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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of DNA metabolic process
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Accession:GO:0051053 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA.
Synonyms:exact_synonym: down regulation of DNA metabolic process;   downregulation of DNA metabolic process;   negative regulation of DNA metabolism
 narrow_synonym: inhibition of DNA metabolic process



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negative regulation of DNA metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sub1 SUB1 regulator of transcription involved_in ISO (PMID:28369605) RGD PMID:28369605 NCBI chr 2:61,005,646...61,020,486 JBrowse link
negative regulation of apoptotic DNA fragmentation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dffa DNA fragmentation factor subunit alpha acts_upstream_of_or_within
involved_in
ISO (PMID:15572351)
MGI:2179456 (PMID:10601318), (PMID:14663139)
(PMID:11371636)
RGD PMID:10601318 PMID:11371636 PMID:14663139 PMID:15572351 NCBI chr 5:159,540,715...159,553,639 JBrowse link
G Dffb DNA fragmentation factor subunit beta involved_in ISO
IEA
(PMID:11371636)
GO_REF:0000107
RGD
Ensembl
PMID:11371636 GO_REF:0000107 NCBI chr 5:169,804,873...169,817,157 JBrowse link
G Nmnat1 nicotinamide nucleotide adenylyltransferase 1 IMP RGD PMID:27184051 RGD:13781945 NCBI chr 5:159,910,242...159,928,201 JBrowse link
G Pam16 presequence translocase associated motor 16 IDA RGD PMID:24069394 RGD:13462066 NCBI chr10:10,942,534...10,950,654 JBrowse link
negative regulation of deoxyribonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dffa DNA fragmentation factor subunit alpha involved_in ISO (PMID:19944011) RGD PMID:19944011 NCBI chr 5:159,540,715...159,553,639 JBrowse link
negative regulation of DNA biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing involved_in ISS
ISO
GO_REF:0000024
(PMID:12070119)
UniProt
RGD
PMID:12070119 GO_REF:0000024 NCBI chr11:91,226,524...91,240,244 JBrowse link
G Ahr aryl hydrocarbon receptor IDA
IMP
RGD PMID:12193573 PMID:17952121 RGD:625678, RGD:405878083 NCBI chr 6:57,961,423...57,998,901 JBrowse link
G Ankrd1 ankyrin repeat domain 1 involved_in ISO
IEA
(PMID:11139470)
GO_REF:0000107
RGD
Ensembl
PMID:11139470 GO_REF:0000107 NCBI chr 1:233,815,851...233,834,891 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A involved_in ISO (PMID:11595739) RGD PMID:11595739 NCBI chr20:7,150,820...7,161,373 JBrowse link
G Chek1 checkpoint kinase 1 IMP RGD PMID:12429946 RGD:2316115 NCBI chr 8:44,609,417...44,629,867 JBrowse link
G Dach1 dachshund family transcription factor 1 involved_in ISO (PMID:16980615) RGD PMID:16980615 NCBI chr15:74,528,122...74,909,811 JBrowse link
G Dnajc2 DnaJ heat shock protein family (Hsp40) member C2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:7559602)
Ensembl
RGD
PMID:7559602 GO_REF:0000107 NCBI chr 4:13,270,239...13,297,438 JBrowse link
G Dusp1 dual specificity phosphatase 1 IDA RGD PMID:10446064 RGD:7771571 NCBI chr10:17,184,853...17,187,646 JBrowse link
G Gja1 gap junction protein, alpha 1 IDA RGD PMID:14702389 RGD:8662403 NCBI chr20:36,302,490...36,315,010 JBrowse link
G Kcnk2 potassium two pore domain channel subfamily K member 2 IMP RGD PMID:23271285 RGD:9831181 NCBI chr13:100,766,101...100,963,435 JBrowse link
G Niban2 niban apoptosis regulator 2 involved_in ISO (PMID:14602737), (PMID:17569660), (PMID:20032057) RGD PMID:14602737 PMID:17569660 PMID:20032057 NCBI chr 3:16,174,674...16,224,293 JBrowse link
G Nppc natriuretic peptide C IDA RGD PMID:12746286 RGD:1580115 NCBI chr 9:94,767,986...94,772,186 JBrowse link
G Rgn regucalcin IMP RGD PMID:11500948 RGD:9590199 NCBI chr  X:1,619,030...1,634,456 JBrowse link
G Tp53 tumor protein p53 IMP RGD PMID:11502571 RGD:70312 NCBI chr10:54,798,871...54,810,300 JBrowse link
negative regulation of DNA catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rgn regucalcin IDA RGD PMID:2001740 RGD:9590215 NCBI chr  X:1,619,030...1,634,456 JBrowse link
negative regulation of DNA endoreduplication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fbxo5 F-box protein 5 involved_in ISO (PMID:17875940) RGD PMID:17875940 NCBI chr 1:44,601,412...44,607,781 JBrowse link
negative regulation of DNA recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Blm BLM RecQ like helicase involved_in ISO (PMID:9671747) RGD PMID:9671747 NCBI chr 1:143,819,072...143,905,300 JBrowse link
G H1f0 H1.0 linker histone involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:112,473,280...112,475,140 JBrowse link
G H1f1 H1.1 linker histone, cluster member involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:41,762,278...41,794,876 JBrowse link
G H1f10 H1.10 linker histone involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:121,997,834...121,998,897 JBrowse link
G H1f2 H1.2 linker histone, cluster member involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:41,818,962...41,820,453 JBrowse link
G H1f4 H1.4 linker histone, cluster member involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:41,914,425...41,915,206 JBrowse link
G H1f5 H1.5 linker histone, cluster member involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:47,421,875...47,422,905 JBrowse link
G H1f6 H1.6 linker histone, cluster member involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:41,427,365...41,428,109 JBrowse link
G H1f7 H1.7 linker histone involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:129,408,521...129,409,888 JBrowse link
G H1f8 H1.8 linker histone involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:148,993,133...148,998,254 JBrowse link
G H4f3 H1.3 linker histone, cluster member involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:41,979,562...41,980,341 JBrowse link
G Hils1 histone linker H1 domain, spermatid-specific 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:79,913,525...79,914,321 JBrowse link
G Lig3 DNA ligase 3 acts_upstream_of_or_within ISO MGI:3629052 (PMID:16648486) RGD PMID:16648486 NCBI chr10:67,717,808...67,741,141 JBrowse link
G Msh2 mutS homolog 2 involved_in
acts_upstream_of_or_within
ISO
IEA
(PMID:17715146)
MGI:1858055 (PMID:10545954), (PMID:7628020)
GO_REF:0000107
RGD
Ensembl
PMID:7628020 PMID:10545954 PMID:17715146 GO_REF:0000107 NCBI chr 6:12,567,368...12,626,534 JBrowse link
G Msh3 mutS homolog 3 involved_in ISO (PMID:17715146) RGD PMID:17715146 NCBI chr 2:25,179,400...25,320,857 JBrowse link
G Msh6 mutS homolog 6 involved_in
acts_upstream_of_or_within
ISO (PMID:17715146)
MGI:2151803 (PMID:10545954)
RGD PMID:10545954 PMID:17715146 NCBI chr 6:12,316,190...12,333,505 JBrowse link
G Rad18 RAD18 E3 ubiquitin protein ligase acts_upstream_of_or_within ISO MGI:3835812 (PMID:12509447) RGD PMID:12509447 NCBI chr 4:145,735,654...145,821,102 JBrowse link
G Rtel1 regulator of telomere elongation helicase 1 involved_in IBA
ISO
GO_REF:0000033
(PMID:22579284)
GO_Central
RGD
PMID:22579284 GO_REF:0000033 NCBI chr 3:168,427,247...168,465,349 JBrowse link
negative regulation of DNA recombination at telomere term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pot1b protection of telomeres 1B involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 9:9,670,355...9,728,624 JBrowse link
G Terf2ip TERF2 interacting protein involved_in ISS
ISO
GO_REF:0000024
(PMID:20339076), (PMID:20622869)
UniProt
RGD
PMID:20339076 PMID:20622869 GO_REF:0000024 NCBI chr19:39,976,965...39,984,055 JBrowse link
negative regulation of DNA repair term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cgas cyclic GMP-AMP synthase involved_in ISO (PMID:35210392) RGD PMID:35210392 NCBI chr 8:79,292,282...79,306,998 JBrowse link
G Rps3 ribosomal protein S3 involved_in ISO (PMID:17049931) RGD PMID:17049931 NCBI chr 1:163,190,476...163,195,885 JBrowse link
negative regulation of DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atr ATR serine/threonine kinase involved_in ISO (PMID:14657349) RGD PMID:14657349 NCBI chr 8:105,306,299...105,403,742 JBrowse link
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 involved_in ISO (PMID:12671034) RGD PMID:12671034 NCBI chr10:104,242,169...104,247,185 JBrowse link
G Gmnn geminin, DNA replication inhibitor involved_in ISO (PMID:9635433)
(PMID:12192004)
RGD PMID:9635433 PMID:12192004 NCBI chr17:40,729,760...40,738,077 JBrowse link
G Gtpbp4 GTP binding protein 4 involved_in ISO
ISS
(PMID:17210637)
GO_REF:0000024
RGD
HGNC-UCL
PMID:17210637 GO_REF:0000024 NCBI chr17:61,308,033...61,328,184 JBrowse link
G Hcrt hypocretin neuropeptide precursor IDA in seminiferous tubules at epithelial cycle stage V RGD PMID:16141395 RGD:1600965 NCBI chr10:86,190,289...86,191,524 JBrowse link
G Hmgb1 high mobility group box 1 IDA RGD PMID:18191612 RGD:2316772 NCBI chr12:11,009,236...11,015,941 JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 IMP RGD PMID:12933696 RGD:1626126 NCBI chr 1:156,183,043...156,197,500 JBrowse link
G Mapk15 mitogen-activated protein kinase 15 IMP RGD PMID:9891064 RGD:632686 NCBI chr 7:109,575,619...109,595,339 JBrowse link
G Pds5a PDS5 cohesin associated factor A involved_in ISO
IEA
ISS
(PMID:19907496)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:19907496 GO_REF:0000024 GO_REF:0000107 NCBI chr14:42,905,734...43,004,740 JBrowse link
G Rad17 RAD17 checkpoint clamp loader component involved_in ISO (PMID:14657349) RGD PMID:14657349 NCBI chr 2:31,764,260...31,794,542 JBrowse link
G Slfn9 schlafen family member 9 involved_in ISO (PMID:29395061) RGD PMID:29395061 NCBI chr10:67,909,105...67,955,912 JBrowse link
G Terf1 telomeric repeat binding factor 1 involved_in ISO (PMID:11327863) RGD PMID:11327863 NCBI chr 5:3,443,103...3,472,377 JBrowse link
G Tp53 tumor protein p53 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1926340 (PMID:11884608)
Ensembl
RGD
PMID:11884608 GO_REF:0000107 NCBI chr10:54,798,871...54,810,300 JBrowse link
G Tspyl2 TSPY-like 2 involved_in ISO (PMID:11395479) RGD PMID:11395479 NCBI chr  X:21,439,478...21,445,208 JBrowse link
G Wapl WAPL cohesin release factor involved_in ISO (PMID:19907496) RGD PMID:19907496 NCBI chr16:10,005,520...10,075,270 JBrowse link
negative regulation of DNA strand resection involved in replication fork processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dynll1 dynein light chain LC8-type 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:30464262), (PMID:37696958)
UniProt
RGD
PMID:30464262 PMID:37696958 GO_REF:0000024 NCBI chr12:46,945,291...46,976,867 JBrowse link
negative regulation of DNA-templated DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdt1 chromatin licensing and DNA replication factor 1 involved_in ISO (PMID:19906994) RGD PMID:19906994 NCBI chr19:67,529,249...67,534,195 JBrowse link
G Gmnn geminin, DNA replication inhibitor involved_in ISO (PMID:11125146), (PMID:19906994) RGD PMID:11125146 PMID:19906994 NCBI chr17:40,729,760...40,738,077 JBrowse link
negative regulation of double-strand break repair term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir221 microRNA 221 involved_in ISO (PMID:24147153) RGD PMID:24147153 NCBI chr  X:6,023,182...6,023,290 JBrowse link
G Otub1 OTU deubiquitinase, ubiquitin aldehyde binding 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:20725033)
UniProt
RGD
PMID:20725033 GO_REF:0000024 NCBI chr 1:204,387,215...204,395,495 JBrowse link
G Rnf169 ring finger protein 169 involved_in ISO (PMID:22492721), (PMID:22733822), (PMID:22742833) RGD PMID:22492721 PMID:22733822 PMID:22742833 NCBI chr 1:154,250,462...154,311,867 JBrowse link
G Twist1 twist family bHLH transcription factor 1 involved_in ISO (PMID:17690110) RGD PMID:17690110 NCBI chr 6:50,674,910...50,676,904 JBrowse link
negative regulation of double-strand break repair via homologous recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase involved_in ISO (PMID:9461559) RGD PMID:9461559 NCBI chr 3:35,377,587...35,480,843 JBrowse link
G C1qbp complement C1q binding protein involved_in IEA
ISO
ISS
GO_REF:0000107
(PMID:31353207)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:31353207 GO_REF:0000024 GO_REF:0000107 NCBI chr10:56,198,534...56,203,185 JBrowse link
G Cgas cyclic GMP-AMP synthase involved_in ISO
IBA
(PMID:30356214), (PMID:31544964)
GO_REF:0000033
RGD
GO_Central
PMID:30356214 PMID:31544964 GO_REF:0000033 NCBI chr 8:79,292,282...79,306,998 JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:28512243)
UniProt
RGD
PMID:28512243 GO_REF:0000024 NCBI chr 3:161,170,295...161,217,073 JBrowse link
G Fancb FA complementation group B involved_in
acts_upstream_of_or_within
IBA
ISO
GO_REF:0000033
MGI:2156841 (PMID:25520194)
GO_Central
RGD
PMID:25520194 GO_REF:0000033 NCBI chr  X:33,035,387...33,051,993 JBrowse link
G Fbh1 F-box DNA helicase 1 involved_in ISO (PMID:19736316)
(PMID:24108124)
RGD PMID:19736316 PMID:24108124 NCBI chr17:66,749,506...66,787,590 JBrowse link
G Helb DNA helicase B involved_in ISO (PMID:26774285) RGD PMID:26774285 NCBI chr 7:57,474,115...57,502,221 JBrowse link
G Kat5 lysine acetyltransferase 5 involved_in ISO
IEA
(PMID:32832608)
GO_REF:0000107
RGD
Ensembl
PMID:32832608 GO_REF:0000107 NCBI chr 1:212,325,089...212,332,640 JBrowse link
G Klhl15 kelch-like family member 15 involved_in ISS
ISO
GO_REF:0000024
(PMID:27561354), (PMID:35219381)
UniProt
RGD
PMID:27561354 PMID:35219381 GO_REF:0000024 NCBI chr  X:58,994,726...59,050,207 JBrowse link
G Kmt5a lysine methyltransferase 5A involved_in ISO (PMID:27338793) RGD PMID:27338793 NCBI chr12:37,800,339...37,823,706 JBrowse link
G Mad2l2 mitotic arrest deficient 2 like 2 involved_in ISO (PMID:29656893) RGD PMID:29656893 NCBI chr 5:163,846,678...163,859,851 JBrowse link
G Parpbp PARP1 binding protein involved_in ISS
IBA
IEA
ISO
GO_REF:0000024
GO_REF:0000033
GO_REF:0000002
(PMID:22153967)
UniProt
GO_Central
InterPro
RGD
PMID:22153967 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 NCBI chr 7:22,511,427...22,580,834 JBrowse link
G Plk1 polo-like kinase 1 involved_in IEA
ISO
ISS
GO_REF:0000107
(PMID:28512243)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:28512243 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:186,147,658...186,157,637 JBrowse link
G Polq DNA polymerase theta involved_in ISO (PMID:25642963), (PMID:28695890), (PMID:36455556)
(PMID:25642960), (PMID:28687761), (PMID:29058711)
RGD PMID:25642960 PMID:25642963 PMID:28687761 PMID:28695890 PMID:29058711 More... NCBI chr11:77,179,190...77,281,270 JBrowse link
G Radx RPA1 related single stranded DNA binding protein, X-linked involved_in ISO
IEA
ISS
(PMID:28735897)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:28735897 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:103,089,284...103,176,840 JBrowse link
G Recql5 RecQ like helicase 5 acts_upstream_of_or_within ISO MGI:2448558 (PMID:25520194) RGD PMID:25520194 NCBI chr10:101,126,544...101,165,739 JBrowse link
G Rif1 replication timing regulatory factor 1 involved_in ISO (PMID:23333306)
(PMID:23306437), (PMID:23333305)
RGD PMID:23306437 PMID:23333305 PMID:23333306 NCBI chr 3:56,963,840...57,017,106 JBrowse link
G Rmi2 RecQ mediated genome instability 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:4,829,333...4,837,264 JBrowse link
G Senp3 SUMO specific peptidase 3 involved_in ISO (PMID:32832608) RGD PMID:32832608 NCBI chr10:54,390,698...54,399,590 JBrowse link
G Shld1 shieldin complex subunit 1 involved_in ISO
IBA
(PMID:29656893)
GO_REF:0000033
RGD
GO_Central
PMID:29656893 GO_REF:0000033 NCBI chr 3:119,938,695...120,011,068 JBrowse link
G Shld2 shieldin complex subunit 2 involved_in ISO (PMID:29656893) RGD PMID:29656893 NCBI chr16:9,544,940...9,640,323 JBrowse link
G Shld3 shieldin complex subunit 3 involved_in ISO
IBA
(PMID:29656893)
GO_REF:0000033
RGD
GO_Central
PMID:29656893 GO_REF:0000033 NCBI chr 2:35,297,255...35,302,071 JBrowse link
G Smchd1 structural maintenance of chromosomes flexible hinge domain containing 1 involved_in ISO (PMID:25294876) RGD PMID:25294876 NCBI chr 9:111,243,445...111,387,272 JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 involved_in ISO (PMID:23333306), (PMID:23345425)
(PMID:20362325), (PMID:23333305)
RGD PMID:20362325 PMID:23333305 PMID:23333306 PMID:23345425 NCBI chr 3:108,166,574...108,270,229 JBrowse link
G Ubqln4 ubiquilin 4 involved_in ISO (PMID:30612738) RGD PMID:30612738 NCBI chr 2:174,012,726...174,028,062 JBrowse link
negative regulation of double-strand break repair via nonhomologous end joining term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aunip aurora kinase A and ninein interacting protein involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:29042561)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:29042561 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:146,722,329...146,734,924 JBrowse link
G Cyren cell cycle regulator of NHEJ involved_in ISO
ISS
IEA
(PMID:28959974)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:28959974 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:63,547,311...63,553,394 JBrowse link
G Ercc6 ERCC excision repair 6, chromatin remodeling factor involved_in ISO (PMID:25820262) RGD PMID:25820262 NCBI chr16:7,771,311...7,841,895 JBrowse link
G Hmga2 high mobility group AT-hook 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:19549901)
UniProt
RGD
PMID:19549901 GO_REF:0000024 NCBI chr 7:57,762,710...57,884,555 JBrowse link
G Hsf1 heat shock transcription factor 1 involved_in ISO (PMID:26359349) RGD PMID:26359349 NCBI chr 7:110,076,710...110,103,665 JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:24316220)
UniProt
Ensembl
RGD
PMID:24316220 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:19,900,211...19,961,906 JBrowse link
G Nudt16l1 nudix hydrolase 16 like 1 involved_in ISO (PMID:28241136) RGD PMID:28241136 NCBI chr10:10,636,174...10,638,090 JBrowse link
negative regulation of double-strand break repair via single-strand annealing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ogg1 8-oxoguanine DNA glycosylase acts_upstream_of_or_within ISO (PMID:19506022) RGD PMID:19506022 NCBI chr 4:148,030,237...148,037,599 JBrowse link
negative regulation of endodeoxyribonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gzma granzyme A involved_in ISO (PMID:12524539) RGD PMID:12524539 NCBI chr 2:44,740,569...44,752,502 JBrowse link
negative regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Parp3 poly (ADP-ribose) polymerase family, member 3 involved_in ISO (PMID:26000965) RGD PMID:26000965 NCBI chr 8:107,111,010...107,117,073 JBrowse link
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO MGI:103034|MGI:2158438 (PMID:10490661) RGD PMID:10490661 NCBI chr11:76,854,090...76,877,389 JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO MGI:3696705 (PMID:16275384) RGD PMID:16275384 NCBI chr  X:17,580,380...17,601,181 JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3695433 (PMID:17137798)
Ensembl
RGD
PMID:17137798 GO_REF:0000107 NCBI chr18:30,265,808...30,316,068 JBrowse link
negative regulation of mitochondrial DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg7 autophagy related 7 IMP RGD PMID:23800874 RGD:11557986 NCBI chr 4:149,390,000...149,597,534 JBrowse link
G Lig3 DNA ligase 3 involved_in ISO (PMID:21878356) RGD PMID:21878356 NCBI chr10:67,717,808...67,741,141 JBrowse link
negative regulation of mitotic recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankle1 ankyrin repeat and LEM domain containing 1 involved_in ISO UniProtKB:O88700 (PMID:27010503) RGD PMID:27010503 NCBI chr16:18,076,413...18,082,356 JBrowse link
G Blm BLM RecQ like helicase acts_upstream_of_or_within
involved_in
ISO MGI:1857708|MGI:2158669|MGI:2158670|MGI:3053044|MGI:3663359 (PMID:11101838), (PMID:16914751), (PMID:17210642), (PMID:9808625)
UniProtKB:A8VU90 (PMID:27010503)
RGD PMID:9808625 PMID:11101838 PMID:16914751 PMID:17210642 PMID:27010503 NCBI chr 1:143,819,072...143,905,300 JBrowse link
G Mlh1 mutL homolog 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1858054 (PMID:15480418)
Ensembl
RGD
PMID:15480418 GO_REF:0000107 NCBI chr 8:120,074,871...120,112,109 JBrowse link
negative regulation of protection from non-homologous end joining at telomere term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit involved_in ISO (PMID:14690602) RGD PMID:14690602 NCBI chr 1:78,971,310...79,007,963 JBrowse link
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit involved_in ISO (PMID:14690602) RGD PMID:14690602 NCBI chr10:2,416,259...2,448,364 JBrowse link
G Xrcc1 X-ray repair cross complementing 1 involved_in ISO (PMID:14690602) RGD PMID:14690602 NCBI chr 1:89,268,721...89,296,619 JBrowse link
G Xrcc4 X-ray repair cross complementing 4 involved_in ISO (PMID:14690602) RGD PMID:14690602 NCBI chr 2:20,948,464...21,197,705 JBrowse link
negative regulation of t-circle formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rtel1 regulator of telomere elongation helicase 1 involved_in ISO
IBA
(PMID:25620558)
(PMID:22579284), (PMID:24115439)
GO_REF:0000033
RGD
GO_Central
PMID:22579284 PMID:24115439 PMID:25620558 GO_REF:0000033 NCBI chr 3:168,427,247...168,465,349 JBrowse link
G Terf2 telomeric repeat binding factor 2 involved_in ISO (PMID:15507207) RGD PMID:15507207 NCBI chr19:34,976,963...35,005,813 JBrowse link
G Xrcc5 X-ray repair cross complementing 5 involved_in ISO (PMID:19581589) RGD PMID:19581589 NCBI chr 9:73,955,216...74,044,020 JBrowse link
negative regulation of telomere capping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase involved_in ISO (PMID:17694070) RGD PMID:17694070 NCBI chr 8:62,724,939...62,829,040 JBrowse link
G Nbn nibrin involved_in IEA
ISO
GO_REF:0000107
(PMID:17694070)
Ensembl
RGD
PMID:17694070 GO_REF:0000107 NCBI chr 5:34,256,678...34,291,163 JBrowse link
G Rad50 RAD50 double strand break repair protein involved_in ISO
IEA
(PMID:17694070)
GO_REF:0000107
RGD
Ensembl
PMID:17694070 GO_REF:0000107 NCBI chr10:37,809,353...37,861,309 JBrowse link
G Smg6 SMG6 nonsense mediated mRNA decay factor involved_in ISO (PMID:12676087) RGD PMID:12676087 NCBI chr10:59,786,258...60,014,395 JBrowse link
G Terf2 telomeric repeat binding factor 2 involved_in ISO (PMID:24270157) RGD PMID:24270157 NCBI chr19:34,976,963...35,005,813 JBrowse link
negative regulation of telomere maintenance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit involved_in ISO (PMID:17055345) RGD PMID:17055345 NCBI chr 1:78,971,310...79,007,963 JBrowse link
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit involved_in ISO (PMID:17055345) RGD PMID:17055345 NCBI chr10:2,416,259...2,448,364 JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase acts_upstream_of ISO (PMID:21531765) RGD PMID:21531765 NCBI chr 3:166,511,616...166,559,463 JBrowse link
G Terf2 telomeric repeat binding factor 2 involved_in ISO (PMID:11971978) RGD PMID:11971978 NCBI chr19:34,976,963...35,005,813 JBrowse link
G Tinf2 TERF1 interacting nuclear factor 2 acts_upstream_of_or_within ISO (PMID:12676566) RGD PMID:12676566 NCBI chr15:29,170,663...29,178,015 JBrowse link
negative regulation of telomere maintenance in response to DNA damage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rtel1 regulator of telomere elongation helicase 1 involved_in ISO (PMID:22579284) RGD PMID:22579284 NCBI chr 3:168,427,247...168,465,349 JBrowse link
negative regulation of telomere maintenance via recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Terf2 telomeric repeat binding factor 2 involved_in ISO
IBA
(PMID:15507207)
(PMID:24120135)
GO_REF:0000033
RGD
GO_Central
PMID:15507207 PMID:24120135 GO_REF:0000033 NCBI chr19:34,976,963...35,005,813 JBrowse link
negative regulation of telomere maintenance via telomerase term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acd ACD, shelterin complex subunit and telomerase recruitment factor involved_in IEA
ISO
IBA
GO_REF:0000107
UniProtKB:Q9NUX5 (PMID:15181449), (PMID:15380063), (PMID:25172512)
GO_REF:0000033
Ensembl
RGD
GO_Central
PMID:15181449 PMID:15380063 PMID:25172512 GO_REF:0000033 GO_REF:0000107 NCBI chr19:33,586,739...33,589,481 JBrowse link
G Ctc1 CST telomere replication complex component 1 involved_in ISO (PMID:22763445) RGD PMID:22763445 NCBI chr10:54,212,537...54,234,146 JBrowse link
G Dcp2 decapping mRNA 2 involved_in ISO (PMID:26950371) RGD PMID:26950371 NCBI chr18:36,750,732...36,787,067 JBrowse link
G Exosc10 exosome component 10 involved_in ISO (PMID:26950371) RGD PMID:26950371 NCBI chr 5:164,278,414...164,302,067 JBrowse link
G Gnl3l G protein nucleolar 3 like involved_in ISO (PMID:18082603) RGD PMID:18082603 NCBI chr  X:19,961,277...19,994,454 JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 involved_in ISO
IEA
(PMID:23935072)
GO_REF:0000107
RGD
Ensembl
PMID:23935072 GO_REF:0000107 NCBI chr 7:136,253,633...136,260,085 JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C involved_in ISO (PMID:18082603) RGD PMID:18082603 NCBI chr15:24,779,593...24,809,213 JBrowse link
G Hnrnpu heterogeneous nuclear ribonucleoprotein U involved_in IEA
ISO
GO_REF:0000107
(PMID:18082603)
Ensembl
RGD
PMID:18082603 GO_REF:0000107 NCBI chr13:92,609,791...92,618,580 JBrowse link
G Nat10 N-acetyltransferase 10 involved_in ISO (PMID:18082603) RGD PMID:18082603 NCBI chr 3:90,111,643...90,149,891 JBrowse link
G Pif1 PIF1 5'-to-3' DNA helicase involved_in ISO (PMID:16522649), (PMID:23657261) RGD PMID:16522649 PMID:23657261 NCBI chr 8:66,110,641...66,120,202 JBrowse link
G Pinx1 PIN2/TERF1 interacting, telomerase inhibitor 1 involved_in ISO
IEA
(PMID:11701125), (PMID:21119197)
GO_REF:0000107
RGD
Ensembl
PMID:11701125 PMID:21119197 GO_REF:0000107 NCBI chr15:38,097,896...38,157,143 JBrowse link
G Pml PML nuclear body scaffold involved_in ISO (PMID:19567472) RGD PMID:19567472 NCBI chr 8:58,627,347...58,661,927 JBrowse link
G Pot1 protection of telomeres 1 involved_in ISO UniProtKB:Q96AP0 (PMID:15181449), (PMID:15632080) RGD PMID:15181449 PMID:15632080 NCBI chr 4:54,205,330...54,263,137 JBrowse link
G Stn1 STN1 subunit of CST complex involved_in ISO
IEA
(PMID:22763445)
GO_REF:0000107
RGD
Ensembl
PMID:22763445 GO_REF:0000107 NCBI chr 1:246,391,311...246,429,844 JBrowse link
G Ten1 TEN1 subunit of CST complex involved_in ISO
IBA
(PMID:22763445)
GO_REF:0000033
RGD
GO_Central
PMID:22763445 GO_REF:0000033 NCBI chr10:101,431,328...101,455,105 JBrowse link
G Tent4b terminal nucleotidyltransferase 4B involved_in ISO (PMID:26950371) RGD PMID:26950371 NCBI chr19:34,984,244...35,042,423 JBrowse link
G Terf1 telomeric repeat binding factor 1 involved_in ISO UniProtKB:O14746 (PMID:11971978) RGD PMID:11971978 NCBI chr 5:3,443,103...3,472,377 JBrowse link
G Terf2 telomeric repeat binding factor 2 involved_in ISO (PMID:17055345) RGD PMID:17055345 NCBI chr19:34,976,963...35,005,813 JBrowse link
G Tinf2 TERF1 interacting nuclear factor 2 involved_in ISO (PMID:10581025), (PMID:15133513) RGD PMID:10581025 PMID:15133513 NCBI chr15:29,170,663...29,178,015 JBrowse link
G Tp53 tumor protein p53 involved_in IEA
ISO
GO_REF:0000107
(PMID:10597287)
Ensembl
RGD
PMID:10597287 GO_REF:0000107 NCBI chr10:54,798,871...54,810,300 JBrowse link
negative regulation of telomere maintenance via telomere lengthening term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit involved_in ISO (PMID:18812185) RGD PMID:18812185 NCBI chr10:2,416,259...2,448,364 JBrowse link
G Mcrs1 microspherule protein 1 involved_in ISO (PMID:15044100) RGD PMID:15044100 NCBI chr 7:132,262,719...132,271,533 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 involved_in ISO (PMID:26586427) RGD PMID:26586427 NCBI chr13:94,839,484...94,871,295 JBrowse link
G Slx1b SLX1 homolog B, structure-specific endonuclease subunit involved_in ISO (PMID:24012755) RGD PMID:24012755 NCBI chr 1:181,286,190...181,291,739 JBrowse link
G Slx4 SLX4 structure-specific endonuclease subunit involved_in ISO (PMID:24012755) RGD PMID:24012755 NCBI chr10:11,526,623...11,549,313 JBrowse link
G Terf2 telomeric repeat binding factor 2 involved_in ISO (PMID:24012755) RGD PMID:24012755 NCBI chr19:34,976,963...35,005,813 JBrowse link
G Tnks tankyrase involved_in ISO (PMID:25939383) RGD PMID:25939383 NCBI chr16:63,922,969...64,073,972 JBrowse link
G Tnks2 tankyrase 2 involved_in ISO (PMID:25939383) RGD PMID:25939383 NCBI chr 1:234,567,888...234,621,079 JBrowse link
negative regulation of telomeric D-loop disassembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Terf1 telomeric repeat binding factor 1 involved_in ISO (PMID:15200954) RGD PMID:15200954 NCBI chr 5:3,443,103...3,472,377 JBrowse link
G Terf2 telomeric repeat binding factor 2 involved_in ISO
IBA
(PMID:15200954)
GO_REF:0000033
RGD
GO_Central
PMID:15200954 GO_REF:0000033 NCBI chr19:34,976,963...35,005,813 JBrowse link
replication fork arrest term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC120094818 TIMELESS-interacting protein-like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:113,693,252...113,694,434 JBrowse link
G Slfn9 schlafen family member 9 involved_in ISO (PMID:29395061) RGD PMID:29395061 NCBI chr10:67,909,105...67,955,912 JBrowse link
G Timeless timeless circadian regulator involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:654,804...678,769 JBrowse link
G Tipin timeless interacting protein involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:64,780,813...64,801,358 JBrowse link
G Tipinl1 TIMELESS interacting protein like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:113,542,841...113,544,022 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20534
    negative regulation of biological process 5816
      negative regulation of cellular process 5588
        negative regulation of metabolic process 3156
          negative regulation of nucleobase-containing compound metabolic process 1552
            negative regulation of DNA metabolic process 140
              negative regulation of DNA biosynthetic process + 33
              negative regulation of DNA catabolic process + 5
              negative regulation of DNA recombination + 52
              negative regulation of DNA repair + 38
              negative regulation of DNA replication + 24
              negative regulation of deoxyribonuclease activity + 2
              negative regulation of meiotic DNA double-strand break formation + 0
              negative regulation of mitochondrial DNA metabolic process + 2
              negative regulation of mitotic recombination-dependent replication fork processing 0
              negative regulation of t-circle formation 3
              negative regulation of telomere maintenance + 36
Path 2
Term Annotations click to browse term
  biological_process 20534
    biological regulation 13821
      regulation of biological process 13375
        regulation of cellular process 13013
          regulation of metabolic process 6834
            regulation of primary metabolic process 5693
              regulation of nucleobase-containing compound metabolic process 4129
                negative regulation of nucleobase-containing compound metabolic process 1552
                  negative regulation of DNA metabolic process 140
                    negative regulation of DNA biosynthetic process + 33
                    negative regulation of DNA catabolic process + 5
                    negative regulation of DNA recombination + 52
                    negative regulation of DNA repair + 38
                    negative regulation of DNA replication + 24
                    negative regulation of deoxyribonuclease activity + 2
                    negative regulation of meiotic DNA double-strand break formation + 0
                    negative regulation of mitochondrial DNA metabolic process + 2
                    negative regulation of mitotic recombination-dependent replication fork processing 0
                    negative regulation of t-circle formation 3
                    negative regulation of telomere maintenance + 36
paths to the root