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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:flecainide
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Accession:CHEBI:75984 term browser browse the term
Definition:A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid with the primary amino group of piperidin-2-ylmethylamine. An antiarrhythmic agent used (in the form of its acetate salt) to prevent and treat tachyarrhythmia (abnormal fast rhythm of the heart).
Synonyms:exact_synonym: N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide
 related_synonym: CCRIS 313;   Flecaine;   Formula=C17H20F6N2O3;   InChI=1S/C17H20F6N2O3/c18-16(19,20)9-27-12-4-5-14(28-10-17(21,22)23)13(7-12)15(26)25-8-11-3-1-2-6-24-11/h4-5,7,11,24H,1-3,6,8-10H2,(H,25,26);   InChIKey=DJBNUMBKLMJRSA-UHFFFAOYSA-N;   N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide;   SMILES=FC(F)(F)COc1ccc(OCC(F)(F)F)c(c1)C(=O)NCC1CCCCN1;   flecainida;   flecainidum
 alt_id: CHEBI:5090
 xref: CAS:54143-55-4;   DrugBank:DB01195;   Drug_Central:1176;   HMDB:HMDB0015326;   KEGG:C07001;   KEGG:D07962;   LINCS:LSM-1297
 xref_mesh: MESH:D005424
 xref: PMID:21029131;   PMID:22526215;   PMID:22882363;   PMID:22913299;   PMID:22981658;   PMID:23067130;   PMID:23188129;   PMID:23202797;   PMID:23286974;   PMID:23329876;   PMID:23334259;   PMID:23410160;   PMID:23518212;   PMID:23558880;   PMID:23635804;   PMID:23647896;   PMID:23700986;   PMID:23714084;   PMID:23756405;   PMID:23954267;   PMID:24019076;   PMID:24084224;   Reaxys:500093;   Wikipedia:Flecainide
 cyclic_relationship: is_conjugate_base_of CHEBI:76033


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flecainide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 decreases expression ISO Flecainide results in decreased expression of AP1S1 mRNA CTD PMID:17175557 NCBI chr12:19,625,267...19,635,792
Ensembl chr12:19,625,332...19,756,713 		JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Flecainide results in increased expression of ASAH1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Flecainide results in increased expression of ASNS mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO Flecainide results in increased activity of CASP3 protein
Palmitic Acid promotes the reaction [Flecainide results in increased activity of CASP3 protein]		 CTD PMID:22700542 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions		 ISO Flecainide results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Flecainide results in increased activity of CASP7 protein]		 CTD PMID:22700542 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Depp1 DEPP autophagy regulator 1 increases expression ISO Flecainide results in increased expression of DEPP1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542 		JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Flecainide results in increased expression of FABP1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Fndc4 fibronectin type III domain containing 4 decreases expression
increases expression		 ISO Flecainide results in decreased expression of FNDC4 mRNA
Flecainide results in increased expression of FNDC4 mRNA		 CTD PMID:15342952 PMID:17175557 NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Flecainide results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Flecainide results in increased expression of GDPD3 mRNA CTD PMID:15342952 NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063 		JBrowse link
G Hcn4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 decreases activity ISO Flecainide results in decreased activity of HCN4 protein CTD PMID:19498275 NCBI chr 8:59,222,206...59,259,626
Ensembl chr 8:59,221,653...59,259,639 		JBrowse link
G Hpn hepsin increases expression ISO Flecainide results in increased expression of HPN mRNA CTD PMID:17175557 NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811 		JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Flecainide results in increased expression of INHBE mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 7:63,177,558...63,178,983
Ensembl chr 7:63,176,219...63,179,172 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity		 ISO Flecainide binds to and results in decreased activity of KCNH2 protein
Flecainide results in decreased activity of KCNH2 protein		 CTD PMID:15272206 PMID:24052561 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Lss lanosterol synthase increases expression ISO Flecainide results in increased expression of LSS mRNA CTD PMID:17175557 NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Flecainide results in increased expression of NR0B2 mRNA CTD PMID:17175557 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Flecainide results in increased expression of NUPR1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 1:181,213,292...181,215,327 JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 affects response to substance ISO SCN5A mutant form affects the susceptibility to Flecainide
SCN5A gene mutant form affects the susceptibility to Flecainide		 CTD PMID:12687841 PMID:17805561 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769 		JBrowse link
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N increases expression ISO Flecainide results in increased expression of SERPINA3 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 6:123,323,632...123,331,166
Ensembl chr 6:123,323,629...123,332,433 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Flecainide inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO Flecainide inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612 		JBrowse link
G Slc22a4 solute carrier family 22 member 4 multiple interactions ISO Flecainide inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium] CTD PMID:21641380 NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720 		JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression
increases expression		 ISO Flecainide results in decreased expression of SLC2A3 mRNA
Flecainide results in increased expression of SLC2A3 mRNA		 CTD PMID:15342952 PMID:17175557 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472 		JBrowse link
G Tagln transgelin decreases expression ISO Flecainide results in decreased expression of TAGLN mRNA CTD PMID:17175557 NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668 		JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Flecainide results in increased expression of WIPI1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19784
      application 19615
        pharmaceutical 19493
          drug 19493
            cardiovascular drug 8503
              anti-arrhythmia drug 1500
                flecainide 25
Path 2
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  CHEBI ontology 19812
    subatomic particle 19810
      composite particle 19810
        hadron 19810
          baryon 19810
            nucleon 19810
              atomic nucleus 19810
                atom 19810
                  main group element atom 19755
                    p-block element atom 19755
                      carbon group element atom 19698
                        carbon atom 19693
                          organic molecular entity 19693
                            organic group 18902
                              organic divalent group 18884
                                organodiyl group 18884
                                  carbonyl group 18850
                                    carbonyl compound 18850
                                      carboxylic acid 18564
                                        carboacyl group 17681
                                          univalent carboacyl group 17681
                                            carbamoyl group 17527
                                              carboxamide 17527
                                                monocarboxylic acid amide 15580
                                                  flecainide 25
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