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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:exemestane
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Accession:CHEBI:4953 term browser browse the term
Definition:A 17-oxo steroid that is androsta-1,4-diene-3,17-dione in which the hydrogens at position 6 are replaced by a double bond to a methylene group. A selective inhibitor of the aromatase (oestrogen synthase) system, it is used in the treatment of advanced breast cancer.
Synonyms:exact_synonym: 6-methylideneandrosta-1,4-diene-3,17-dione
 related_synonym: 6-methyleneandrosta-1,4-diene-3,17-dione;   Formula=C20H24O2;   InChI=1S/C20H24O2/c1-12-10-14-15-4-5-18(22)20(15,3)9-7-16(14)19(2)8-6-13(21)11-17(12)19/h6,8,11,14-16H,1,4-5,7,9-10H2,2-3H3/t14-,15-,16-,19+,20-/m0/s1;   InChIKey=BFYIZQONLCFLEV-DAELLWKTSA-N;   SMILES=[H][C@@]12CC(=C)C3=CC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)C(=O)CC[C@@]21[H];   exemestano;   exemestanum
 xref: CAS:107868-30-4;   DrugBank:DB00990;   Drug_Central:1122;   KEGG:C08162;   KEGG:D00963
 xref_mesh: MESH:C056516
 xref: PMID:10882163;   Reaxys:6609645;   Wikipedia:Exemestane


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exemestane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg4 ATP binding cassette subfamily G member 4 increases expression ISO exemestane results in increased expression of ABCG4 mRNA CTD PMID:17254854 NCBI chr 8:44,611,187...44,629,818
Ensembl chr 8:44,611,187...44,626,881 		JBrowse link
G Adcyap1r1 ADCYAP receptor type I increases expression ISO exemestane results in increased expression of ADCYAP1R1 mRNA CTD PMID:17254854 NCBI chr 4:84,593,558...84,642,700
Ensembl chr 4:84,593,892...84,642,700 		JBrowse link
G Ar androgen receptor multiple interactions
affects localization		 ISO exemestane binds to and results in increased activity of AR protein
exemestane affects the localization of AR protein		 CTD PMID:25752796 PMID:28478275 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Areg amphiregulin increases expression ISO exemestane results in increased expression of AREG mRNA CTD PMID:18677558 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535 		JBrowse link
G Cd83 CD83 molecule increases expression ISO exemestane results in increased expression of CD83 mRNA CTD PMID:17254854 NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO exemestane results in decreased activity of CYP19A1 protein CTD PMID:15837728 PMID:15909811 PMID:16034487 PMID:16054421 PMID:21341743 More... NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Dab2 DAB adaptor protein 2 increases expression ISO exemestane results in increased expression of DAB2 mRNA CTD PMID:17254854 NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476 		JBrowse link
G Dnaaf9 dynein axonemal assembly factor 9 increases expression ISO exemestane results in increased expression of DNAAF9 mRNA CTD PMID:17254854 NCBI chr 3:117,918,047...118,052,641
Ensembl chr 3:117,921,620...118,052,630 		JBrowse link
G Ebf1 EBF transcription factor 1 increases expression ISO exemestane results in increased expression of EBF1 mRNA CTD PMID:17254854 NCBI chr10:29,095,858...29,489,142
Ensembl chr10:29,099,933...29,487,665 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [exemestane binds to and results in increased activity of ESR1 protein]; exemestane binds to and results in increased activity of ESR1 protein; Fulvestrant inhibits the reaction [exemestane binds to and results in increased activity of ESR1 protein] CTD PMID:18677558 PMID:25752796 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Gpc2 glypican 2 increases expression ISO exemestane results in increased expression of GPC2 mRNA CTD PMID:17254854 NCBI chr12:17,277,875...17,284,297
Ensembl chr12:17,277,875...17,284,208 		JBrowse link
G Hoxd11 homeobox D11 increases expression ISO exemestane results in increased expression of HOXD11 mRNA CTD PMID:17254854 NCBI chr 3:59,584,840...59,587,257
Ensembl chr 3:59,585,039...59,586,783 		JBrowse link
G Inpp5k inositol polyphosphate-5-phosphatase K increases expression ISO exemestane results in increased expression of INPP5K mRNA CTD PMID:17254854 NCBI chr10:60,474,262...60,495,813
Ensembl chr10:60,475,897...60,496,773 		JBrowse link
G Ints4 integrator complex subunit 4 increases expression ISO exemestane results in increased expression of INTS4 mRNA CTD PMID:17254854 NCBI chr 1:151,790,062...151,853,827
Ensembl chr 1:151,786,553...151,853,827 		JBrowse link
G Kif13b kinesin family member 13B increases expression ISO exemestane results in increased expression of KIF13B mRNA CTD PMID:17254854 NCBI chr15:38,908,318...39,062,849
Ensembl chr15:38,924,624...39,084,879 		JBrowse link
G Klk7 kallikrein-related peptidase 7 increases expression ISO exemestane results in increased expression of KLK7 mRNA CTD PMID:17254854 NCBI chr 1:94,267,170...94,271,332
Ensembl chr 1:94,266,605...94,271,332 		JBrowse link
G Metrn meteorin, glial cell differentiation regulator increases expression ISO exemestane results in increased expression of METRN mRNA CTD PMID:17254854 NCBI chr10:14,816,684...14,818,702
Ensembl chr10:14,816,572...14,818,701 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO exemestane results in decreased expression of MKI67 protein CTD PMID:16002280 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mybl2 MYB proto-oncogene like 2 increases expression ISO exemestane results in increased expression of MYBL2 mRNA CTD PMID:17254854 NCBI chr 3:151,705,254...151,733,714
Ensembl chr 3:151,705,288...151,733,708 		JBrowse link
G Myo9b myosin IXb increases expression ISO exemestane results in increased expression of MYO9B mRNA CTD PMID:17254854 NCBI chr16:17,945,379...18,030,114
Ensembl chr16:17,945,448...18,030,126 		JBrowse link
G Ostm1 osteoclastogenesis associated transmembrane protein 1 increases expression ISO exemestane results in increased expression of OSTM1 mRNA CTD PMID:17254854 NCBI chr20:46,071,657...46,187,049
Ensembl chr20:46,153,075...46,187,023 		JBrowse link
G Pgr progesterone receptor decreases expression
increases expression		 ISO exemestane results in decreased expression of PGR protein
exemestane results in increased expression of PGR mRNA		 CTD PMID:15909811 PMID:16002280 PMID:18677558 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Plcg2 phospholipase C, gamma 2 increases expression ISO exemestane results in increased expression of PLCG2 mRNA CTD PMID:17254854 NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930 		JBrowse link
G Rnf123 ring finger protein 123 increases expression ISO exemestane results in increased expression of RNF123 mRNA CTD PMID:17254854 NCBI chr 8:108,740,176...108,768,177
Ensembl chr 8:108,739,620...108,767,675 		JBrowse link
G Rrp12 ribosomal RNA processing 12 increases expression ISO exemestane results in increased expression of RRP12 mRNA CTD PMID:17254854 NCBI chr 1:240,672,378...240,706,499
Ensembl chr 1:240,672,382...240,706,018 		JBrowse link
G Slc13a4 solute carrier family 13 member 4 increases expression ISO exemestane results in increased expression of SLC13A4 mRNA CTD PMID:17254854 NCBI chr 4:63,943,369...63,988,852
Ensembl chr 4:63,943,395...63,988,857 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO exemestane inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Smim43 small integral membrane protein 43 increases expression ISO exemestane results in increased expression of SMIM43 mRNA CTD PMID:17254854 NCBI chr 2:119,366,977...119,386,664
Ensembl chr 2:119,385,754...119,385,945 		JBrowse link
G Tbc1d17 TBC1 domain family, member 17 increases expression ISO exemestane results in increased expression of TBC1D17 mRNA CTD PMID:17254854 NCBI chr 1:95,324,770...95,333,156
Ensembl chr 1:95,322,737...95,333,005 		JBrowse link
G Tff1 trefoil factor 1 increases expression ISO exemestane results in increased expression of TFF1 mRNA CTD PMID:18677558 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Tnfrsf14 TNF receptor superfamily member 14 increases expression ISO exemestane results in increased expression of TNFRSF14 mRNA CTD PMID:17254854 NCBI chr 5:165,486,069...165,494,421
Ensembl chr 5:165,484,262...165,493,703 		JBrowse link
G Triobp TRIO and F-actin binding protein increases expression ISO exemestane results in increased expression of TRIOBP mRNA CTD PMID:17254854 NCBI chr 7:110,505,916...110,569,301
Ensembl chr 7:110,506,248...110,562,474 		JBrowse link
G Xist X inactive specific transcript increases expression ISO exemestane results in increased expression of XIST mRNA CTD PMID:17254854 NCBI chr  X:68,474,987...68,492,500 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      biological role 19788
        xenobiotic 18687
          exemestane 33
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            organic group 18905
                              organic divalent group 18887
                                organodiyl group 18887
                                  carbonyl group 18853
                                    carbonyl compound 18853
                                      ketone 17140
                                        oxo steroid 10326
                                          3-oxo steroid 9926
                                            3-oxo-Delta(1) steroid 5204
                                              3-oxo-Delta(1),Delta(4)-steroid 5204
                                                exemestane 33
paths to the root