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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of DNA recombination
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Accession:GO:0045910 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination.
Synonyms:exact_synonym: down regulation of DNA recombination;   downregulation of DNA recombination
 narrow_synonym: inhibition of DNA recombination


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negative regulation of DNA recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BLM BLM RecQ like helicase involved_in IMP (PMID:9671747) UniProt PMID:9671747 NCBI chr15:90,717,346...90,816,166
Ensembl chr15:90,717,346...90,816,166 		JBrowse link
G H1-0 H1.0 linker histone involved_in IBA GO_Central GO_REF:0000033 NCBI chr22:37,805,229...37,807,432
Ensembl chr22:37,805,229...37,807,432 		JBrowse link
G H1-1 H1.1 linker histone, cluster member involved_in IBA GO_Central GO_REF:0000033 NCBI chr 6:26,017,032...26,017,787
Ensembl chr 6:26,017,032...26,017,787 		JBrowse link
G H1-10 H1.10 linker histone involved_in IBA GO_Central GO_REF:0000033 NCBI chr 3:129,314,771...129,316,286
Ensembl chr 3:129,314,771...129,316,286 		JBrowse link
G H1-2 H1.2 linker histone, cluster member involved_in IBA GO_Central GO_REF:0000033 NCBI chr 6:26,055,740...26,056,470
Ensembl chr 6:26,055,740...26,056,470 		JBrowse link
G H1-3 H1.3 linker histone, cluster member involved_in IBA GO_Central GO_REF:0000033 NCBI chr 6:26,234,212...26,234,987
Ensembl chr 6:26,234,212...26,234,987 		JBrowse link
G H1-4 H1.4 linker histone, cluster member involved_in IBA GO_Central GO_REF:0000033 NCBI chr 6:26,156,329...26,157,115
Ensembl chr 6:26,156,329...26,157,115 		JBrowse link
G H1-5 H1.5 linker histone, cluster member involved_in IBA GO_Central GO_REF:0000033 NCBI chr 6:27,866,792...27,867,588
Ensembl chr 6:27,866,792...27,867,588 		JBrowse link
G H1-6 H1.6 linker histone, cluster member involved_in IBA GO_Central GO_REF:0000033 NCBI chr 6:26,107,412...26,108,135
Ensembl chr 6:26,107,412...26,108,135 		JBrowse link
G H1-7 H1.7 linker histone involved_in IBA GO_Central GO_REF:0000033 NCBI chr12:48,328,980...48,330,279
Ensembl chr12:48,328,980...48,330,279 		JBrowse link
G H1-8 H1.8 linker histone involved_in IBA GO_Central GO_REF:0000033 NCBI chr 3:129,543,175...129,551,467
Ensembl chr 3:129,543,175...129,551,467 		JBrowse link
G H1-9P H1.9 linker histone, pseudogene involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:50,171,428...50,172,476
Ensembl chr17:50,171,514...50,171,936 		JBrowse link
G LIG3 DNA ligase 3 acts_upstream_of_or_within ISO (PMID:16648486) MGI PMID:16648486 NCBI chr17:34,980,512...35,010,872
Ensembl chr17:34,980,512...35,009,743 		JBrowse link
G MSH2 mutS homolog 2 involved_in
acts_upstream_of_or_within		 IDA
ISO
IEA
ISS		 (PMID:17715146)
(PMID:10545954), (PMID:7628020)		 BHF-UCL
MGI
Ensembl		 PMID:7628020 PMID:10545954 PMID:17715146 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:47,403,067...47,709,830
Ensembl chr 2:47,403,067...47,663,146 		JBrowse link
G MSH3 mutS homolog 3 involved_in IDA (PMID:17715146) BHF-UCL PMID:17715146 NCBI chr 5:80,654,652...80,876,815
Ensembl chr 5:80,654,652...80,876,815 		JBrowse link
G MSH6 mutS homolog 6 involved_in
acts_upstream_of_or_within		 IEA
ISO
IDA		 (PMID:10545954)
(PMID:17715146)		 Ensembl
MGI
BHF-UCL		 PMID:10545954 PMID:17715146 GO_REF:0000107 NCBI chr 2:47,783,145...47,810,101
Ensembl chr 2:47,695,530...47,810,063 		JBrowse link
G RAD18 RAD18 E3 ubiquitin protein ligase acts_upstream_of_or_within ISO (PMID:12509447) MGI PMID:12509447 NCBI chr 3:8,877,075...8,963,472
Ensembl chr 3:8,775,402...8,963,773 		JBrowse link
G RTEL1 regulator of telomere elongation helicase 1 involved_in ISS
IEA
IBA		 BHF-UCL
TreeGrafter
GO_Central
Ensembl		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr20:63,657,810...63,696,253
Ensembl chr20:63,657,810...63,696,253 		JBrowse link
G ZRANB3 zinc finger RANBP2-type containing 3 involved_in IDA (PMID:22704558) UniProt PMID:22704558 NCBI chr 2:135,196,969...135,531,218
Ensembl chr 2:135,136,916...135,531,218 		JBrowse link
negative regulation of DNA recombination at telomere term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TERF2IP TERF2 interacting protein involved_in ISO (MGI:4440768|PMID:20339076), (MGI:4839412|PMID:20622869) UniProt PMID:20339076 PMID:20622869 MGI:4440768 MGI:4839412 NCBI chr16:75,760,050...75,914,672
Ensembl chr16:75,647,773...75,761,872 		JBrowse link
G TERF2IP TERF2 interacting protein involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr16:75,647,773...75,657,432
Ensembl chr16:75,647,773...75,761,872 		JBrowse link
negative regulation of double-strand break repair via homologous recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase involved_in IDA (PMID:9461559) UniProt PMID:9461559 NCBI chr 9:130,713,043...130,887,675
Ensembl chr 9:130,713,043...130,887,675 		JBrowse link
G C1QBP complement C1q binding protein involved_in IDA (PMID:31353207) UniProt PMID:31353207 NCBI chr17:5,432,777...5,439,155
Ensembl chr17:5,432,777...5,448,830 		JBrowse link
G CGAS cyclic GMP-AMP synthase involved_in IDA
IBA
IEA		 (PMID:30356214), (PMID:31544964) UniProt
GO_Central
Ensembl		 PMID:30356214 PMID:31544964 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:73,423,711...73,452,297
Ensembl chr 6:73,413,515...73,452,297 		JBrowse link
G CSNK2A1 casein kinase 2 alpha 1 involved_in IDA (PMID:28512243) UniProt PMID:28512243 NCBI chr20:472,498...543,790
Ensembl chr20:472,498...543,835 		JBrowse link
G FANCB FA complementation group B involved_in
acts_upstream_of_or_within		 IBA
ISO		 (PMID:25520194) GO_Central
MGI		 PMID:25520194 GO_REF:0000033 NCBI chr  X:14,689,524...14,873,069
Ensembl chr  X:14,690,388...14,873,255 		JBrowse link
G FBH1 F-box DNA helicase 1 involved_in IDA
IEA		 (PMID:19736316) UniProt
Ensembl		 PMID:19736316 GO_REF:0000107 NCBI chr10:5,889,572...5,937,593
Ensembl chr10:5,890,203...5,937,594 		JBrowse link
G HELB DNA helicase B involved_in IEA
IBA
IMP		 (PMID:26774285) Ensembl
GO_Central
UniProt		 PMID:26774285 GO_REF:0000033 GO_REF:0000107 NCBI chr12:66,302,493...66,343,643
Ensembl chr12:66,302,493...66,343,643 		JBrowse link
G KAT5 lysine acetyltransferase 5 involved_in IDA (PMID:32832608) UniProt PMID:32832608 NCBI chr11:65,712,018...65,719,604
Ensembl chr11:65,711,996...65,719,604 		JBrowse link
G KLHL15 kelch like family member 15 involved_in IDA (PMID:27561354), (PMID:35219381) UniProt PMID:27561354 PMID:35219381 NCBI chr  X:23,983,720...24,027,186
Ensembl chr  X:23,983,716...24,027,186 		JBrowse link
G KMT5A lysine methyltransferase 5A involved_in IDA (PMID:27338793) UniProt PMID:27338793 NCBI chr12:123,384,132...123,409,353
Ensembl chr12:123,384,132...123,409,353 		JBrowse link
G MAD2L2 mitotic arrest deficient 2 like 2 involved_in IDA (PMID:29656893) UniProt PMID:29656893 NCBI chr 1:11,674,480...11,691,830
Ensembl chr 1:11,658,918...11,691,811 		JBrowse link
G MAGEF1 MAGE family member F1 involved_in IDA (PMID:29225034) UniProt PMID:29225034 NCBI chr 3:184,710,364...184,712,064
Ensembl chr 3:184,710,364...184,712,064 		JBrowse link
G PARPBP PARP1 binding protein involved_in IEA
IBA
IMP		 (PMID:22153967) InterPro
GO_Central
UniProt		 PMID:22153967 GO_REF:0000002 GO_REF:0000033 NCBI chr12:102,120,183...102,197,520
Ensembl chr12:102,120,183...102,197,520 		JBrowse link
G PLK1 polo like kinase 1 involved_in IDA (PMID:28512243) UniProt PMID:28512243 NCBI chr16:23,678,889...23,690,367
Ensembl chr16:23,677,656...23,690,367 		JBrowse link
G POLQ DNA polymerase theta involved_in IEA
IMP
IDA		 (PMID:28695890)
(PMID:25642963), (PMID:36455556)		 Ensembl
UniProt		 PMID:25642963 PMID:28695890 PMID:36455556 GO_REF:0000107 NCBI chr 3:121,431,431...121,545,988
Ensembl chr 3:121,431,431...121,545,988 		JBrowse link
G RADX RPA1 related single stranded DNA binding protein, X-linked involved_in IDA (PMID:28735897) UniProt PMID:28735897 NCBI chr  X:106,611,978...106,679,439
Ensembl chr  X:106,611,930...106,679,439 		JBrowse link
G RECQL5 RecQ like helicase 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25520194) Ensembl
MGI		 PMID:25520194 GO_REF:0000107 NCBI chr17:75,626,854...75,667,154
Ensembl chr17:75,626,845...75,667,189 		JBrowse link
G RIF1 replication timing regulatory factor 1 involved_in IEA
IDA		 (PMID:23333306) Ensembl
UniProt		 PMID:23333306 GO_REF:0000107 NCBI chr 2:151,409,902...151,534,435
Ensembl chr 2:151,409,883...151,508,013 		JBrowse link
G RMI2 RecQ mediated genome instability 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr16:11,345,459...11,351,760
Ensembl chr16:11,249,619...11,381,662 		JBrowse link
G SENP3 SUMO specific peptidase 3 involved_in IDA (PMID:32832608) UniProt PMID:32832608 NCBI chr17:7,561,919...7,571,969
Ensembl chr17:7,561,919...7,571,969 		JBrowse link
G SHLD1 shieldin complex subunit 1 involved_in IDA
IBA		 (PMID:29656893) UniProt
GO_Central		 PMID:29656893 GO_REF:0000033 NCBI chr20:5,750,193...5,864,395
Ensembl chr20:5,750,393...5,864,395 		JBrowse link
G SHLD2 shieldin complex subunit 2 involved_in IDA (PMID:29656893) UniProt PMID:29656893 NCBI chr10:87,094,473...87,191,465
Ensembl chr10:87,094,161...87,191,465 		JBrowse link
G SHLD3 shieldin complex subunit 3 involved_in IDA
IBA		 (PMID:29656893) UniProt
GO_Central		 PMID:29656893 GO_REF:0000033 NCBI chr 5:65,625,027...65,630,928
Ensembl chr 5:65,625,027...65,630,928 		JBrowse link
G SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 involved_in IMP (PMID:25294876) UniProt PMID:25294876 NCBI chr18:2,655,726...2,805,017
Ensembl chr18:2,655,726...2,805,017 		JBrowse link
G TP53BP1 tumor protein p53 binding protein 1 involved_in IDA
IEA		 (PMID:23333306), (PMID:23345425) UniProt
Ensembl		 PMID:23333306 PMID:23345425 GO_REF:0000107 NCBI chr15:43,403,061...43,510,640
Ensembl chr15:43,403,061...43,510,728 		JBrowse link
G UBQLN4 ubiquilin 4 involved_in IDA (PMID:30612738) UniProt PMID:30612738 NCBI chr 1:156,031,247...156,053,798
Ensembl chr 1:156,035,299...156,053,798 		JBrowse link
negative regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PARP3 poly(ADP-ribose) polymerase family member 3 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:51,942,363...51,948,867
Ensembl chr 3:51,942,345...51,948,867 		JBrowse link
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL6 BCL6 transcription repressor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10490661) Ensembl
MGI		 PMID:10490661 GO_REF:0000107 NCBI chr 3:187,721,377...187,745,468
Ensembl chr 3:187,721,377...187,745,725 		JBrowse link
G FOXP3 forkhead box P3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16275384) Ensembl
MGI		 PMID:16275384 GO_REF:0000107 NCBI chr  X:49,250,438...49,264,710
Ensembl chr  X:49,250,438...49,264,800 		JBrowse link
G NDFIP1 Nedd4 family interacting protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17137798) Ensembl
MGI		 PMID:17137798 GO_REF:0000107 NCBI chr 5:142,108,779...142,154,440
Ensembl chr 5:142,108,779...142,154,440 		JBrowse link
negative regulation of mitotic recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANKLE1 ankyrin repeat and LEM domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:17,281,901...17,287,646
Ensembl chr19:17,281,645...17,287,646 		JBrowse link
G BLM BLM RecQ like helicase involved_in
acts_upstream_of_or_within		 ISO (MGI:5800654|PMID:27010503)
(PMID:17210642)
(PMID:16914751), (PMID:9808625)
(PMID:11101838)		 UniProt
MGI		 PMID:9808625 PMID:11101838 PMID:16914751 PMID:17210642 PMID:27010503 MGI:5800654 NCBI chr15:90,717,346...90,816,166
Ensembl chr15:90,717,346...90,816,166 		JBrowse link
G MLH1 mutL homolog 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15480418) Ensembl
MGI		 PMID:15480418 GO_REF:0000107 NCBI chr 3:36,993,466...37,050,846
Ensembl chr 3:36,993,226...37,050,896 		JBrowse link
G ZSCAN4 zinc finger and SCAN domain containing 4 involved_in ISS (PMID:20336070) BHF-UCL PMID:20336070 NCBI chr19:57,651,476...57,679,152
Ensembl chr19:57,668,935...57,679,152 		JBrowse link
negative regulation of telomere maintenance via recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TERF2 telomeric repeat binding factor 2 involved_in IMP
IBA
ISS
IEA		 (PMID:15507207) BHF-UCL
GO_Central
Ensembl		 PMID:15507207 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr16:69,355,567...69,386,007
Ensembl chr16:69,355,567...69,408,571 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19670
    negative regulation of biological process 6435
      negative regulation of metabolic process 3628
        negative regulation of macromolecule metabolic process 3381
          negative regulation of DNA metabolic process 154
            negative regulation of DNA recombination 55
              inactivation of recombination (HML) 0
              negative regulation of DNA recombination at centromere 0
              negative regulation of DNA recombination at telomere + 3
              negative regulation of double-strand break repair via homologous recombination + 26
              negative regulation of isotype switching + 4
              negative regulation of mitotic recombination + 5
              negative regulation of reciprocal meiotic recombination 0
              negative regulation of single-strand break repair via homologous recombination 0
              negative regulation of strand invasion 0
Path 2
Term Annotations click to browse term
  biological_process 19670
    metabolic process 12471
      organic substance metabolic process 11974
        organic cyclic compound metabolic process 7070
          nucleobase-containing compound metabolic process 6539
            nucleic acid metabolic process 5935
              DNA metabolic process 1074
                regulation of DNA metabolic process 542
                  negative regulation of DNA metabolic process 154
                    negative regulation of DNA recombination 55
                      inactivation of recombination (HML) 0
                      negative regulation of DNA recombination at centromere 0
                      negative regulation of DNA recombination at telomere + 3
                      negative regulation of double-strand break repair via homologous recombination + 26
                      negative regulation of isotype switching + 4
                      negative regulation of mitotic recombination + 5
                      negative regulation of reciprocal meiotic recombination 0
                      negative regulation of single-strand break repair via homologous recombination 0
                      negative regulation of strand invasion 0
paths to the root