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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Cirsimarin
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Accession:CHEBI:192417 term browser browse the term
Synonyms:exact_synonym: 5-hydroxy-6,7-dimethoxy-2-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]chromen-4-one
 related_synonym: Formula=C23H24O11;   InChI=1S/C23H24O11/c1-30-15-8-14-17(19(27)22(15)31-2)12(25)7-13(33-14)10-3-5-11(6-4-10)32-23-21(29)20(28)18(26)16(9-24)34-23/h3-8,16,18,20-21,23-24,26-29H,9H2,1-2H3/t16-,18-,20+,21-,23-/m1/s1;   InChIKey=RETJLKUBHXTIGH-FZFRBNDOSA-N;   SMILES=O1[C@@H]([C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC2=CC=C(C=C2)C=3OC=4C(C(=O)C3)=C(O)C(OC)=C(OC)C4)CO
 xref: CAS:13020-19-4;   Chemspider:140227
 xref_mesh: MESH:C107783


show annotations for term's descendants           Sort by:
Cirsimarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator decreases expression EXP cirsimarin results in decreased expression of BAX mRNA CTD PMID:35710092 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2L1 BCL2 like 1 decreases expression EXP cirsimarin results in decreased expression of BCL2L1 mRNA CTD PMID:35710092 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989 		JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 decreases expression EXP cirsimarin results in decreased expression of BIRC5 mRNA CTD PMID:35710092 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636 		JBrowse link
G CASP9 caspase 9 decreases expression EXP cirsimarin results in decreased expression of CASP9 mRNA CTD PMID:35710092 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CCNA2 cyclin A2 decreases expression EXP cirsimarin results in decreased expression of CCNA2 mRNA CTD PMID:35710092 NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883 		JBrowse link
G CCND1 cyclin D1 decreases expression EXP cirsimarin results in decreased expression of CCND1 mRNA CTD PMID:35710092 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CCR5 C-C motif chemokine receptor 5 decreases expression EXP cirsimarin results in decreased expression of CCR5 mRNA CTD PMID:35710092 NCBI chr 3:46,370,142...46,376,206
Ensembl chr 3:46,370,946...46,376,206 		JBrowse link
G CDH1 cadherin 1 decreases expression EXP cirsimarin results in decreased expression of CDH1 mRNA CTD PMID:35710092 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537 		JBrowse link
G CDK2 cyclin dependent kinase 2 decreases expression EXP cirsimarin results in decreased expression of CDK2 mRNA CTD PMID:35710092 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789 		JBrowse link
G CDK4 cyclin dependent kinase 4 decreases expression EXP cirsimarin results in decreased expression of CDK4 mRNA CTD PMID:35710092 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013 		JBrowse link
G IFNB1 interferon beta 1 multiple interactions ISO cirsimarin inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNB1 mRNA] CTD PMID:30053449 NCBI chr 9:21,077,104...21,077,942
Ensembl chr 9:21,077,104...21,077,942 		JBrowse link
G IL6 interleukin 6 multiple interactions ISO cirsimarin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 mRNA]; cirsimarin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:30053449 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G IRF3 interferon regulatory factor 3 multiple interactions ISO cirsimarin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein] CTD PMID:30053449 NCBI chr19:49,659,572...49,665,857
Ensembl chr19:49,659,569...49,665,875 		JBrowse link
G JAK1 Janus kinase 1 multiple interactions ISO cirsimarin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JAK1 protein] CTD PMID:30053449 NCBI chr 1:64,833,229...65,067,746
Ensembl chr 1:64,833,223...65,067,754 		JBrowse link
G JAK2 Janus kinase 2 multiple interactions ISO cirsimarin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JAK2 protein] CTD PMID:30053449 NCBI chr 9:4,984,390...5,129,948
Ensembl chr 9:4,984,390...5,129,948 		JBrowse link
G MMP11 matrix metallopeptidase 11 decreases expression EXP cirsimarin results in decreased expression of MMP11 mRNA CTD PMID:35710092 NCBI chr22:23,772,849...23,784,316
Ensembl chr22:23,768,226...23,784,316 		JBrowse link
G MMP9 matrix metallopeptidase 9 decreases expression EXP cirsimarin results in decreased expression of MMP9 mRNA CTD PMID:35710092 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO cirsimarin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; cirsimarin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:30053449 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO cirsimarin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; cirsimarin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:30053449 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G STAT1 signal transducer and activator of transcription 1 multiple interactions ISO cirsimarin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein] CTD PMID:30053449 NCBI chr 2:190,969,149...191,014,171
Ensembl chr 2:190,908,460...191,020,960 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions ISO cirsimarin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein] CTD PMID:30053449 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568 		JBrowse link
G TNF tumor necrosis factor multiple interactions
decreases expression		 ISO
EXP		 cirsimarin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF mRNA]; cirsimarin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
cirsimarin results in decreased expression of TNF mRNA		 CTD PMID:30053449 PMID:35710092 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TP53 tumor protein p53 decreases expression EXP cirsimarin results in decreased expression of TP53 mRNA CTD PMID:35710092 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26089
    chemical entity 26068
      atom 26064
        nonmetal atom 25556
          oxygen atom 24852
            oxygen molecular entity 24852
              flavonoids 12284
                Cirsimarin 23
Path 2
Term Annotations click to browse term
  CHEBI ontology 26089
    subatomic particle 26064
      composite particle 26064
        hadron 26064
          baryon 26064
            nucleon 26064
              atomic nucleus 26064
                atom 26064
                  main group element atom 25891
                    p-block element atom 25891
                      carbon group element atom 25478
                        carbon atom 25437
                          organic molecular entity 25437
                            heteroorganic entity 24805
                              organochalcogen compound 24413
                                organooxygen compound 24093
                                  carbohydrates and carbohydrate derivatives 16793
                                    carbohydrate 16793
                                      carbohydrate derivative 15668
                                        glycosyl compound 13731
                                          glycoside 12289
                                            Cirsimarin 23
paths to the root