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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of isotype switching
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Accession:GO:0045829 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching.
Synonyms:exact_synonym: down regulation of isotype switching;   downregulation of isotype switching;   negative regulation of class switch recombination;   negative regulation of class switching;   negative regulation of isotype switch recombination
 narrow_synonym: inhibition of isotype switching



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negative regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Parp3 poly (ADP-ribose) polymerase family, member 3 involved_in ISO (MGI:6214451|PMID:26000965) RGD PMID:26000965 MGI:6214451 NCBI chr 8:107,111,010...107,117,073
Ensembl chr 8:107,111,012...107,116,782
JBrowse link
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO MGI:103034|MGI:2158438 (PMID:10490661) RGD PMID:10490661 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO MGI:3696705 (PMID:16275384) RGD PMID:16275384 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3695433 (PMID:17137798)
Ensembl
RGD
PMID:17137798 GO_REF:0000107 NCBI chr18:30,265,808...30,316,068
Ensembl chr18:30,250,613...30,322,311
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19872
    developmental process 6994
      negative regulation of developmental process 1103
        negative regulation of isotype switching 4
          negative regulation of isotype switching to IgA isotypes 0
          negative regulation of isotype switching to IgD isotypes 0
          negative regulation of isotype switching to IgE isotypes 3
          negative regulation of isotype switching to IgG isotypes 0
Path 2
Term Annotations click to browse term
  biological_process 19872
    metabolic process 11602
      biosynthetic process 8273
        cellular biosynthetic process 7844
          macromolecule biosynthetic process 7299
            gene expression 6861
              production of molecular mediator of immune response 245
                immunoglobulin production 116
                  immunoglobulin production involved in immunoglobulin-mediated immune response 64
                    somatic diversification of immunoglobulins involved in immune response 59
                      somatic recombination of immunoglobulin genes involved in immune response 59
                        isotype switching 59
                          regulation of isotype switching 41
                            negative regulation of isotype switching 4
                              negative regulation of isotype switching to IgA isotypes 0
                              negative regulation of isotype switching to IgD isotypes 0
                              negative regulation of isotype switching to IgE isotypes 3
                              negative regulation of isotype switching to IgG isotypes 0
paths to the root