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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:exemestane
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Accession:CHEBI:4953 term browser browse the term
Definition:A 17-oxo steroid that is androsta-1,4-diene-3,17-dione in which the hydrogens at position 6 are replaced by a double bond to a methylene group. A selective inhibitor of the aromatase (oestrogen synthase) system, it is used in the treatment of advanced breast cancer.
Synonyms:exact_synonym: 6-methylideneandrosta-1,4-diene-3,17-dione
 related_synonym: 6-methyleneandrosta-1,4-diene-3,17-dione;   Formula=C20H24O2;   InChI=1S/C20H24O2/c1-12-10-14-15-4-5-18(22)20(15,3)9-7-16(14)19(2)8-6-13(21)11-17(12)19/h6,8,11,14-16H,1,4-5,7,9-10H2,2-3H3/t14-,15-,16-,19+,20-/m0/s1;   InChIKey=BFYIZQONLCFLEV-DAELLWKTSA-N;   SMILES=[H][C@@]12CC(=C)C3=CC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)C(=O)CC[C@@]21[H];   exemestano;   exemestanum
 xref: CAS:107868-30-4;   DrugBank:DB00990;   Drug_Central:1122;   KEGG:C08162;   KEGG:D00963
 xref_mesh: MESH:C056516
 xref: PMID:10882163;   Reaxys:6609645;   Wikipedia:Exemestane


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exemestane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg4 ATP binding cassette subfamily G member 4 increases expression ISO exemestane results in increased expression of ABCG4 mRNA CTD PMID:17254854 NCBI chr 8:48,604,915...48,626,219
Ensembl chr 8:48,606,403...48,619,592
JBrowse link
G Adcyap1r1 ADCYAP receptor type I increases expression ISO exemestane results in increased expression of ADCYAP1R1 mRNA CTD PMID:17254854 NCBI chr 4:85,662,809...85,711,696
Ensembl chr 4:85,662,892...85,711,696
JBrowse link
G Ar androgen receptor multiple interactions
affects localization
ISO exemestane binds to and results in increased activity of AR protein
exemestane affects the localization of AR protein
CTD PMID:25752796 PMID:28478275 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Areg amphiregulin increases expression ISO exemestane results in increased expression of AREG mRNA CTD PMID:18677558 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Cd83 CD83 molecule increases expression ISO exemestane results in increased expression of CD83 mRNA CTD PMID:17254854 NCBI chr17:24,416,651...24,435,790
Ensembl chr17:24,416,651...24,435,790
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO exemestane results in decreased activity of CYP19A1 protein CTD PMID:15837728 PMID:15909811 PMID:16034487 PMID:16054421 PMID:21341743 PMID:26141389 PMID:31953017 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Dnaaf9 dynein axonemal assembly factor 9 increases expression ISO exemestane results in increased expression of DNAAF9 mRNA CTD PMID:17254854 NCBI chr 3:123,243,873...123,376,458
Ensembl chr 3:123,245,481...123,376,455
JBrowse link
G Ebf1 EBF transcription factor 1 increases expression ISO exemestane results in increased expression of EBF1 mRNA CTD PMID:17254854 NCBI chr10:23,654,849...24,051,627
Ensembl chr10:23,661,013...24,050,209
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [exemestane binds to and results in increased activity of ESR1 protein]; exemestane binds to and results in increased activity of ESR1 protein; Fulvestrant inhibits the reaction [exemestane binds to and results in increased activity of ESR1 protein] CTD PMID:18677558 PMID:25752796 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Gpc2 glypican 2 increases expression ISO exemestane results in increased expression of GPC2 mRNA CTD PMID:17254854 NCBI chr12:19,593,041...19,599,374
Ensembl chr12:19,593,041...19,599,374
JBrowse link
G Hoxd11 homeobox D11 increases expression ISO exemestane results in increased expression of HOXD11 mRNA CTD PMID:17254854 NCBI chr 3:61,604,256...61,606,874
Ensembl chr 3:61,604,672...61,606,400
JBrowse link
G Inpp5k inositol polyphosphate-5-phosphatase K increases expression ISO exemestane results in increased expression of INPP5K mRNA CTD PMID:17254854 NCBI chr10:63,775,639...63,796,879
Ensembl chr10:63,776,378...63,795,899
JBrowse link
G Ints4 integrator complex subunit 4 increases expression ISO exemestane results in increased expression of INTS4 mRNA CTD PMID:17254854 NCBI chr 1:162,447,692...162,511,350
Ensembl chr 1:162,447,680...162,511,355
JBrowse link
G Kif13b kinesin family member 13B increases expression ISO exemestane results in increased expression of KIF13B mRNA CTD PMID:17254854 NCBI chr15:48,030,837...48,192,932
Ensembl chr15:48,030,973...48,189,951
JBrowse link
G Klk7 kallikrein-related peptidase 7 increases expression ISO exemestane results in increased expression of KLK7 mRNA CTD PMID:17254854 NCBI chr 1:99,749,991...99,754,723
Ensembl chr 1:99,749,936...99,754,435
JBrowse link
G Metrn meteorin, glial cell differentiation regulator increases expression ISO exemestane results in increased expression of METRN mRNA CTD PMID:17254854 NCBI chr10:15,164,439...15,166,457
Ensembl chr10:15,164,439...15,166,457
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO exemestane results in decreased expression of MKI67 protein CTD PMID:16002280 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mybl2 MYB proto-oncogene like 2 increases expression ISO exemestane results in increased expression of MYBL2 mRNA CTD PMID:17254854 NCBI chr 3:159,421,638...159,450,087
Ensembl chr 3:159,421,671...159,450,086
JBrowse link
G Myo9b myosin IXb increases expression ISO exemestane results in increased expression of MYO9B mRNA CTD PMID:17254854 NCBI chr16:19,669,373...19,754,065
Ensembl chr16:19,669,411...19,754,069
JBrowse link
G Ostm1 osteoclastogenesis associated transmembrane protein 1 increases expression ISO exemestane results in increased expression of OSTM1 mRNA CTD PMID:17254854 NCBI chr20:47,394,979...47,430,304
Ensembl chr20:47,395,014...47,430,284
JBrowse link
G Pgr progesterone receptor decreases expression
increases expression
ISO exemestane results in decreased expression of PGR protein
exemestane results in increased expression of PGR mRNA
CTD PMID:15909811 PMID:16002280 PMID:18677558 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Plcg2 phospholipase C, gamma 2 increases expression ISO exemestane results in increased expression of PLCG2 mRNA CTD PMID:17254854 NCBI chr19:50,039,410...50,173,543
Ensembl chr19:50,045,020...50,173,220
JBrowse link
G Rnf123 ring finger protein 123 increases expression ISO exemestane results in increased expression of RNF123 mRNA CTD PMID:17254854 NCBI chr 8:116,829,050...116,857,050
Ensembl chr 8:116,829,050...116,856,548
JBrowse link
G Rrp12 ribosomal RNA processing 12 homolog increases expression ISO exemestane results in increased expression of RRP12 mRNA CTD PMID:17254854 NCBI chr 1:261,106,768...261,140,416
Ensembl chr 1:261,106,760...261,140,389
JBrowse link
G Slc13a4 solute carrier family 13 member 4 increases expression ISO exemestane results in increased expression of SLC13A4 mRNA CTD PMID:17254854 NCBI chr 4:62,796,732...62,841,053
Ensembl chr 4:62,797,677...62,840,357
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO exemestane inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Smim43 small integral membrane protein 43 increases expression ISO exemestane results in increased expression of SMIM43 mRNA CTD PMID:17254854 NCBI chr 2:123,227,621...123,235,170 JBrowse link
G Tbc1d17 TBC1 domain family, member 17 increases expression ISO exemestane results in increased expression of TBC1D17 mRNA CTD PMID:17254854 NCBI chr 1:100,836,993...100,845,216
Ensembl chr 1:100,836,990...100,845,392
JBrowse link
G Tff1 trefoil factor 1 increases expression ISO exemestane results in increased expression of TFF1 mRNA CTD PMID:18677558 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
G Tnfrsf14 TNF receptor superfamily member 14 increases expression ISO exemestane results in increased expression of TNFRSF14 mRNA CTD PMID:17254854 NCBI chr 5:172,328,259...172,337,221
Ensembl chr 5:172,328,262...172,335,892
JBrowse link
G Triobp TRIO and F-actin binding protein increases expression ISO exemestane results in increased expression of TRIOBP mRNA CTD PMID:17254854 NCBI chr 7:120,173,892...120,237,145
Ensembl chr 7:120,176,530...120,230,420
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      biological role 19716
        xenobiotic 18392
          exemestane 31
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic group 18599
                              organic divalent group 18590
                                organodiyl group 18590
                                  carbonyl group 18505
                                    carbonyl compound 18505
                                      ketone 16829
                                        oxo steroid 9722
                                          3-oxo steroid 9283
                                            3-oxo-Delta(1) steroid 5140
                                              3-oxo-Delta(1),Delta(4)-steroid 5140
                                                exemestane 31
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