Symbol: |
Shank2 |
Name: |
SH3 and multiple ankyrin repeat domains 2 |
RGD ID: |
18908611 |
Description: |
ENCODES a protein that exhibits SH3 domain binding (ortholog); structural constituent of postsynaptic density (ortholog); INVOLVED IN adult behavior (ortholog); adult locomotory behavior (ortholog); associative learning (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); bipolar disorder (ortholog); FOUND IN apical plasma membrane (ortholog); asymmetric synapse (ortholog); brush border membrane (ortholog) |
Type: |
protein-coding
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RefSeq Status: |
MODEL |
Previously known as: |
SH3 and multiple ankyrin repeat domains protein 2 |
RGD Orthologs |
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Alliance Orthologs |
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More Info |
more info ...
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More Info |
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Latest Assembly: |
HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly |
Position: |
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JBrowse: |
View Region in Genome Browser (JBrowse)
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Model |
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Shank2 | Naked Mole-Rat | autism spectrum disorder | | ISO | RGD:736232 | 8554872 | ClinVar Annotator: match by term: Autism spectrum disorder | ClinVar Annotator: match by term: Autism more ... | ClinVar | PMID:22346768|PMID:25741868|PMID:27569545|PMID:30763456 | Shank2 | Naked Mole-Rat | autistic disorder | | ISO | RGD:736232 | 8554872 | ClinVar Annotator: match by term: Autism | ClinVar Annotator: match by term: Autism, susceptibility to, more ... | ClinVar | PMID:20473310|PMID:21994763|PMID:22346768|PMID:25560758|PMID:25741868|PMID:26467025|PMID:27001614|PMID:28263302|PMID:28492532|PMID:29991577|PMID:30072871|PMID:30911184|PMID:35456494 | Shank2 | Naked Mole-Rat | autistic disorder | | ISO | RGD:736232 | 8554872 | ClinVar Annotator: match by term: Autism | ClinVar Annotator: match by term: Autism, susceptibility to, more ... | ClinVar | PMID:20473310|PMID:21994763|PMID:22346768|PMID:25560758|PMID:25741868|PMID:26467025|PMID:27001614|PMID:28263302|PMID:28492532|PMID:29991577|PMID:30072871|PMID:30911184 | Shank2 | Naked Mole-Rat | autistic disorder | | ISO | RGD:736232 | 8554872 | ClinVar Annotator: match by term: Autism | ClinVar Annotator: match by term: Autism, susceptibility to, more ... | ClinVar | PMID:20473310|PMID:21994763|PMID:22346768|PMID:25560758|PMID:25741868|PMID:26467025|PMID:27001614|PMID:28492532|PMID:29991577|PMID:30072871|PMID:30911184 | Shank2 | Naked Mole-Rat | developmental and epileptic encephalopathy 11 | | ISO | RGD:736232 | 8554872 | ClinVar Annotator: match by term: Complex neurodevelopmental disorder | ClinVar | PMID:25741868 | Shank2 | Naked Mole-Rat | Developmental Disabilities | | ISO | RGD:736232 | 8554872 | ClinVar Annotator: match by term: Global developmental delay | ClinVar | PMID:25741868 | Shank2 | Naked Mole-Rat | genetic disease | | ISO | RGD:736232 | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | PMID:25741868 | Shank2 | Naked Mole-Rat | intellectual disability | | ISO | RGD:736232 | 8554872 | ClinVar Annotator: match by term: Intellectual disability | ClinVar | PMID:25741868 | Shank2 | Naked Mole-Rat | Neurodevelopmental Disorders | | ISO | RGD:736232 | 8554872 | ClinVar Annotator: match by term: Neurodevelopmental disorder | ClinVar | PMID:20473310|PMID:25741868|PMID:30911184 |
Shank2 (Heterocephalus glaber - naked mole-rat) |
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SHANK2 (Homo sapiens - human) |
Human Assembly | Chr | Position (strand) | Source | Genome Browsers |
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JBrowse | NCBI | UCSC | Ensembl |
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GRCh38 | 11 | 70,467,854 - 71,253,228 (-) | NCBI | GRCh38 | GRCh38 | hg38 | GRCh38 | GRCh38.p14 Ensembl | 11 | 70,467,854 - 71,252,577 (-) | Ensembl | GRCh38 | | hg38 | GRCh38 | GRCh37 | 11 | 70,313,959 - 70,963,623 (-) | NCBI | GRCh37 | GRCh37 | hg19 | GRCh37 | Build 36 | 11 | 69,991,609 - 70,185,520 (-) | NCBI | NCBI36 | Build 36 | hg18 | NCBI36 | Build 34 | 11 | 70,012,765 - 70,185,520 | NCBI | | | | | Celera | 11 | 67,575,145 - 68,227,408 (-) | NCBI | | Celera | | | Cytogenetic Map | 11 | q13.3-q13.4 | NCBI | | | | | HuRef | 11 | 66,575,130 - 67,004,438 (-) | NCBI | | HuRef | | | HuRef | 11 | 67,062,872 - 67,229,732 (-) | NCBI | | HuRef | | | CHM1_1 | 11 | 70,197,402 - 70,819,749 (-) | NCBI | | CHM1_1 | | | T2T-CHM13v2.0 | 11 | 70,488,279 - 71,179,617 (-) | NCBI | | T2T-CHM13v2.0 | | |
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Shank2 (Mus musculus - house mouse) |
Mouse Assembly | Chr | Position (strand) | Source | Genome Browsers |
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JBrowse | NCBI | UCSC | Ensembl |
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GRCm39 | 7 | 143,531,819 - 143,979,780 (+) | NCBI | GRCm39 | GRCm39 | mm39 | | GRCm39 Ensembl | 7 | 143,555,665 - 143,978,231 (+) | Ensembl | | GRCm39 Ensembl | | | GRCm38 | 7 | 143,978,077 - 144,426,043 (+) | NCBI | GRCm38 | GRCm38 | mm10 | GRCm38 | GRCm38.p6 Ensembl | 7 | 144,001,928 - 144,424,494 (+) | Ensembl | GRCm38 | | mm10 | GRCm38 | MGSCv37 | 7 | 151,361,425 - 151,608,580 (+) | NCBI | GRCm37 | MGSCv37 | mm9 | NCBIm37 | MGSCv36 | 7 | 143,840,654 - 144,232,065 (+) | NCBI | | MGSCv36 | mm8 | | Celera | 7 | 143,939,514 - 144,185,177 (+) | NCBI | | Celera | | | Cytogenetic Map | 7 | F5 | NCBI | | | | | cM Map | 7 | 88.45 | NCBI | | | | |
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Shank2 (Rattus norvegicus - Norway rat) |
Rat Assembly | Chr | Position (strand) | Source | Genome Browsers |
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JBrowse | NCBI | UCSC | Ensembl |
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GRCr8 | 1 | 208,575,144 - 209,020,300 (+) | NCBI | | GRCr8 | | | mRatBN7.2 | 1 | 199,146,210 - 199,590,962 (+) | NCBI | mRatBN7.2 | mRatBN7.2 | | | mRatBN7.2 Ensembl | 1 | 199,169,429 - 199,589,394 (+) | Ensembl | | mRatBN7.2 Ensembl | | | UTH_Rnor_SHR_Utx | 1 | 207,554,601 - 207,972,754 (+) | NCBI | Rnor_SHR | UTH_Rnor_SHR_Utx | | | UTH_Rnor_SHRSP_BbbUtx_1.0 | 1 | 214,636,692 - 215,056,974 (+) | NCBI | Rnor_SHRSP | UTH_Rnor_SHRSP_BbbUtx_1.0 | | | UTH_Rnor_WKY_Bbb_1.0 | 1 | 207,310,858 - 207,731,152 (+) | NCBI | Rnor_WKY | UTH_Rnor_WKY_Bbb_1.0 | | | Rnor_6.0 | 1 | 217,149,156 - 217,593,950 (+) | NCBI | Rnor6.0 | Rnor_6.0 | rn6 | Rnor6.0 | Rnor_6.0 Ensembl | 1 | 217,151,166 - 217,592,763 (+) | Ensembl | Rnor6.0 | | rn6 | Rnor6.0 | Rnor_5.0 | 1 | 222,118,530 - 222,150,341 (+) | NCBI | Rnor5.0 | Rnor_5.0 | rn5 | Rnor5.0 | Rnor_5.0 | 1 | 224,028,791 - 224,450,737 (+) | NCBI | Rnor5.0 | Rnor_5.0 | rn5 | Rnor5.0 | RGSC_v3.4 | 1 | 204,399,856 - 204,855,474 (+) | NCBI | RGSC3.4 | RGSC_v3.4 | rn4 | RGSC3.4 | RGSC_v3.1 | 1 | 204,553,308 - 205,005,561 (+) | NCBI | | | | | Celera | 1 | 196,732,183 - 197,149,084 (+) | NCBI | | Celera | | | Cytogenetic Map | 1 | q42 | NCBI | | | | |
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Shank2 (Chinchilla lanigera - long-tailed chinchilla) |
Chinchilla Assembly | Chr | Position (strand) | Source | Genome Browsers |
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JBrowse | NCBI | UCSC | Ensembl |
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ChiLan1.0 Ensembl | NW_004955422 | 15,295,772 - 15,814,711 (+) | Ensembl | ChiLan1.0 | | | | ChiLan1.0 | NW_004955422 | 15,295,800 - 15,818,067 (+) | NCBI | ChiLan1.0 | ChiLan1.0 | | |
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SHANK2 (Pan paniscus - bonobo/pygmy chimpanzee) |
Bonobo Assembly | Chr | Position (strand) | Source | Genome Browsers |
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JBrowse | NCBI | UCSC | Ensembl |
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NHGRI_mPanPan1-v2 | 9 | 71,441,934 - 72,138,948 (-) | NCBI | | NHGRI_mPanPan1-v2 | | | NHGRI_mPanPan1 | 11 | 72,486,126 - 73,180,580 (-) | NCBI | | NHGRI_mPanPan1 | | | Mhudiblu_PPA_v0 | 11 | 65,570,677 - 66,268,139 (-) | NCBI | Mhudiblu_PPA_v0 | Mhudiblu_PPA_v0 | panPan3 | | PanPan1.1 | 11 | 68,857,186 - 69,495,237 (-) | NCBI | panpan1.1 | PanPan1.1 | panPan2 | | PanPan1.1 Ensembl | 11 | 68,860,606 - 69,437,925 (-) | Ensembl | panpan1.1 | | panPan2 | |
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SHANK2 (Canis lupus familiaris - dog) |
Dog Assembly | Chr | Position (strand) | Source | Genome Browsers |
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JBrowse | NCBI | UCSC | Ensembl |
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CanFam3.1 | 18 | 47,477,625 - 47,915,557 (+) | NCBI | CanFam3.1 | CanFam3.1 | canFam3 | CanFam3.1 | CanFam3.1 Ensembl | 18 | 47,635,788 - 47,912,117 (+) | Ensembl | CanFam3.1 | | canFam3 | CanFam3.1 | Dog10K_Boxer_Tasha | 18 | 46,010,915 - 46,522,454 (+) | NCBI | | Dog10K_Boxer_Tasha | | | ROS_Cfam_1.0 | 18 | 48,113,005 - 48,589,823 (+) | NCBI | | ROS_Cfam_1.0 | | | ROS_Cfam_1.0 Ensembl | 18 | 48,098,110 - 48,589,819 (+) | Ensembl | | ROS_Cfam_1.0 Ensembl | | | UMICH_Zoey_3.1 | 18 | 47,525,882 - 48,036,670 (+) | NCBI | | UMICH_Zoey_3.1 | | | UNSW_CanFamBas_1.0 | 18 | 47,111,601 - 47,622,440 (+) | NCBI | | UNSW_CanFamBas_1.0 | | | UU_Cfam_GSD_1.0 | 18 | 47,858,659 - 48,368,562 (+) | NCBI | | UU_Cfam_GSD_1.0 | | |
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Shank2 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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SHANK2 (Sus scrofa - pig) |
Pig Assembly | Chr | Position (strand) | Source | Genome Browsers |
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JBrowse | NCBI | UCSC | Ensembl |
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Sscrofa11.1 Ensembl | 2 | 2,864,331 - 3,015,314 (+) | Ensembl | Sscrofa11.1 | | susScr11 | Sscrofa11.1 | Sscrofa11.1 | 2 | 2,517,853 - 3,016,959 (+) | NCBI | Sscrofa11.1 | Sscrofa11.1 | susScr11 | Sscrofa11.1 | Sscrofa10.2 | 2 | 924,313 - 1,073,976 (+) | NCBI | Sscrofa10.2 | Sscrofa10.2 | susScr3 | |
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SHANK2 (Chlorocebus sabaeus - green monkey) |
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.
Ensembl Acc Id: |
ENSHGLT00000017368 ⟹ ENSHGLP00000017195 |
Type: |
CODING |
Position: |
Naked Mole-Rat Assembly | Chr | Position (strand) | Source |
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HetGla_female_1.0 Ensembl | NW_004624767 | 16,380,751 - 16,823,577 (+) | Ensembl |
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Ensembl Acc Id: |
ENSHGLT00000017369 ⟹ ENSHGLP00000017196 |
Type: |
CODING |
Position: |
Naked Mole-Rat Assembly | Chr | Position (strand) | Source |
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HetGla_female_1.0 Ensembl | NW_004624767 | 16,546,317 - 16,823,577 (+) | Ensembl |
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Ensembl Acc Id: |
ENSHGLT00000017370 ⟹ ENSHGLP00000017197 |
Type: |
CODING |
Position: |
Naked Mole-Rat Assembly | Chr | Position (strand) | Source |
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HetGla_female_1.0 Ensembl | NW_004624767 | 16,673,906 - 16,823,577 (+) | Ensembl |
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RefSeq Acc Id: |
XM_004852142 ⟹ XP_004852199 |
Type: |
CODING |
Position: |
Naked Mole-Rat Assembly | Chr | Position (strand) | Source |
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HetGla 1.0 | NW_004624767 | 16,545,903 - 16,828,714 (+) | NCBI |
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RefSeq Acc Id: |
XM_021264446 ⟹ XP_021120105 |
Type: |
CODING |
Position: |
Naked Mole-Rat Assembly | Chr | Position (strand) | Source |
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HetGla 1.0 | NW_004624767 | 16,296,053 - 16,828,714 (+) | NCBI |
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RefSeq Acc Id: |
XP_021120105 ⟸ XM_021264446 |
- Peptide Label: |
isoform X1 |
- UniProtKB: |
A0AAX6TEH3 (UniProtKB/TrEMBL) |
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RefSeq Acc Id: |
XP_004852199 ⟸ XM_004852142 |
- Peptide Label: |
isoform X2 |
- UniProtKB: |
A0AAX6PI19 (UniProtKB/TrEMBL), G5BSS8 (UniProtKB/TrEMBL) |
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Ensembl Acc Id: |
ENSHGLP00000017197 ⟸ ENSHGLT00000017370 |
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Ensembl Acc Id: |
ENSHGLP00000017195 ⟸ ENSHGLT00000017368 |
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Ensembl Acc Id: |
ENSHGLP00000017196 ⟸ ENSHGLT00000017369 |
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