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Gene: KLHL15 (kelch like family member 15) Homo sapiens
Symbol: KLHL15
Name: kelch like family member 15
Description: Involved in negative regulation of double-strand break repair via homologous recombination and nuclear protein quality control by the ubiquitin-proteasome system. Localizes to the nucleus. Colocalizes with the Cul3-RING ubiquitin ligase complex. Implicated in non-syndromic X-linked intellectual disability.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: epididymis secretory protein Li 305; HEL-S-305; kelch-like 15; kelch-like family member 15; kelch-like protein 15; KIAA1677; MGC126148; MGC126149
Mus musculus (house mouse) : Klhl15 (kelch-like 15)  MGI  Alliance
Rattus norvegicus (Norway rat) : Klhl15 (kelch-like family member 15)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Klhl15 (kelch like family member 15)
Pan paniscus (bonobo/pygmy chimpanzee) : KLHL15 (kelch like family member 15)
Canis lupus familiaris (dog) : KLHL15 (kelch like family member 15)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Klhl15 (kelch like family member 15)
Sus scrofa (pig) : KLHL15 (kelch like family member 15)
Chlorocebus sabaeus (green monkey) : KLHL15 (kelch like family member 15)
Heterocephalus glaber (naked mole-rat) : Klhl15 (kelch like family member 15)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 EnsemblX23,983,720 - 24,027,186 (-)Ensembl
GRCh38X23,983,720 - 24,027,186 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X24,001,833 - 24,045,303 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X23,915,884 - 23,955,224 (-)NCBINCBI36hg18NCBI36
CeleraX28,123,598 - 28,167,503 (-)NCBI
Cytogenetic MapXp22.11NCBI
HuRefX21,746,167 - 21,788,942 (-)NCBIHuRef
CHM1_1X24,033,076 - 24,076,523 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on KLHL15
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1351915
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.