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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:exemestane
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Accession:CHEBI:4953 term browser browse the term
Definition:A 17-oxo steroid that is androsta-1,4-diene-3,17-dione in which the hydrogens at position 6 are replaced by a double bond to a methylene group. A selective inhibitor of the aromatase (oestrogen synthase) system, it is used in the treatment of advanced breast cancer.
Synonyms:exact_synonym: 6-methylideneandrosta-1,4-diene-3,17-dione
 related_synonym: 6-methyleneandrosta-1,4-diene-3,17-dione;   Formula=C20H24O2;   InChI=1S/C20H24O2/c1-12-10-14-15-4-5-18(22)20(15,3)9-7-16(14)19(2)8-6-13(21)11-17(12)19/h6,8,11,14-16H,1,4-5,7,9-10H2,2-3H3/t14-,15-,16-,19+,20-/m0/s1;   InChIKey=BFYIZQONLCFLEV-DAELLWKTSA-N;   SMILES=[H][C@@]12CC(=C)C3=CC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)C(=O)CC[C@@]21[H];   exemestano;   exemestanum
 xref: CAS:107868-30-4;   DrugBank:DB00990;   Drug_Central:1122;   KEGG:C08162;   KEGG:D00963
 xref_mesh: MESH:C056516
 xref: PMID:10882163;   Reaxys:6609645;   Wikipedia:Exemestane



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exemestane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg4 ATP binding cassette subfamily G member 4 increases expression ISO exemestane results in increased expression of ABCG4 mRNA CTD PMID:17254854 NCBI chr 8:44,611,187...44,629,818
Ensembl chr 8:44,611,187...44,626,881
JBrowse link
G Adcyap1r1 ADCYAP receptor type I increases expression ISO exemestane results in increased expression of ADCYAP1R1 mRNA CTD PMID:17254854 NCBI chr 4:84,593,558...84,642,700
Ensembl chr 4:84,593,892...84,642,700
JBrowse link
G Ar androgen receptor multiple interactions
affects localization
ISO exemestane binds to and results in increased activity of AR protein
exemestane affects the localization of AR protein
CTD PMID:25752796 PMID:28478275 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Areg amphiregulin increases expression ISO exemestane results in increased expression of AREG mRNA CTD PMID:18677558 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
JBrowse link
G Cd83 CD83 molecule increases expression ISO exemestane results in increased expression of CD83 mRNA CTD PMID:17254854 NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO exemestane results in decreased activity of CYP19A1 protein CTD PMID:15837728 PMID:15909811 PMID:16034487 PMID:16054421 PMID:21341743 More... NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Dnaaf9 dynein axonemal assembly factor 9 increases expression ISO exemestane results in increased expression of DNAAF9 mRNA CTD PMID:17254854 NCBI chr 3:117,918,047...118,052,641
Ensembl chr 3:117,921,620...118,052,630
JBrowse link
G Ebf1 EBF transcription factor 1 increases expression ISO exemestane results in increased expression of EBF1 mRNA CTD PMID:17254854 NCBI chr10:29,095,858...29,489,142
Ensembl chr10:29,099,933...29,487,665
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [exemestane binds to and results in increased activity of ESR1 protein]; exemestane binds to and results in increased activity of ESR1 protein; Fulvestrant inhibits the reaction [exemestane binds to and results in increased activity of ESR1 protein] CTD PMID:18677558 PMID:25752796 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Gpc2 glypican 2 increases expression ISO exemestane results in increased expression of GPC2 mRNA CTD PMID:17254854 NCBI chr12:17,277,875...17,284,297
Ensembl chr12:17,277,875...17,284,208
JBrowse link
G Hoxd11 homeobox D11 increases expression ISO exemestane results in increased expression of HOXD11 mRNA CTD PMID:17254854 NCBI chr 3:59,584,840...59,587,257
Ensembl chr 3:59,585,039...59,586,783
JBrowse link
G Inpp5k inositol polyphosphate-5-phosphatase K increases expression ISO exemestane results in increased expression of INPP5K mRNA CTD PMID:17254854 NCBI chr10:60,474,262...60,495,813
Ensembl chr10:60,475,897...60,496,773
JBrowse link
G Ints4 integrator complex subunit 4 increases expression ISO exemestane results in increased expression of INTS4 mRNA CTD PMID:17254854 NCBI chr 1:151,790,062...151,853,827
Ensembl chr 1:151,786,553...151,853,827
JBrowse link
G Kif13b kinesin family member 13B increases expression ISO exemestane results in increased expression of KIF13B mRNA CTD PMID:17254854 NCBI chr15:38,908,318...39,062,849
Ensembl chr15:38,924,624...39,084,879
JBrowse link
G Klk7 kallikrein-related peptidase 7 increases expression ISO exemestane results in increased expression of KLK7 mRNA CTD PMID:17254854 NCBI chr 1:94,267,170...94,271,332
Ensembl chr 1:94,266,605...94,271,332
JBrowse link
G Metrn meteorin, glial cell differentiation regulator increases expression ISO exemestane results in increased expression of METRN mRNA CTD PMID:17254854 NCBI chr10:14,816,684...14,818,702
Ensembl chr10:14,816,572...14,818,701
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO exemestane results in decreased expression of MKI67 protein CTD PMID:16002280 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mybl2 MYB proto-oncogene like 2 increases expression ISO exemestane results in increased expression of MYBL2 mRNA CTD PMID:17254854 NCBI chr 3:151,705,254...151,733,714
Ensembl chr 3:151,705,288...151,733,708
JBrowse link
G Myo9b myosin IXb increases expression ISO exemestane results in increased expression of MYO9B mRNA CTD PMID:17254854 NCBI chr16:17,945,379...18,030,114
Ensembl chr16:17,945,448...18,030,126
JBrowse link
G Ostm1 osteoclastogenesis associated transmembrane protein 1 increases expression ISO exemestane results in increased expression of OSTM1 mRNA CTD PMID:17254854 NCBI chr20:46,071,657...46,187,049
Ensembl chr20:46,153,075...46,187,023
JBrowse link
G Pgr progesterone receptor decreases expression
increases expression
ISO exemestane results in decreased expression of PGR protein
exemestane results in increased expression of PGR mRNA
CTD PMID:15909811 PMID:16002280 PMID:18677558 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Plcg2 phospholipase C, gamma 2 increases expression ISO exemestane results in increased expression of PLCG2 mRNA CTD PMID:17254854 NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930
JBrowse link
G Rnf123 ring finger protein 123 increases expression ISO exemestane results in increased expression of RNF123 mRNA CTD PMID:17254854 NCBI chr 8:108,740,176...108,768,177
Ensembl chr 8:108,739,620...108,767,675
JBrowse link
G Rrp12 ribosomal RNA processing 12 homolog increases expression ISO exemestane results in increased expression of RRP12 mRNA CTD PMID:17254854 NCBI chr 1:240,672,378...240,706,499
Ensembl chr 1:240,672,382...240,706,018
JBrowse link
G Slc13a4 solute carrier family 13 member 4 increases expression ISO exemestane results in increased expression of SLC13A4 mRNA CTD PMID:17254854 NCBI chr 4:63,943,369...63,988,852
Ensembl chr 4:63,943,395...63,988,857
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO exemestane inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Smim43 small integral membrane protein 43 increases expression ISO exemestane results in increased expression of SMIM43 mRNA CTD PMID:17254854 NCBI chr 2:119,366,977...119,386,664
Ensembl chr 2:119,385,754...119,385,945
JBrowse link
G Tbc1d17 TBC1 domain family, member 17 increases expression ISO exemestane results in increased expression of TBC1D17 mRNA CTD PMID:17254854 NCBI chr 1:95,324,770...95,333,156
Ensembl chr 1:95,322,737...95,333,005
JBrowse link
G Tff1 trefoil factor 1 increases expression ISO exemestane results in increased expression of TFF1 mRNA CTD PMID:18677558 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
JBrowse link
G Tnfrsf14 TNF receptor superfamily member 14 increases expression ISO exemestane results in increased expression of TNFRSF14 mRNA CTD PMID:17254854 NCBI chr 5:165,486,069...165,494,421
Ensembl chr 5:165,484,262...165,493,703
JBrowse link
G Triobp TRIO and F-actin binding protein increases expression ISO exemestane results in increased expression of TRIOBP mRNA CTD PMID:17254854 NCBI chr 7:110,505,916...110,569,301
Ensembl chr 7:110,506,248...110,562,474
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20050
    role 20001
      biological role 20000
        xenobiotic 18623
          exemestane 31
Path 2
Term Annotations click to browse term
  CHEBI ontology 20050
    subatomic particle 20048
      composite particle 20048
        hadron 20048
          baryon 20048
            nucleon 20048
              atomic nucleus 20048
                atom 20048
                  main group element atom 19948
                    p-block element atom 19948
                      carbon group element atom 19872
                        carbon atom 19863
                          organic molecular entity 19863
                            organic group 18937
                              organic divalent group 18922
                                organodiyl group 18922
                                  carbonyl group 18872
                                    carbonyl compound 18872
                                      ketone 17097
                                        oxo steroid 10295
                                          3-oxo steroid 9895
                                            3-oxo-Delta(1) steroid 5159
                                              3-oxo-Delta(1),Delta(4)-steroid 5159
                                                exemestane 31
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