630 MGI:6467699 MGI:6467703 MGI:6467707 MGI:6467712 NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055 		JBrowse link
G Gsdmdl1 gasdermin D like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:95,620,052...95,630,546
Ensembl chr 7:95,620,061...95,630,532 		JBrowse link
G Gsdme gasdermin E involved_in ISO (PMID:31953257), (PMID:32188940)
(MGI:5901785|PMID:28045099)
(PMID:28459430)
(PMID:33852854), (PMID:35594856)		 RGD PMID:28045099 PMID:28459430 PMID:31953257 PMID:32188940 PMID:33852854 More... MGI:5901785 NCBI chr 4:79,258,799...79,321,129
Ensembl chr 4:79,257,804...79,320,806 		JBrowse link
G Gzma granzyme A involved_in ISO (PMID:32299851) RGD PMID:32299851 NCBI chr 2:44,740,569...44,752,502
Ensembl chr 2:44,740,569...44,752,493 		JBrowse link
G Gzmb granzyme B involved_in ISS
ISO		 GO_REF:0000024
(PMID:32188940)		 UniProt
RGD		 PMID:32188940 GO_REF:0000024 NCBI chr15:30,343,352...30,346,814
Ensembl chr15:30,173,603...30,346,814 		JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 involved_in ISO (PMID:36426955) RGD PMID:36426955 NCBI chr 6:122,590,461...122,596,996
Ensembl chr 6:122,590,472...122,779,294 		JBrowse link
G Map3k20 mitogen-activated protein kinase kinase kinase 20 acts_upstream_of_positive_effect ISS
ISO		 GO_REF:0000024
(PMID:35857590)		 UniProt
RGD		 PMID:35857590 GO_REF:0000024 NCBI chr 3:57,130,539...57,289,943
Ensembl chr 3:57,130,551...57,289,626 		JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 involved_in ISO
IBA		 (MGI:5289703|PMID:21874021)
GO_REF:0000033		 RGD
GO_Central		 PMID:21874021 GO_REF:0000033 MGI:5289703 NCBI chr 2:31,507,423...31,559,098
Ensembl chr 2:31,507,424...31,570,542 		JBrowse link
G Ninj1 ninjurin 1 involved_in ISO (MGI:7410598|PMID:36468682), (MGI:7510059|PMID:37196676), (MGI:7510060|PMID:37198476) RGD PMID:36468682 PMID:37196676 PMID:37198476 MGI:7410598 MGI:7510059 MGI:7510060 NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704 		JBrowse link
G Nlrc4 NLR family, CARD domain containing 4 involved_in ISO
ISS		 (MGI:3662989|PMID:16648853), (MGI:3662990|PMID:16648852), (MGI:5289703|PMID:21874021), (MGI:5428366|PMID:22484733), (MGI:5444805|PMID:22885697)
GO_REF:0000024		 RGD
UniProt		 PMID:16648852 PMID:16648853 PMID:21874021 PMID:22484733 PMID:22885697 GO_REF:0000024 MGI:3662989 MGI:3662990 MGI:5289703 MGI:5428366 MGI:5444805 NCBI chr 6:20,991,785...21,018,254
Ensembl chr 6:20,995,266...21,018,248 		JBrowse link
G Nlrp1a NLR family, pyrin domain containing 1A involved_in ISO (PMID:33093214)
(PMID:33731929)		 RGD PMID:33093214 PMID:33731929 NCBI chr10:55,778,560...55,833,639
Ensembl chr10:55,778,560...55,825,180 		JBrowse link
G Nlrp6 NLR family, pyrin domain containing 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:30248149)
(MGI:6833928|PMID:34678144)		 Ensembl
RGD		 PMID:30248149 PMID:34678144 GO_REF:0000107 MGI:6833928 NCBI chr 1:196,004,854...196,011,615
Ensembl chr 1:196,004,953...196,011,113 		JBrowse link
G Nlrp9 NLR family, pyrin domain containing 9 involved_in ISO (MGI:5908739|PMID:28636595) RGD PMID:28636595 MGI:5908739 NCBI chr 1:68,291,180...68,341,512
Ensembl chr 1:68,291,180...68,341,512 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 acts_upstream_of_or_within_negative_effect ISO (MGI:6391726|PMID:29887864) RGD PMID:29887864 MGI:6391726 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
G Trim21 tripartite motif-containing 21 involved_in ISO (PMID:36426955) RGD PMID:36426955 NCBI chr 1:156,964,896...156,987,504
Ensembl chr 1:156,964,913...156,987,440 		JBrowse link
G Zbp1 Z-DNA binding protein 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:6442612|PMID:27917412), (MGI:6453154|PMID:32350114), (MGI:6490907|PMID:33109609)		 UniProt
RGD		 PMID:27917412 PMID:32350114 PMID:33109609 GO_REF:0000024 MGI:6442612 MGI:6453154 MGI:6490907 NCBI chr 3:161,993,351...162,009,297
Ensembl chr 3:161,993,351...162,003,870 		JBrowse link
G Zeb2 zinc finger E-box binding homeobox 2 IDA RGD PMID:34852714 RGD:155882542 NCBI chr 3:29,214,581...29,344,890
Ensembl chr 3:29,218,301...29,345,157 		JBrowse link
cytotoxic T cell pyroptotic cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gzma granzyme A involved_in ISO (PMID:32299851) RGD PMID:32299851 NCBI chr 2:44,740,569...44,752,502
Ensembl chr 2:44,740,569...44,752,493 		JBrowse link
negative regulation of pyroptotic inflammatory response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir223 microRNA 223 involved_in ISO (PMID:34637033) RGD PMID:34637033 NCBI chr  X:61,141,887...61,141,996
Ensembl chr  X:61,141,887...61,141,996 		JBrowse link
positive regulation of pyroptotic inflammatory response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 involved_in ISO (PMID:28459430), (PMID:33852854), (PMID:35594856) RGD PMID:28459430 PMID:33852854 PMID:35594856 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Gbp1 guanylate binding protein 1 involved_in ISO (MGI:5565107|PMID:24715728)
(PMID:31268602)		 RGD PMID:24715728 PMID:31268602 MGI:5565107 NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131
Ensembl chr 2:231,398,163...231,432,131 		JBrowse link
G Gbp2 guanylate binding protein 2 involved_in ISO
IEA
ISS		 (MGI:5565107|PMID:24715728), (MGI:5774627|PMID:25774716), (MGI:5774628|PMID:25774715), (MGI:7432484|PMID:30062052)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:24715728 PMID:25774715 PMID:25774716 PMID:30062052 GO_REF:0000024 GO_REF:0000107 MGI:5565107 MGI:5774627 MGI:5774628 MGI:7432484 NCBI chr 2:231,332,488...231,348,573
Ensembl chr 2:231,332,284...231,348,571 		JBrowse link
G Gbp4 guanylate binding protein 4 involved_in ISO (MGI:5565107|PMID:24715728) RGD PMID:24715728 MGI:5565107 NCBI chr 2:231,304,910...231,318,883
Ensembl chr 2:231,305,244...231,318,879 		JBrowse link
G Gbp5 guanylate binding protein 5 involved_in ISO (MGI:5565107|PMID:24715728), (MGI:5774627|PMID:25774716), (MGI:5774628|PMID:25774715), (MGI:7432483|PMID:30589883) RGD PMID:24715728 PMID:25774715 PMID:25774716 PMID:30589883 MGI:5565107 MGI:5774627 MGI:5774628 MGI:7432483 NCBI chr 2:231,237,748...231,257,071
Ensembl chr 2:231,237,748...231,257,061 		JBrowse link
G Nlrp1a NLR family, pyrin domain containing 1A involved_in IMP
IEA		 GO_REF:0000117 UniProt
RGD		 PMID:24626226 GO_REF:0000117, RGD:38549348 NCBI chr10:55,778,560...55,833,639
Ensembl chr10:55,778,560...55,825,180 		JBrowse link
G Nlrp1b NLR family, pyrin domain containing 1B involved_in IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr10:55,838,381...55,904,374
Ensembl chr10:55,843,001...55,912,774 		JBrowse link
G Nod1 nucleotide-binding oligomerization domain containing 1 involved_in IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr 4:84,060,871...84,111,668
Ensembl chr 4:84,060,880...84,111,404 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 involved_in IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177 		JBrowse link
G Zdhhc5 zinc finger DHHC-type palmitoyltransferase 5 involved_in ISO
ISS		 (PMID:38530158)
(PMID:38530158), (PMID:38599239)
GO_REF:0000024		 RGD
UniProt		 PMID:38530158 PMID:38599239 GO_REF:0000024 NCBI chr 3:69,772,037...69,800,142
Ensembl chr 3:69,771,890...69,799,921 		JBrowse link
G Zdhhc9 zinc finger DHHC-type palmitoyltransferase 9 involved_in ISO (PMID:38530158)
(PMID:38530158), (PMID:38599239)		 RGD PMID:38530158 PMID:38599239 NCBI chr  X:127,352,340...127,388,245
Ensembl chr  X:127,352,345...127,388,245 		JBrowse link
pyroptotic cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp4 caspase 4 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Gsdmd gasdermin D involved_in ISO (PMID:27339137), (PMID:27383986), (PMID:38632402)
(PMID:32109412), (PMID:33883744), (PMID:38632402)
(PMID:36227980)
(PMID:32820063), (PMID:38530158), (PMID:38599239)		 RGD PMID:27339137 PMID:27383986 PMID:32109412 PMID:32820063 PMID:33883744 More... NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055 		JBrowse link
G Gsdme gasdermin E involved_in ISO
IEA		 (PMID:32188940), (PMID:33852854), (PMID:35594856)
GO_REF:0000107		 RGD
Ensembl		 PMID:32188940 PMID:33852854 PMID:35594856 GO_REF:0000107 NCBI chr 4:79,258,799...79,321,129
Ensembl chr 4:79,257,804...79,320,806 		JBrowse link
G Ninj1 ninjurin 1 involved_in ISO
IEA		 (PMID:36468682), (PMID:37196676), (PMID:37198476), (PMID:38614101)
GO_REF:0000107		 RGD
Ensembl		 PMID:36468682 PMID:37196676 PMID:37198476 PMID:38614101 GO_REF:0000107 NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20115
    response to stimulus 10591
      response to stress 4211
        defense response 1879
          inflammatory response 866
            pyroptotic inflammatory response 38
              negative regulation of pyroptotic inflammatory response 1
              positive regulation of pyroptotic inflammatory response 11
              pyroptotic cell death + 5
paths to the root