PLK1 (polo like kinase 1) - Rat Genome Database

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Gene: PLK1 (polo like kinase 1) Homo sapiens
Analyze
Symbol: PLK1
Name: polo like kinase 1
RGD ID: 1353801
HGNC Page HGNC
Description: Enables several functions, including ATP binding activity; anaphase-promoting complex binding activity; and magnesium ion binding activity. Involved in several processes, including microtubule cytoskeleton organization; regulation of cell cycle process; and regulation of cellular protein metabolic process. Acts upstream of or within establishment of protein localization. Located in several cellular components, including kinetochore; microtubule cytoskeleton; and midbody. Part of outer kinetochore. Colocalizes with spindle microtubule. Implicated in urinary bladder cancer. Biomarker of breast carcinoma; endometriosis; ovary epithelial cancer; prostate carcinoma; and urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cell cycle regulated protein kinase; PLK; PLK-1; polo (Drosophia)-like kinase; polo like kinase; polo-like kinase 1; serine/threonine-protein kinase 13; serine/threonine-protein kinase PLK1; STPK13
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: LOC392226   LOC648774  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1623,677,656 - 23,690,367 (+)EnsemblGRCh38hg38GRCh38
GRCh381623,678,889 - 23,690,367 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371623,690,210 - 23,701,688 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361623,597,702 - 23,609,189 (+)NCBINCBI36hg18NCBI36
Build 341623,597,701 - 23,609,191NCBI
Celera1622,468,373 - 22,479,857 (+)NCBI
Cytogenetic Map16p12.2NCBI
HuRef1621,779,829 - 21,791,312 (+)NCBIHuRef
CHM1_11624,701,920 - 24,713,407 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,3-dinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3-dimethoxynaphthalene-1,4-dione  (EXP)
2,4-dinitrotoluene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-methoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrolein  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
alpha-pinene  (EXP)
ammonium chloride  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
beauvericin  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[b]fluoranthene  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
cadmium atom  (EXP)
calcitriol  (EXP)
carbon nanotube  (ISO)
cefaloridine  (ISO)
choline  (ISO)
chromium atom  (EXP)
ciprofloxacin  (ISO)
cis-caffeic acid  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
corticosterone  (ISO)
coumestrol  (EXP)
Cuprizon  (ISO)
curcumin  (EXP)
cyclosporin A  (EXP)
D-glucose  (ISO)
diazinon  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (EXP)
dieldrin  (ISO)
diethyl maleate  (EXP)
dioxygen  (EXP)
doxorubicin  (EXP)
Echimidine  (EXP)
Enterolactone  (EXP)
enzalutamide  (EXP)
etoposide  (ISO)
folic acid  (EXP,ISO)
fulvestrant  (EXP)
furan  (ISO)
gemcitabine  (EXP)
genistein  (EXP)
geraniol  (EXP)
glucose  (ISO)
hydrogen peroxide  (EXP)
indole-3-methanol  (ISO)
irinotecan  (EXP)
ivermectin  (EXP)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
Lasiocarpine  (EXP)
leflunomide  (EXP,ISO)
lucanthone  (EXP)
luteolin  (EXP)
menadione  (EXP)
methotrexate  (EXP)
methoxyacetic acid  (ISO)
methylseleninic acid  (EXP)
microcystin-LR  (EXP)
mitomycin C  (ISO)
monocrotaline  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (EXP)
nickel atom  (EXP)
nickel dichloride  (ISO)
O-methyleugenol  (EXP,ISO)
ochratoxin A  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paclitaxel  (EXP)
palbociclib  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorononanoic acid  (EXP)
phenethyl isothiocyanate  (EXP)
phenformin  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
promethazine  (ISO)
propanal  (EXP)
quercetin  (EXP)
resveratrol  (EXP)
riddelliine  (EXP)
rotenone  (EXP,ISO)
serpentine asbestos  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sulforaphane  (EXP)
sunitinib  (EXP)
tamoxifen  (EXP)
tebufenpyrad  (EXP)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thioacetamide  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (ISO)
trans-caffeic acid  (EXP)
trichloroethene  (ISO)
trichostatin A  (EXP)
trimellitic anhydride  (ISO)
Triptolide  (ISO)
troglitazone  (EXP)
valproic acid  (EXP,ISO)
zaragozic acid A  (ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
centrosome cycle  (IMP)
establishment of mitotic spindle orientation  (IDA)
establishment of protein localization  (IMP)
female meiosis chromosome segregation  (IEA,ISO)
G2/M transition of mitotic cell cycle  (IDA,TAS)
homologous chromosome segregation  (IEA,ISO)
microtubule bundle formation  (IDA)
mitotic cell cycle  (IBA,IDA,IMP)
mitotic chromosome condensation  (TAS)
mitotic cytokinesis  (IDA)
mitotic G2 DNA damage checkpoint signaling  (IDA)
mitotic nuclear membrane disassembly  (TAS)
mitotic sister chromatid segregation  (IMP)
mitotic spindle assembly checkpoint signaling  (IMP)
mitotic spindle organization  (TAS)
negative regulation of apoptotic process  (IMP)
negative regulation of cyclin-dependent protein serine/threonine kinase activity  (IMP)
negative regulation of transcription by RNA polymerase II  (IMP)
nuclear membrane disassembly  (IMP)
peptidyl-serine phosphorylation  (IDA,ISO)
polar body extrusion after meiotic divisions  (ISO)
positive regulation of peptidyl-threonine phosphorylation  (IMP)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IMP)
positive regulation of protein localization to nucleus  (TAS)
positive regulation of proteolysis  (IDA)
positive regulation of ubiquitin protein ligase activity  (IDA,TAS)
positive regulation of ubiquitin-protein transferase activity  (IMP)
protein destabilization  (IDA)
protein localization to chromatin  (IDA)
protein localization to nuclear envelope  (IMP)
protein localization to organelle  (ISO)
protein phosphorylation  (IDA,IEA,IMP,ISO)
protein ubiquitination  (IDA)
regulation of anaphase-promoting complex-dependent catabolic process  (TAS)
regulation of cell cycle  (TAS)
regulation of cytokinesis  (IBA,IDA,IMP)
regulation of mitotic cell cycle  (IMP)
regulation of mitotic cell cycle phase transition  (TAS)
regulation of mitotic metaphase/anaphase transition  (IDA,IMP)
regulation of mitotic spindle assembly  (IDA)
regulation of protein binding  (IMP,ISO)
regulation of protein localization to cell cortex  (IDA)
response to antibiotic  (ISO)
sister chromatid cohesion  (TAS)
synaptonemal complex disassembly  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

Additional References at PubMed
PMID:7478607   PMID:7790358   PMID:7902533   PMID:7962193   PMID:8018557   PMID:8127874   PMID:8524282   PMID:8991084   PMID:9083047   PMID:9154840   PMID:9177283   PMID:9499405  
PMID:10037602   PMID:10191277   PMID:10793135   PMID:10973490   PMID:11076968   PMID:11111111   PMID:11127806   PMID:11194558   PMID:11202906   PMID:11205743   PMID:11242082   PMID:11256614  
PMID:11283617   PMID:11447294   PMID:11807090   PMID:11854496   PMID:11897663   PMID:11901158   PMID:11931760   PMID:12024051   PMID:12034729   PMID:12077309   PMID:12082631   PMID:12147700  
PMID:12167714   PMID:12207013   PMID:12221128   PMID:12242661   PMID:12364337   PMID:12429910   PMID:12442251   PMID:12447691   PMID:12477932   PMID:12493754   PMID:12524548   PMID:12548019  
PMID:12592388   PMID:12595692   PMID:12639966   PMID:12708489   PMID:12732729   PMID:12738781   PMID:12815053   PMID:12852856   PMID:12852857   PMID:12939256   PMID:14532005   PMID:14592974  
PMID:14647413   PMID:14654792   PMID:14734534   PMID:14735186   PMID:15015605   PMID:15024021   PMID:15070733   PMID:15105433   PMID:15125835   PMID:15141022   PMID:15148369   PMID:15176053  
PMID:15190079   PMID:15199097   PMID:15210710   PMID:15280449   PMID:15350223   PMID:15458642   PMID:15469984   PMID:15489334   PMID:15611664   PMID:15616186   PMID:15654075   PMID:15661742  
PMID:15661849   PMID:15664519   PMID:15678101   PMID:15713655   PMID:15737063   PMID:15766665   PMID:15855824   PMID:15876876   PMID:15923617   PMID:16118204   PMID:16127294   PMID:16157594  
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PMID:16478733   PMID:16481748   PMID:16582488   PMID:16630118   PMID:16648550   PMID:16753148   PMID:16760428   PMID:16815967   PMID:16860740   PMID:16864798   PMID:16865274   PMID:16873548  
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PMID:18056432   PMID:18062778   PMID:18171681   PMID:18174154   PMID:18195732   PMID:18250300   PMID:18278450   PMID:18297112   PMID:18298087   PMID:18298903   PMID:18329369   PMID:18331714  
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PMID:18625707   PMID:18662541   PMID:18676680   PMID:18694934   PMID:18695677   PMID:18773538   PMID:18794143   PMID:18820703   PMID:18854154   PMID:18922800   PMID:18950845   PMID:18957422  
PMID:18980975   PMID:19001871   PMID:19004025   PMID:19033445   PMID:19152411   PMID:19160488   PMID:19170196   PMID:19177004   PMID:19182791   PMID:19289504   PMID:19351716   PMID:19386263  
PMID:19390576   PMID:19400994   PMID:19452252   PMID:19454010   PMID:19458358   PMID:19468300   PMID:19468302   PMID:19473992   PMID:19487276   PMID:19490893   PMID:19503101   PMID:19509060  
PMID:19543530   PMID:19546225   PMID:19554017   PMID:19572149   PMID:19596235   PMID:19597481   PMID:19615732   PMID:19625176   PMID:19631697   PMID:19668228   PMID:19690138   PMID:19692168  
PMID:19706541   PMID:19725153   PMID:19738611   PMID:19739117   PMID:19758559   PMID:19775446   PMID:19804365   PMID:19821153   PMID:19822658   PMID:19833129   PMID:19855194   PMID:19889641  
PMID:19953087   PMID:20089605   PMID:20103597   PMID:20126263   PMID:20130082   PMID:20145140   PMID:20146883   PMID:20170163   PMID:20198330   PMID:20360068   PMID:20404504   PMID:20427271  
PMID:20467437   PMID:20470222   PMID:20484576   PMID:20508983   PMID:20511645   PMID:20534861   PMID:20562859   PMID:20573420   PMID:20577264   PMID:20581060   PMID:20581453   PMID:20615875  
PMID:20622363   PMID:20624918   PMID:20656208   PMID:20664522   PMID:20679239   PMID:20819778   PMID:20823832   PMID:20860994   PMID:20869364   PMID:20890306   PMID:20937827   PMID:20962589  
PMID:21041660   PMID:21051833   PMID:21078677   PMID:21079244   PMID:21111234   PMID:21145461   PMID:21148584   PMID:21169242   PMID:21170987   PMID:21184800   PMID:21242189   PMID:21244100  
PMID:21253604   PMID:21271384   PMID:21330050   PMID:21399492   PMID:21399614   PMID:21436619   PMID:21454580   PMID:21474997   PMID:21480320   PMID:21507953   PMID:21519187   PMID:21522128  
PMID:21533207   PMID:21576470   PMID:21602893   PMID:21610149   PMID:21635870   PMID:21636267   PMID:21640712   PMID:21642957   PMID:21690413   PMID:21700221   PMID:21723128   PMID:21726628  
PMID:21750699   PMID:21768102   PMID:21813642   PMID:21816470   PMID:21818122   PMID:21832049   PMID:21857030   PMID:21857149   PMID:21873635   PMID:21880710   PMID:21887822   PMID:21890624  
PMID:21900206   PMID:21947279   PMID:21953073   PMID:21962513   PMID:21978935   PMID:21987589   PMID:21988832   PMID:22000864   PMID:22064247   PMID:22108192   PMID:22115795   PMID:22120675  
PMID:22154349   PMID:22184120   PMID:22184200   PMID:22188812   PMID:22192978   PMID:22249248   PMID:22262171   PMID:22268729   PMID:22281053   PMID:22305495   PMID:22309939   PMID:22314839  
PMID:22325354   PMID:22365832   PMID:22390279   PMID:22391203   PMID:22405092   PMID:22427657   PMID:22467873   PMID:22535524   PMID:22566210   PMID:22593191   PMID:22609948   PMID:22617334  
PMID:22621898   PMID:22641346   PMID:22648245   PMID:22653443   PMID:22701722   PMID:22753241   PMID:22753416   PMID:22795848   PMID:22818914   PMID:22820163   PMID:22826617   PMID:22854038  
PMID:22863584   PMID:22869522   PMID:22890325   PMID:22892842   PMID:22902628   PMID:22908307   PMID:22918237   PMID:22939629   PMID:22948661   PMID:22972498   PMID:23027877   PMID:23036704  
PMID:23037713   PMID:23045552   PMID:23046929   PMID:23047923   PMID:23063527   PMID:23079597   PMID:23105120   PMID:23144294   PMID:23151088   PMID:23160376   PMID:23188630   PMID:23345402  
PMID:23354166   PMID:23359173   PMID:23383273   PMID:23455152   PMID:23455478   PMID:23494182   PMID:23509069   PMID:23520509   PMID:23525475   PMID:23566315   PMID:23574746   PMID:23615397  
PMID:23643811   PMID:23661607   PMID:23695676   PMID:23713868   PMID:23750008   PMID:23753023   PMID:23757039   PMID:23770244   PMID:23790466   PMID:23792639   PMID:23804033   PMID:23887393  
PMID:23972993   PMID:23977272   PMID:23983103   PMID:24018379   PMID:24032677   PMID:24067368   PMID:24067371   PMID:24076372   PMID:24157919   PMID:24166892   PMID:24196446   PMID:24204733  
PMID:24205328   PMID:24255178   PMID:24271645   PMID:24327015   PMID:24338364   PMID:24349352   PMID:24407240   PMID:24407358   PMID:24413556   PMID:24427308   PMID:24447338   PMID:24448238  
PMID:24451569   PMID:24482237   PMID:24484936   PMID:24498222   PMID:24501426   PMID:24510904   PMID:24519995   PMID:24613305   PMID:24626184   PMID:24706748   PMID:24722282   PMID:24767679  
PMID:24771642   PMID:24777477   PMID:24785407   PMID:24797263   PMID:24835992   PMID:24844881   PMID:24874015   PMID:24876664   PMID:24893992   PMID:24931513   PMID:24981860   PMID:25036634  
PMID:25047839   PMID:25169932   PMID:25246616   PMID:25329897   PMID:25347203   PMID:25347426   PMID:25395579   PMID:25398439   PMID:25430493   PMID:25453754   PMID:25480943   PMID:25483079  
PMID:25483104   PMID:25486482   PMID:25501367   PMID:25503564   PMID:25504441   PMID:25505174   PMID:25505268   PMID:25524551   PMID:25537513   PMID:25565629   PMID:25592872   PMID:25607646  
PMID:25659891   PMID:25666058   PMID:25670858   PMID:25697066   PMID:25714006   PMID:25737075   PMID:25754767   PMID:25826089   PMID:25830382   PMID:25852190   PMID:25855382   PMID:25917079  
PMID:25921289   PMID:25925375   PMID:25975351   PMID:25986610   PMID:26012549   PMID:26047016   PMID:26057687   PMID:26070557   PMID:26090465   PMID:26119734   PMID:26124292   PMID:26171916  
PMID:26186194   PMID:26192437   PMID:26206521   PMID:26242183   PMID:26259146   PMID:26280018   PMID:26291670   PMID:26293378   PMID:26302797   PMID:26317649   PMID:26318737   PMID:26323689  
PMID:26344197   PMID:26387737   PMID:26401039   PMID:26406118   PMID:26468278   PMID:26493360   PMID:26496610   PMID:26503893   PMID:26513691   PMID:26549165   PMID:26557691   PMID:26576650  
PMID:26577686   PMID:26595675   PMID:26608325   PMID:26638075   PMID:26647647   PMID:26693507   PMID:26745677   PMID:26786872   PMID:26794530   PMID:26811421   PMID:26876462   PMID:26912231  
PMID:26919439   PMID:26919559   PMID:26972000   PMID:27002166   PMID:27003818   PMID:27043190   PMID:27064522   PMID:27068477   PMID:27102712   PMID:27127172   PMID:27160062   PMID:27173435  
PMID:27219065   PMID:27220401   PMID:27245623   PMID:27390342   PMID:27398835   PMID:27409838   PMID:27432908   PMID:27498003   PMID:27538997   PMID:27542221   PMID:27557495   PMID:27557660  
PMID:27558135   PMID:27566175   PMID:27579920   PMID:27579997   PMID:27637333   PMID:27647547   PMID:27662907   PMID:27712975   PMID:27721411   PMID:27773673   PMID:27793694   PMID:27831827  
PMID:27861885   PMID:27880917   PMID:27965426   PMID:27979967   PMID:28036269   PMID:28102733   PMID:28126323   PMID:28178660   PMID:28184925   PMID:28235541   PMID:28267710   PMID:28283778  
PMID:28286049   PMID:28314279   PMID:28341486   PMID:28346135   PMID:28351953   PMID:28387346   PMID:28410192   PMID:28430578   PMID:28445592   PMID:28474672   PMID:28512243   PMID:28514442  
PMID:28591578   PMID:28607002   PMID:28652654   PMID:28675297   PMID:28708135   PMID:28717250   PMID:28718761   PMID:28820331   PMID:28973348   PMID:28985013   PMID:28986522   PMID:29117863  
PMID:29138396   PMID:29154753   PMID:29166606   PMID:29191835   PMID:29229926   PMID:29254517   PMID:29282278   PMID:29293652   PMID:29295989   PMID:29348559   PMID:29393385   PMID:29437878  
PMID:29467282   PMID:29513927   PMID:29549256   PMID:29559472   PMID:29565459   PMID:29649211   PMID:29652009   PMID:29653924   PMID:29656893   PMID:29663364   PMID:29716963   PMID:29749476  
PMID:29764989   PMID:29771424   PMID:29843122   PMID:29844126   PMID:29865033   PMID:29913237   PMID:29955894   PMID:29973324   PMID:30008317   PMID:30021153   PMID:30069007   PMID:30108183  
PMID:30118839   PMID:30133120   PMID:30135525   PMID:30194290   PMID:30202980   PMID:30260324   PMID:30267576   PMID:30277841   PMID:30321399   PMID:30367032   PMID:30414309   PMID:30415952  
PMID:30463901   PMID:30578313   PMID:30585266   PMID:30622182   PMID:30633621   PMID:30642632   PMID:30728176   PMID:30760542   PMID:30854428   PMID:30859681   PMID:30912195   PMID:30915753  
PMID:30945288   PMID:30995489   PMID:30996295   PMID:31042116   PMID:31081105   PMID:31091453   PMID:31118282   PMID:31122263   PMID:31186254   PMID:31186514   PMID:31204940   PMID:31227645  
PMID:31253795   PMID:31259656   PMID:31281496   PMID:31286138   PMID:31303441   PMID:31337246   PMID:31340145   PMID:31343991   PMID:31422918   PMID:31437238   PMID:31462741   PMID:31468671  
PMID:31493507   PMID:31495888   PMID:31511529   PMID:31544294   PMID:31548612   PMID:31586073   PMID:31597699   PMID:31601613   PMID:31730000   PMID:31782084   PMID:31815296   PMID:31863092  
PMID:31864714   PMID:31904480   PMID:31980649   PMID:32017920   PMID:32060361   PMID:32060423   PMID:32076268   PMID:32129710   PMID:32144855   PMID:32151748   PMID:32182129   PMID:32271878  
PMID:32286328   PMID:32296183   PMID:32375580   PMID:32463161   PMID:32541091   PMID:32694731   PMID:32728610   PMID:32732289   PMID:32814053   PMID:32875973   PMID:32877691   PMID:32896567  
PMID:32961751   PMID:32962858   PMID:33001583   PMID:33009634   PMID:33106477   PMID:33125045   PMID:33171265   PMID:33177155   PMID:33207738   PMID:33226137   PMID:33248027   PMID:33277362  
PMID:33288550   PMID:33306668   PMID:33321102   PMID:33376114   PMID:33450211   PMID:33547392   PMID:33596090   PMID:33990570   PMID:34006870   PMID:34079125   PMID:34143546   PMID:34197606  
PMID:34397869  


Genomics

Comparative Map Data
PLK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1623,677,656 - 23,690,367 (+)EnsemblGRCh38hg38GRCh38
GRCh381623,678,889 - 23,690,367 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371623,690,210 - 23,701,688 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361623,597,702 - 23,609,189 (+)NCBINCBI36hg18NCBI36
Build 341623,597,701 - 23,609,191NCBI
Celera1622,468,373 - 22,479,857 (+)NCBI
Cytogenetic Map16p12.2NCBI
HuRef1621,779,829 - 21,791,312 (+)NCBIHuRef
CHM1_11624,701,920 - 24,713,407 (+)NCBICHM1_1
Plk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397121,758,658 - 121,769,107 (+)NCBIGRCm39mm39
GRCm39 Ensembl7121,758,662 - 121,769,096 (+)Ensembl
GRCm387122,159,435 - 122,169,884 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7122,159,439 - 122,169,873 (+)EnsemblGRCm38mm10GRCm38
MGSCv377129,302,951 - 129,313,389 (+)NCBIGRCm37mm9NCBIm37
MGSCv367121,950,641 - 121,961,011 (+)NCBImm8
Celera7122,049,692 - 122,060,205 (+)NCBICelera
Cytogenetic Map7F2NCBI
cM Map765.52NCBI
Plk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21176,716,420 - 176,726,400 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1176,716,420 - 176,726,400 (+)Ensembl
Rnor_6.01192,115,990 - 192,125,969 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1192,115,966 - 192,125,989 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01199,178,259 - 199,188,238 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41181,002,811 - 181,012,741 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11181,142,728 - 181,152,656 (+)NCBI
Celera1174,424,809 - 174,434,922 (+)NCBICelera
Cytogenetic Map1q36NCBI
Plk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554932,206,353 - 2,217,231 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554932,206,353 - 2,217,231 (+)NCBIChiLan1.0ChiLan1.0
PLK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11623,928,773 - 23,940,779 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1623,928,773 - 23,940,779 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01614,420,972 - 14,432,821 (-)NCBIMhudiblu_PPA_v0panPan3
PLK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1622,165,338 - 22,176,847 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl622,165,338 - 22,176,441 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha623,732,161 - 23,743,926 (-)NCBI
ROS_Cfam_1.0622,309,120 - 22,320,926 (-)NCBI
UMICH_Zoey_3.1622,112,754 - 22,124,540 (-)NCBI
UNSW_CanFamBas_1.0622,014,857 - 22,026,662 (-)NCBI
UU_Cfam_GSD_1.0622,410,301 - 22,422,125 (-)NCBI
Plk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344120,223,455 - 120,234,564 (+)NCBI
SpeTri2.0NW_0049365018,321,415 - 8,332,414 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl322,537,816 - 22,555,023 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1322,537,814 - 22,550,901 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PLK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1521,388,957 - 21,408,574 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl521,396,204 - 21,410,718 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660688,388,349 - 8,407,454 (-)NCBIVero_WHO_p1.0
Plk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247828,811,593 - 8,823,060 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
G06491  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371623,701,404 - 23,701,681UniSTSGRCh37
Build 361623,608,905 - 23,609,182RGDNCBI36
Celera1622,479,573 - 22,479,850RGD
Cytogenetic Map16p12.2UniSTS
HuRef1621,791,028 - 21,791,305UniSTS
PLK1_8546  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371623,701,182 - 23,701,692UniSTSGRCh37
Build 361623,608,683 - 23,609,193RGDNCBI36
Celera1622,479,351 - 22,479,861RGD
HuRef1621,790,806 - 21,791,316UniSTS
RH104431  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371623,700,847 - 23,701,666UniSTSGRCh37
Celera1622,479,016 - 22,479,835UniSTS
Cytogenetic Map16p12.2UniSTS
HuRef1621,790,471 - 21,791,290UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR593hsa-miR-593-5pOncomiRDBexternal_infoNANA21170987
MIR100hsa-miR-100-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI19739117
MIR100hsa-miR-100-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22120675
MIR100hsa-miR-100-5pMirecordsexternal_infoNANA19739117
MIR100hsa-miR-100-5pOncomiRDBexternal_infoNANA23151088
MIR100hsa-miR-100-5pOncomiRDBexternal_infoNANA22249248
MIR100hsa-miR-100-5pOncomiRDBexternal_infoNANA22246341
MIR100hsa-miR-100-5pOncomiRDBexternal_infoNANA22120675
MIR100hsa-miR-100-5pOncomiRDBexternal_infoNANA19739117

Predicted Target Of
Summary Value
Count of predictions:2435
Count of miRNA genes:875
Interacting mature miRNAs:1038
Transcripts:ENST00000300093, ENST00000562272, ENST00000562407, ENST00000564202, ENST00000564794, ENST00000564947, ENST00000567897, ENST00000568568, ENST00000570220
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 492 60 82 70 915 62 408 60 361 89 701 335 21 19 66 3
Low 1943 2685 1585 504 1020 354 3786 1843 3308 277 746 1269 151 1184 2561 1
Below cutoff 3 240 56 48 15 49 161 292 44 50 6 5 1 1 161 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_005030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB084459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB209179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC008870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK308276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC002369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC014846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC300189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FB665815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FB750126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L19559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U01038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U78073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X73458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X90725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000300093   ⟹   ENSP00000300093
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1623,678,889 - 23,690,367 (+)Ensembl
RefSeq Acc Id: ENST00000562272
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1623,677,656 - 23,690,366 (+)Ensembl
RefSeq Acc Id: ENST00000562407
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1623,683,902 - 23,687,820 (+)Ensembl
RefSeq Acc Id: ENST00000564202
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1623,678,971 - 23,681,054 (+)Ensembl
RefSeq Acc Id: ENST00000564794
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1623,688,676 - 23,690,038 (+)Ensembl
RefSeq Acc Id: ENST00000564947
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1623,687,137 - 23,688,732 (+)Ensembl
RefSeq Acc Id: ENST00000567897   ⟹   ENSP00000459688
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1623,679,583 - 23,684,089 (+)Ensembl
RefSeq Acc Id: ENST00000568568   ⟹   ENSP00000460084
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1623,679,732 - 23,683,948 (+)Ensembl
RefSeq Acc Id: ENST00000570220   ⟹   ENSP00000460266
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1623,678,869 - 23,681,022 (+)Ensembl
RefSeq Acc Id: NM_005030   ⟹   NP_005021
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381623,678,889 - 23,690,367 (+)NCBI
GRCh371623,690,201 - 23,701,688 (+)ENTREZGENE
Build 361623,597,702 - 23,609,189 (+)NCBI Archive
HuRef1621,779,829 - 21,791,312 (+)ENTREZGENE
CHM1_11624,701,812 - 24,713,407 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_005021   ⟸   NM_005030
- UniProtKB: P53350 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000460266   ⟸   ENST00000570220
RefSeq Acc Id: ENSP00000300093   ⟸   ENST00000300093
RefSeq Acc Id: ENSP00000459688   ⟸   ENST00000567897
RefSeq Acc Id: ENSP00000460084   ⟸   ENST00000568568
Protein Domains
POLO box   Protein kinase

Promoters
RGD ID:6793384
Promoter ID:HG_KWN:23313
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000330792,   OTTHUMT00000214057
Position:
Human AssemblyChrPosition (strand)Source
Build 361623,597,391 - 23,597,891 (+)MPROMDB
RGD ID:6853364
Promoter ID:EP74507
Type:initiation region
Name:HS_PLK
Description:Polo-like kinase (Drosophila).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 361623,597,721 - 23,597,781EPD
RGD ID:7231615
Promoter ID:EPDNEW_H21553
Type:initiation region
Name:PLK1_1
Description:polo like kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H21552  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381623,678,890 - 23,678,950EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 16p13.11-12.1(chr16:14954894-28306843)x3 copy number gain See cases [RCV000051828] Chr16:14954894..28306843 [GRCh38]
Chr16:15048751..28318164 [GRCh37]
Chr16:14956252..28225665 [NCBI36]
Chr16:16p13.11-12.1
pathogenic
GRCh38/hg38 16p12.2-11.2(chr16:21463739-29249579)x3 copy number gain See cases [RCV000051829] Chr16:21463739..29249579 [GRCh38]
Chr16:21475060..29260900 [GRCh37]
Chr16:21382561..29168401 [NCBI36]
Chr16:16p12.2-11.2
pathogenic
GRCh38/hg38 16p12.2-11.2(chr16:21602183-29314373)x3 copy number gain See cases [RCV000051842] Chr16:21602183..29314373 [GRCh38]
Chr16:21613504..29325694 [GRCh37]
Chr16:21521005..29233195 [NCBI36]
Chr16:16p12.2-11.2
pathogenic
GRCh38/hg38 16p12.2-11.2(chr16:23047969-30632245)x3 copy number gain See cases [RCV000052401] Chr16:23047969..30632245 [GRCh38]
Chr16:23059290..30643566 [GRCh37]
Chr16:22966791..30551067 [NCBI36]
Chr16:16p12.2-11.2
pathogenic
GRCh38/hg38 16p12.2-12.1(chr16:21600992-28323344)x1 copy number loss See cases [RCV000052519] Chr16:21600992..28323344 [GRCh38]
Chr16:21612313..28334665 [GRCh37]
Chr16:21519814..28242166 [NCBI36]
Chr16:16p12.2-12.1
pathogenic
NM_005030.4(PLK1):c.624G>A (p.Lys208=) single nucleotide variant Malignant melanoma [RCV000071050] Chr16:23680960 [GRCh38]
Chr16:23692281 [GRCh37]
Chr16:23599782 [NCBI36]
Chr16:16p12.2
not provided
NM_005030.4(PLK1):c.1434C>T (p.Leu478=) single nucleotide variant Malignant melanoma [RCV000063005] Chr16:23689502 [GRCh38]
Chr16:23700823 [GRCh37]
Chr16:23608324 [NCBI36]
Chr16:16p12.2
not provided
GRCh38/hg38 16p13.3-11.2(chr16:4644892-29170820)x3 copy number gain See cases [RCV000133809] Chr16:4644892..29170820 [GRCh38]
Chr16:4694893..29182141 [GRCh37]
Chr16:4634894..29089642 [NCBI36]
Chr16:16p13.3-11.2
pathogenic
GRCh38/hg38 16p12.2-11.2(chr16:22634385-29227323)x3 copy number gain See cases [RCV000135594] Chr16:22634385..29227323 [GRCh38]
Chr16:22645706..29238644 [GRCh37]
Chr16:22553207..29146145 [NCBI36]
Chr16:16p12.2-11.2
likely pathogenic
GRCh38/hg38 16p12.2-11.2(chr16:21350622-29202837)x3 copy number gain See cases [RCV000140235] Chr16:21350622..29202837 [GRCh38]
Chr16:21361943..29214158 [GRCh37]
Chr16:21269444..29121659 [NCBI36]
Chr16:16p12.2-11.2
likely pathogenic
GRCh37/hg19 16p13.3-11.2(chr16:102839-28327676)x3 copy number gain See cases [RCV000203445] Chr16:102839..28327676 [GRCh37]
Chr16:16p13.3-11.2
pathogenic
GRCh37/hg19 16p12.3-11.2(chr16:19590412-29814175)x3 copy number gain Ductal breast carcinoma [RCV000207226] Chr16:19590412..29814175 [GRCh37]
Chr16:16p12.3-11.2
uncertain significance
GRCh37/hg19 16p13.3-11.2(chr16:1279324-31926800)x3 copy number gain Ductal breast carcinoma [RCV000207053] Chr16:1279324..31926800 [GRCh37]
Chr16:16p13.3-11.2
uncertain significance
GRCh37/hg19 16p12.3-11.2(chr16:19424115-30142220)x3 copy number gain See cases [RCV000449403] Chr16:19424115..30142220 [GRCh37]
Chr16:16p12.3-11.2
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:69193-90274381)x3 copy number gain See cases [RCV000446684] Chr16:69193..90274381 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.2-q24.3(chr16:9273328-89548493)x3 copy number gain See cases [RCV000511622] Chr16:9273328..89548493 [GRCh37]
Chr16:16p13.2-q24.3
uncertain significance
GRCh37/hg19 16p12.2-11.2(chr16:22718350-28858721)x4 copy number gain See cases [RCV000511587] Chr16:22718350..28858721 [GRCh37]
Chr16:16p12.2-11.2
pathogenic
GRCh37/hg19 16p12.2-11.2(chr16:21596299-30399167)x1 copy number loss See cases [RCV000511271] Chr16:21596299..30399167 [GRCh37]
Chr16:16p12.2-11.2
pathogenic
maternal UPD(16p) complex Hemimegalencephaly [RCV000494707] Chr16:1280042..33710558 [GRCh37]
Chr16:16p13.3-11.2
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062) copy number gain See cases [RCV000511296] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062)x3 copy number gain See cases [RCV000512138] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p12.3-11.2(chr16:18238275-30177240)x3 copy number gain See cases [RCV000512428] Chr16:18238275..30177240 [GRCh37]
Chr16:16p12.3-11.2
pathogenic
GRCh37/hg19 16p12.2-11.2(chr16:21379628-29351826)x3 copy number gain See cases [RCV000512478] Chr16:21379628..29351826 [GRCh37]
Chr16:16p12.2-11.2
pathogenic
GRCh37/hg19 16p12.2-11.2(chr16:21379628-29379768)x1 copy number loss not provided [RCV000683786] Chr16:21379628..29379768 [GRCh37]
Chr16:16p12.2-11.2
pathogenic
GRCh37/hg19 16p12.2-12.1(chr16:23610466-24743657)x1 copy number loss not provided [RCV000683797] Chr16:23610466..24743657 [GRCh37]
Chr16:16p12.2-12.1
uncertain significance
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90163275)x3 copy number gain not provided [RCV000738917] Chr16:88165..90163275 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90274695)x3 copy number gain not provided [RCV000738918] Chr16:88165..90274695 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:61451-90294632)x3 copy number gain not provided [RCV000738915] Chr16:61451..90294632 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
NM_005030.6(PLK1):c.128T>C (p.Val43Ala) single nucleotide variant Recurrent spontaneous abortion [RCV001250902] Chr16:23679060 [GRCh38]
Chr16:23690381 [GRCh37]
Chr16:16p12.2
uncertain significance
NM_005030.6(PLK1):c.420G>A (p.Glu140=) single nucleotide variant not provided [RCV000974285] Chr16:23680095 [GRCh38]
Chr16:23691416 [GRCh37]
Chr16:16p12.2
benign
GRCh37/hg19 16p12.2-11.2(chr16:21576802-29351826)x3 copy number gain not provided [RCV001006786] Chr16:21576802..29351826 [GRCh37]
Chr16:16p12.2-11.2
pathogenic
GRCh37/hg19 16p12.2-11.2(chr16:21312200-29646379)x3 copy number gain not provided [RCV001249228] Chr16:21312200..29646379 [GRCh37]
Chr16:16p12.2-11.2
not provided
GRCh37/hg19 16p13.3-11.2(chr16:5805001-34230001) copy number gain Microcephaly [RCV001252948] Chr16:5805001..34230001 [GRCh37]
Chr16:16p13.3-11.2
pathogenic
GRCh37/hg19 16p13.3-11.2(chr16:2959279-30190593)x3 copy number gain See cases [RCV001263169] Chr16:2959279..30190593 [GRCh37]
Chr16:16p13.3-11.2
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9077 AgrOrtholog
COSMIC PLK1 COSMIC
Ensembl Genes ENSG00000166851 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000300093 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000459688 UniProtKB/TrEMBL
  ENSP00000460084 UniProtKB/TrEMBL
  ENSP00000460266 UniProtKB/TrEMBL
Ensembl Transcript ENST00000300093 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000567897 UniProtKB/TrEMBL
  ENST00000568568 UniProtKB/TrEMBL
  ENST00000570220 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1120.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000166851 GTEx
HGNC ID HGNC:9077 ENTREZGENE
Human Proteome Map PLK1 Human Proteome Map
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLK1_cat UniProtKB/Swiss-Prot
  POLO_box_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLO_box_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLO_box_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLO_box_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report hsa:5347 UniProtKB/Swiss-Prot
NCBI Gene 5347 ENTREZGENE
OMIM 602098 OMIM
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLO_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA33410 PharmGKB
PROSITE POLO_BOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3DWF3_HUMAN UniProtKB/TrEMBL
  I3L2H5_HUMAN UniProtKB/TrEMBL
  I3L309_HUMAN UniProtKB/TrEMBL
  I3L387_HUMAN UniProtKB/TrEMBL
  P53350 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q15153 UniProtKB/Swiss-Prot
  Q99746 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-26 PLK1  polo like kinase 1    polo-like kinase 1  Symbol and/or name change 5135510 APPROVED
2011-07-27 PLK1  polo-like kinase 1  PLK1  polo-like kinase 1 (Drosophila)  Symbol and/or name change 5135510 APPROVED