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Gene: CGAS (cyclic GMP-AMP synthase) Homo sapiens
Symbol: CGAS
Name: cyclic GMP-AMP synthase
Description: Exhibits several functions, including chromatin binding activity; cyclic-GMP-AMP synthase activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including cellular response to exogenous dsRNA; positive regulation of intracellular signal transduction; and regulation of defense response. Localizes to several cellular components, including cytosol; nucleus; and site of double-strand break; INTERACTS WITH antirheumatic drug; benzo[a]pyrene; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2'3'-cGAMP synthase; C6orf150; cGAMP synthase; h-cGAS; hypothetical protein LOC115004; Mab-21 domain containing 1; mab-21 domain-containing protein 1; MB21D1; MGC131892; MGC142166; MGC142168
Mus musculus (house mouse) : Cgas (cyclic GMP-AMP synthase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cgas (cyclic GMP-AMP synthase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cgas (cyclic GMP-AMP synthase)
Pan paniscus (bonobo/pygmy chimpanzee) : CGAS (cyclic GMP-AMP synthase)
Canis lupus familiaris (dog) : CGAS (cyclic GMP-AMP synthase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cgas (cyclic GMP-AMP synthase)
Sus scrofa (pig) : CGAS (cyclic GMP-AMP synthase)
Chlorocebus sabaeus (African green monkey) : CGAS (cyclic GMP-AMP synthase)
Heterocephalus glaber (naked mole-rat) : Cgas (cyclic GMP-AMP synthase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl673,413,515 - 73,452,297 (-)EnsemblGRCh38hg38GRCh38
GRCh38673,423,711 - 73,452,297 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37674,134,856 - 74,162,043 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36674,191,577 - 74,218,764 (-)NCBINCBI36hg18NCBI36
Build 34674,191,313 - 74,218,720NCBI
Celera674,529,415 - 74,556,286 (-)NCBI
Cytogenetic Map6q13NCBI
HuRef671,333,337 - 71,360,196 (-)NCBIHuRef
CHM1_1674,301,681 - 74,328,872 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CGAS
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1353865
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.