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ONTOLOGY REPORT - ANNOTATIONS

Term:SH3 domain binding
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Accession:GO:0017124 term browser browse the term
Definition:Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.

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SH3 domain binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abi1 abl interactor 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624796:2,312,005...2,431,284 JBrowse link
G Abi2 abl interactor 2 enables ISO (PMID:7590236) UniProt PMID:7590236 NCBI chrNW_004624765:12,971,867...13,091,446
Ensembl chrNW_004624765:12,998,315...13,091,370 		JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase enables ISO (PMID:7590236) UniProt PMID:7590236 NCBI chrNW_004624760:4,878,811...5,032,719
Ensembl chrNW_004624760:4,878,556...5,031,491 		JBrowse link
G Acp1 acid phosphatase 1 ISO RGD PMID:11971983 RGD:1625292 NCBI chrNW_004624846:1,735,944...1,748,495
Ensembl chrNW_004624846:1,736,038...1,747,009 		JBrowse link
G Adam10 ADAM metallopeptidase domain 10 enables IEA UniProt GO_REF:0000043 NCBI chrNW_004624781:13,195,390...13,321,823
Ensembl chrNW_004624781:13,195,755...13,321,823 		JBrowse link
G Adam12 ADAM metallopeptidase domain 12 enables ISO (PMID:15280379) BHF-UCL PMID:15280379 NCBI chrNW_004624737:20,650,365...21,107,171
Ensembl chrNW_004624737:20,650,427...21,065,944 		JBrowse link
G Adam15 ADAM metallopeptidase domain 15 enables ISO (PMID:10531379) BHF-UCL PMID:10531379 NCBI chrNW_004624885:2,441,298...2,451,061
Ensembl chrNW_004624885:2,441,217...2,451,057 		JBrowse link
G Adam19 ADAM metallopeptidase domain 19 enables ISO (MGI:6158822|PMID:12615925) UniProt PMID:12615925 MGI:6158822 NCBI chrNW_004624733:31,857,795...31,944,252
Ensembl chrNW_004624733:31,858,450...31,944,893 		JBrowse link
G Adam9 ADAM metallopeptidase domain 9 enables ISO (MGI:78959|PMID:8647900)
(PMID:10531379)		 BHF-UCL PMID:8647900 PMID:10531379 MGI:78959 NCBI chrNW_004624780:4,482,696...4,612,475
Ensembl chrNW_004624780:4,480,647...4,612,477 		JBrowse link
G Afap1 actin filament associated protein 1 enables ISO
IEA		 RGD
TreeGrafter		 PMID:12114187 GO_REF:0000118 RGD:625602 NCBI chrNW_004624755:23,659,997...23,771,148
Ensembl chrNW_004624755:23,659,490...23,769,325 		JBrowse link
G Afap1l1 actin filament associated protein 1 like 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624774:8,640,643...8,702,149
Ensembl chrNW_004624774:8,640,684...8,701,107 		JBrowse link
G Afap1l2 actin filament associated protein 1 like 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624737:32,189,377...32,297,110
Ensembl chrNW_004624737:32,195,126...32,326,607 		JBrowse link
G Akap5 A-kinase anchoring protein 5 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624734:36,550,020...36,555,142
Ensembl chrNW_004624734:36,550,447...36,551,742 		JBrowse link
G Arhgap27 Rho GTPase activating protein 27 enables ISO PMID:15147912 HGNC-UCL PMID:15147912 RGD:1302833 NCBI chrNW_004624795:88,650...140,578
Ensembl chrNW_004624795:106,694...121,120 		JBrowse link
G Arhgap31 Rho GTPase activating protein 31 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624731:28,780,180...28,894,018
Ensembl chrNW_004624731:28,785,015...28,894,645 		JBrowse link
G Casp9 caspase 9 enables ISO (PMID:15657060) UniProt PMID:15657060 NCBI chrNW_004624764:1,769,270...1,789,399
Ensembl chrNW_004624764:1,773,455...1,789,423 		JBrowse link
G Cbl Cbl proto-oncogene enables ISO
IEA		 RGD
TreeGrafter		 PMID:9259313 PMID:17675467 GO_REF:0000118 RGD:11038829 RGD:11576315 NCBI chrNW_004624784:14,577,582...14,671,816
Ensembl chrNW_004624784:14,577,515...14,667,575 		JBrowse link
G Cblb Cbl proto-oncogene B enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624731:43,803,743...44,018,682
Ensembl chrNW_004624731:43,803,768...44,015,870 		JBrowse link
G Cblc Cbl proto-oncogene C enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624907:1,676,296...1,690,479
Ensembl chrNW_004624907:1,676,021...1,691,137 		JBrowse link
G Cd2ap CD2 associated protein enables ISO (PMID:10339567) UniProt PMID:10339567 NCBI chrNW_004624754:13,420,594...13,511,672
Ensembl chrNW_004624754:13,420,603...13,511,523 		JBrowse link
G Cd3e CD3e molecule enables ISO (PMID:12110186) UniProt PMID:12110186 NCBI chrNW_004624784:13,714,667...13,726,881
Ensembl chrNW_004624784:13,712,920...13,726,950 		JBrowse link
G Cntnap1 contactin associated protein 1 ISO RGD PMID:9118959 RGD:70689 NCBI chrNW_004624795:1,470,234...1,482,066
Ensembl chrNW_004624795:1,470,760...1,481,973 		JBrowse link
G Crb3 crumbs cell polarity complex component 3 enables ISO (PMID:17332497) BHF-UCL PMID:17332497 NCBI chrNW_004624828:3,571,833...3,578,281 JBrowse link
G Crk CRK proto-oncogene, adaptor protein enables ISO (PMID:12384576) CAFA PMID:12384576 NCBI chrNW_004624786:4,153,783...4,177,611
Ensembl chrNW_004624786:4,153,889...4,177,716 		JBrowse link
G Cttnbp2 cortactin binding protein 2 ISO RGD PMID:9813110 RGD:632437 NCBI chrNW_004624827:1,481,082...1,656,279
Ensembl chrNW_004624827:1,481,082...1,655,871 		JBrowse link
G Dab2ip DAB2 interacting protein enables ISO (PMID:19033661) UniProt PMID:19033661 NCBI chrNW_004624760:13,472,500...13,658,070
Ensembl chrNW_004624760:13,472,672...13,657,930 		JBrowse link
G Dennd1a DENN domain containing 1A enables ISO (PMID:17182770) MGI PMID:17182770 NCBI chrNW_004624760:11,043,099...11,576,600
Ensembl chrNW_004624760:11,043,348...11,575,531 		JBrowse link
G Dnm1 dynamin 1 ISO RGD PMID:9348539 PMID:16648848 RGD:13504740 RGD:631926 NCBI chrNW_004624760:6,605,902...6,646,575
Ensembl chrNW_004624760:6,604,787...6,646,622 		JBrowse link
G Dnm2 dynamin 2 enables ISO (PMID:18388313) UniProt
RGD		 PMID:18388313 PMID:19122684 RGD:9685149 NCBI chrNW_004624828:2,727,136...2,805,248
Ensembl chrNW_004624828:2,727,112...2,807,319 		JBrowse link
G Dpysl3 dihydropyrimidinase like 3 ISO RGD PMID:12684468 RGD:1298810 NCBI chrNW_004624774:6,836,198...6,943,528
Ensembl chrNW_004624774:6,835,299...6,943,552 		JBrowse link
G Drd4 dopamine receptor D4 enables ISO (PMID:9843378) BHF-UCL PMID:9843378 NCBI chrNW_004624766:21,834,093...21,837,314
Ensembl chrNW_004624766:21,834,169...21,836,710 		JBrowse link
G Efs embryonal Fyn-associated substrate enables ISO (PMID:9126384) MGI PMID:9126384 NCBI chrNW_004624820:9,200,383...9,206,387
Ensembl chrNW_004624820:9,200,287...9,207,263 		JBrowse link
G Elmo1 engulfment and cell motility 1 enables IEA UniProt GO_REF:0000043 NCBI chrNW_004624740:23,776,788...24,354,682
Ensembl chrNW_004624740:23,881,197...24,353,526 		JBrowse link
G Elmo2 engulfment and cell motility 2 enables IEA UniProt GO_REF:0000043 NCBI chrNW_004624790:8,228,234...8,266,585
Ensembl chrNW_004624790:8,228,259...8,267,179 		JBrowse link
G Elmo3 engulfment and cell motility 3 enables IEA UniProt GO_REF:0000043 NCBI chrNW_004624746:19,112,808...19,117,406
Ensembl chrNW_004624746:19,112,808...19,117,494 		JBrowse link
G Enah ENAH actin regulator enables ISO (PMID:9126384) MGI PMID:9126384 NCBI chrNW_004624835:6,292,808...6,442,349 JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 ISO RGD PMID:11003669 RGD:9685556 NCBI chrNW_004624818:3,868,089...3,882,960
Ensembl chrNW_004624818:3,868,814...3,882,960 		JBrowse link
G Espn espin enables ISO PMID:12598619 UniProt PMID:12598619 RGD:632657 NCBI chrNW_004624818:5,015,275...5,042,862
Ensembl chrNW_004624818:5,016,019...5,042,724 		JBrowse link
G Evl Enah/Vasp-like enables ISO (MGI:3687814|PMID:10945997) UniProt PMID:10945997 MGI:3687814 NCBI chrNW_004624734:3,926,939...4,023,841
Ensembl chrNW_004624734:3,927,004...4,071,621 		JBrowse link
G Fmn1 formin 1 enables ISO (PMID:8438166) MGI PMID:8438166 NCBI chrNW_004624804:1,124,322...1,558,781
Ensembl chrNW_004624804:1,155,071...1,558,145 		JBrowse link
G Fut8 fucosyltransferase 8 enables IEA UniProt GO_REF:0000043 NCBI chrNW_004624734:35,257,666...35,617,275
Ensembl chrNW_004624734:35,264,019...35,458,277 		JBrowse link
G Gja1 gap junction protein alpha 1 enables ISO PMID:14699011
PMID:15492000
dependent on acidic pH		 CAFA
DisProt
RGD		 PMID:14699011 PMID:15492000 RGD:12793032 RGD:1582694 NCBI chrNW_004624798:9,358,996...9,364,413
Ensembl chrNW_004624798:9,359,004...9,364,313 		JBrowse link
G Gpx1 glutathione peroxidase 1 enables ISO (PMID:12893824) BHF-UCL PMID:12893824 NCBI chrNW_004624730:3,313,773...3,314,870
Ensembl chrNW_004624730:3,313,972...3,314,626 		JBrowse link
G Grb2 growth factor receptor bound protein 2 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624801:5,143,239...5,219,136
Ensembl chrNW_004624801:5,143,141...5,219,244 		JBrowse link
G Grik5 glutamate ionotropic receptor kainate type subunit 5 enables ISO PMID:1127911 UniProt PMID:1127911 RGD:8553546 NCBI chrNW_004624907:653,568...711,358
Ensembl chrNW_004624907:653,895...710,791 		JBrowse link
G Hcls1 hematopoietic cell-specific Lyn substrate 1 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624731:26,528,163...26,559,108
Ensembl chrNW_004624731:26,528,097...26,560,695 		JBrowse link
G Hip1r huntingtin interacting protein 1 related enables ISO (MGI:5805366|PMID:17318189) ParkinsonsUK-UCL PMID:17318189 MGI:5805366 NCBI chrNW_004624747:22,876,183...22,897,557
Ensembl chrNW_004624747:22,876,276...22,896,584 		JBrowse link
G Ilk integrin linked kinase ISO SH3 domain of c-src (unknown species) RGD PMID:18252715 RGD:2301742 NCBI chrNW_004624817:8,096,539...8,103,096
Ensembl chrNW_004624817:8,096,898...8,106,683 		JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D enables IEA UniProt GO_REF:0000043 NCBI chrNW_004624843:5,685,409...5,774,459
Ensembl chrNW_004624843:5,685,502...5,773,469 		JBrowse link
G Inppl1 inositol polyphosphate phosphatase like 1 enables IEA UniProt GO_REF:0000043 NCBI chrNW_004624817:4,779,875...4,794,644
Ensembl chrNW_004624817:4,779,057...4,793,732 		JBrowse link
G Khdrbs1 KH RNA binding domain containing, signal transduction associated 1 enables ISO
IEA		 RGD
Ensembl
UniProt		 PMID:12112020 GO_REF:0000043 GO_REF:0000107 RGD:634064 NCBI chrNW_004624764:15,244,521...15,292,901
Ensembl chrNW_004624764:15,244,390...15,275,379 		JBrowse link
G Khdrbs2 KH RNA binding domain containing, signal transduction associated 2 enables IEA UniProt GO_REF:0000043 NCBI chrNW_004624753:20,174,101...20,757,402
Ensembl chrNW_004624753:20,209,485...20,757,679 		JBrowse link
G Khdrbs3 KH RNA binding domain containing, signal transduction associated 3 enables IEA UniProt GO_REF:0000043 NCBI chrNW_004624735:20,415,996...20,586,632
Ensembl chrNW_004624735:20,425,148...20,586,626 		JBrowse link
G Lancl1 LanC like glutathione S-transferase 1 enables ISO (PMID:19528316) UniProt PMID:19528316 NCBI chrNW_004624765:5,731,236...5,766,907
Ensembl chrNW_004624765:5,730,866...5,767,058 		JBrowse link
G LOC101701229 formin-like protein 20 enables IEA UniProt GO_REF:0000043 NCBI chrNW_004624819:6,305,766...6,386,316
Ensembl chrNW_004624819:6,324,227...6,425,942 		JBrowse link
G LOC101717043 cytochrome b-245 light chain enables ISO (PMID:7938008) BHF-UCL PMID:7938008 NCBI chrNW_004624746:911,852...919,361
Ensembl chrNW_004624746:911,842...919,362 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase enables ISO (PMID:19064729) MGI PMID:19064729 NCBI chrNW_004624886:4,029,318...4,168,797
Ensembl chrNW_004624886:4,027,178...4,168,902 		JBrowse link
G Map4k3 mitogen-activated protein kinase kinase kinase kinase 3 ISO RGD PMID:11384986 RGD:727317 NCBI chrNW_004624738:20,716,430...20,874,930
Ensembl chrNW_004624738:20,715,296...20,875,393 		JBrowse link
G Mapt microtubule associated protein tau enables ISO (PMID:9763511) UniProt PMID:9763511 NCBI chrNW_004624849:2,320,887...2,421,099 JBrowse link
G Mical1 microtubule associated monooxygenase, calponin and LIM domain containing 1 enables ISO (PMID:11827972) UniProt PMID:11827972 NCBI chrNW_004624916:701,118...712,254
Ensembl chrNW_004624916:701,249...710,148 		JBrowse link
G Mypn myopalladin enables ISO (PMID:11309420) BHF-UCL PMID:11309420 NCBI chrNW_004624754:2,466,980...2,596,288
Ensembl chrNW_004624754:2,467,071...2,598,386 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 enables ISO (PMID:7938008) BHF-UCL PMID:7938008 NCBI chrNW_004624740:13,428,375...13,439,915
Ensembl chrNW_004624740:13,429,476...13,439,807 		JBrowse link
G Noxa1 NADPH oxidase activator 1 enables ISO (PMID:19755710) UniProt PMID:19755710 NCBI chrNW_004624760:602,403...610,775
Ensembl chrNW_004624760:603,528...610,942 		JBrowse link
G Ostf1 osteoclast stimulating factor 1 enables ISO (PMID:9630982) MGI PMID:9630982 NCBI chrNW_004624811:2,686,474...2,745,317
Ensembl chrNW_004624811:2,686,417...2,746,904 		JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein ISO RGD PMID:10858458 RGD:68284 NCBI chrNW_004624788:11,772,268...11,849,040
Ensembl chrNW_004624788:11,772,396...11,845,765 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein ISO RGD PMID:10926122 RGD:1600757 NCBI chrNW_004624845:3,875,601...3,990,347
Ensembl chrNW_004624845:3,891,061...3,990,342 		JBrowse link
G Prkce protein kinase C epsilon ISO RGD PMID:17084383 RGD:2326120 NCBI chrNW_004624738:27,118,764...27,630,733
Ensembl chrNW_004624738:27,118,145...27,627,606 		JBrowse link
G Prrt2 proline rich transmembrane protein 2 enables ISO PMID:26797119 MGI PMID:26797119 RGD:11528976 NCBI chrNW_004624782:13,390,347...13,393,775 JBrowse link
G Ptpn12 protein tyrosine phosphatase non-receptor type 12 enables ISO (PMID:9285683) UniProt PMID:9285683 NCBI chrNW_004624739:26,747,830...26,828,535 JBrowse link
G Ptpn22 protein tyrosine phosphatase non-receptor type 22 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624772:9,472,869...9,552,751
Ensembl chrNW_004624772:9,472,913...9,550,990 		JBrowse link
G Ptpn6 protein tyrosine phosphatase non-receptor type 6 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624860:3,580,225...3,595,403
Ensembl chrNW_004624860:3,580,560...3,595,090 		JBrowse link
G Rad9a RAD9 checkpoint clamp component A enables ISO (PMID:11971963) UniProt PMID:11971963 NCBI chrNW_004624767:19,123,710...19,180,505
Ensembl chrNW_004624767:19,124,517...19,176,231 		JBrowse link
G Reps1 RALBP1 associated Eps domain containing 1 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624753:14,970,693...15,057,033
Ensembl chrNW_004624753:14,970,706...15,057,037 		JBrowse link
G Rufy1 RUN and FYVE domain containing 1 enables ISO (PMID:11877430) UniProt PMID:11877430 NCBI chrNW_004624733:42,490,864...42,537,431
Ensembl chrNW_004624733:42,490,851...42,537,436 		JBrowse link
G Rufy2 RUN and FYVE domain containing 2 enables ISO (PMID:11877430) UniProt PMID:11877430 NCBI chrNW_004624754:2,709,727...2,743,436 JBrowse link
G Sgip1 SH3GL interacting endocytic adaptor 1 enables ISO (PMID:20946875) UniProt PMID:20946875 NCBI chrNW_004624742:28,245,140...28,439,705
Ensembl chrNW_004624742:28,247,127...28,439,482 		JBrowse link
G Sh3bp1 SH3 domain binding protein 1 enables ISO (PMID:8438166) MGI PMID:8438166 NCBI chrNW_004624752:10,253,384...10,264,483
Ensembl chrNW_004624752:10,253,719...10,264,483 		JBrowse link
G Sh3bp2 SH3 domain binding protein 2 enables ISO (PMID:8438166) MGI PMID:8438166 NCBI chrNW_004624755:24,942,542...24,968,384
Ensembl chrNW_004624755:24,941,813...24,957,004 		JBrowse link
G Sh3bp5 SH3 domain binding protein 5 enables IEA UniProt GO_REF:0000104 NCBI chrNW_004624822:4,950,735...5,021,233
Ensembl chrNW_004624822:4,950,735...5,021,337 		JBrowse link
G Sh3gl1 SH3 domain containing GRB2 like 1, endophilin A2 ISO RGD PMID:22750032 RGD:13463484 NCBI chrNW_004624828:5,304,887...5,330,440
Ensembl chrNW_004624828:5,305,070...5,330,440 		JBrowse link
G Shank1 SH3 and multiple ankyrin repeat domains 1 enables ISO PMID:15496675 BHF-UCL PMID:15496675 RGD:8553458 NCBI chrNW_004624832:3,934,525...3,978,607
Ensembl chrNW_004624832:3,938,170...3,976,870 		JBrowse link
G Shank2 SH3 and multiple ankyrin repeat domains 2 ISO RGD PMID:15014124 RGD:1599734 NCBI chrNW_004624767:16,296,053...16,828,714
Ensembl chrNW_004624767:16,380,751...16,823,577 		JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 ISO RGD PMID:15014124 RGD:1599734 NCBI chrNW_004624752:72,545...127,321
Ensembl chrNW_004624752:72,615...127,325 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 ISO RGD PMID:10913276 RGD:1581107 NCBI chrNW_004624738:20,466,120...20,591,966
Ensembl chrNW_004624738:20,466,117...20,591,910 		JBrowse link
G Synj1 synaptojanin 1 enables ISO
IEA		 also binds SH3 domain of endophilins RGD
TreeGrafter		 PMID:8552192 PMID:11498538 PMID:17097615 GO_REF:0000118 RGD:13513210 RGD:628465 RGD:69388 NCBI chrNW_004624745:20,881,312...20,984,242
Ensembl chrNW_004624745:20,881,317...20,984,184 		JBrowse link
G Synj2 synaptojanin 2 enables ISO
IEA		 also binds SH3 domain of endophilins RGD
TreeGrafter		 PMID:11498538 GO_REF:0000118 RGD:628465 NCBI chrNW_004624785:157,455...265,926
Ensembl chrNW_004624785:145,228...266,022 		JBrowse link
G Uvrag UV radiation resistance associated enables ISO (PMID:17891140) MGI PMID:17891140 NCBI chrNW_004624817:989,362...1,371,096 JBrowse link
G Vasp vasodilator stimulated phosphoprotein enables IEA UniProt
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000043 GO_REF:0000118 NCBI chrNW_004624832:7,619,211...7,631,576
Ensembl chrNW_004624832:7,619,134...7,630,943 		JBrowse link
G Was WASP actin nucleation promoting factor enables ISO (PMID:8892607)
(PMID:19798448)		 BHF-UCL
UniProt		 PMID:8892607 PMID:19798448 NCBI chrNW_004624893:453,793...493,696
Ensembl chrNW_004624893:487,396...493,482 		JBrowse link
G Wasf2 WASP family member 2 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624764:11,292,677...11,392,202
Ensembl chrNW_004624764:11,292,272...11,383,386 		JBrowse link
G Wipf1 WAS/WASL interacting protein family member 1 enables ISO (PMID:19798448) UniProt PMID:19798448 NCBI chrNW_004624787:11,787,384...11,908,727
Ensembl chrNW_004624787:11,787,295...11,822,523 		JBrowse link
G Wipf3 WAS/WASL interacting protein family member 3 ISO RGD PMID:8906616 RGD:1302419 NCBI chrNW_004624739:843,193...971,646
Ensembl chrNW_004624739:872,213...944,184 		JBrowse link
G Znf106 zinc finger protein 106 enables IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624804:9,513,090...9,606,758 JBrowse link
G Znf384 zinc finger protein 384 ISO RGD PMID:10669742 RGD:1299381 NCBI chrNW_004624860:3,365,103...3,389,907
Ensembl chrNW_004624860:3,365,339...3,389,346 		JBrowse link
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  molecular_function 16258
    binding 14754
      protein binding 13366
        protein domain specific binding 759
          SH3 domain binding 94
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