Rtel1 (regulator of telomere elongation helicase 1) - Rat Genome Database

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Gene: Rtel1 (regulator of telomere elongation helicase 1) Rattus norvegicus
Analyze
Symbol: Rtel1
Name: regulator of telomere elongation helicase 1
RGD ID: 1306721
Description: Predicted to enable ATP binding activity; DNA helicase activity; and DNA polymerase binding activity. Predicted to be involved in DNA duplex unwinding; DNA metabolic process; and regulation of DNA metabolic process. Predicted to be located in chromosome, telomeric region; nuclear membrane; and nuclear speck. Predicted to be active in nucleus. Biomarker of silicosis. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive dyskeratosis congenita 5; female breast cancer; gastric adenocarcinoma; high grade glioma (multiple); and lung disease (multiple). Orthologous to human RTEL1 (regulator of telomere elongation helicase 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: helicase-like protein NHL; LOC362288; RGD1306721; similar to helicase-like protein NHL isoform 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Bp286
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23168,427,247 - 168,465,349 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3168,419,579 - 168,465,348 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3172,810,949 - 172,845,752 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03181,770,049 - 181,804,855 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03178,431,399 - 178,466,278 (+)NCBIRnor_WKY
Rnor_6.03176,818,012 - 176,856,531 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3176,818,437 - 176,856,531 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03180,528,554 - 180,566,701 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43170,461,613 - 170,496,959 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13170,367,632 - 170,402,995 (+)NCBI
Celera3164,121,122 - 164,155,994 (-)NCBICelera
Cytogenetic Map3q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromosome, telomeric region  (ISO)
nuclear membrane  (IEA,ISO)
nuclear speck  (IEA,ISO)
nucleoplasm  (ISO)
nucleus  (IBA,IEA,ISO)
nucleus  (ISO)
nucleus  (ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. CCDC26, CDKN2BAS, RTEL1 and TERT Polymorphisms in pediatric brain tumor susceptibility. Adel Fahmideh M, etal., Carcinogenesis. 2015 Aug;36(8):876-82. doi: 10.1093/carcin/bgv074. Epub 2015 May 25.
2. Recurrent amplification of RTEL1 and ABCA13 and its synergistic effect associated with clinicopathological data of gastric adenocarcinoma. Ara├║jo TM, etal., Mol Cytogenet. 2016 Jun 29;9:52. doi: 10.1186/s13039-016-0260-x. eCollection 2016.
3. Inherited mutations in the helicase RTEL1 cause telomere dysfunction and Hoyeraal-Hreidarsson syndrome. Deng Z, etal., Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):E3408-16. doi: 10.1073/pnas.1300600110. Epub 2013 Aug 19.
4. Association between RTEL1 gene polymorphisms and COPD susceptibility in a Chinese Han population. Ding Y, etal., Int J Chron Obstruct Pulmon Dis. 2017 Mar 17;12:931-936. doi: 10.2147/COPD.S131246. eCollection 2017.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Familial breast cancer and DNA repair genes: Insights into known and novel susceptibility genes from the GENESIS study, and implications for multigene panel testing. Girard E, etal., Int J Cancer. 2019 Apr 15;144(8):1962-1974. doi: 10.1002/ijc.31921. Epub 2018 Nov 13.
7. Genetic variants in RTEL1 influencing telomere length are associated with prostate cancer risk. Gu CY, etal., J Cancer. 2019 Oct 15;10(24):6170-6174. doi: 10.7150/jca.35917. eCollection 2019.
8. The effect on melanoma risk of genes previously associated with telomere length. Iles MM, etal., J Natl Cancer Inst. 2014 Sep 17;106(10). pii: dju267. doi: 10.1093/jnci/dju267. Print 2014 Oct.
9. Genetic analysis of the relation of telomere length-related gene (RTEL1) and coronary heart disease risk. Lu S, etal., Mol Genet Genomic Med. 2019 Mar;7(3):e550. doi: 10.1002/mgg3.550. Epub 2019 Jan 8.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Association analysis of RTEL1 variants with risk of adult gliomas in a Korean population. Namgoong S, etal., PLoS One. 2018 Nov 21;13(11):e0207660. doi: 10.1371/journal.pone.0207660. eCollection 2018.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Silica inhalation altered telomere length and gene expression of telomere regulatory proteins in lung tissue of rats. Shoeb M, etal., Sci Rep. 2017 Dec 11;7(1):17284. doi: 10.1038/s41598-017-17645-y.
16. RTEL1 polymorphisms are associated with lung cancer risk in the Chinese Han population. Yan S, etal., Oncotarget. 2016 Oct 25;7(43):70475-70480. doi: 10.18632/oncotarget.12297.
Additional References at PubMed
PMID:12477932   PMID:15210109   PMID:18957201   PMID:22579284   PMID:23453664   PMID:23585563   PMID:24115439   PMID:25620558  


Genomics

Comparative Map Data
Rtel1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23168,427,247 - 168,465,349 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3168,419,579 - 168,465,348 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3172,810,949 - 172,845,752 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03181,770,049 - 181,804,855 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03178,431,399 - 178,466,278 (+)NCBIRnor_WKY
Rnor_6.03176,818,012 - 176,856,531 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3176,818,437 - 176,856,531 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03180,528,554 - 180,566,701 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43170,461,613 - 170,496,959 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13170,367,632 - 170,402,995 (+)NCBI
Celera3164,121,122 - 164,155,994 (-)NCBICelera
Cytogenetic Map3q43NCBI
RTEL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382063,657,810 - 63,696,253 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2063,657,810 - 63,696,253 (+)EnsemblGRCh38hg38GRCh38
GRCh372062,289,163 - 62,327,606 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362061,760,091 - 61,798,045 (+)NCBINCBI36Build 36hg18NCBI36
Build 342061,760,090 - 61,800,495NCBI
Celera2058,970,388 - 59,011,862 (+)NCBICelera
Cytogenetic Map20q13.33NCBI
HuRef2059,019,189 - 59,060,580 (+)NCBIHuRef
CHM1_12062,190,825 - 62,229,469 (+)NCBICHM1_1
T2T-CHM13v2.02065,471,931 - 65,516,559 (+)NCBIT2T-CHM13v2.0
Rtel1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392180,961,504 - 180,998,409 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2180,961,532 - 180,998,409 (+)EnsemblGRCm39 Ensembl
GRCm382181,319,711 - 181,356,616 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2181,319,739 - 181,356,616 (+)EnsemblGRCm38mm10GRCm38
MGSCv372181,054,429 - 181,091,321 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362181,249,192 - 181,286,023 (+)NCBIMGSCv36mm8
Celera2185,402,416 - 185,438,885 (+)NCBICelera
Cytogenetic Map2H4NCBI
Rtel1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955528532,385 - 572,398 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955528531,680 - 578,003 (-)NCBIChiLan1.0ChiLan1.0
RTEL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12061,580,222 - 61,619,172 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2061,581,331 - 61,618,718 (+)Ensemblpanpan1.1panPan2
RTEL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12447,219,977 - 47,248,791 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
ROS_Cfam_1.02448,358,971 - 48,387,747 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12447,203,889 - 47,232,649 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02447,328,761 - 47,357,499 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02448,066,842 - 48,095,619 (+)NCBIUU_Cfam_GSD_1.0
Rtel1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640195,467,576 - 195,500,840 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651410,922,322 - 10,954,402 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493651410,920,979 - 10,954,483 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RTEL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1762,611,909 - 62,634,690 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11762,611,844 - 62,636,628 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RTEL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12531,905 - 567,430 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2531,085 - 566,840 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605048,086,325 - 48,123,114 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rtel1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474129,304,427 - 29,343,842 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474129,303,844 - 29,344,123 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rtel1
123 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:130
Count of miRNA genes:104
Interacting mature miRNAs:112
Transcripts:ENSRNOT00000055030
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3161192952169034231Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 32 56 40 19 40 4 5 74 34 35 11 4
Low 11 1 1 1 4 6 1 6 4
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001191857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC095847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC117053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC086436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC161910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000055030   ⟹   ENSRNOP00000051909
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3168,430,452 - 168,465,348 (+)Ensembl
Rnor_6.0 Ensembl3176,821,652 - 176,856,531 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000087279   ⟹   ENSRNOP00000069471
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3168,430,449 - 168,465,348 (+)Ensembl
Rnor_6.0 Ensembl3176,818,437 - 176,856,530 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098539   ⟹   ENSRNOP00000094899
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3168,430,452 - 168,465,348 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098630   ⟹   ENSRNOP00000087672
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3168,419,579 - 168,465,348 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100640   ⟹   ENSRNOP00000088333
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3168,419,579 - 168,465,348 (+)Ensembl
RefSeq Acc Id: NM_001191857   ⟹   NP_001178786
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,430,452 - 168,465,348 (+)NCBI
Rnor_6.03176,821,652 - 176,856,531 (+)NCBI
Rnor_5.03180,528,554 - 180,566,701 (+)NCBI
Celera3164,121,122 - 164,155,994 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006235772   ⟹   XP_006235834
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,430,386 - 168,465,349 (+)NCBI
Rnor_6.03176,821,599 - 176,856,531 (+)NCBI
Rnor_5.03180,528,554 - 180,566,701 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006235773   ⟹   XP_006235835
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,427,247 - 168,465,349 (+)NCBI
Rnor_6.03176,818,012 - 176,856,531 (+)NCBI
Rnor_5.03180,528,554 - 180,566,701 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006235774   ⟹   XP_006235836
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,430,386 - 168,465,348 (+)NCBI
Rnor_6.03176,821,599 - 176,856,531 (+)NCBI
Rnor_5.03180,528,554 - 180,566,701 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006235775   ⟹   XP_006235837
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,430,386 - 168,465,349 (+)NCBI
Rnor_6.03176,821,599 - 176,856,531 (+)NCBI
Rnor_5.03180,528,554 - 180,566,701 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006235776   ⟹   XP_006235838
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,430,386 - 168,465,349 (+)NCBI
Rnor_6.03176,821,599 - 176,856,531 (+)NCBI
Rnor_5.03180,528,554 - 180,566,701 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006235778   ⟹   XP_006235840
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,442,020 - 168,465,349 (+)NCBI
Rnor_6.03176,833,240 - 176,856,531 (+)NCBI
Rnor_5.03180,528,554 - 180,566,701 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039105561   ⟹   XP_038961489
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,430,617 - 168,465,349 (+)NCBI
RefSeq Acc Id: XM_039105562   ⟹   XP_038961490
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,430,386 - 168,465,349 (+)NCBI
RefSeq Acc Id: XM_039105563   ⟹   XP_038961491
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,430,386 - 168,464,064 (+)NCBI
RefSeq Acc Id: XM_039105564   ⟹   XP_038961492
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,436,027 - 168,465,349 (+)NCBI
RefSeq Acc Id: XM_039105565   ⟹   XP_038961493
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,442,042 - 168,465,349 (+)NCBI
RefSeq Acc Id: XM_039105566   ⟹   XP_038961494
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,449,207 - 168,465,349 (+)NCBI
RefSeq Acc Id: XM_039105568   ⟹   XP_038961496
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23168,456,625 - 168,465,349 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001178786   ⟸   NM_001191857
- UniProtKB: Q5RJZ1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006235835   ⟸   XM_006235773
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JVG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235834   ⟸   XM_006235772
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JVG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235836   ⟸   XM_006235774
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006235837   ⟸   XM_006235775
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006235838   ⟸   XM_006235776
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006235840   ⟸   XM_006235778
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: ENSRNOP00000051909   ⟸   ENSRNOT00000055030
RefSeq Acc Id: ENSRNOP00000069471   ⟸   ENSRNOT00000087279
RefSeq Acc Id: XP_038961490   ⟸   XM_039105562
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038961491   ⟸   XM_039105563
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038961489   ⟸   XM_039105561
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038961492   ⟸   XM_039105564
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038961493   ⟸   XM_039105565
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038961494   ⟸   XM_039105566
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038961496   ⟸   XM_039105568
- Peptide Label: isoform X10
RefSeq Acc Id: ENSRNOP00000087672   ⟸   ENSRNOT00000098630
RefSeq Acc Id: ENSRNOP00000094899   ⟸   ENSRNOT00000098539
RefSeq Acc Id: ENSRNOP00000088333   ⟸   ENSRNOT00000100640
Protein Domains
Helicase ATP-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5RJZ1-F1-model_v2 AlphaFold Q5RJZ1 1-1274 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692752
Promoter ID:EPDNEW_R3277
Type:initiation region
Name:Rtel1_1
Description:regulator of telomere elongation helicase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03176,821,632 - 176,821,692EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306721 AgrOrtholog
BioCyc Gene G2FUF-46291 BioCyc
Ensembl Genes ENSRNOG00000027513 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000051909 ENTREZGENE
  ENSRNOP00000051909.3 UniProtKB/Swiss-Prot
  ENSRNOP00000069471 ENTREZGENE
  ENSRNOP00000069471.2 UniProtKB/TrEMBL
  ENSRNOP00000087672 ENTREZGENE
  ENSRNOP00000087672.1 UniProtKB/TrEMBL
  ENSRNOP00000088333 ENTREZGENE
  ENSRNOP00000088333.1 UniProtKB/TrEMBL
  ENSRNOP00000094899.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000055030 ENTREZGENE
  ENSRNOT00000055030.4 UniProtKB/Swiss-Prot
  ENSRNOT00000087279 ENTREZGENE
  ENSRNOT00000087279.2 UniProtKB/TrEMBL
  ENSRNOT00000098539.1 UniProtKB/TrEMBL
  ENSRNOT00000098630 ENTREZGENE
  ENSRNOT00000098630.1 UniProtKB/TrEMBL
  ENSRNOT00000100640 ENTREZGENE
  ENSRNOT00000100640.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1160.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7302407 IMAGE-MGC_LOAD
  IMAGE:8368052 IMAGE-MGC_LOAD
InterPro ATP-dep_Helicase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEAD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DinG/Rad3-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helic_SF1/SF2_ATP-bd_DinG/Rad3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase-like_DEXD_c2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rad3/Chl1-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RTEL1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:362288 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105962 IMAGE-MGC_LOAD
  MGC:187633 IMAGE-MGC_LOAD
NCBI Gene 362288 ENTREZGENE
PANTHER PTHR11472 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  REGULATOR OF TELOMERE ELONGATION HELICASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DEAD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase_C_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rtel1 PhenoGen
PROSITE HELICASE_ATP_BIND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DEXDc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HELICc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs rad3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JVG0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A605_RAT UniProtKB/TrEMBL
  A0A8I6A8F3_RAT UniProtKB/TrEMBL
  A0A8I6AMG5_RAT UniProtKB/TrEMBL
  B1WBW1_RAT UniProtKB/TrEMBL
  Q5RJZ1 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-10-20 Rtel1  regulator of telomere elongation helicase 1  RGD1306721  similar to helicase-like protein NHL isoform 2  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1306721  similar to helicase-like protein NHL isoform 2  RGD1306721_predicted  similar to helicase-like protein NHL isoform 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1306721_predicted  similar to helicase-like protein NHL isoform 2 (predicted)  LOC362288_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC362288_predicted  similar to helicase-like protein NHL isoform 2 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL