Pot1b (protection of telomeres 1B) - Rat Genome Database

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Gene: Pot1b (protection of telomeres 1B) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Pot1b
Name: protection of telomeres 1B
RGD ID: 1582873
Description: Predicted to enable G-rich strand telomeric DNA binding activity and telomerase inhibitor activity. Predicted to be involved in regulation of telomere maintenance via telomerase and telomere capping. Predicted to be part of nuclear telomere cap complex. Human ortholog(s) of this gene implicated in colorectal cancer; familial melanoma; hepatocellular carcinoma; lung cancer; and ovarian cancer. Orthologous to human POT1 (protection of telomeres 1).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC690237; protection of telomeres protein 1-like; similar to Protection of telomeres 1 (hPot1) (POT1-like telomere end-binding protein)
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr899,997,508 - 10,055,752 (-)NCBIGRCr8
mRatBN7.299,670,355 - 9,728,624 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl99,670,362 - 9,728,532 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.097,845,697 - 7,902,270 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl97,845,845 - 7,891,514 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.096,885,142 - 6,941,700 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera95,445,558 - 5,502,756 (-)NCBICelera
Cytogenetic Map9q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Pot1b
407 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:70
Count of miRNA genes:65
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000072684
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9114209783Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)9795472022071169Rat
1578675Bss17Bone structure and strength QTL 173.8femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)9336865213533896Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_001073777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_002727151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008757909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039084415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039084416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039084417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039084418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039084419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039084421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039084422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039084426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010054687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000072684   ⟹   ENSRNOP00000064381
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl99,670,362 - 9,728,532 (-)Ensembl
Rnor_6.0 Ensembl97,845,845 - 7,891,514 (-)Ensembl
RefSeq Acc Id: XM_006244268   ⟹   XP_006244330
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr899,997,508 - 10,055,749 (-)NCBI
mRatBN7.299,670,355 - 9,728,622 (-)NCBI
Rnor_6.097,845,697 - 7,902,269 (-)NCBI
Rnor_5.096,885,142 - 6,941,700 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039084415   ⟹   XP_038940343
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr899,997,508 - 10,055,752 (-)NCBI
mRatBN7.299,670,355 - 9,728,623 (-)NCBI
RefSeq Acc Id: XM_039084416   ⟹   XP_038940344
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr899,997,508 - 10,055,667 (-)NCBI
mRatBN7.299,670,355 - 9,728,475 (-)NCBI
RefSeq Acc Id: XM_039084417   ⟹   XP_038940345
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr899,997,508 - 10,055,700 (-)NCBI
mRatBN7.299,670,355 - 9,728,248 (-)NCBI
RefSeq Acc Id: XM_039084418   ⟹   XP_038940346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr899,997,508 - 10,055,400 (-)NCBI
mRatBN7.299,670,355 - 9,728,248 (-)NCBI
RefSeq Acc Id: XM_039084419   ⟹   XP_038940347
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr899,997,508 - 10,055,629 (-)NCBI
mRatBN7.299,670,355 - 9,728,475 (-)NCBI
RefSeq Acc Id: XM_039084421   ⟹   XP_038940349
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr899,997,508 - 10,055,746 (-)NCBI
mRatBN7.299,670,355 - 9,728,612 (-)NCBI
RefSeq Acc Id: XM_039084422   ⟹   XP_038940350
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr899,997,508 - 10,055,629 (-)NCBI
mRatBN7.299,670,355 - 9,728,475 (-)NCBI
RefSeq Acc Id: XM_039084426   ⟹   XP_038940354
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr899,997,508 - 10,032,418 (-)NCBI
mRatBN7.299,670,355 - 9,705,265 (-)NCBI
RefSeq Acc Id: XM_063267863   ⟹   XP_063123933
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr899,997,508 - 10,043,324 (-)NCBI
RefSeq Acc Id: XM_063267864   ⟹   XP_063123934
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr899,997,508 - 10,043,324 (-)NCBI
RefSeq Acc Id: XM_063267865   ⟹   XP_063123935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr899,997,508 - 10,055,400 (-)NCBI
RefSeq Acc Id: XM_063267866   ⟹   XP_063123936
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr899,997,508 - 10,055,746 (-)NCBI
RefSeq Acc Id: XM_063267867   ⟹   XP_063123937
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr899,997,508 - 10,055,639 (-)NCBI
RefSeq Acc Id: XM_063267868   ⟹   XP_063123938
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr899,997,508 - 10,043,324 (-)NCBI
RefSeq Acc Id: XM_063267869   ⟹   XP_063123939
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr899,997,508 - 10,055,752 (-)NCBI
RefSeq Acc Id: XM_063267870   ⟹   XP_063123940
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr899,997,508 - 10,055,746 (-)NCBI
RefSeq Acc Id: XM_063267871   ⟹   XP_063123941
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr899,997,508 - 10,055,700 (-)NCBI
RefSeq Acc Id: XM_063267872   ⟹   XP_063123942
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8910,008,763 - 10,043,324 (-)NCBI
RefSeq Acc Id: XR_010054687
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8910,006,802 - 10,043,324 (-)NCBI
RefSeq Acc Id: XP_006244330   ⟸   XM_006244268
- Peptide Label: isoform X4
- UniProtKB: M0R4T5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064381   ⟸   ENSRNOT00000072684
RefSeq Acc Id: XP_038940343   ⟸   XM_039084415
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038940349   ⟸   XM_039084421
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038940347   ⟸   XM_039084419
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038940350   ⟸   XM_039084422
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038940344   ⟸   XM_039084416
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038940346   ⟸   XM_039084418
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038940345   ⟸   XM_039084417
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038940354   ⟸   XM_039084426
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063123939   ⟸   XM_063267869
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063123940   ⟸   XM_063267870
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063123936   ⟸   XM_063267866
- Peptide Label: isoform X4
- UniProtKB: M0R4T5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123941   ⟸   XM_063267871
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063123937   ⟸   XM_063267867
- Peptide Label: isoform X4
- UniProtKB: M0R4T5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123935   ⟸   XM_063267865
- Peptide Label: isoform X4
- UniProtKB: M0R4T5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123938   ⟸   XM_063267868
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063123934   ⟸   XM_063267864
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063123933   ⟸   XM_063267863
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063123942   ⟸   XM_063267872
- Peptide Label: isoform X8
Protein Domains
Telomeric single stranded DNA binding POT1/Cdc13

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R4T5-F1-model_v2 AlphaFold M0R4T5 1-639 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1582873 AgrOrtholog
BioCyc Gene G2FUF-28369 BioCyc
Ensembl Genes ENSRNOG00000047439 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072684.3 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.140 UniProtKB/TrEMBL
InterPro NA-bd_OB-fold UniProtKB/TrEMBL
  POT1 UniProtKB/TrEMBL
  POT1_C_insert UniProtKB/TrEMBL
  POT1PC UniProtKB/TrEMBL
  Telomer_end-bd UniProtKB/TrEMBL
KEGG Report rno:690237 UniProtKB/TrEMBL
NCBI Gene 690237 ENTREZGENE
PANTHER PROTECTION OF TELOMERES PROTEIN 1 UniProtKB/TrEMBL
  PTHR14513 UniProtKB/TrEMBL
Pfam POT1_C_insert UniProtKB/TrEMBL
  POT1PC UniProtKB/TrEMBL
  Telo_bind UniProtKB/TrEMBL
PhenoGen Pot1b PhenoGen
RatGTEx ENSRNOG00000047439 RatGTEx
SMART Telo_bind UniProtKB/TrEMBL
Superfamily-SCOP Nucleic_acid_OB UniProtKB/TrEMBL
UniProt M0R4T5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Pot1b  protection of telomeres 1B  LOC681796  similar to Protection of telomeres 1 (hPot1) (POT1-like telomere end-binding protein)  Data merged from RGD:1591610 1643240 APPROVED
2008-03-06 Pot1b  protection of telomeres 1B  LOC690237  similar to Protection of telomeres 1 (hPot1) (POT1-like telomere end-binding protein)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC681796  similar to Protection of telomeres 1 (hPot1) (POT1-like telomere end-binding protein)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC690237  similar to Protection of telomeres 1 (hPot1) (POT1-like telomere end-binding protein)      Symbol and Name status set to provisional 70820 PROVISIONAL