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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:rubimaillin
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Accession:CHEBI:141063 term browser browse the term
Definition:A benzochromene that is 2H-benzo[h]chromene which is substituted by two methyl groups at position 2, a methoxycarbonyl group at position 5, and a hydroxy group at position 6. Found in the Chinese medical plant Rubia cordifola, It has an anti-cancer effect by inhibition of TNF-alpha-induced NF-kappaB activation. It is also a dual inhibitor of acyl-CoA:cholesterol acyltransferase 1 and 2 (ACAT1 and ACAT2), but is more selective for the ACAT2 isozyme.
Synonyms:exact_synonym: methyl 6-hydroxy-2,2-dimethyl-2H-benzo[h]chromene-5-carboxylate
 related_synonym: Formula=C17H16O4;   InChI=1S/C17H16O4/c1-17(2)9-8-12-13(16(19)20-3)14(18)10-6-4-5-7-11(10)15(12)21-17/h4-9,18H,1-3H3;   InChIKey=VLGATXOTCNBWIT-UHFFFAOYSA-N;   SMILES=C12=CC=CC=C1C3=C(C(=C2O)C(OC)=O)C=CC(O3)(C)C;   mollugin
 xref: CAS:55481-88-4
 xref_mesh: MESH:C046245
 xref: PMID:19652367;   PMID:19716835;   PMID:19765578;   PMID:21077262;   PMID:21236252;   PMID:22997839;   PMID:23000442;   PMID:23065756;   PMID:23318249;   PMID:23466342;   PMID:23738323;   PMID:23845549;   PMID:24887566;   PMID:25310176;   PMID:25636867;   PMID:26126771;   PMID:26681510;   PMID:26697688;   PMID:27258244;   PMID:28933726;   PMID:29027119


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rubimaillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression
multiple interactions		 ISO rubimaillin results in decreased expression of ABCB1 mRNA; rubimaillin results in decreased expression of ABCB1 protein
dorsomorphin inhibits the reaction [rubimaillin results in decreased expression of ABCB1 mRNA]; rubimaillin inhibits the reaction [RELA protein results in increased expression of ABCB1 protein]		 CTD PMID:23466342 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases phosphorylation ISO rubimaillin results in increased phosphorylation of ACACA protein CTD PMID:23466342 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions		 ISO rubimaillin results in decreased phosphorylation of AKT1 protein
dorsomorphin inhibits the reaction [rubimaillin results in decreased phosphorylation of AKT1 protein]		 CTD PMID:23466342 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP12 protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP3 protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP7 protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP8 protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP9 protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased cleavage of BID protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased cleavage of CFLAR protein]; BCL2L1 protein inhibits the reaction [rubimaillin results in increased degradation of PARP1 protein] CTD PMID:19716835 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bid BH3 interacting domain death agonist increases cleavage
multiple interactions		 ISO rubimaillin results in increased cleavage of BID protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased cleavage of BID protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [rubimaillin results in increased cleavage of BID protein]		 CTD PMID:19716835 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Casp12 caspase 12 increases activity
multiple interactions		 ISO rubimaillin results in increased activity of CASP12 protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP12 protein]		 CTD PMID:19716835 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO rubimaillin results in increased activity of CASP3 protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP3 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone affects the reaction [rubimaillin results in increased activity of CASP3 protein]		 CTD PMID:19716835 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions		 ISO rubimaillin results in increased activity of CASP7 protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP7 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [rubimaillin results in increased activity of CASP7 protein]		 CTD PMID:19716835 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions		 ISO rubimaillin results in increased activity of CASP8 protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP8 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [rubimaillin results in increased activity of CASP8 protein]		 CTD PMID:19716835 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions		 ISO rubimaillin results in increased activity of CASP9 protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased activity of CASP9 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone affects the reaction [rubimaillin results in increased activity of CASP9 protein]		 CTD PMID:19716835 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccna2 cyclin A2 multiple interactions
decreases expression		 ISO Glutathione inhibits the reaction [rubimaillin results in decreased expression of CCNA2 protein] CTD PMID:35007525 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression
multiple interactions		 ISO rubimaillin results in decreased expression of CDK2 protein
Glutathione inhibits the reaction [rubimaillin results in decreased expression of CDK2 protein]		 CTD PMID:35007525 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator increases cleavage
multiple interactions		 ISO rubimaillin results in increased cleavage of CFLAR protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased cleavage of CFLAR protein]		 CTD PMID:19716835 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases expression
decreases phosphorylation		 ISO rubimaillin results in decreased expression of CREB1 mRNA
rubimaillin results in decreased phosphorylation of CREB1 protein		 CTD PMID:23466342 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation ISO rubimaillin results in increased phosphorylation of GSK3B protein CTD PMID:23466342 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G H2ax H2A.X variant histone increases phosphorylation
multiple interactions		 ISO rubimaillin results in increased phosphorylation of H2AX protein
Glutathione inhibits the reaction [rubimaillin results in increased phosphorylation of H2AX protein]		 CTD PMID:35007525 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation ISO rubimaillin results in increased phosphorylation of NFKBIA protein CTD PMID:23466342 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases degradation
multiple interactions		 ISO rubimaillin results in increased degradation of PARP1 protein
BCL2L1 protein inhibits the reaction [rubimaillin results in increased degradation of PARP1 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [rubimaillin results in increased degradation of PARP1 protein]		 CTD PMID:19716835 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO rubimaillin results in decreased expression of PTGS2 mRNA; rubimaillin results in decreased expression of PTGS2 protein CTD PMID:23466342 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression		 ISO rubimaillin inhibits the reaction [RELA protein results in increased expression of ABCB1 protein]
rubimaillin results in decreased expression of RELA protein		 CTD PMID:23466342 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Stk11 serine/threonine kinase 11 increases phosphorylation ISO rubimaillin results in increased phosphorylation of STK11 protein CTD PMID:23466342 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315 		JBrowse link
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  CHEBI ontology 19808
    role 19784
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        anti-inflammatory agent 16580
          rubimaillin 21
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                      chalcogen 19513
                        oxygen atom 19488
                          oxygen molecular entity 19488
                            hydroxides 19299
                              organic hydroxy compound 18923
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                                  aliphatic alcohol 11870
                                    alkyl alcohol 11778
                                      methanol 3959
                                        methyl ester 3905
                                          rubimaillin 21
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