Sos1 (SOS Ras/Rac guanine nucleotide exchange factor 1)

Gene: Sos1 (SOS Ras/Rac guanine nucleotide exchange factor 1) Heterocephalus glaber

Analyze

Symbol:

Sos1

Name:

SOS Ras/Rac guanine nucleotide exchange factor 1

RGD ID:

18905907

Description:

ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); molecular condensate scaffold activity (ortholog); SH3 domain binding (ortholog); INVOLVED IN B cell homeostasis (ortholog); B cell receptor signaling pathway (ortholog); blood vessel morphogenesis (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; Fc epsilon receptor mediated signaling pathway; ASSOCIATED WITH arrhythmogenic right ventricular cardiomyopathy (ortholog); atrial heart septal defect (ortholog); Atrial Septal Defect, Secundum Type (ortholog); FOUND IN cytoplasm (ortholog); GTPase complex (ortholog); neuronal cell body (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

son of sevenless homolog 1; Son of sevenless-like protein 1

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624738	20,466,117 - 20,591,910 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624738	20,466,120 - 20,591,966 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

arrhythmogenic right ventricular cardiomyopathy (ISO)

atrial heart septal defect (ISO)

Atrial Septal Defect, Secundum Type (ISO)

brain ischemia (ISO)

Brugada syndrome (ISO)

Cafe au lait Spots, Multiple (ISO)

cardiomyopathy (ISO)

cerebral infarction (ISO)

cervical cancer (ISO)

congenital heart disease (ISO)

dilated cardiomyopathy (ISO)

Dwarfism (ISO)

familial hypertrophic cardiomyopathy (ISO)

genetic disease (ISO)

gingival fibromatosis (ISO)

Gingival Fibromatosis 1 (ISO)

hypertrophic cardiomyopathy (ISO)

hypertrophic cardiomyopathy 1 (ISO)

intellectual disability (ISO)

Joubert syndrome 3 (ISO)

lung adenocarcinoma (ISO)

Lynch syndrome (ISO)

Muscle Hypotonia (ISO)

Neurodevelopmental Disorders (ISO)

Noonan Like Syndrome (ISO)

Noonan syndrome (ISO)

Noonan syndrome 1 (ISO)

Noonan syndrome 3 (ISO)

Noonan syndrome 4 (ISO)

Nuchal Bleb, Familial (ISO)

prostate cancer (ISO)

ptosis (ISO)

pulmonary valve stenosis (ISO)

RASopathy (ISO)

Stroke (ISO)

Sudden Unexpected Nocturnal Death Syndrome (ISO)

uterine cancer (ISO)

Ventricular Tachycardia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

B cell homeostasis (ISO)

B cell receptor signaling pathway (ISO)

blood vessel morphogenesis (ISO)

cardiac atrium morphogenesis (ISO)

epidermal growth factor receptor signaling pathway (ISO)

eyelid development in camera-type eye (ISO)

fibroblast growth factor receptor signaling pathway (ISO)

hair follicle development (ISO)

heart morphogenesis (ISO)

heart trabecula morphogenesis (ISO)

insulin receptor signaling pathway (ISO)

insulin-like growth factor receptor signaling pathway (ISO)

lymphocyte homeostasis (ISO)

midbrain morphogenesis (ISO)

multicellular organism growth (ISO)

myelination (ISO)

neurotrophin TRK receptor signaling pathway (ISO)

pericardium morphogenesis (ISO)

positive regulation of epidermal growth factor receptor signaling pathway (ISO)

positive regulation of small GTPase mediated signal transduction (ISO)

Ras protein signal transduction (IEA,ISO)

regulation of cell population proliferation (ISO)

regulation of pro-B cell differentiation (ISO)

regulation of T cell differentiation in thymus (ISO)

regulation of T cell proliferation (ISO)

regulation of transcription by RNA polymerase II (ISO)

response to ischemia (ISO)

roof of mouth development (ISO)

Schwann cell development (ISO)

small GTPase-mediated signal transduction (IEA,ISO)

vitellogenesis (ISO)

Cellular Component

cytoplasm (ISO)

GTPase complex (ISO)

neuronal cell body (ISO)

plasma membrane (IEA)

Molecular Function

epidermal growth factor receptor binding (ISO)

guanyl-nucleotide exchange factor activity (IEA)

molecular condensate scaffold activity (ISO)

protein binding (ISO)

protein heterodimerization activity (IEA)

SH3 domain binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

epidermal growth factor/neuregulin signaling pathway (ISO)

erythropoietin signaling pathway (ISO)

Fc epsilon receptor mediated signaling pathway (ISO)

fibroblast growth factor signaling pathway (ISO)

granulocyte-macrophage colony-stimulating factor signaling pathway (ISO)

insulin signaling pathway (ISO)

insulin-like growth factor signaling pathway (ISO)

interleukin-2 signaling pathway (ISO)

interleukin-6 signaling pathway (ISO)

nerve growth factor signaling pathway (ISO)

platelet-derived growth factor signaling pathway (ISO)

Ras family mediated signaling pathway (ISO)

transforming growth factor-beta Smad dependent signaling pathway (ISO)

References

Additional References at PubMed

PMID:21993625	PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Sos1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624738	20,466,117 - 20,591,910 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624738	20,466,120 - 20,591,966 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

SOS1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	38,981,549 - 39,124,868 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	38,962,206 - 39,124,345 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	39,208,690 - 39,352,009 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	39,066,469 - 39,201,067 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	39,124,615 - 39,259,214	NCBI
Celera	2	39,049,411 - 39,188,687 (-)	NCBI		Celera
Cytogenetic Map	2	p22.1	NCBI
HuRef	2	38,947,128 - 39,086,120 (-)	NCBI		HuRef
CHM1_1	2	39,139,128 - 39,278,182 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	38,990,066 - 39,133,839 (-)	NCBI		T2T-CHM13v2.0

Sos1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	80,701,181 - 80,787,882 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	80,701,180 - 80,787,882 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	80,393,752 - 80,480,453 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	80,393,751 - 80,480,453 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	80,793,092 - 80,879,793 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	80,305,779 - 80,388,265 (-)	NCBI		MGSCv36	mm8
Celera	17	84,712,016 - 84,797,777 (-)	NCBI		Celera
Cytogenetic Map	17	E3	NCBI
cM Map	17	50.67	NCBI

Sos1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	20,286,117 - 20,363,350 (+)	NCBI		GRCr8
mRatBN7.2	6	14,533,870 - 14,613,348 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	14,533,360 - 14,611,107 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	14,832,784 - 14,910,104 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	15,154,472 - 15,231,727 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	14,650,751 - 14,727,998 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	3,105,443 - 3,182,977 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	3,104,861 - 3,182,996 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	3,082,456 - 3,159,445 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	3,308,778 - 3,390,661 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	3,310,822 - 3,394,313 (-)	NCBI
Celera	6	14,210,655 - 14,287,471 (+)	NCBI		Celera
Cytogenetic Map	6	q12	NCBI

Sos1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955441	6,646,385 - 6,713,028 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955441	6,649,895 - 6,724,271 (-)	NCBI	ChiLan1.0	ChiLan1.0

SOS1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	87,342,622 - 87,487,223 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	87,346,597 - 87,488,030 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	39,019,046 - 39,162,248 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	39,773,758 - 39,911,964 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	39,773,760 - 39,911,961 (-)	Ensembl	panpan1.1		panPan2

SOS1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	31,007,940 - 31,181,569 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	31,009,257 - 31,142,063 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	30,825,007 - 30,830,255 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	31,664,627 - 31,805,012 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	31,664,631 - 31,805,021 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	30,886,361 - 31,025,725 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	30,956,021 - 31,095,889 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	31,169,723 - 31,309,388 (-)	NCBI		UU_Cfam_GSD_1.0

Sos1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	40,733,944 - 40,853,206 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936508	12,162,547 - 12,281,820 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936508	12,162,553 - 12,281,812 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SOS1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	101,209,641 - 101,362,723 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	101,209,568 - 101,366,057 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	107,318,421 - 107,466,093 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SOS1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	68,259,509 - 68,404,167 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	68,259,360 - 68,399,895 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	43,577,050 - 43,723,991 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_004839335	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_004839336	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021253743	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021253744	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AHKG01016003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AHKG01016004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AHKG01016005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AHKG01016006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JH174163	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSHGLT00000012081 ⟹ ENSHGLP00000011949

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla_female_1.0 Ensembl	NW_004624738	20,466,117 - 20,591,910 (-)	Ensembl

RefSeq Acc Id:

XM_004839335 ⟹ XP_004839392

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624738	20,466,120 - 20,591,964 (-)	NCBI

RefSeq Acc Id:

XM_004839336 ⟹ XP_004839393

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624738	20,466,120 - 20,591,965 (-)	NCBI

RefSeq Acc Id:

XM_021253743 ⟹ XP_021109402

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624738	20,478,883 - 20,591,966 (-)	NCBI

RefSeq Acc Id:

XM_021253744 ⟹ XP_021109403

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624738	20,466,120 - 20,533,653 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_004839392	(Get FASTA)	NCBI Sequence Viewer
	XP_004839393	(Get FASTA)	NCBI Sequence Viewer
	XP_021109402	(Get FASTA)	NCBI Sequence Viewer
	XP_021109403	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EHB18426	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSHGLP00000011949
	ENSHGLP00000041735
	ENSHGLP00100013169

RefSeq Acc Id:	XP_004839393 ⟸ XM_004839336
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_004839392 ⟸ XM_004839335
- Peptide Label:	isoform X1
- UniProtKB:	G5CA65 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_021109403 ⟸ XM_021253744
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_021109402 ⟸ XM_021253743
- Peptide Label:	isoform X3

RefSeq Acc Id:

ENSHGLP00000011949 ⟸ ENSHGLT00000012081

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSHGLG00000008560	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSHGLG00100009751	UniProtKB/TrEMBL
Ensembl Transcript	ENSHGLT00000012081	ENTREZGENE
	ENSHGLT00000041552	UniProtKB/TrEMBL
	ENSHGLT00100013320	UniProtKB/TrEMBL
Gene3D-CATH	1.10.20.10	UniProtKB/TrEMBL
	1.10.840.10	UniProtKB/TrEMBL
	1.20.900.10	UniProtKB/TrEMBL
	2.30.29.30	UniProtKB/TrEMBL
	6.10.250.3060	UniProtKB/TrEMBL
	Son of sevenless (SoS) protein Chain: S domain 1	UniProtKB/TrEMBL
InterPro	DBL_dom_sf	UniProtKB/TrEMBL
	DH-domain	UniProtKB/TrEMBL
	Histone-fold	UniProtKB/TrEMBL
	PH-like_dom_sf	UniProtKB/TrEMBL
	PH_domain	UniProtKB/TrEMBL
	Ras-like_GEF	UniProtKB/TrEMBL
	Ras-like_Gua-exchang_fac_N	UniProtKB/TrEMBL
	Ras_G-nucl-exch_fac_CS	UniProtKB/TrEMBL
	Ras_GEF_dom_sf	UniProtKB/TrEMBL
	RASGEF_cat_dom	UniProtKB/TrEMBL
	RASGEF_cat_dom_sf	UniProtKB/TrEMBL
KEGG Report	hgl:101707893	UniProtKB/TrEMBL
NCBI Gene	Sos1	ENTREZGENE
PANTHER	PTHR23113	UniProtKB/TrEMBL
	SON OF SEVENLESS HOMOLOG 1	UniProtKB/TrEMBL
Pfam	PF00169	UniProtKB/TrEMBL
	RasGEF	UniProtKB/TrEMBL
	RasGEF_N	UniProtKB/TrEMBL
	RhoGEF	UniProtKB/TrEMBL
PROSITE	DH_2	UniProtKB/TrEMBL
	PH_DOMAIN	UniProtKB/TrEMBL
	RASGEF	UniProtKB/TrEMBL
	RASGEF_CAT	UniProtKB/TrEMBL
	RASGEF_NTER	UniProtKB/TrEMBL
SMART	RasGEF	UniProtKB/TrEMBL
	RasGEFN	UniProtKB/TrEMBL
	RhoGEF	UniProtKB/TrEMBL
	SM00233	UniProtKB/TrEMBL
Superfamily-SCOP	PH domain-like	UniProtKB/TrEMBL
	SSF47113	UniProtKB/TrEMBL
	SSF48065	UniProtKB/TrEMBL
	SSF48366	UniProtKB/TrEMBL
UniProt	G5CA65	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - PID (archival)