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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:chemokine-mediated signaling pathway
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Accession:GO:0070098 term browser browse the term
Definition:The series of molecular signals initiated by a chemokine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: chemokine-mediated signalling pathway


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chemokine-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACKR1 atypical chemokine receptor 1 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr38:22,762,584...22,765,330
Ensembl chr38:22,758,013...22,763,958 		JBrowse link
G ACKR2 atypical chemokine receptor 2 involved_in IEA UniProt GO_REF:0000117 NCBI chr23:11,904,020...11,962,291
Ensembl chr23:11,960,981...11,962,135 		JBrowse link
G ACKR3 atypical chemokine receptor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:47,327,921...47,339,632
Ensembl chr25:47,327,963...47,339,622 		JBrowse link
G ACKR4 atypical chemokine receptor 4 involved_in IEA GOC GO_REF:0000108 NCBI chr23:29,586,250...29,591,627
Ensembl chr23:29,589,767...29,590,819 		JBrowse link
G AGTR1 angiotensin II receptor type 1 involved_in IEA GOC GO_REF:0000108
G AGTR2 angiotensin II receptor type 2 involved_in IEA GOC GO_REF:0000108 NCBI chr  X:88,703,551...88,708,451
Ensembl chr  X:88,705,765...88,706,853 		JBrowse link
G APLNR apelin receptor involved_in IEA GOC GO_REF:0000108 NCBI chr18:38,878,621...38,882,280
Ensembl chr18:38,878,947...38,886,206 		JBrowse link
G BDKRB1 bradykinin receptor B1 involved_in IEA GOC GO_REF:0000108 NCBI chr 8:65,017,655...65,028,899 JBrowse link
G BDKRB2 bradykinin receptor B2 involved_in IEA GOC GO_REF:0000108 NCBI chr 8:64,974,588...65,005,682
Ensembl chr 8:64,974,997...65,003,407 		JBrowse link
G CCL13 chemokine (C-C motif) ligand 13 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 9:38,938,944...38,940,231
Ensembl chr 9:38,938,135...38,940,231 		JBrowse link
G CCL17 C-C motif chemokine ligand 17 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 2:59,001,463...59,014,347
Ensembl chr 2:59,001,464...59,005,230 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 involved_in ISO
IBA		 RGD
GO_Central		 PMID:18584881 GO_REF:0000033 RGD:2303073 NCBI chr 9:39,008,187...39,009,932 JBrowse link
G CCL20 C-C motif chemokine ligand 20 involved_in IBA GO_Central GO_REF:0000033 NCBI chr25:40,506,385...40,509,903
Ensembl chr25:40,506,753...40,509,709 		JBrowse link
G CCL24 C-C motif chemokine ligand 24 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 6:7,166,165...7,179,606
Ensembl chr 6:7,166,479...7,180,051 		JBrowse link
G CCL25 C-C motif chemokine ligand 25 involved_in IBA GO_Central GO_REF:0000033 NCBI chr20:52,689,674...52,722,291
Ensembl chr20:52,712,979...52,722,018 		JBrowse link
G CCL26 C-C motif chemokine ligand 26 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 6:7,151,352...7,154,509
Ensembl chr 6:7,151,212...7,154,726 		JBrowse link
G CCL3 chemokine (C-C motif) ligand 3 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 9:37,693,711...37,695,137
Ensembl chr 9:37,686,480...37,695,573 		JBrowse link
G CCL4 chemokine (C-C motif) ligand 4 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 9:37,681,342...37,682,691
Ensembl chr 9:37,676,966...37,710,209 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 involved_in ISS
IBA		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000033 NCBI chr 9:37,817,409...37,823,852
Ensembl chr 9:37,817,305...37,823,852 		JBrowse link
G CCL8 C-C motif chemokine ligand 8 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 9:38,949,184...38,950,702
Ensembl chr 9:38,948,184...38,950,803 		JBrowse link
G CCR1 chemokine (C-C motif) receptor 1 involved_in IEA Ensembl
GOC		 GO_REF:0000107 GO_REF:0000108 NCBI chr20:42,421,356...42,427,177
Ensembl chr20:42,421,356...42,426,958 		JBrowse link
G CCR10 C-C motif chemokine receptor 10 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:1354873|PMID:10725696) GOC
GOC		 PMID:10725696 GO_REF:0000108 MGI:1354873 NCBI chr 9:20,307,755...20,312,613
Ensembl chr 9:20,307,584...20,311,464 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 involved_in
acts_upstream_of_or_within		 ISO
IEA		 (MGI:79768|PMID:8631787) RGD
GOC
GOC		 PMID:8631787 PMID:18584881 GO_REF:0000108 MGI:79768 RGD:2303073 NCBI chr20:42,305,344...42,313,258
Ensembl chr20:42,307,580...42,308,698 		JBrowse link
G CCR3 C-C motif chemokine receptor 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:77397|PMID:7594543) GOC
GOC		 PMID:7594543 GO_REF:0000108 MGI:77397 NCBI chr20:42,382,380...42,398,449
Ensembl chr20:42,383,135...42,384,217 		JBrowse link
G CCR4 C-C motif chemokine receptor 4 involved_in IEA GOC GO_REF:0000108 NCBI chr23:3,844,072...3,847,770
Ensembl chr23:3,844,173...3,845,255 		JBrowse link
G CCR5 C-C motif chemokine receptor 5 involved_in IEA GOC GO_REF:0000108 NCBI chr20:42,293,288...42,297,952
Ensembl chr20:42,294,996...42,297,952 		JBrowse link
G CCR6 C-C motif chemokine receptor 6 involved_in IEA GOC GO_REF:0000108 NCBI chr 1:54,932,798...54,960,646
Ensembl chr 1:54,932,690...54,959,740 		JBrowse link
G CCR6 C-C motif chemokine receptor 6 involved_in IEA GOC GO_REF:0000108
G CCR7 C-C motif chemokine receptor 7 involved_in IEA GOC GO_REF:0000108 NCBI chr 9:22,077,976...22,092,818
Ensembl chr 9:22,068,775...22,090,656 		JBrowse link
G CCR9 C-C motif chemokine receptor 9 involved_in IEA GOC GO_REF:0000108 NCBI chr20:42,607,024...42,616,823
Ensembl chr20:42,607,024...42,616,823 		JBrowse link
G CCRL2 C-C motif chemokine receptor like 2 involved_in IEA GOC GO_REF:0000108 NCBI chr20:42,270,431...42,272,498
Ensembl chr20:42,270,477...42,271,526 		JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:59,022,794...59,032,095
Ensembl chr 2:59,022,794...59,032,095 		JBrowse link
G CX3CR1 C-X3-C motif chemokine receptor 1 involved_in IEA GOC GO_REF:0000108 NCBI chr23:8,937,069...8,954,738
Ensembl chr23:8,938,906...8,952,808 		JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 involved_in IBA GO_Central GO_REF:0000033 NCBI chr32:598,406...599,925
Ensembl chr32:597,987...599,979 		JBrowse link
G CXCL11 C-X-C motif chemokine ligand 11 involved_in ISO (PMID:18645041) UniProt PMID:18645041 NCBI chr32:631,084...636,997
Ensembl chr32:631,478...632,868
Ensembl chr32:631,478...632,868 		JBrowse link
G CXCL11 C-X-C motif chemokine ligand 11 involved_in IEA Ensembl GO_REF:0000107
G CXCL12 C-X-C motif chemokine ligand 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:2,895,916...2,903,543 JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 involved_in IBA GO_Central GO_REF:0000033 NCBI chr13:62,435,035...62,438,354
Ensembl chr13:62,434,422...62,438,354 		JBrowse link
G CXCR1 chemokine (C-X-C motif) receptor 1 involved_in IEA GOC GO_REF:0000108 NCBI chr37:24,862,129...24,866,069 JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 involved_in IEA GOC GO_REF:0000108 NCBI chr37:24,831,351...24,846,387
Ensembl chr37:24,843,171...24,844,247 		JBrowse link
G CXCR3 C-X-C motif chemokine receptor 3 involved_in IEA GOC GO_REF:0000108 NCBI chr  X:55,882,433...55,884,582
Ensembl chr  X:55,882,433...55,884,582 		JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 involved_in IEA UniProt GO_REF:0000117 NCBI chr19:38,874,650...38,877,740
Ensembl chr19:38,874,145...38,877,740 		JBrowse link
G CXCR5 C-X-C motif chemokine receptor 5 involved_in IEA GOC GO_REF:0000108 NCBI chr 5:14,921,447...14,932,937
Ensembl chr 5:14,923,089...14,932,762 		JBrowse link
G CXCR6 C-X-C motif chemokine receptor 6 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:1891794|PMID:11017100) GOC
GOC		 PMID:11017100 GO_REF:0000108 MGI:1891794 NCBI chr20:42,565,251...42,569,647
Ensembl chr20:42,565,251...42,566,276 		JBrowse link
G FOXC1 forkhead box C1 involved_in ISO (MGI:3773495|PMID:18187037) UniProt PMID:18187037 MGI:3773495
G GPR15 G protein-coupled receptor 15 involved_in IEA GOC GO_REF:0000108 NCBI chr33:5,368,509...5,380,024
Ensembl chr33:5,396,083...5,397,165
Ensembl chr33:5,396,083...5,397,165 		JBrowse link
G GPR25 G protein-coupled receptor 25 involved_in IEA GOC GO_REF:0000108
G GPR35 G protein-coupled receptor 35 involved_in ISO (PMID:25411203) MGI PMID:25411203 NCBI chr25:50,566,263...50,841,473 JBrowse link
G GPR75 G protein-coupled receptor 75 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:54,858,380...54,862,734 JBrowse link
G PTK2B protein tyrosine kinase 2 beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:30,137,546...30,264,221
Ensembl chr25:30,138,209...30,264,133 		JBrowse link
G RXFP3 relaxin family peptide receptor 3 involved_in IEA GOC GO_REF:0000108
G TFF2 trefoil factor 2 involved_in
acts_upstream_of_or_within		 IBA
ISO
IEA		 (PMID:19064997) GO_Central
MGI
TreeGrafter		 PMID:19064997 GO_REF:0000033 GO_REF:0000118 NCBI chr31:36,665,647...36,668,423
Ensembl chr31:36,665,514...36,668,440 		JBrowse link
G XCR1 X-C motif chemokine receptor 1 involved_in IEA GOC GO_REF:0000108 NCBI chr20:42,505,534...42,516,524
Ensembl chr20:42,511,431...42,512,423 		JBrowse link
C-X-C chemokine receptor CXCR4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LYN LYN proto-oncogene, Src family tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr29:7,367,617...7,448,862
Ensembl chr29:7,332,684...7,448,507 		JBrowse link
chemokine (C-C motif) ligand 19 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCR7 C-C motif chemokine receptor 7 involved_in IEA GOC GO_REF:0000108 NCBI chr 9:22,077,976...22,092,818
Ensembl chr 9:22,068,775...22,090,656 		JBrowse link
chemokine (C-C motif) ligand 21 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL21 C-C motif chemokine ligand 21 involved_in ISO (MGI:6141968|PMID:27400149) BHF-UCL PMID:27400149 MGI:6141968 NCBI chr11:51,375,107...51,375,790 JBrowse link
G CCR7 C-C motif chemokine receptor 7 involved_in IEA GOC GO_REF:0000108 NCBI chr 9:22,077,976...22,092,818
Ensembl chr 9:22,068,775...22,090,656 		JBrowse link
G OXSR1 oxidative stress responsive kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:7,931,636...8,026,591
Ensembl chr23:7,932,254...8,024,323 		JBrowse link
G WNK1 WNK lysine deficient protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:42,764,184...42,914,591
Ensembl chr27:42,765,181...42,912,806 		JBrowse link
chemokine (C-X-C motif) ligand 12 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CXCL12 C-X-C motif chemokine ligand 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:2,895,916...2,903,543 JBrowse link
G OXSR1 oxidative stress responsive kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:7,931,636...8,026,591
Ensembl chr23:7,932,254...8,024,323 		JBrowse link
G STK39 serine/threonine kinase 39 involved_in IEA Ensembl GO_REF:0000107 NCBI chr36:12,866,867...13,118,736
Ensembl chr36:12,867,188...13,183,160 		JBrowse link
CXCL12-activated CXCR4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CXCL12 C-X-C motif chemokine ligand 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:2,895,916...2,903,543 JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 involved_in
acts_upstream_of_or_within		 ISS
ISO		 (PMID:31845480) UniProt
MGI		 PMID:31845480 GO_REF:0000024 NCBI chr19:38,874,650...38,877,740
Ensembl chr19:38,874,145...38,877,740 		JBrowse link
G ENTREP1 endosomal transmembrane epsin interactor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:88,004,174...88,067,491
Ensembl chr 1:88,004,615...88,067,495 		JBrowse link
G TREML1 triggering receptor expressed on myeloid cells like 1 acts_upstream_of_or_within_positive_effect ISO (PMID:33097708) ARUK-UCL PMID:33097708 NCBI chr12:9,915,692...9,928,322
Ensembl chr12:9,915,677...9,928,174 		JBrowse link
G WBP1L WW domain binding protein 1 like involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:31845480) Ensembl
MGI		 PMID:31845480 GO_REF:0000107 NCBI chr28:15,218,883...15,285,211
Ensembl chr28:15,218,775...15,282,416 		JBrowse link
negative regulation of chemokine-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MIR101-1 microRNA mir-101-1 involved_in ISO (PMID:27693460) BHF-UCL PMID:27693460 NCBI chr 5:45,184,774...45,184,828
Ensembl chr 5:45,184,759...45,184,841 		JBrowse link
G MIR101-2 microRNA mir-101-2 involved_in ISO (PMID:27693460) BHF-UCL PMID:27693460 NCBI chr 1:93,194,328...93,194,382
Ensembl chr 1:93,194,309...93,194,399 		JBrowse link
G MIR20A microRNA mir-20a involved_in ISO (PMID:28972028) ARUK-UCL PMID:28972028 NCBI chr22:42,478,462...42,478,520
Ensembl chr22:42,478,462...42,478,520 		JBrowse link
G PADI2 peptidyl arginine deiminase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:81,116,031...81,147,889
Ensembl chr 2:81,116,140...81,145,043 		JBrowse link
G RNF113A ring finger protein 113A involved_in ISO (PMID:28978524) UniProt PMID:28978524 NCBI chr  X:91,884,757...91,885,998
Ensembl chr  X:91,884,808...91,885,854 		JBrowse link
G ROBO1 roundabout guidance receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr31:8,082,363...8,594,623
Ensembl chr31:7,626,126...8,593,728 		JBrowse link
G SH2B3 SH2B adaptor protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:9,033,851...9,073,095
Ensembl chr26:9,005,281...9,070,204 		JBrowse link
G SLIT2 slit guidance ligand 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:88,964,707...89,311,817
Ensembl chr 3:88,966,232...89,312,955 		JBrowse link
G SLIT3 slit guidance ligand 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:42,506,680...43,099,053
Ensembl chr 4:42,508,426...43,094,714 		JBrowse link
positive regulation of C-C chemokine receptor CCR7 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TREML1 triggering receptor expressed on myeloid cells like 1 involved_in ISO (PMID:11602640) BHF-UCL PMID:11602640 NCBI chr12:9,915,692...9,928,322
Ensembl chr12:9,915,677...9,928,174 		JBrowse link
positive regulation of chemokine-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 acts_upstream_of ISO (PMID:17178876) BHF-UCL PMID:17178876 NCBI chr35:11,808,892...11,815,383
Ensembl chr35:11,808,892...11,815,383 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha acts_upstream_of
involved_in		 ISO
IEA		 (PMID:17178876) BHF-UCL
Ensembl		 PMID:17178876 GO_REF:0000107 NCBI chr 8:36,614,045...36,656,692
Ensembl chr 8:36,614,045...36,656,692 		JBrowse link
thrombopoietin-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CIB1 calcium and integrin binding 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:53,184,713...53,209,195
Ensembl chr 3:53,184,714...53,188,224 		JBrowse link
G MPL MPL proto-oncogene, thrombopoietin receptor involved_in IEA GOC
TreeGrafter		 GO_REF:0000108 GO_REF:0000118 NCBI chr15:16,815,102...16,825,321
Ensembl chr15:16,815,294...16,825,350 		JBrowse link
G RBM15 RNA binding motif protein 15 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:41,645,765...41,653,621
Ensembl chr 6:41,645,769...41,653,799 		JBrowse link
G SH2B3 SH2B adaptor protein 3 acts_upstream_of_or_within_negative_effect
involved_in
acts_upstream_of_negative_effect		 ISO
IEA		 (PMID:20404132)
(MGI:5905608|PMID:27430239)		 ARUK-UCL
Ensembl
BHF-UCL		 PMID:20404132 PMID:27430239 GO_REF:0000107 MGI:5905608 NCBI chr26:9,033,851...9,073,095
Ensembl chr26:9,005,281...9,070,204 		JBrowse link
G THPO thrombopoietin involved_in ISS
IBA
IEA		 UniProt
GO_Central
TreeGrafter
Ensembl		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr34:17,245,006...17,255,250
Ensembl chr34:17,247,731...17,253,033 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17925
    cellular process 16910
      signal transduction 6317
        G protein-coupled receptor signaling pathway 1709
          chemokine-mediated signaling pathway 76
            C-C chemokine receptor CCR2 signaling pathway + 0
            C-C chemokine receptor CCR4 signaling pathway + 0
            C-C chemokine receptor CCR7 signaling pathway + 1
            C-X-C chemokine receptor CXCR4 signaling pathway + 6
            chemokine (C-C motif) ligand 19 signaling pathway + 1
            chemokine (C-C motif) ligand 2 signaling pathway + 0
            chemokine (C-C motif) ligand 21 signaling pathway + 4
            chemokine (C-C motif) ligand 5 signaling pathway 0
            chemokine (C-X-C motif) ligand 12 signaling pathway + 7
            negative regulation of chemokine-mediated signaling pathway + 9
            positive regulation of chemokine-mediated signaling pathway + 3
            regulation of chemokine-mediated signaling pathway + 12
            thrombopoietin-mediated signaling pathway 5
Path 2
Term Annotations click to browse term
  biological_process 17925
    biological regulation 12446
      regulation of biological process 12082
        signaling 6866
          signal transduction 6317
            cell surface receptor signaling pathway 2807
              cytokine-mediated signaling pathway 493
                chemokine-mediated signaling pathway 76
                  C-C chemokine receptor CCR2 signaling pathway + 0
                  C-C chemokine receptor CCR4 signaling pathway + 0
                  C-C chemokine receptor CCR7 signaling pathway + 1
                  C-X-C chemokine receptor CXCR4 signaling pathway + 6
                  chemokine (C-C motif) ligand 19 signaling pathway + 1
                  chemokine (C-C motif) ligand 2 signaling pathway + 0
                  chemokine (C-C motif) ligand 21 signaling pathway + 4
                  chemokine (C-C motif) ligand 5 signaling pathway 0
                  chemokine (C-X-C motif) ligand 12 signaling pathway + 7
                  negative regulation of chemokine-mediated signaling pathway + 9
                  positive regulation of chemokine-mediated signaling pathway + 3
                  regulation of chemokine-mediated signaling pathway + 12
                  thrombopoietin-mediated signaling pathway 5
paths to the root