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Gene: MSH6 (mutS homolog 6) Homo sapiens
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Symbol: MSH6
Name: mutS homolog 6
Description: Exhibits enzyme binding activity; methylated histone binding activity; and mismatched DNA binding activity. Contributes to several functions, including DNA binding activity; MutLalpha complex binding activity; and adenyl ribonucleotide binding activity. Involved in mismatch repair; negative regulation of DNA recombination; and positive regulation of helicase activity. Localizes to Golgi apparatus; cytosol; and nucleus. Implicated in Lynch syndrome; colorectal carcinoma; endometrial cancer; and hereditary nonpolyposis colorectal cancer type 5. Biomarker of breast carcinoma and urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DNA mismatch repair protein Msh6; G/T mismatch-binding protein; GTBP; GTMBP; hMSH6; HNPCC5; HSAP; mutS protein homolog 6; mutS-alpha 160 kDa subunit; p160; sperm-associated protein
Orthologs:
Mus musculus (house mouse) : Msh6 (mutS homolog 6)  MGI  Alliance
Rattus norvegicus (Norway rat) : Msh6 (mutS homolog 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Msh6 (mutS homolog 6)
Pan paniscus (bonobo/pygmy chimpanzee) : MSH6 (mutS homolog 6)
Canis lupus familiaris (dog) : MSH6 (mutS homolog 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Msh6 (mutS homolog 6)
Sus scrofa (pig) : MSH6 (mutS homolog 6)
Chlorocebus sabaeus (African green monkey) : MSH6 (mutS homolog 6)
Heterocephalus glaber (naked mole-rat) : Msh6 (mutS homolog 6)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl247,695,530 - 47,810,101 (+)EnsemblGRCh38hg38GRCh38
GRCh38 Ensembl247,695,530 - 47,810,063 (+)EnsemblGRCh38hg38GRCh38
GRCh38247,783,082 - 47,806,954 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37248,010,221 - 48,034,092 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36247,863,725 - 47,887,596 (+)NCBINCBI36hg18NCBI36
Build 34247,921,936 - 47,945,743NCBI
Celera247,849,755 - 47,873,614 (+)NCBI
Cytogenetic Map2p16.3NCBI
HuRef247,746,516 - 47,770,575 (+)NCBIHuRef
CHM1_1247,940,665 - 47,964,487 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model