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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2-furoic acid
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Accession:CHEBI:30845 term browser browse the term
Definition:A furoic acid having the carboxylic acid group located at position 2.
Synonyms:exact_synonym: furan-2-carboxylic acid
 related_synonym: 2-Furancarboxylic acid;   2-carboxyfuran;   2-furanoic acid;   Formula=C5H4O3;   Furan-2-carbonsaeure;   InChI=1S/C5H4O3/c6-5(7)4-2-1-3-8-4/h1-3H,(H,6,7);   InChIKey=SMNDYUVBFMFKNZ-UHFFFAOYSA-N;   Pyromucic acid;   SMILES=OC(=O)C1=CC=CO1;   acide 2-furoique;   acido 2-furoico;   alpha-furancarboxylic acid;   alpha-furoic acid
 alt_id: CHEBI:1101;   CHEBI:19583;   CHEBI:42470
 xref: Beilstein:110149;   CAS:88-14-2;   Chemspider:10251740;   FooDB:FDB000951;   Gmelin:3056;   HMDB:HMDB0000617;   KEGG:C01546;   KNApSAcK:C00000151;   PDBeChem:FOA;   PMID:12587683;   PMID:16306695;   PMID:18492059;   PMID:19938546;   PMID:20393580;   PMID:22031465;   PMID:23421908;   PMID:26378464;   PMID:29097752;   Reaxys:110149;   Wikipedia:2-Furoic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:16739


show annotations for term's descendants           Sort by:
5-(tetradecyloxy)-2-furoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO 5-(tetradecyloxy)-2-furancarboxylic acid inhibits the reaction [Palmitates results in decreased expression of SLC2A4 mRNA] CTD PMID:21802492 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
mometasone furoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO Mometasone Furoate inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; Mometasone Furoate inhibits the reaction [ABCB1 protein results in increased export of fluorexon] CTD PMID:16442095 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases activity		 ISO Mometasone Furoate inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]
Mometasone Furoate results in increased activity of ABCG2 protein		 CTD PMID:16442095 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Mometasone Furoate inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein] CTD PMID:10460758 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Mometasone Furoate results in decreased activity of CYP2C8 protein CTD PMID:15601807
G F3 coagulation factor III, tissue factor increases expression ISO Mometasone Furoate results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO Mometasone Furoate results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Il10 interleukin 10 decreases secretion ISO Mometasone Furoate results in decreased secretion of IL10 protein CTD PMID:9819297 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO Mometasone Furoate inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of IL12B protein] CTD PMID:19422381 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Mometasone Furoate inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein] CTD PMID:10460758 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects binding EXP
ISO		 Mometasone Furoate binds to NR3C1 protein CTD PMID:16507850 PMID:19422381 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 affects binding ISO Mometasone Furoate binds to NR3C2 protein CTD PMID:19422381 NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885 		JBrowse link
G Pgr progesterone receptor multiple interactions
affects binding		 ISO Mometasone Furoate binds to and results in increased activity of PGR protein
Mometasone Furoate binds to PGR protein		 CTD PMID:15189034 PMID:19422381 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO Mometasone Furoate results in increased expression of SPP1 protein CTD PMID:21885873 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Tat tyrosine aminotransferase increases activity ISO Mometasone Furoate results in increased activity of TAT protein CTD PMID:19422381 NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031 		JBrowse link
G Tgm2 transglutaminase 2 increases expression ISO Mometasone Furoate results in increased expression of TGM2 protein CTD PMID:21885873 NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases secretion		 ISO Mometasone Furoate inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
Mometasone Furoate results in decreased secretion of TNF protein		 CTD PMID:9819297 PMID:10100995 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Mometasone Furoate inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:10100995 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      biological role 19815
        inhibitor 18907
          2-furoic acid 18
            2-Phenylethyl 2-furancarboxylate 0
            2-Propenyl 2-furancarboxylate 0
            2-furancarboxylic acid (2-acetyl-1-benzothiophen-3-yl) ester 0
            2-furoate ester + 17
            2-furoyl-CoA + 0
            4-acetyl-3,5-dimethyl-1H-pyrrole-2-carboxylic acid (5-methoxycarbonyl-2-furanyl)methyl ester 0
            5-(tetradecyloxy)-2-furoic acid 1
            5-Bromopyridin-3-yl furan-2-carboxylate 0
            5-Chloro-3-pyridinyl 2-furoate 0
            5-Chloropyridin-3-yl 5-(4-chlorophenyl)furan-2-carboxylate 0
            5-[[(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)thio]methyl]-2-furancarboxylic acid methyl ester 0
            5-[[[(5-tert-butyl-2-methyl-3-furanyl)-oxomethyl]amino]methyl]-2-furancarboxylic acid ethyl ester 0
            5-bromo-2-furancarboxylic acid [2-[1-(2-methoxyethyl)-2,5-dimethyl-3-pyrrolyl]-2-oxoethyl] ester 0
            5-nitro-2-furancarboxylic acid (5-phenyl-1,3,4-oxadiazol-2-yl)methyl ester 0
            Amyl 2-furoate 0
            Asperfuran A 0
            Dimethyl 3,4-dihydroxyfuran-2,5-dicarboxylate 0
            Epoxydine B 0
            Ethyl 2-phenyl-3-furancarboxylate 0
            Ethyl 3-furoate 0
            Ethyl furoate 0
            GNF5343 0
            HS071 0
            Hexyl 2-furoate 0
            Isoamyl 2-furoate 0
            LSM-26546 0
            Methyl 2-Furancarboxylate 0
            Methyl 5-nitro-2-furoate 0
            N-(2-furoyl)glycine 0
            N-2-furoyl-L-leucine 0
            Octyl 2-furoate 0
            Propyl 2-furoate 0
            Robillafuran 0
            [(1R)-1-\{[N-(furan-2-ylcarbonyl)-L-leucyl]amino\}-2-(1H-indol-3-yl)ethyl]phosphonic acid 0
            methyl 5-(hydroxymethyl) furan-2-carboxylate 0
            methyl 5-\{[2-(ethoxycarbonyl)-3-oxohex-1-enyl]amino\}-2-furoate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            heteroorganic entity 19492
                              organochalcogen compound 19255
                                organooxygen compound 19172
                                  carbon oxoacid 18641
                                    carboxylic acid 18638
                                      monocarboxylic acid 18008
                                        furoic acid 18
                                          2-furoic acid 18
                                            2-Phenylethyl 2-furancarboxylate 0
                                            2-Propenyl 2-furancarboxylate 0
                                            2-furancarboxylic acid (2-acetyl-1-benzothiophen-3-yl) ester 0
                                            2-furoate ester + 17
                                            2-furoyl-CoA + 0
                                            4-acetyl-3,5-dimethyl-1H-pyrrole-2-carboxylic acid (5-methoxycarbonyl-2-furanyl)methyl ester 0
                                            5-(tetradecyloxy)-2-furoic acid 1
                                            5-Bromopyridin-3-yl furan-2-carboxylate 0
                                            5-Chloro-3-pyridinyl 2-furoate 0
                                            5-Chloropyridin-3-yl 5-(4-chlorophenyl)furan-2-carboxylate 0
                                            5-[[(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)thio]methyl]-2-furancarboxylic acid methyl ester 0
                                            5-[[[(5-tert-butyl-2-methyl-3-furanyl)-oxomethyl]amino]methyl]-2-furancarboxylic acid ethyl ester 0
                                            5-bromo-2-furancarboxylic acid [2-[1-(2-methoxyethyl)-2,5-dimethyl-3-pyrrolyl]-2-oxoethyl] ester 0
                                            5-nitro-2-furancarboxylic acid (5-phenyl-1,3,4-oxadiazol-2-yl)methyl ester 0
                                            Amyl 2-furoate 0
                                            Asperfuran A 0
                                            Dimethyl 3,4-dihydroxyfuran-2,5-dicarboxylate 0
                                            Epoxydine B 0
                                            Ethyl 2-phenyl-3-furancarboxylate 0
                                            Ethyl 3-furoate 0
                                            Ethyl furoate 0
                                            GNF5343 0
                                            HS071 0
                                            Hexyl 2-furoate 0
                                            Isoamyl 2-furoate 0
                                            LSM-26546 0
                                            Methyl 2-Furancarboxylate 0
                                            Methyl 5-nitro-2-furoate 0
                                            N-(2-furoyl)glycine 0
                                            N-2-furoyl-L-leucine 0
                                            Octyl 2-furoate 0
                                            Propyl 2-furoate 0
                                            Robillafuran 0
                                            [(1R)-1-\{[N-(furan-2-ylcarbonyl)-L-leucyl]amino\}-2-(1H-indol-3-yl)ethyl]phosphonic acid 0
                                            methyl 5-(hydroxymethyl) furan-2-carboxylate 0
                                            methyl 5-\{[2-(ethoxycarbonyl)-3-oxohex-1-enyl]amino\}-2-furoate 0
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