MSH6 (mutS homolog 6) - Rat Genome Database

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Gene: MSH6 (mutS homolog 6) Homo sapiens
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Symbol: MSH6
Name: mutS homolog 6
RGD ID: 1321738
HGNC Page HGNC
Description: Enables ATP-dependent activity, acting on DNA; enzyme binding activity; and methylated histone binding activity. Contributes to several functions, including DNA binding activity; MutLalpha complex binding activity; and adenyl ribonucleotide binding activity. Involved in mismatch repair; negative regulation of DNA recombination; and positive regulation of helicase activity. Located in Golgi apparatus; cytosol; and nucleoplasm. Part of MutSalpha complex. Implicated in Lynch syndrome; colorectal carcinoma; endometrial cancer; hereditary nonpolyposis colorectal cancer type 5; and mismatch repair cancer syndrome. Biomarker of breast carcinoma; osteosarcoma; and urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: DNA mismatch repair protein Msh6; G/T mismatch-binding protein; GTBP; GTMBP; hMSH6; HNPCC5; HSAP; MMRCS3; MSH-6; mutS protein homolog 6; mutS-alpha 160 kDa subunit; p160; sperm-associated protein; truncated MSH6
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38247,783,145 - 47,806,953 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl247,695,530 - 47,810,063 (+)EnsemblGRCh38hg38GRCh38
GRCh37248,010,284 - 48,034,092 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36247,863,725 - 47,887,596 (+)NCBINCBI36hg18NCBI36
Build 34247,921,936 - 47,945,743NCBI
Celera247,849,755 - 47,873,614 (+)NCBI
Cytogenetic Map2p16.3NCBI
HuRef247,746,516 - 47,770,575 (+)NCBIHuRef
CHM1_1247,940,665 - 47,964,487 (+)NCBICHM1_1
T2T-CHM13v2.0247,789,083 - 47,812,902 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model