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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:furoic acid
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Accession:CHEBI:36055 term browser browse the term
Definition:A monocarboxylic acid that consists of a furan ring having a single carboxylic acid group on any ring position and derivatives thereof.
Synonyms:related_synonym: furoic acids


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5-(tetradecyloxy)-2-furoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO 5-(tetradecyloxy)-2-furancarboxylic acid inhibits the reaction [Palmitates results in decreased expression of SLC2A4 mRNA] CTD PMID:21802492 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
mometasone furoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO Mometasone Furoate inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; Mometasone Furoate inhibits the reaction [ABCB1 protein results in increased export of fluorexon] CTD PMID:16442095 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases activity
ISO Mometasone Furoate inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]
Mometasone Furoate results in increased activity of ABCG2 protein
CTD PMID:16442095 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Mometasone Furoate inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein] CTD PMID:10460758 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Mometasone Furoate results in decreased activity of CYP2C8 protein CTD PMID:15601807 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO Mometasone Furoate results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Il10 interleukin 10 decreases secretion ISO Mometasone Furoate results in decreased secretion of IL10 protein CTD PMID:9819297 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Mometasone Furoate inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of IL12B protein] CTD PMID:19422381 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Mometasone Furoate inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein] CTD PMID:10460758 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects binding EXP
ISO
Mometasone Furoate binds to NR3C1 protein CTD PMID:16507850, PMID:19422381 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 affects binding ISO Mometasone Furoate binds to NR3C2 protein CTD PMID:19422381 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Pgr progesterone receptor multiple interactions
affects binding
ISO Mometasone Furoate binds to and results in increased activity of PGR protein
Mometasone Furoate binds to PGR protein
CTD PMID:15189034, PMID:19422381 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO Mometasone Furoate results in increased expression of SPP1 protein CTD PMID:21885873 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Tat tyrosine aminotransferase increases activity ISO Mometasone Furoate results in increased activity of TAT protein CTD PMID:19422381 NCBI chr19:41,675,639...41,686,195
Ensembl chr19:41,675,355...41,686,229
JBrowse link
G Tgm2 transglutaminase 2 increases expression ISO Mometasone Furoate results in increased expression of TGM2 protein CTD PMID:21885873 NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases secretion
ISO Mometasone Furoate inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
Mometasone Furoate results in decreased secretion of TNF protein
CTD PMID:9819297, PMID:10100995 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Mometasone Furoate inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:10100995 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      atom 19782
        nonmetal atom 19657
          oxygen atom 19321
            oxygen molecular entity 19321
              organooxygen compound 18777
                oxacycle 17181
                  furans 4128
                    furoic acid 17
                      (5-bromo-2-furanyl)-[2-[(3-methylphenyl)methylthio]-4,5-dihydroimidazol-1-yl]methanone 0
                      1-[[(5-bromo-2-furanyl)-oxomethyl]amino]-3-(2,5-dimethylphenyl)thiourea 0
                      1-[[(5-bromo-2-furanyl)-oxomethyl]amino]-3-[(4-chlorophenyl)methyl]thiourea 0
                      1-[[2-furanyl(oxo)methyl]amino]-3-(3-methylphenyl)thiourea 0
                      1-butyl-3-[[2-furanyl(oxo)methyl]amino]thiourea 0
                      2,5-dimethyl-N-[(phenylmethylene)amino]-3-furancarboxamide 0
                      2-(2-carboxyethyl)-4-methyl-5-propylfuran-3-carboxylic acid 0
                      2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoic acid + 0
                      2-(carboxymethyl)-5-oxo-2,5-dihydro-3-furoic acid 0
                      2-furanyl-[3-hydroxy-3-(trifluoromethyl)-3a,4,5,6,7,8-hexahydrocyclohepta[c]pyrazol-2-yl]methanone 0
                      2-furoic acid + 17
                      2-methyl-N-(3-pyridinylmethylideneamino)-3-furancarboxamide 0
                      2-methyl-N-[(5-methyl-2-furanyl)methylideneamino]-3-furancarboxamide 0
                      2-methyl-N-[1-(3-pyridinyl)ethylideneamino]-3-furancarboxamide 0
                      3-furoic acid + 0
                      5-(2,5-dichlorophenyl)furan-2-carboxylic acid 0
                      5-(4-bromophenyl)-N-[[(2-propyl-5-tetrazolyl)amino]-sulfanylidenemethyl]-2-furancarboxamide 0
                      5-(dihydroxymethyl)-2-furoic acid 0
                      5-(tetradecyloxy)-2-furoic acid 1
                      5-Methylfuran-2-carboxylic acid 0
                      5-[(4-bromo-3-nitro-1-pyrazolyl)methyl]-N-[(3-chlorophenyl)methylideneamino]-2-furancarboxamide 0
                      5-bromo-N-(2-pyridinylmethylideneamino)-2-furancarboxamide 0
                      5-bromo-N-(cycloheptylideneamino)-2-furancarboxamide 0
                      5-bromo-N-[(4-tert-butylcyclohexylidene)amino]-2-furancarboxamide 0
                      5-formyl-2-furoic acid 0
                      5-hydroxymethyl-2-furoic acid 0
                      5-propyl-4-(1-pyrrolidinylmethyl)-2-furancarboxylic acid 0
                      N(2)-carbamimidoyl-N-\{2-[4-(3-\{4-[(5-carboxyfuran-2-yl)methoxy]-2,3-dichlorophenyl\}-1-methyl-1H-pyrazol-5-yl)piperidin-1-yl]-2-oxoethyl\}-D-leucinamide 0
                      N-[(2-bromo-3-phenylprop-2-enylidene)amino]-2,5-dimethyl-3-furancarboxamide 0
                      N-[(4-methylphenyl)methylideneamino]-2-furancarboxamide 0
                      N-[1-(3-pyridinyl)ethylideneamino]-2-furancarboxamide 0
                      N-[4-(4-chlorophenyl)-3,5-dimethyl-2-thiazolylidene]-2-furancarboxamide 0
                      N-[[(2-chloro-3-pyridinyl)amino]-sulfanylidenemethyl]-2-furancarboxamide 0
                      N-[[2-(1-cyclohexenyl)ethylamino]-sulfanylidenemethyl]-2-furancarboxamide 0
                      N-[[4-(diethylamino)phenyl]methylideneamino]-2-furancarboxamide 0
                      [2-[(2-chloro-6-fluorophenyl)methylthio]-4,5-dihydroimidazol-1-yl]-(2-furanyl)methanone 0
                      [5-[(3,5-dimethyl-4-nitro-1-pyrazolyl)methyl]-2-furanyl]-[5-hydroxy-3-methyl-5-(trifluoromethyl)-4H-pyrazol-1-yl]methanone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        monocarboxylic acid 17406
                                          furoic acid 17
                                            (5-bromo-2-furanyl)-[2-[(3-methylphenyl)methylthio]-4,5-dihydroimidazol-1-yl]methanone 0
                                            1-[[(5-bromo-2-furanyl)-oxomethyl]amino]-3-(2,5-dimethylphenyl)thiourea 0
                                            1-[[(5-bromo-2-furanyl)-oxomethyl]amino]-3-[(4-chlorophenyl)methyl]thiourea 0
                                            1-[[2-furanyl(oxo)methyl]amino]-3-(3-methylphenyl)thiourea 0
                                            1-butyl-3-[[2-furanyl(oxo)methyl]amino]thiourea 0
                                            2,5-dimethyl-N-[(phenylmethylene)amino]-3-furancarboxamide 0
                                            2-(2-carboxyethyl)-4-methyl-5-propylfuran-3-carboxylic acid 0
                                            2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoic acid + 0
                                            2-(carboxymethyl)-5-oxo-2,5-dihydro-3-furoic acid 0
                                            2-furanyl-[3-hydroxy-3-(trifluoromethyl)-3a,4,5,6,7,8-hexahydrocyclohepta[c]pyrazol-2-yl]methanone 0
                                            2-furoic acid + 17
                                            2-methyl-N-(3-pyridinylmethylideneamino)-3-furancarboxamide 0
                                            2-methyl-N-[(5-methyl-2-furanyl)methylideneamino]-3-furancarboxamide 0
                                            2-methyl-N-[1-(3-pyridinyl)ethylideneamino]-3-furancarboxamide 0
                                            3-furoic acid + 0
                                            5-(2,5-dichlorophenyl)furan-2-carboxylic acid 0
                                            5-(4-bromophenyl)-N-[[(2-propyl-5-tetrazolyl)amino]-sulfanylidenemethyl]-2-furancarboxamide 0
                                            5-(dihydroxymethyl)-2-furoic acid 0
                                            5-(tetradecyloxy)-2-furoic acid 1
                                            5-Methylfuran-2-carboxylic acid 0
                                            5-[(4-bromo-3-nitro-1-pyrazolyl)methyl]-N-[(3-chlorophenyl)methylideneamino]-2-furancarboxamide 0
                                            5-bromo-N-(2-pyridinylmethylideneamino)-2-furancarboxamide 0
                                            5-bromo-N-(cycloheptylideneamino)-2-furancarboxamide 0
                                            5-bromo-N-[(4-tert-butylcyclohexylidene)amino]-2-furancarboxamide 0
                                            5-formyl-2-furoic acid 0
                                            5-hydroxymethyl-2-furoic acid 0
                                            5-propyl-4-(1-pyrrolidinylmethyl)-2-furancarboxylic acid 0
                                            N(2)-carbamimidoyl-N-\{2-[4-(3-\{4-[(5-carboxyfuran-2-yl)methoxy]-2,3-dichlorophenyl\}-1-methyl-1H-pyrazol-5-yl)piperidin-1-yl]-2-oxoethyl\}-D-leucinamide 0
                                            N-[(2-bromo-3-phenylprop-2-enylidene)amino]-2,5-dimethyl-3-furancarboxamide 0
                                            N-[(4-methylphenyl)methylideneamino]-2-furancarboxamide 0
                                            N-[1-(3-pyridinyl)ethylideneamino]-2-furancarboxamide 0
                                            N-[4-(4-chlorophenyl)-3,5-dimethyl-2-thiazolylidene]-2-furancarboxamide 0
                                            N-[[(2-chloro-3-pyridinyl)amino]-sulfanylidenemethyl]-2-furancarboxamide 0
                                            N-[[2-(1-cyclohexenyl)ethylamino]-sulfanylidenemethyl]-2-furancarboxamide 0
                                            N-[[4-(diethylamino)phenyl]methylideneamino]-2-furancarboxamide 0
                                            [2-[(2-chloro-6-fluorophenyl)methylthio]-4,5-dihydroimidazol-1-yl]-(2-furanyl)methanone 0
                                            [5-[(3,5-dimethyl-4-nitro-1-pyrazolyl)methyl]-2-furanyl]-[5-hydroxy-3-methyl-5-(trifluoromethyl)-4H-pyrazol-1-yl]methanone 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.