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Gene: Cttnbp2 (cortactin binding protein 2) Heterocephalus glaber

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Symbol:

Cttnbp2

Name:

cortactin binding protein 2

RGD ID:

18924339

Description:

ENCODES a protein that exhibits SH3 domain binding (ortholog); INVOLVED IN regulation of modification of postsynaptic actin cytoskeleton (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); cystic fibrosis (ortholog); Myocardial Ischemia (ortholog); FOUND IN FAR/SIN/STRIPAK complex (ortholog); glutamatergic synapse (ortholog); postsynaptic actin cytoskeleton (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

cortactin-binding protein 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624827	1,481,082 - 1,655,871 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624827	1,481,082 - 1,656,279 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Cttnbp2	Naked Mole-Rat	cystic fibrosis		ISO	RGD:1353355	8554872	ClinVar Annotator: match by term: Cystic fibrosis	ClinVar	PMID:11938439\|PMID:22020151\|PMID:25910067\|PMID:28492532\|PMID:28544683\|PMID:30444886
Cttnbp2	Naked Mole-Rat	pleomorphic xanthoastrocytoma		ISO	RGD:1353355	8554872	ClinVar Annotator: match by term: Pleomorphic xanthoastrocytoma	ClinVar	PMID:28299358
Cttnbp2	Naked Mole-Rat	prostate cancer		ISO	RGD:1353355	8554872	ClinVar Annotator: match by term: Malignant tumor of prostate	ClinVar

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Cttnbp2	Naked Mole-Rat	autism spectrum disorder		ISO	RGD:1353355	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:28191889
Cttnbp2	Naked Mole-Rat	Myocardial Ischemia		ISO	RGD:1353355	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:16214533

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Cttnbp2	Naked Mole-Rat	regulation of modification of postsynaptic actin cytoskeleton	involved_in	ISO	RGD:628691	9068941	PMID:22262902	SynGO	PMID:22262902\|REF_RGD_ID:13702362
Cttnbp2	Naked Mole-Rat	regulation of synapse organization	involved_in	IEA	PANTHER:PTN001539116	150520179		TreeGrafter	GO_REF:0000118

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Cttnbp2	Naked Mole-Rat	actin cytoskeleton	located_in	IEA	PANTHER:PTN009063691	150520179		TreeGrafter	GO_REF:0000118
Cttnbp2	Naked Mole-Rat	cell cortex	located_in	IEA	UniProtKB-SubCell:SL-0138	150520179		UniProt	GO_REF:0000044
Cttnbp2	Naked Mole-Rat	cell projection	located_in	IEA	UniProtKB-KW:KW-0966	150520179		UniProt	GO_REF:0000043
Cttnbp2	Naked Mole-Rat	dendritic spine	located_in	IEA	UniProtKB-SubCell:SL-0284	150520179		UniProt	GO_REF:0000044
Cttnbp2	Naked Mole-Rat	FAR/SIN/STRIPAK complex	part_of	ISO	RGD:1617585	9068941	PMID:23015759	UniProt	PMID:23015759
Cttnbp2	Naked Mole-Rat	glutamatergic synapse	is_active_in	ISO	RGD:1617585	9068941	PMID:22262902	SynGO	PMID:22262902
Cttnbp2	Naked Mole-Rat	glutamatergic synapse	located_in	IEA	PANTHER:PTN001539116	150520179		TreeGrafter	GO_REF:0000118
Cttnbp2	Naked Mole-Rat	glutamatergic synapse	is_active_in	ISO	RGD:628691	9068941	PMID:22262902	SynGO	PMID:22262902\|REF_RGD_ID:13702362
Cttnbp2	Naked Mole-Rat	postsynaptic actin cytoskeleton	is_active_in	ISO	RGD:1617585	9068941	PMID:22262902	SynGO	PMID:22262902
Cttnbp2	Naked Mole-Rat	synapse	located_in	IEA	UniProtKB-KW:KW-0770	150520179		UniProt	GO_REF:0000043
Cttnbp2	Naked Mole-Rat	synaptic vesicle		ISO	RGD:628691	9068941		RGD	PMID:9813110\|REF_RGD_ID:632437

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Cttnbp2	Naked Mole-Rat	protein binding	enables	ISO	UniProtKB:A8MW99\|UniProtKB:O75031\|UniProtKB:P02533\|UniProtKB:P43364\|UniProtKB:Q0VD86\|UniProtKB:Q8WYA1-3\|UniProtKB:Q96KN3\|UniProtKB:Q9NVL1-2	9068941	PMID:32296183	IntAct	PMID:32296183
Cttnbp2	Naked Mole-Rat	protein binding	enables	ISO	UniProtKB:O55106,UniProtKB:P58404,UniProtKB:Q6PEB6	9068941	PMID:23015759	UniProt	PMID:23015759
Cttnbp2	Naked Mole-Rat	protein phosphatase 2A binding	enables	IEA	PANTHER:PTN009063691	150520179		TreeGrafter	GO_REF:0000118
Cttnbp2	Naked Mole-Rat	SH3 domain binding		ISO	RGD:619839	9068941		RGD	PMID:9813110\|REF_RGD_ID:632437

PMID:22301074	PMID:30032202

Cttnbp2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624827	1,481,082 - 1,655,871 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624827	1,481,082 - 1,656,279 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

CTTNBP2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	117,710,651 - 117,873,441 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	117,710,651 - 117,874,139 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	117,350,705 - 117,513,495 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	117,137,941 - 117,300,797 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	116,944,658 - 117,107,512	NCBI
Celera	7	112,158,873 - 112,321,703 (-)	NCBI		Celera
Cytogenetic Map	7	q31.31	NCBI
HuRef	7	111,716,178 - 111,879,317 (-)	NCBI		HuRef
CHM1_1	7	117,284,164 - 117,447,123 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	119,026,042 - 119,189,157 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	116,746,141 - 116,908,979 (-)	NCBI

Cttnbp2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	18,366,470 - 18,515,216 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	18,366,477 - 18,514,842 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	18,366,471 - 18,515,217 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	18,366,478 - 18,514,843 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	18,316,477 - 18,464,825 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	18,316,472 - 18,464,869 (-)	NCBI		MGSCv36	mm8
Celera	6	18,439,130 - 18,588,875 (-)	NCBI		Celera
Cytogenetic Map	6	A2	NCBI
cM Map	6	8.12	NCBI

Cttnbp2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	47,766,867 - 47,930,598 (-)	NCBI		GRCr8
mRatBN7.2	4	46,800,975 - 46,964,681 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	46,800,981 - 46,964,631 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	51,794,547 - 51,957,758 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	47,715,681 - 47,878,895 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	46,139,573 - 46,302,508 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	42,932,897 - 43,096,454 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	42,932,903 - 43,096,399 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	42,516,933 - 42,680,639 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	44,114,097 - 44,277,748 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	44,402,924 - 44,507,501 (-)	NCBI
Celera	4	42,060,024 - 42,223,096 (-)	NCBI		Celera
Cytogenetic Map	4	q22	NCBI

Cttnbp2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955432	23,364,933 - 23,518,550 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955432	23,364,193 - 23,527,300 (-)	NCBI	ChiLan1.0	ChiLan1.0

CTTNBP2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	154,535,118 - 154,697,070 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	6,545,375 - 6,707,311 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	109,675,275 - 109,837,178 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	122,369,733 - 122,531,604 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	122,370,616 - 122,520,397 (-)	Ensembl	panpan1.1		panPan2

CTTNBP2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	56,514,114 - 56,665,437 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	56,514,381 - 56,657,958 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	55,909,374 - 56,053,305 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	56,553,566 - 56,624,854 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	14	56,592,187 - 56,735,831 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	14	56,273,353 - 56,344,334 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	14	56,644,651 - 56,715,671 (-)	NCBI		UU_Cfam_GSD_1.0

Cttnbp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	45,166,957 - 45,304,112 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936589	1,393,141 - 1,522,048 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936589	1,385,342 - 1,522,911 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CTTNBP2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	28,415,067 - 28,573,159 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	18	28,130,213 - 28,573,166 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	30,230,103 - 30,342,035 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CTTNBP2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	86,376,005 - 86,539,662 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	86,376,011 - 86,527,223 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666042	17,181,391 - 17,344,562 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	XM_004865255	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021244753	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AHKG01082772	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AHKG01082773	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AHKG01082774	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AHKG01082775	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GEBF01005190	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSHGLT00000002802 ⟹ ENSHGLP00000002748

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla_female_1.0 Ensembl	NW_004624827	1,481,082 - 1,655,871 (+)	Ensembl

RefSeq Acc Id:

XM_004865255 ⟹ XP_004865312

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624827	1,481,082 - 1,656,279 (+)	NCBI

RefSeq Acc Id:

XM_021244753 ⟹ XP_021100412

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624827	1,544,456 - 1,656,279 (+)	NCBI


Protein RefSeqs	XP_004865312	(Get FASTA)	NCBI Sequence Viewer
	XP_021100412	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSHGLP00000002748
GenBank Protein	JAN98442	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_004865312 ⟸ XM_004865255
- Peptide Label:	isoform X1
- UniProtKB:	A0AAX6Q4K8 (UniProtKB/TrEMBL), A0A0P6J266 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_021100412 ⟸ XM_021244753
- Peptide Label:	isoform X2
- UniProtKB:	A0AAX6RUW6 (UniProtKB/TrEMBL), G5B3Q6 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSHGLP00000002748 ⟸ ENSHGLT00000002802

Database	Acc Id	Source(s)
Ensembl Genes	ENSHGLG00000002067	Ensembl, ENTREZGENE
Ensembl Transcript	ENSHGLT00000002802	ENTREZGENE
Gene3D-CATH	1.25.40.20	UniProtKB/TrEMBL
InterPro	Ankyrin_rpt	UniProtKB/TrEMBL
	Ankyrin_rpt-contain_sf	UniProtKB/TrEMBL
	Cortactin-Actin_Reg	UniProtKB/TrEMBL
	Cortactin-binding_p2_N	UniProtKB/TrEMBL
	Dendritic_Spine_Reg/Scaffold	UniProtKB/TrEMBL
NCBI Gene	Cttnbp2	ENTREZGENE
PANTHER	CORTACTIN-BINDING PROTEIN 2	UniProtKB/TrEMBL
	CTTNBP2 N-TERMINAL-LIKE PROTEIN	UniProtKB/TrEMBL
	FILAMIN/GPBP-INTERACTING PROTEIN	UniProtKB/TrEMBL
	ROLLING PEBBLES, ISOFORM B	UniProtKB/TrEMBL
Pfam	Ank	UniProtKB/TrEMBL
	Ank_2	UniProtKB/TrEMBL
	CortBP2	UniProtKB/TrEMBL
PROSITE	ANK_REP_REGION	UniProtKB/TrEMBL
	ANK_REPEAT	UniProtKB/TrEMBL
SMART	ANK	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48403	UniProtKB/TrEMBL
UniProt	A0A0P6J266	ENTREZGENE, UniProtKB/TrEMBL
	A0AAX6Q4K8	ENTREZGENE, UniProtKB/TrEMBL
	A0AAX6RUW6	ENTREZGENE, UniProtKB/TrEMBL
	G5B3Q6	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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