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ONTOLOGY REPORT - ANNOTATIONS

Term:pyroptosis
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Accession:GO:0070269 term browser browse the term
Definition:A caspase-1-dependent cell death subroutine that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18.


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pyroptosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aim2 absent in melanoma 2 involved_in ISO (PMID:19158675), (PMID:19158676)
(MGI:3839523|PMID:19158676)		 RGD PMID:19158675 PMID:19158676 MGI:3839523 NCBI chr13:85,865,206...85,906,996
Ensembl chr13:85,866,284...85,906,975 		JBrowse link
G Apip APAF1 interacting protein involved_in ISO (PMID:24367089) RGD PMID:24367089 NCBI chr 3:89,431,973...89,457,999
Ensembl chr 3:89,432,037...89,458,340 		JBrowse link
G Casp1 caspase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO
ISS		 GO_REF:0000107
(MGI:5751630|PMID:26611636), (MGI:6716955|PMID:21147462)
MGI:2158744 (MGI:5468674|PMID:22002608)
GO_REF:0000024
(PMID:32109412), (PMID:32553275)		 Ensembl
RGD
UniProt		 PMID:21147462 PMID:22002608 PMID:26611636 PMID:32109412 PMID:32553275 GO_REF:0000024 GO_REF:0000107 MGI:5468674 MGI:5751630 MGI:6716955 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp4 caspase 4 involved_in
acts_upstream_of_or_within		 ISO (PMID:32109412)
(MGI:5468357|PMID:23348507), (MGI:6467703|PMID:32109412), (MGI:6865810|PMID:34671164)
(PMID:32109412), (PMID:34671164)
(MGI:6467703|PMID:32109412)
MGI:5468949 (MGI:5468674|PMID:22002608)		 RGD PMID:22002608 PMID:23348507 PMID:32109412 PMID:34671164 MGI:5468357 MGI:5468674 MGI:6467703 MGI:6865810 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Casp6 caspase 6 involved_in ISO
ISS		 (PMID:32298652)
GO_REF:0000024		 RGD
UniProt		 PMID:32298652 GO_REF:0000024 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Casp8 caspase 8 involved_in ISS
ISO		 GO_REF:0000024
(MGI:6270017|PMID:30361383), (MGI:6401035|PMID:31748744)		 UniProt
RGD		 PMID:30361383 PMID:31748744 GO_REF:0000024 MGI:6270017 MGI:6401035 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Dhx9 DExH-box helicase 9 involved_in ISO (MGI:5908739|PMID:28636595) RGD PMID:28636595 MGI:5908739 NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069 		JBrowse link
G Dpp9 dipeptidyl peptidase 9 acts_upstream_of_negative_effect ISO (PMID:33731929), (PMID:34019797) RGD PMID:33731929 PMID:34019797 NCBI chr 9:1,011,347...1,046,337
Ensembl chr 9:1,011,351...1,046,541 		JBrowse link
G Gsdma gasdermin A involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:83,614,336...83,639,543
Ensembl chr10:83,627,051...83,639,543 		JBrowse link
G Gsdmc gasdermin C involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:95,594,015...95,606,106
Ensembl chr 7:95,594,015...95,611,344 		JBrowse link
G Gsdmd gasdermin D involved_in IBA
ISO		 PMID:21873635
(PMID:28392147), (PMID:30361383), (PMID:32109412), (PMID:32820063), (PMID:33883744)
(MGI:5751630|PMID:26611636), (MGI:5789813|PMID:27339137), (MGI:5796057|PMID:27383986), (MGI:6467699|PMID:29576317), (MGI:6467703|PMID:32109412), (MGI:6467707|PMID:32553275), (MGI:6467712|PMID:32820063)		 RGD PMID:26611636 PMID:27339137 PMID:27383986 PMID:28392147 PMID:29576317 More... MGI:5751630 MGI:5789813 MGI:5796057 MGI:6467699 MGI:6467703 MGI:6467707 MGI:6467712, RGD:13792537 NCBI chr 7:107,542,242...107,547,052
Ensembl chr 7:107,542,083...107,547,055 		JBrowse link
G Gsdme gasdermin E involved_in ISO (PMID:28459430)
(PMID:31953257), (PMID:32188940)		 RGD PMID:28459430 PMID:31953257 PMID:32188940 NCBI chr 4:79,258,799...79,321,129
Ensembl chr 4:79,257,804...79,320,806 		JBrowse link
G Gzma granzyme A involved_in ISO (PMID:32299851) RGD PMID:32299851 NCBI chr 2:44,740,638...44,752,471
Ensembl chr 2:44,740,569...44,752,493 		JBrowse link
G Gzmb granzyme B involved_in ISS
ISO		 GO_REF:0000024
(PMID:32188940)		 UniProt
RGD		 PMID:32188940 GO_REF:0000024 NCBI chr15:30,343,361...30,346,792
Ensembl chr15:30,173,603...30,346,814 		JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 involved_in ISO
IBA		 (MGI:5289703|PMID:21874021)
PMID:21873635		 RGD PMID:21874021 PMID:21873635 MGI:5289703, RGD:13792537 NCBI chr 2:31,507,423...31,559,098
Ensembl chr 2:31,507,424...31,570,542 		JBrowse link
G Nlrc4 NLR family, CARD domain containing 4 involved_in ISS
ISO		 GO_REF:0000024
(MGI:3662989|PMID:16648853), (MGI:3662990|PMID:16648852), (MGI:5289703|PMID:21874021), (MGI:5428366|PMID:22484733), (MGI:5444805|PMID:22885697)		 UniProt
RGD		 PMID:16648852 PMID:16648853 PMID:21874021 PMID:22484733 PMID:22885697 GO_REF:0000024 MGI:3662989 MGI:3662990 MGI:5289703 MGI:5428366 MGI:5444805 NCBI chr 6:20,991,785...21,018,254
Ensembl chr 6:20,995,266...21,018,248 		JBrowse link
G Nlrp1a NLR family, pyrin domain containing 1A involved_in ISO (PMID:33093214)
(PMID:33731929)		 RGD PMID:33093214 PMID:33731929 NCBI chr10:55,778,560...55,833,639
Ensembl chr10:55,778,560...55,825,180 		JBrowse link
G Nlrp1b NLR family, pyrin domain containing 1B involved_in ISO (PMID:32840892), (PMID:33542150)
(PMID:32840892), (PMID:33542150), (PMID:34019797)		 RGD PMID:32840892 PMID:33542150 PMID:34019797 NCBI chr10:55,838,381...55,904,374
Ensembl chr10:55,843,001...55,912,774 		JBrowse link
G Nlrp6 NLR family, pyrin domain containing 6 acts_upstream_of_or_within
involved_in		 ISO (MGI:6453663|PMID:30248149)
(MGI:6833928|PMID:34678144)		 RGD PMID:30248149 PMID:34678144 MGI:6453663 MGI:6833928 NCBI chr 1:196,004,854...196,011,615
Ensembl chr 1:196,004,953...196,011,113 		JBrowse link
G Nlrp9 NLR family, pyrin domain containing 9 involved_in ISO (MGI:5908739|PMID:28636595) RGD PMID:28636595 MGI:5908739 NCBI chr 1:68,291,180...68,341,512
Ensembl chr 1:68,291,180...68,341,512 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 acts_upstream_of_or_within_negative_effect ISO (MGI:6391726|PMID:29887864) RGD PMID:29887864 MGI:6391726 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
G Zbp1 Z-DNA binding protein 1 involved_in ISO
ISS		 (MGI:6442612|PMID:27917412), (MGI:6453154|PMID:32350114), (MGI:6490907|PMID:33109609)
GO_REF:0000024		 RGD
UniProt		 PMID:27917412 PMID:32350114 PMID:33109609 GO_REF:0000024 MGI:6442612 MGI:6453154 MGI:6490907 NCBI chr 3:161,993,351...162,009,297
Ensembl chr 3:161,993,351...162,003,870 		JBrowse link
cytotoxic T cell pyroptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gzma granzyme A involved_in ISO (PMID:32299851) RGD PMID:32299851 NCBI chr 2:44,740,638...44,752,471
Ensembl chr 2:44,740,569...44,752,493 		JBrowse link
negative regulation of pyroptosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir223 microRNA 223 involved_in ISO (PMID:34637033) RGD PMID:34637033 NCBI chr  X:61,141,887...61,141,996
Ensembl chr  X:61,141,887...61,141,996 		JBrowse link
positive regulation of pyroptosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nlrp1a NLR family, pyrin domain containing 1A IMP RGD PMID:24626226 RGD:38549348 NCBI chr10:55,778,560...55,833,639
Ensembl chr10:55,778,560...55,825,180 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18737
    cellular process 17432
      cell death 2210
        programmed cell death 2017
          pyroptosis 23
            cytotoxic T cell pyroptotic process 1
            negative regulation of pyroptosis 1
            positive regulation of pyroptosis 1
paths to the root