Adam15 (ADAM metallopeptidase domain 15) - Rat Genome Database

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Gene: Adam15 (ADAM metallopeptidase domain 15) Heterocephalus glaber
Analyze
Symbol: Adam15
Name: ADAM metallopeptidase domain 15
RGD ID: 18923313
Description: ENCODES a protein that exhibits immunoglobulin receptor binding (ortholog); metallopeptidase activity (ortholog); SH3 domain binding (ortholog); INVOLVED IN apoptotic process (ortholog); cardiac epithelial to mesenchymal transition (ortholog); cellular response to phorbol 13-acetate 12-myristate (ortholog); ASSOCIATED WITH Brain Hypoxia (ortholog); Charcot-Marie-Tooth disease type 2 (ortholog); COVID-19 (ortholog); FOUND IN cell surface (ortholog); extracellular exosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: disintegrin and metalloproteinase domain-containing protein 15; disintegrin and metalloproteinase domain-containing protein 15 isoform 7 preproprotein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248852,441,217 - 2,451,057 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248852,441,298 - 2,451,061 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Adam15
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248852,441,217 - 2,451,057 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248852,441,298 - 2,451,061 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
ADAM15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381155,051,316 - 155,062,775 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1155,050,566 - 155,062,775 (+)EnsemblGRCh38hg38GRCh38
GRCh371155,023,792 - 155,035,251 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361153,290,386 - 153,301,876 (+)NCBINCBI36Build 36hg18NCBI36
Build 341151,836,834 - 151,848,325NCBI
Celera1128,094,785 - 128,106,774 (+)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1126,385,749 - 126,397,256 (+)NCBIHuRef
CHM1_11156,419,572 - 156,431,076 (+)NCBICHM1_1
T2T-CHM13v2.01154,190,701 - 154,202,162 (+)NCBIT2T-CHM13v2.0
Adam15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39389,246,947 - 89,257,589 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl389,245,849 - 89,257,303 (-)EnsemblGRCm39 Ensembl
GRCm38389,339,640 - 89,350,028 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl389,338,542 - 89,349,996 (-)EnsemblGRCm38mm10GRCm38
MGSCv37389,143,562 - 89,153,932 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36389,424,469 - 89,435,909 (-)NCBIMGSCv36mm8
Celera389,374,683 - 89,385,053 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.07NCBI
Adam15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82177,052,363 - 177,062,879 (-)NCBIGRCr8
mRatBN7.22174,754,629 - 174,765,136 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,754,633 - 174,765,113 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2181,899,637 - 181,910,172 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,922,013 - 179,932,548 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02174,522,552 - 174,533,074 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02188,661,831 - 188,672,337 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,661,699 - 188,672,247 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02208,071,874 - 208,082,531 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42181,527,175 - 181,537,640 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12181,477,282 - 181,487,746 (-)NCBI
Celera2168,696,199 - 168,706,661 (-)NCBICelera
Cytogenetic Map2q34NCBI
Adam15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555451,545,635 - 1,555,614 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555451,545,532 - 1,555,826 (+)NCBIChiLan1.0ChiLan1.0
ADAM15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2194,778,158 - 94,789,698 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,510,197 - 94,521,712 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01130,398,961 - 130,410,860 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11134,008,959 - 134,020,467 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1134,008,959 - 134,020,467 (+)Ensemblpanpan1.1panPan2
ADAM15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1742,432,067 - 42,443,463 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl742,428,113 - 42,443,429 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha741,923,026 - 41,933,600 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0742,301,837 - 42,312,428 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl742,301,842 - 42,312,494 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1742,081,565 - 42,092,138 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0742,135,440 - 42,145,971 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0742,418,961 - 42,429,316 (-)NCBIUU_Cfam_GSD_1.0
Adam15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505825,557,826 - 25,568,277 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365804,588,039 - 4,599,014 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365804,588,182 - 4,598,659 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAM15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl494,736,646 - 94,748,098 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1494,736,639 - 94,748,093 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24103,518,254 - 103,529,683 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADAM15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1208,767,836 - 8,779,399 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl208,768,112 - 8,779,311 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660388,102,189 - 8,113,704 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000026282   ⟹   ENSHGLP00000026052
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248852,441,217 - 2,451,057 (-)Ensembl
RefSeq Acc Id: XM_013068018   ⟹   XP_012923472
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248852,441,298 - 2,451,061 (-)NCBI
RefSeq Acc Id: XM_013068019   ⟹   XP_012923473
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248852,441,298 - 2,451,061 (-)NCBI
RefSeq Acc Id: XM_013068020   ⟹   XP_012923474
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248852,441,298 - 2,451,061 (-)NCBI
RefSeq Acc Id: XM_013068021   ⟹   XP_012923475
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248852,443,554 - 2,451,061 (-)NCBI
RefSeq Acc Id: XM_013068022   ⟹   XP_012923476
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248852,443,554 - 2,451,061 (-)NCBI
RefSeq Acc Id: XM_021249423   ⟹   XP_021105082
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248852,441,298 - 2,451,061 (-)NCBI
RefSeq Acc Id: XM_021249424   ⟹   XP_021105083
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248852,442,032 - 2,451,061 (-)NCBI
RefSeq Acc Id: XR_001182754
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248852,442,057 - 2,451,061 (-)NCBI
RefSeq Acc Id: XR_001182755
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248852,441,665 - 2,451,061 (-)NCBI
RefSeq Acc Id: XR_002391353
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248852,441,665 - 2,451,061 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_012923473   ⟸   XM_013068019
- Peptide Label: isoform X2
- UniProtKB: A0A0P6JBF3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012923474   ⟸   XM_013068020
- Peptide Label: isoform X4
- UniProtKB: A0A0P6JBF3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021105082   ⟸   XM_021249423
- Peptide Label: isoform X3
- UniProtKB: A0A0P6JBF3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012923472   ⟸   XM_013068018
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JBF3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021105083   ⟸   XM_021249424
- Peptide Label: isoform X5
- UniProtKB: A0A0P6JBF3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012923476   ⟸   XM_013068022
- Peptide Label: isoform X6
- UniProtKB: A0A0P6JBF3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012923475   ⟸   XM_013068021
- Peptide Label: isoform X6
- UniProtKB: A0A0P6JBF3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000026052   ⟸   ENSHGLT00000026282


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000018549 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000026282 ENTREZGENE
Gene3D-CATH 3.40.390.10 UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/TrEMBL
InterPro ADAM_Cys-rich UniProtKB/TrEMBL
  Disintegrin_dom UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/TrEMBL
NCBI Gene Adam15 ENTREZGENE
PANTHER ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/TrEMBL
  PTHR11905:SF130 UniProtKB/TrEMBL
Pfam ADAM_CR UniProtKB/TrEMBL
  Disintegrin UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
SMART ACR UniProtKB/TrEMBL
  DISIN UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF57552 UniProtKB/TrEMBL
UniProt A0A0P6JBF3 ENTREZGENE, UniProtKB/TrEMBL