RGD Reference Report - Serum neurofilaments increase at progressive multifocal leukoencephalopathy onset in natalizumab-treated multiple sclerosis patients. - Rat Genome Database

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Serum neurofilaments increase at progressive multifocal leukoencephalopathy onset in natalizumab-treated multiple sclerosis patients.

Authors: Dalla Costa, Gloria  Martinelli, Vittorio  Moiola, Lucia  Sangalli, Francesca  Colombo, Bruno  Finardi, Annamaria  Cinque, Paola  Kolb, Eva-Maria  Haghikia, Aiden  Gold, Ralf  Furlan, Roberto  Comi, Giancarlo 
Citation: Dalla Costa G, etal., Ann Neurol. 2019 Apr;85(4):606-610. doi: 10.1002/ana.25437. Epub 2019 Mar 5.
RGD ID: 127285025
Pubmed: PMID:30761586   (View Abstract at PubMed)
DOI: DOI:10.1002/ana.25437   (Journal Full-text)

This study analyzed serum neurofilament light chains (NfL) in 2 European cohorts of 312 multiple sclerosis (MS) patients to investigate whether NfL are biomarkers of progressive multifocal leukoencephalopathy (PML) during natalizumab treatment. The cohort comprised 25 PML, 136 natalizumab-treated, and 151 untreated MS patients. Patients subsequently developing PML had similar NfL to other natalizumab-treated MS patients. At PML onset, NfL were 10-fold higher than in the pre-PML condition and in natalizumab-treated or untreated MS patients, and NfL continued to increase until onset of immune reconstitution inflammatory syndrome. The results suggest that in natalizumab-treated patients, NfL may represent an early and accessible marker of PML. Ann Neurol 2019;85:606-610.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
progressive multifocal leukoencephalopathy  IEP 127285025associated with relapsing-remitting multiple sclerosis and protein:increased expression:serum (human)RGD 
progressive multifocal leukoencephalopathy  ISONEFL (Homo sapiens)127285025; 127285025associated with relapsing-remitting multiple sclerosis and protein:increased expression:serum (human)RGD 
relapsing-remitting multiple sclerosis  IEP 127285025associated with relapse and protein:increased expression:serum (human)RGD 
relapsing-remitting multiple sclerosis  ISONEFL (Homo sapiens)127285025; 127285025associated with relapse and protein:increased expression:serum (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Nefl  (neurofilament light chain)

Genes (Mus musculus)
Nefl  (neurofilament, light polypeptide)

Genes (Homo sapiens)
NEFL  (neurofilament light chain)


Additional Information