relapsing-remitting multiple sclerosis - Ontology Report - Rat Genome Database

Submit Data | Help | Video Tutorials | News | Publications | Download | REST API | Citing RGD | Contact

RGD DISEASE ONTOLOGY - ANNOTATIONS

{{ watchLinkText }}

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:	relapsing-remitting multiple sclerosis	go back to main search page
Accession:	DOID:2378	browse the term
Definition:	A multiple sclerosis that is characterized by relapse (attacks of symptom flare-ups) followed by remission (periods of recovery). Symptoms may vary from mild to severe, and relapses and remissions may last for days or months. More than 80 percent of people who have MS begin with relapsing-remitting cycles. (DO)
Synonyms:	exact_synonym:	Acute Relapsing Multiple Sclerosis; RRMS; Relapsing-remitting MS
	primary_id:	MESH:D020529
	xref:	EFO:0003929; NCI:C165675
For additional species annotation, visit the Alliance of Genome Resources.

show annotations for term's descendants Sort by:
Rat (23) Mouse (23) Human (30) Chinchilla (23) Bonobo (23) Dog (23) Squirrel (22) Pig (23) Green Monkey (22) Naked Mole-rat (23) All
Genes (23)

relapsing-remitting multiple sclerosis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

atypical chemokine receptor 3

CTD Direct Evidence: marker/mechanism

NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237

G

ADAM metallopeptidase with thrombospondin type 1 motif, 14

DNA:SNP:intron: C>T (human)

RGD

NCBI chr20:29,143,029...29,219,846
Ensembl chr20:29,144,354...29,219,866

G

apolipoprotein A4

onset

protein:decreased expression:cerebrospinal fluid (human)

RGD

NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469

G

apolipoprotein E

CTD Direct Evidence: marker/mechanism

PMID:15096402 PMID:34624384

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

CD36 molecule

RGD

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

Cd80 molecule

protein:increased expression:blood, B cell

RGD

NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030

G

chondroitin sulfate proteoglycan 4

RGD

NCBI chr 8:57,264,962...57,300,010
Ensembl chr 8:57,264,962...57,300,010

G

cathepsin S

mRNA, protein:increased expression:blood, leukocyte

RGD

NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483

G

Fas cell surface death receptor

susceptibility

DNA:polymorphism:intron:735T>C(human)

RGD

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

granulin precursor

disease_progression

protein:increased expression:cerebrospinal fluids

RGD

NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775

G

hepatitis A virus cellular receptor 1

RGD

NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698

G

heterogeneous nuclear ribonucleoprotein A1

ClinVar Annotator: match by term: Relapsing remitting multiple sclerosis

NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609

G

heat shock protein family A (Hsp70) member 8

protein: increased expression

RGD

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

kinesin light chain 1

susceptibility

DNA:SNP:intron:56836G>C (rs8702) (human)

RGD

NCBI chr 6:130,823,416...130,866,729
Ensembl chr 6:130,823,419...130,867,031

G

matrix metallopeptidase 19

mRNA:increased expression:mononuclear cell

RGD

NCBI chr 7:1,221,229...1,229,555
Ensembl chr 7:1,221,343...1,229,555

G

matrix metallopeptidase 9

treatment

RGD

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

neurofilament heavy chain

treatment

RGD

NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351

G

neurofilament light chain

associated with relapse;protein:increased expression:serum (human)
protein:increased expression:CSF (human)

RGD

PMID:30761586 PMID:33658322

RGD:127285025, RGD:127285027

NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793

G

nucleotide-binding oligomerization domain containing 2

disease_progression

DNA:SNPs: :rs3135499,rs2066842(human)

RGD

NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177

G

noggin

mRNA,protein:decreased expression:mononuclear cell"

RGD

NCBI chr10:74,128,712...74,130,339
Ensembl chr10:74,128,712...74,130,339

G

S100 calcium binding protein B

protein:increased expression:brain, cerebrospinal fluid

RGD

NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743

G

serpin family E member 1

disease_progression

protein:increased expression:plasma:

RGD

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

TIMP metallopeptidase inhibitor 1

treatment

RGD

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

Term paths to the root

Path 1
Term	Annotations
disease	18969
disease of anatomical entity	18249
nervous system disease	14090
central nervous system disease	12430
autoimmune disease of central nervous system	385
Demyelinating Autoimmune Diseases, CNS	378
multiple sclerosis	219
relapsing-remitting multiple sclerosis	23
Path 2
Term	Annotations
disease	18969
disease of anatomical entity	18249
Immune & Inflammatory Diseases	5574
immune system disease	4782
primary immunodeficiency disease	4152
autoimmune disease	2326
autoimmune disease of the nervous system	672
autoimmune disease of central nervous system	385
Demyelinating Autoimmune Diseases, CNS	378
multiple sclerosis	219
relapsing-remitting multiple sclerosis	23

paths to the root