ONTOLOGY REPORT - ANNOTATIONS
Term: pyroptotic inflammatory response
Accession: GO:0070269
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Definition: A gasdermin-dependent inflammatory response that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18. Gasdermins are activated by caspase-1 or caspase-4/11, or by certain granzymes. In some, but not all cells, it can lead to pyroptotic programmed cell death.
Synonyms: broad_synonym: pyroptosis
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Aim2
absent in melanoma 2
involved_in
ISO
(PMID:19158675), (PMID:19158676) (MGI:3839523|PMID:19158676), (MGI:5807418|PMID:27846608), (MGI:6101070|PMID:29033131), (MGI:6445914|PMID:32350463), (MGI:6713897|PMID:34006824)
RGD
PMID:19158675 PMID:19158676 PMID:27846608 PMID:29033131 PMID:32350463 PMID:34006824 More...
MGI:3839523 MGI:5807418 MGI:6101070 MGI:6445914 MGI:6713897
NCBI chr13:85,865,206...85,906,996
Ensembl chr13:85,866,284...85,906,975
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Apip
APAF1 interacting protein
involved_in
ISO
(PMID:24367089)
RGD
PMID:24367089
NCBI chr 3:89,431,964...89,458,000
Ensembl chr 3:89,432,037...89,458,340
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Casp1
caspase 1
involved_in acts_upstream_of_or_within
ISS IEA ISO
GO_REF:0000024 GO_REF:0000107 (PMID:32109412), (PMID:32553275) (MGI:6716955|PMID:21147462) MGI:2158744 (PMID:22002608)
UniProt Ensembl RGD
PMID:21147462 PMID:22002608 PMID:32109412 PMID:32553275
GO_REF:0000024 GO_REF:0000107 MGI:6716955
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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Casp3
caspase 3
involved_in
ISO
(PMID:36426955)
RGD
PMID:36426955
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp4
caspase 4
involved_in acts_upstream_of_or_within
ISO
(MGI:5468357|PMID:23348507), (MGI:6201935|PMID:30135078), (MGI:6467703|PMID:32109412), (MGI:6865810|PMID:34671164), (MGI:7432483|PMID:30589883) MGI:5468949 (PMID:22002608) (PMID:31268602), (PMID:32109412), (PMID:34671164)
RGD
PMID:22002608 PMID:23348507 PMID:30135078 PMID:30589883 PMID:31268602 PMID:32109412 PMID:34671164 More...
MGI:5468357 MGI:6201935 MGI:6467703 MGI:6865810 MGI:7432483
NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
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Casp6
caspase 6
involved_in
IEA ISO ISS
GO_REF:0000107 (PMID:32298652) GO_REF:0000024
Ensembl RGD UniProt
PMID:32298652
GO_REF:0000024 GO_REF:0000107
NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
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Casp8
caspase 8
involved_in
ISS ISO
GO_REF:0000024 (MGI:6270017|PMID:30361383), (MGI:6401035|PMID:31748744)
UniProt RGD
PMID:30361383 PMID:31748744
GO_REF:0000024 MGI:6270017 MGI:6401035
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Dhx9
DExH-box helicase 9
involved_in
ISO
(MGI:5908739|PMID:28636595)
RGD
PMID:28636595
MGI:5908739
NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069
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Dpp9
dipeptidyl peptidase 9
acts_upstream_of_negative_effect
ISO
(PMID:33731929), (PMID:34019797)
RGD
PMID:33731929 PMID:34019797
NCBI chr 9:1,011,347...1,046,337
Ensembl chr 9:1,011,351...1,046,541
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Gsdma
gasdermin A
involved_in
ISO IBA
(PMID:35110732), (PMID:35545676) GO_REF:0000033
RGD GO_Central
PMID:35110732 PMID:35545676
GO_REF:0000033
NCBI chr10:83,614,336...83,639,543
Ensembl chr10:83,627,051...83,639,543
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Gsdmc
gasdermin C
involved_in
ISO IBA
(PMID:32929201), (PMID:34012073) GO_REF:0000033
RGD GO_Central
PMID:32929201 PMID:34012073
GO_REF:0000033
NCBI chr 7:95,594,015...95,606,106
Ensembl chr 7:95,594,015...95,611,344
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Gsdmd
gasdermin D
involved_in
ISO IBA
(MGI:5751630|PMID:26611636), (MGI:6467699|PMID:29576317), (MGI:6467703|PMID:32109412), (MGI:6467707|PMID:32553275), (MGI:6467712|PMID:32820063), (PMID:27383986), (PMID:35705808) GO_REF:0000033 (PMID:32109412), (PMID:33883744) (PMID:28392147), (PMID:30361383) (PMID:36227980)
RGD GO_Central
PMID:26611636 PMID:27383986 PMID:28392147 PMID:29576317 PMID:30361383 PMID:32109412 PMID:32553275 PMID:32820063 PMID:33883744 PMID:35705808 PMID:36227980 More...
GO_REF:0000033 MGI:5751630 MGI:6467699 MGI:6467703 MGI:6467707 MGI:6467712
NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055
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Gsdmdl1
gasdermin D like 1
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 7:95,620,052...95,630,546
Ensembl chr 7:95,620,061...95,630,532
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Gsdme
gasdermin E
involved_in
ISO
(PMID:31953257), (PMID:32188940) (MGI:5901785|PMID:28045099) (PMID:28459430) (PMID:33852854), (PMID:35594856)
RGD
PMID:28045099 PMID:28459430 PMID:31953257 PMID:32188940 PMID:33852854 PMID:35594856 More...
MGI:5901785
NCBI chr 4:79,258,799...79,321,129
Ensembl chr 4:79,257,804...79,320,806
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Gzma
granzyme A
involved_in
ISO
(PMID:32299851)
RGD
PMID:32299851
NCBI chr 2:44,740,569...44,752,502
Ensembl chr 2:44,740,569...44,752,493
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Gzmb
granzyme B
involved_in
ISS ISO
GO_REF:0000024 (PMID:32188940)
UniProt RGD
PMID:32188940
GO_REF:0000024
NCBI chr15:30,343,352...30,346,814
Ensembl chr15:30,173,603...30,346,814
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Ifi27
interferon, alpha-inducible protein 27
involved_in
ISO
(PMID:36426955)
RGD
PMID:36426955
NCBI chr 6:122,590,461...122,596,996
Ensembl chr 6:122,590,472...122,779,294
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Map3k20
mitogen-activated protein kinase kinase kinase 20
acts_upstream_of_positive_effect
ISS ISO
GO_REF:0000024 (PMID:35857590)
UniProt RGD
PMID:35857590
GO_REF:0000024
NCBI chr 3:57,130,539...57,289,943
Ensembl chr 3:57,130,551...57,289,626
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Naip6
NLR family, apoptosis inhibitory protein 6
involved_in
ISO IBA
(MGI:5289703|PMID:21874021) GO_REF:0000033
RGD GO_Central
PMID:21874021
GO_REF:0000033 MGI:5289703
NCBI chr 2:31,507,423...31,559,098
Ensembl chr 2:31,507,424...31,570,542
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Ninj1
ninjurin 1
involved_in
ISO
(MGI:7410598|PMID:36468682), (MGI:7510059|PMID:37196676), (MGI:7510060|PMID:37198476)
RGD
PMID:36468682 PMID:37196676 PMID:37198476
MGI:7410598 MGI:7510059 MGI:7510060
NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704
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Nlrc4
NLR family, CARD domain containing 4
involved_in
ISO ISS
(MGI:3662989|PMID:16648853), (MGI:3662990|PMID:16648852), (MGI:5289703|PMID:21874021), (MGI:5428366|PMID:22484733), (MGI:5444805|PMID:22885697) GO_REF:0000024
RGD UniProt
PMID:16648852 PMID:16648853 PMID:21874021 PMID:22484733 PMID:22885697
GO_REF:0000024 MGI:3662989 MGI:3662990 MGI:5289703 MGI:5428366 MGI:5444805
NCBI chr 6:20,991,785...21,018,254
Ensembl chr 6:20,995,266...21,018,248
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Nlrp1a
NLR family, pyrin domain containing 1A
involved_in
ISO
(PMID:33093214) (PMID:33731929)
RGD
PMID:33093214 PMID:33731929
NCBI chr10:55,778,560...55,833,639
Ensembl chr10:55,778,560...55,825,180
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Nlrp6
NLR family, pyrin domain containing 6
involved_in acts_upstream_of_or_within
IEA ISO
GO_REF:0000107 (PMID:30248149) (MGI:6833928|PMID:34678144)
Ensembl RGD
PMID:30248149 PMID:34678144
GO_REF:0000107 MGI:6833928
NCBI chr 1:196,004,854...196,011,615
Ensembl chr 1:196,004,953...196,011,113
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Nlrp9
NLR family, pyrin domain containing 9
involved_in
ISO
(MGI:5908739|PMID:28636595)
RGD
PMID:28636595
MGI:5908739
NCBI chr 1:68,291,180...68,341,512
Ensembl chr 1:68,291,180...68,341,512
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Trem2
triggering receptor expressed on myeloid cells 2
acts_upstream_of_or_within_negative_effect
ISO
(MGI:6391726|PMID:29887864)
RGD
PMID:29887864
MGI:6391726
NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170
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Trim21
tripartite motif-containing 21
involved_in
ISO
(PMID:36426955)
RGD
PMID:36426955
NCBI chr 1:156,964,896...156,987,504
Ensembl chr 1:156,964,913...156,987,440
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Zbp1
Z-DNA binding protein 1
involved_in
ISS ISO
GO_REF:0000024 (MGI:6442612|PMID:27917412), (MGI:6453154|PMID:32350114), (MGI:6490907|PMID:33109609)
UniProt RGD
PMID:27917412 PMID:32350114 PMID:33109609
GO_REF:0000024 MGI:6442612 MGI:6453154 MGI:6490907
NCBI chr 3:161,993,351...162,009,297
Ensembl chr 3:161,993,351...162,003,870
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Zeb2
zinc finger E-box binding homeobox 2
IDA
RGD
PMID:34852714
RGD:155882542
NCBI chr 3:29,214,581...29,344,890
Ensembl chr 3:29,218,301...29,345,157
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Gzma
granzyme A
involved_in
ISO
(PMID:32299851)
RGD
PMID:32299851
NCBI chr 2:44,740,569...44,752,502
Ensembl chr 2:44,740,569...44,752,493
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Mir223
microRNA 223
involved_in
ISO
(PMID:34637033)
RGD
PMID:34637033
NCBI chr X:61,141,887...61,141,996
Ensembl chr X:61,141,887...61,141,996
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Casp3
caspase 3
involved_in
ISO
(PMID:28459430), (PMID:33852854), (PMID:35594856)
RGD
PMID:28459430 PMID:33852854 PMID:35594856
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Gbp1
guanylate binding protein 1
involved_in
ISO
(MGI:5565107|PMID:24715728) (PMID:31268602)
RGD
PMID:24715728 PMID:31268602
MGI:5565107
NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131 Ensembl chr 2:231,398,163...231,432,131
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Gbp2
guanylate binding protein 2
involved_in
ISO IEA ISS
(MGI:5565107|PMID:24715728), (MGI:5774627|PMID:25774716), (MGI:5774628|PMID:25774715), (MGI:7432484|PMID:30062052) GO_REF:0000107 GO_REF:0000024
RGD Ensembl UniProt
PMID:24715728 PMID:25774715 PMID:25774716 PMID:30062052
GO_REF:0000024 GO_REF:0000107 MGI:5565107 MGI:5774627 MGI:5774628 MGI:7432484
NCBI chr 2:231,332,488...231,348,573
Ensembl chr 2:231,332,284...231,348,571
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Gbp4
guanylate binding protein 4
involved_in
ISO
(MGI:5565107|PMID:24715728)
RGD
PMID:24715728
MGI:5565107
NCBI chr 2:231,304,910...231,318,883
Ensembl chr 2:231,305,244...231,318,879
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Gbp5
guanylate binding protein 5
involved_in
ISO
(MGI:5565107|PMID:24715728), (MGI:5774627|PMID:25774716), (MGI:5774628|PMID:25774715), (MGI:7432483|PMID:30589883)
RGD
PMID:24715728 PMID:25774715 PMID:25774716 PMID:30589883
MGI:5565107 MGI:5774627 MGI:5774628 MGI:7432483
NCBI chr 2:231,237,748...231,257,071
Ensembl chr 2:231,237,748...231,257,061
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Nlrp1a
NLR family, pyrin domain containing 1A
involved_in
IMP IEA
GO_REF:0000117
UniProt RGD
PMID:24626226
GO_REF:0000117, RGD:38549348
NCBI chr10:55,778,560...55,833,639
Ensembl chr10:55,778,560...55,825,180
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Nlrp1b
NLR family, pyrin domain containing 1B
involved_in
IEA
GO_REF:0000117
UniProt
GO_REF:0000117
NCBI chr10:55,838,381...55,904,374
Ensembl chr10:55,843,001...55,912,774
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Nod1
nucleotide-binding oligomerization domain containing 1
involved_in
IEA
GO_REF:0000117
UniProt
GO_REF:0000117
NCBI chr 4:84,060,871...84,111,668
Ensembl chr 4:84,060,880...84,111,404
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Nod2
nucleotide-binding oligomerization domain containing 2
involved_in
IEA
GO_REF:0000117
UniProt
GO_REF:0000117
NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177
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Zdhhc5
zinc finger DHHC-type palmitoyltransferase 5
involved_in
ISO ISS
(PMID:38530158) (PMID:38530158), (PMID:38599239) GO_REF:0000024
RGD UniProt
PMID:38530158 PMID:38599239
GO_REF:0000024
NCBI chr 3:69,772,037...69,800,142
Ensembl chr 3:69,771,890...69,799,921
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Zdhhc9
zinc finger DHHC-type palmitoyltransferase 9
involved_in
ISO
(PMID:38530158) (PMID:38530158), (PMID:38599239)
RGD
PMID:38530158 PMID:38599239
NCBI chr X:127,352,340...127,388,245
Ensembl chr X:127,352,345...127,388,245
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Casp4
caspase 4
involved_in
IEA
GO_REF:0000107
Ensembl
GO_REF:0000107
NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
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Gsdmd
gasdermin D
involved_in
ISO
(PMID:27339137), (PMID:27383986), (PMID:38632402) (PMID:32109412), (PMID:33883744), (PMID:38632402) (PMID:36227980) (PMID:32820063), (PMID:38530158), (PMID:38599239)
RGD
PMID:27339137 PMID:27383986 PMID:32109412 PMID:32820063 PMID:33883744 PMID:36227980 PMID:38530158 PMID:38599239 PMID:38632402 More...
NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055
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Gsdme
gasdermin E
involved_in
ISO IEA
(PMID:32188940), (PMID:33852854), (PMID:35594856) GO_REF:0000107
RGD Ensembl
PMID:32188940 PMID:33852854 PMID:35594856
GO_REF:0000107
NCBI chr 4:79,258,799...79,321,129
Ensembl chr 4:79,257,804...79,320,806
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Ninj1
ninjurin 1
involved_in
ISO IEA
(PMID:36468682), (PMID:37196676), (PMID:37198476), (PMID:38614101) GO_REF:0000107
RGD Ensembl
PMID:36468682 PMID:37196676 PMID:37198476 PMID:38614101
GO_REF:0000107
NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704
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