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ONTOLOGY REPORT - ANNOTATIONS

Term:telomere capping
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Accession:GO:0016233 term browser browse the term
Definition:A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins.
Synonyms:exact_synonym: telomere end protection


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telomere capping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acd ACD, shelterin complex subunit and telomerase recruitment factor involved_in ISO
IBA		 UniProtKB:Q9NUX5 (PMID:17632522), (PMID:21852327), (PMID:25172512)
GO_REF:0000033		 RGD
GO_Central		 PMID:17632522 PMID:21852327 PMID:25172512 GO_REF:0000033 NCBI chr19:33,586,739...33,589,481
Ensembl chr19:33,586,745...33,589,461 		JBrowse link
G Dclre1b DNA cross-link repair 1B involved_in ISO (PMID:20479256) RGD PMID:20479256 NCBI chr 2:191,309,909...191,318,399
Ensembl chr 2:191,309,913...191,318,423 		JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 involved_in IDA PMID:15659580 UniProt PMID:15659580 RGD:10680046 NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249 		JBrowse link
G Pot1 protection of telomeres 1 involved_in ISO
IBA		 UniProtKB:Q96AP0 (PMID:15657433), (PMID:17632522), (PMID:21852327), (PMID:27013236), (PMID:30586141), (PMID:35420632), (PMID:37140166)
GO_REF:0000033		 RGD
GO_Central		 PMID:15657433 PMID:17632522 PMID:21852327 PMID:27013236 PMID:30586141 More... GO_REF:0000033 NCBI chr 4:54,205,330...54,263,137
Ensembl chr 4:54,205,332...54,263,042 		JBrowse link
G Pot1b protection of telomeres 1B involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:9,670,355...9,728,624
Ensembl chr 9:9,670,362...9,728,532 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit involved_in ISO (PMID:18710952) RGD PMID:18710952 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Spdya speedy/RINGO cell cycle regulator family member A acts_upstream_of_or_within ISO MGI:5888863 (PMID:28031483) RGD PMID:28031483 NCBI chr 6:23,905,574...23,954,926
Ensembl chr 6:23,910,223...23,954,850 		JBrowse link
G Stn1 STN1 subunit of CST complex involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:246,391,311...246,429,844
Ensembl chr 1:246,395,613...246,429,531 		JBrowse link
G Terf1 telomeric repeat binding factor 1 involved_in ISO (PMID:21852327) RGD PMID:21852327 NCBI chr 5:3,443,103...3,472,377
Ensembl chr 5:3,443,106...3,472,340 		JBrowse link
G Terf2 telomeric repeat binding factor 2 involved_in ISO (PMID:12768206), (PMID:14690602), (PMID:15657433), (PMID:21852327) RGD PMID:12768206 PMID:14690602 PMID:15657433 PMID:21852327 NCBI chr19:34,976,963...35,005,813
Ensembl chr19:34,977,471...35,005,819 		JBrowse link
G Tinf2 TERF1 interacting nuclear factor 2 involved_in ISO
IBA		 (PMID:15133513), (PMID:18443218), (PMID:21852327)
GO_REF:0000033		 RGD
GO_Central		 PMID:15133513 PMID:18443218 PMID:21852327 GO_REF:0000033 NCBI chr15:29,170,663...29,178,015
Ensembl chr15:29,170,652...29,176,984 		JBrowse link
negative regulation of protection from non-homologous end joining at telomere term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit involved_in ISO (PMID:14690602) RGD PMID:14690602 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963 		JBrowse link
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit involved_in ISO (PMID:14690602) RGD PMID:14690602 NCBI chr10:2,416,259...2,448,364
Ensembl chr10:2,419,038...2,448,369 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 involved_in ISO (PMID:14690602) RGD PMID:14690602 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 involved_in ISO (PMID:14690602) RGD PMID:14690602 NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808 		JBrowse link
negative regulation of telomere capping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase involved_in ISO (PMID:17694070) RGD PMID:17694070 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Nbn nibrin involved_in IEA
ISO		 GO_REF:0000107
(PMID:17694070)		 Ensembl
RGD		 PMID:17694070 GO_REF:0000107 NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150 		JBrowse link
G Rad50 RAD50 double strand break repair protein involved_in ISO
IEA		 (PMID:17694070)
GO_REF:0000107		 RGD
Ensembl		 PMID:17694070 GO_REF:0000107 NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396 		JBrowse link
G Smg6 SMG6 nonsense mediated mRNA decay factor involved_in ISO (PMID:12676087) RGD PMID:12676087 NCBI chr10:59,786,258...60,014,395
Ensembl chr10:59,786,258...60,014,395 		JBrowse link
G Terf2 telomeric repeat binding factor 2 involved_in ISO (PMID:24270157) RGD PMID:24270157 NCBI chr19:34,976,963...35,005,813
Ensembl chr19:34,977,471...35,005,819 		JBrowse link
positive regulation of telomere capping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hnrnpd heterogeneous nuclear ribonucleoprotein D acts_upstream_of ISO (PMID:22633954) RGD PMID:22633954 NCBI chr14:9,615,375...9,638,975
Ensembl chr14:9,615,479...9,633,786 		JBrowse link
G Nabp2 nucleic acid binding protein 2 involved_in ISO
IEA		 (PMID:25589350)
GO_REF:0000107		 RGD
Ensembl		 PMID:25589350 GO_REF:0000107 NCBI chr 7:830,949...836,551
Ensembl chr 7:830,949...838,027 		JBrowse link
G Rtel1 regulator of telomere elongation helicase 1 involved_in ISO (PMID:23959892) RGD PMID:23959892 NCBI chr 3:168,427,247...168,465,349
Ensembl chr 3:168,419,579...168,465,348 		JBrowse link
G Tnks tankyrase involved_in IBA
ISO		 GO_REF:0000033
(PMID:25939383)		 GO_Central
RGD		 PMID:25939383 GO_REF:0000033 NCBI chr16:57,223,174...57,370,740
Ensembl chr16:57,225,094...57,366,260 		JBrowse link
G Tnks2 tankyrase 2 involved_in IBA
ISO		 GO_REF:0000033
(PMID:25939383)		 GO_Central
RGD		 PMID:25939383 GO_REF:0000033 NCBI chr 1:234,567,888...234,621,079
Ensembl chr 1:234,567,858...234,621,079 		JBrowse link
protection from non-homologous end joining at telomere term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acd ACD, shelterin complex subunit and telomerase recruitment factor involved_in IEA
ISO		 GO_REF:0000107
(PMID:18185984)		 Ensembl
RGD		 PMID:18185984 GO_REF:0000107 NCBI chr19:33,586,739...33,589,481
Ensembl chr19:33,586,745...33,589,461 		JBrowse link
G Dclre1b DNA cross-link repair 1B involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:20551906), (PMID:20619712)
GO_REF:0000024
(PMID:16730175), (PMID:20479256)		 Ensembl
RGD
UniProt		 PMID:16730175 PMID:20479256 PMID:20551906 PMID:20619712 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:191,309,909...191,318,399
Ensembl chr 2:191,309,913...191,318,423 		JBrowse link
G Nbn nibrin involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:28216226)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:28216226 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150 		JBrowse link
G Pot1b protection of telomeres 1B involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 9:9,670,355...9,728,624
Ensembl chr 9:9,670,362...9,728,532 		JBrowse link
G Terf2 telomeric repeat binding factor 2 involved_in
acts_upstream_of_or_within		 ISO
IBA		 ComplexPortal:CPX-1993 (PMID:14690602), (PMID:17499040), (PMID:24095731)
(PMID:20619712), (PMID:24120135)
MGI:3619525 (PMID:15968270)
GO_REF:0000033		 RGD
GO_Central		 PMID:14690602 PMID:15968270 PMID:17499040 PMID:20619712 PMID:24095731 More... GO_REF:0000033 NCBI chr19:34,976,963...35,005,813
Ensembl chr19:34,977,471...35,005,819 		JBrowse link
G Terf2ip TERF2 interacting protein NOT|involved_in ISS
ISO
IBA		 GO_REF:0000024
(PMID:20339076), (PMID:20622869)
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:20339076 PMID:20622869 GO_REF:0000024 GO_REF:0000033 NCBI chr19:39,976,965...39,984,055
Ensembl chr19:39,976,906...39,984,064 		JBrowse link
telomeric 3' overhang formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dclre1b DNA cross-link repair 1B involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:20551906), (PMID:20619712)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:20551906 PMID:20619712 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:191,309,909...191,318,399
Ensembl chr 2:191,309,913...191,318,423 		JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease involved_in ISO
IEA		 (PMID:16374507)
GO_REF:0000107		 RGD
Ensembl		 PMID:16374507 GO_REF:0000107 NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279 		JBrowse link
G Nbn nibrin involved_in ISO
IEA		 (PMID:16374507)
GO_REF:0000107		 RGD
Ensembl		 PMID:16374507 GO_REF:0000107 NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150 		JBrowse link
G Rad50 RAD50 double strand break repair protein involved_in ISO
IEA		 (PMID:16374507)
GO_REF:0000107		 RGD
Ensembl		 PMID:16374507 GO_REF:0000107 NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20069
    cellular process 19150
      metabolic process 11949
        macromolecule metabolic process 9808
          nucleic acid metabolic process 5183
            DNA metabolic process 967
              telomere maintenance 144
                telomere capping 26
                  negative regulation of telomere capping + 9
                  positive regulation of telomere capping 5
                  protection from non-homologous end joining at telomere + 10
                  regulation of telomere capping + 14
                  telomeric 3' overhang formation 4
Path 2
Term Annotations click to browse term
  biological_process 20069
    cellular process 19150
      metabolic process 11949
        primary metabolic process 10579
          nucleobase-containing compound metabolic process 5792
            nucleic acid metabolic process 5183
              DNA metabolic process 967
                telomere maintenance 144
                  telomere capping 26
                    negative regulation of telomere capping + 9
                    positive regulation of telomere capping 5
                    protection from non-homologous end joining at telomere + 10
                    regulation of telomere capping + 14
                    telomeric 3' overhang formation 4
paths to the root