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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:kynurenic acid
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Accession:CHEBI:18344 term browser browse the term
Definition:A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.
Synonyms:related_synonym: 4-Hydroxy-2-chinolincarbonsaeure;   4-Hydroxy-2-quinolinecarboxylic acid;   4-Hydroxyquinoline-2-carboxylic acid;   4-hydroxyquinaldic acid;   4-hydroxyquinaldinic acid;   Formula=C10H7NO3;   InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14);   InChIKey=HCZHHEIFKROPDY-UHFFFAOYSA-N;   Kynurenate;   Kynurensaeure;   SMILES=OC(=O)c1cc(O)c2ccccc2n1
 alt_id: CHEBI:14495;   CHEBI:1841;   CHEBI:20378
 xref: Beilstein:147451;   CAS:492-27-3;   HMDB:HMDB0000715;   KEGG:C01717;   KNApSAcK:C00026453;   KNApSAcK:C00026494;   LINCS:LSM-24962
 xref_mesh: MESH:D007736
 xref: MetaCyc:KYNURENATE;   PDBeChem:KYA;   PMID:10088651;   PMID:10867830;   PMID:10881031;   PMID:11051465;   PMID:11129102;   PMID:11191832;   PMID:11244357;   PMID:11334243;   PMID:11452979;   PMID:11521749;   PMID:11982504;   PMID:12503245;   PMID:12757473;   PMID:12926536;   PMID:14724046;   PMID:14770276;   PMID:15206728;   PMID:15364012;   PMID:15517427;   PMID:15605380;   PMID:15961072;   PMID:16088227;   PMID:16220290;   PMID:16388784;   PMID:16416446;   PMID:16457470;   PMID:16603336;   PMID:16644124;   PMID:16845213;   PMID:16888405;   PMID:16920787;   PMID:17023091;   PMID:17364732;   PMID:17573079;   PMID:17959203;   PMID:18231708;   PMID:18235993;   PMID:18346850;   PMID:18462830;   PMID:18836681;   PMID:18950711;   PMID:19187269;   PMID:19523966;   PMID:19616570;   PMID:19815960;   PMID:19816853;   PMID:22065206;   PMID:22108572;   PMID:22224417;   PMID:22732505;   PMID:22770225;   PMID:22814028;   PMID:22915278;   PMID:23030614;   PMID:7882580;   PMID:8579218;   PMID:8637415;   PMID:9078543;   Reaxys:147451;   Wikipedia:Kynurenic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:58454



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kynurenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO Kynurenic Acid inhibits the reaction [ABCB11 protein results in increased uptake of Taurocholic Acid] CTD PMID:30639138 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO Kynurenic Acid inhibits the reaction [ABCC4 protein results in increased export of Methotrexate] CTD PMID:21483698 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Kynurenic Acid inhibits the reaction [ABCG2 protein results in increased export of estrone sulfate] CTD PMID:21483698 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity
ISO AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of IL6 mRNA]; Kynurenic Acid binds to and results in increased activity of AHR protein
Kynurenic Acid analog results in increased activity of AHR protein; Kynurenic Acid results in increased activity of AHR protein
CTD PMID:20106948 PMID:27020609 PMID:28336214 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Kynurenic Acid CTD PMID:24709313 NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases activity
increases expression
ISO [Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA; AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA]
Kynurenic Acid results in increased activity of CYP1A1 protein
Kynurenic Acid results in increased expression of CYP1A1 mRNA
CTD PMID:20106948 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Fgf1 fibroblast growth factor 1 decreases secretion ISO Kynurenic Acid results in decreased secretion of FGF1 protein CTD PMID:16392031 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
JBrowse link
G Gpr35 G protein-coupled receptor 35 multiple interactions ISO Kynurenic Acid binds to and results in increased activity of GPR35 protein CTD PMID:20826425 NCBI chr 9:93,527,165...93,539,573
Ensembl chr 9:93,527,127...93,539,299
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA; AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of IL6 mRNA]; IL1B protein promotes the reaction [Kynurenic Acid results in increased expression of IL6 mRNA]
Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]; Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL1B protein]; methyl 5-((tert-butylcarbamothioylhydrazinylidene)methyl)-1-(2,4-difluorophenyl)pyrazole-4-carboxylate inhibits the reaction [Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]]
CTD PMID:20106948 PMID:35123988 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of IL6 mRNA]; IL1B protein promotes the reaction [Kynurenic Acid results in increased expression of IL6 mRNA] CTD PMID:20106948 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins2 insulin 2 multiple interactions ISO Kynurenic Acid inhibits the reaction [[INS protein co-treated with Glucose] results in decreased chemical synthesis of Nitric Oxide]; Kynurenic Acid inhibits the reaction [[INS protein co-treated with Glucose] results in decreased expression of SLC2A3 protein] CTD PMID:28951307 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Kmo kynurenine 3-monooxygenase multiple interactions EXP [Ro 61-8048 results in decreased activity of KMO protein] which results in increased abundance of Kynurenic Acid CTD PMID:30151725 NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of MPO protein] CTD PMID:35123988 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein] CTD PMID:35123988 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Ocln occludin multiple interactions ISO Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of OCLN protein] CTD PMID:35123988 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein]; Kynurenic Acid promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of RELA protein] CTD PMID:35123988 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Slc2a3 solute carrier family 2 member 3 multiple interactions ISO Kynurenic Acid inhibits the reaction [[INS protein co-treated with Glucose] results in decreased expression of SLC2A3 protein] CTD PMID:28951307 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of TJP1 protein] CTD PMID:35123988 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]; methyl 5-((tert-butylcarbamothioylhydrazinylidene)methyl)-1-(2,4-difluorophenyl)pyrazole-4-carboxylate inhibits the reaction [Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]] CTD PMID:35123988 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      biological role 19815
        pharmacological role 19058
          agonist 18604
            G-protein-coupled receptor agonist 47
              kynurenic acid 19
                4-hydroxy-8-methoxyquinaldic acid 0
                7,8-dihydro-7,8-dihydroxykynurenic acid 0
                7,8-dihydroxykynurenic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            heteroorganic entity 19492
                              organochalcogen compound 19255
                                organooxygen compound 19172
                                  carbon oxoacid 18641
                                    carboxylic acid 18638
                                      aromatic carboxylic acid 12618
                                        quinolinemonocarboxylic acid 107
                                          kynurenic acid 19
                                            4-hydroxy-8-methoxyquinaldic acid 0
                                            7,8-dihydro-7,8-dihydroxykynurenic acid 0
                                            7,8-dihydroxykynurenic acid 0
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