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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of isotype switching
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Accession:GO:0045829 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching.
Synonyms:exact_synonym: down regulation of isotype switching;   downregulation of isotype switching;   negative regulation of class switch recombination;   negative regulation of class switching;   negative regulation of isotype switch recombination
 narrow_synonym: inhibition of isotype switching


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negative regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Parp3 poly (ADP-ribose) polymerase family, member 3 involved_in ISO (MGI:6214451|PMID:26000965) RGD PMID:26000965 MGI:6214451 NCBI chr 8:107,111,010...107,117,073
Ensembl chr 8:107,111,012...107,116,782
JBrowse link
negative regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Da2-19 uncharacterized LOC302729 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr  X:44,820,693...44,837,935
Ensembl chr  X:44,820,820...44,837,934
JBrowse link
G Thoc1 THO complex 1 involved_in ISO (MGI:5520039|PMID:22144908) RGD PMID:22144908 MGI:5520039 NCBI chr18:983,606...1,020,379
Ensembl chr18:983,824...1,019,114
JBrowse link
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO MGI:103034|MGI:2158438 (MGI:1345885|PMID:10490661) RGD PMID:10490661 MGI:1345885 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO MGI:3696705 (MGI:3695768|PMID:16275384) RGD PMID:16275384 MGI:3695768 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 acts_upstream_of_or_within ISO MGI:3695433 (MGI:3694584|PMID:17137798) RGD PMID:17137798 MGI:3694584 NCBI chr18:30,265,808...30,316,068
Ensembl chr18:30,250,613...30,322,311
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    developmental process 6770
      negative regulation of developmental process 1023
        negative regulation of isotype switching 6
          negative regulation of isotype switching to IgA isotypes 2
          negative regulation of isotype switching to IgD isotypes 0
          negative regulation of isotype switching to IgE isotypes 3
          negative regulation of isotype switching to IgG isotypes 0
Path 2
Term Annotations click to browse term
  biological_process 19492
    metabolic process 11797
      cellular metabolic process 10717
        cellular aromatic compound metabolic process 5596
          nucleobase-containing compound metabolic process 5378
            nucleic acid metabolic process 4888
              DNA metabolic process 883
                DNA recombination 308
                  somatic cell DNA recombination 78
                    somatic diversification of immune receptors via germline recombination within a single locus 78
                      somatic recombination of immunoglobulin gene segments 66
                        somatic recombination of immunoglobulin genes involved in immune response 58
                          isotype switching 58
                            regulation of isotype switching 43
                              negative regulation of isotype switching 6
                                negative regulation of isotype switching to IgA isotypes 2
                                negative regulation of isotype switching to IgD isotypes 0
                                negative regulation of isotype switching to IgE isotypes 3
                                negative regulation of isotype switching to IgG isotypes 0
paths to the root