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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:9-Methoxycamptothecin
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Accession:CHEBI:228847 term browser browse the term
Synonyms:exact_synonym: (19S)-19-ethyl-19-hydroxy-8-methoxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione
 related_synonym: Formula=C21H18N2O5;   InChI=1S/C21H18N2O5/c1-3-21(26)14-8-16-18-11(7-12-15(22-18)5-4-6-17(12)27-2)9-23(16)19(24)13(14)10-28-20(21)25/h4-8,26H,3,9-10H2,1-2H3/t21-/m0/s1;   InChIKey=XVMZDZFTCKLZTF-NRFANRHFSA-N;   SMILES=O1CC2=C([C@@](O)(CC)C1=O)C=C3N(CC=4C3=NC5=C(C4)C(OC)=CC=C5)C2=O
 xref: Chemspider:110207
 xref_mesh: MESH:C025724


show annotations for term's descendants           Sort by:
9-Methoxycamptothecin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death increases expression ISO 9-methoxycamptothecin results in increased expression of BAD mRNA CTD PMID:23369935 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO 9-methoxycamptothecin results in increased expression of BAX mRNA CTD PMID:23369935 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression ISO 9-methoxycamptothecin results in increased expression of BCL2 mRNA CTD PMID:23369935 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO 9-methoxycamptothecin results in increased expression of BCL2L1 mRNA CTD PMID:23369935 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Casp3 caspase 3 increases activity ISO 9-methoxycamptothecin results in increased activity of CASP3 protein CTD PMID:23369935 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity ISO 9-methoxycamptothecin results in increased activity of CASP8 protein CTD PMID:23369935 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity ISO 9-methoxycamptothecin results in increased activity of CASP9 protein CTD PMID:23369935 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccnb1 cyclin B1 increases expression ISO 9-methoxycamptothecin results in increased expression of CCNB1 mRNA CTD PMID:23369935 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccne1 cyclin E1 increases expression ISO 9-methoxycamptothecin results in increased expression of CCNE1 mRNA CTD PMID:23369935 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO 9-methoxycamptothecin results in increased expression of CDKN1A mRNA CTD PMID:23369935 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO 9-methoxycamptothecin results in increased expression of CDKN1B mRNA; 9-methoxycamptothecin results in increased expression of CDKN1B protein CTD PMID:23369935 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO 9-methoxycamptothecin results in increased expression of FAS mRNA; 9-methoxycamptothecin results in increased expression of FAS protein CTD PMID:23369935 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand increases expression ISO 9-methoxycamptothecin results in increased expression of FASLG mRNA CTD PMID:23369935 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO 9-methoxycamptothecin results in increased expression of FOS mRNA CTD PMID:23369935 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO 9-methoxycamptothecin results in increased expression of JUN mRNA CTD PMID:23369935 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression ISO 9-methoxycamptothecin results in increased expression of JUNB mRNA CTD PMID:23369935 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO 9-methoxycamptothecin results in increased expression of PTGS2 mRNA CTD PMID:23369935 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO 9-methoxycamptothecin results in increased expression of TNF mRNA; 9-methoxycamptothecin results in increased expression of TNF protein CTD PMID:23369935 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO 9-methoxycamptothecin results in increased expression of TP53 mRNA; 9-methoxycamptothecin results in increased expression of TP53 protein CTD PMID:23369935 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19832
    chemical entity 19830
      atom 19830
        nonmetal atom 19768
          nitrogen atom 18958
            nitrogen molecular entity 18958
              organonitrogen compound 18807
                organonitrogen heterocyclic compound 18150
                  pyranoindolizinoquinoline 3253
                    9-Methoxycamptothecin 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 19832
    subatomic particle 19830
      composite particle 19830
        hadron 19830
          baryon 19830
            nucleon 19830
              atomic nucleus 19830
                atom 19830
                  main group element atom 19780
                    p-block element atom 19780
                      carbon group element atom 19729
                        carbon atom 19725
                          organic molecular entity 19725
                            organic molecule 19678
                              organic cyclic compound 19491
                                organic heterocyclic compound 18854
                                  organic heteropolycyclic compound 18298
                                    organic heteropentacyclic compound 13511
                                      pyranoindolizinoquinoline 3253
                                        9-Methoxycamptothecin 19
paths to the root