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Wallerian Degeneration - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Wallerian Degeneration
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Accession:DOID:9002498 term browser browse the term
Definition:Degeneration of distal aspects of a nerve axon following injury to the cell body or proximal portion of the axon. The process is characterized by fragmentation of the axon and its MYELIN SHEATH.
Synonyms:primary_id: MESH:D014855

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Wallerian Degeneration term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccar2 cell cycle and apoptosis regulator 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24252177 NCBI chr15:51,622,519...51,637,911
Ensembl chr15:45,212,803...45,227,636 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 IEP RGD PMID:9030624 RGD:68774 NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 IEP RGD PMID:9030624 RGD:68774 NCBI chr 7:1,579,079...1,600,379
Ensembl chr 7:996,225...1,015,525 		JBrowse link
G Fcgr2a Fc gamma receptor 2A IEP mRNA:increased expression:sciatic nerve, macrophage RGD PMID:1533683 RGD:2316290 NCBI chr13:85,813,516...85,830,269
Ensembl chr13:83,280,784...83,295,967 		JBrowse link
G Il18 interleukin 18 IEP mRNA, protein:increased expression:macrophage, microglia: RGD PMID:11494369 RGD:4889526 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Mag myelin-associated glycoprotein IEP RGD PMID:12730963 RGD:9685301 NCBI chr 1:95,275,728...95,291,133
Ensembl chr 1:86,148,228...86,163,656 		JBrowse link
G Nefh neurofilament heavy chain IEP protein:decreased expression:neuron RGD PMID:10646539 RGD:9698439 NCBI chr14:84,044,428...84,054,413
Ensembl chr14:79,830,362...79,840,351 		JBrowse link
G Nefl neurofilament light chain IEP protein:decreased expression:neuron RGD PMID:10646539 RGD:9698439 NCBI chr15:46,477,330...46,481,203
Ensembl chr15:42,301,916...42,305,793 		JBrowse link
G Nefm neurofilament medium chain IEP protein:decreased expression:neuron RGD PMID:10646539 RGD:9698439 NCBI chr15:46,535,857...46,541,161
Ensembl chr15:42,360,454...42,365,755 		JBrowse link
G Nf1 neurofibromin 1 IEP protein:increased expression:sciatic nerve: RGD PMID:8847098 RGD:12790590 NCBI chr10:64,803,986...65,037,086
Ensembl chr10:64,306,301...64,536,658 		JBrowse link
G Nmnat1 nicotinamide nucleotide adenylyltransferase 1 ISO CTD Direct Evidence: therapeutic CTD PMID:27822499 NCBI chr 5:165,193,301...165,211,213
Ensembl chr 5:159,910,242...159,928,180 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 IEP RGD PMID:10320723 RGD:1642322 NCBI chr16:27,804,416...27,814,070
Ensembl chr16:23,037,789...23,046,759 		JBrowse link
G Pgf placental growth factor ISO RGD PMID:21264946 RGD:6483582 NCBI chr 6:110,547,165...110,557,747
Ensembl chr 6:104,816,104...104,826,685 		JBrowse link
G Pla2g4a phospholipase A2 group 4A IEP
ISO		 RGD PMID:14664823 PMID:18718965 RGD:1642469, RGD:6482738 NCBI chr13:64,427,921...64,572,352
Ensembl chr13:61,877,813...62,022,266 		JBrowse link
G Pla2g6 phospholipase A2 group VI ISO RGD PMID:18718965 RGD:6482738 NCBI chr 7:112,731,803...112,771,978
Ensembl chr 7:110,851,378...110,891,114 		JBrowse link
G Rxra retinoid X receptor alpha IEP mRNA:increased expression:sciatic nerve RGD PMID:16782282 RGD:1643108 NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:10,989,832...11,073,712 		JBrowse link
G Sirt1 sirtuin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24252177 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Srsf3 serine and arginine rich splicing factor 3 IEP associated with Sciatic Neuropathy RGD PMID:8568916 RGD:10059662 NCBI chr20:7,093,529...7,103,517
Ensembl chr20:7,091,910...7,101,078 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 IEP mRNA:increased expression:optic (II) nerve, sciatic nerve RGD PMID:14997937 RGD:2302105 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 IEP protein:decreased expression:sciatic nerve RGD PMID:14997937 RGD:2302105 NCBI chr13:100,691,540...100,793,227
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 IEP mRNA, protein:increased expression:dorsal root ganglion RGD PMID:16683235 RGD:1600154 NCBI chr10:104,041,604...104,089,214
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 IEP mRNA, protein:increased expression:dorsal root ganglion RGD PMID:16683235 RGD:1600154 NCBI chr 7:19,408,539...19,459,558
Ensembl chr 7:17,521,919...17,571,839 		JBrowse link
G Tlr2 toll-like receptor 2 ISO RGD PMID:18003835 RGD:2312723 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr4 toll-like receptor 4 ISO RGD PMID:18003835 RGD:2312723 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Ube4b ubiquitination factor E4B ISO CTD Direct Evidence: therapeutic CTD PMID:27822499 NCBI chr 5:165,049,897...165,153,572
Ensembl chr 5:159,766,829...159,870,509 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19140
    Pathological Conditions, Signs and Symptoms 13626
      Pathologic Processes 8329
        Nerve Degeneration 136
          Wallerian Degeneration 25
            Wallerian Degeneration of the Pyramidal Tract 0
paths to the root