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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:benazepril
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Accession:CHEBI:3011 term browser browse the term
Definition:A benzazepine that is benazeprilat in which the carboxy group of the 2-amino-4-phenylbutanoic acid moiety has been converted to the corresponding ethyl ester. It is used (generally as its hydrochloride salt) as a prodrug for the angiotensin-converting enzyme inhibitor benazeprilat in the treatment of hypertension and heart failure.
Synonyms:exact_synonym: [(3S)-3-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid
 related_synonym: 1H-1-Benzazepine-1-acetic acid, 3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2,3,4,5-tetrahydro-2-oxo-, (S-(R*,R*))-;   Formula=C24H28N2O5;   InChI=1S/C24H28N2O5/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28)/t19-,20-/m0/s1;   InChIKey=XPCFTKFZXHTYIP-PMACEKPBSA-N;   SMILES=CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(O)=O)C1=O;   benazeprilum
 xref: CAS:86541-75-5;   DrugBank:DB00542;   Drug_Central:299;   HMDB:HMDB0014682;   KEGG:C06843;   KEGG:D07499;   LINCS:LSM-5609
 xref_mesh: MESH:C044946
 xref: MetaCyc:CPD-15329;   PMID:25224804;   PMID:25738503;   PMID:25784709;   PMID:25912588;   Patent:EP72352;   Patent:US4410520;   Reaxys:4302258;   Wikipedia:Benazepril
 cyclic_relationship: is_conjugate_base_of CHEBI:88201


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benazepril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases activity
affects response to substance		 ISO benazepril results in decreased activity of ACE protein
ACE gene polymorphism affects the susceptibility to benazepril		 CTD PMID:8359184 PMID:11007831 PMID:12652327 PMID:12848919 PMID:15498266 More... NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ace2 angiotensin converting enzyme 2 affects response to substance
multiple interactions
increases response to substance		 ISO ACE2 gene SNP affects the susceptibility to benazepril
[AGT gene polymorphism co-treated with ACE2 gene polymorphism] affects the susceptibility to benazepril
ACE2 gene SNP results in increased susceptibility to benazepril		 CTD PMID:20559404 PMID:21449848 PMID:27121444 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP [irbesartan co-treated with benazepril] results in decreased expression of ACTA2 protein; benazepril inhibits the reaction [Doxorubicin results in increased expression of ACTA2 mRNA] CTD PMID:15149348 PMID:20493835 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Adrb2 adrenoceptor beta 2 affects response to substance ISO ADRB2 protein polymorphism affects the susceptibility to benazepril CTD PMID:15554460 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Ager advanced glycosylation end product-specific receptor decreases expression EXP benazepril results in decreased expression of AGER mRNA; benazepril results in decreased expression of AGER protein CTD PMID:19018797 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Agt angiotensinogen decreases expression
multiple interactions
affects response to substance		 ISO
EXP		 benazepril results in decreased expression of AGT protein; benazepril results in decreased expression of AGT protein modified form
[AGT gene polymorphism co-treated with ACE2 gene polymorphism] affects the susceptibility to benazepril; [AGT gene polymorphism co-treated with AGTR1 gene polymorphism] affects the susceptibility to benazepril; [benazepril co-treated with Valsartan] results in decreased expression of AGT protein modified form; Valsartan inhibits the reaction [benazepril results in decreased expression of AGT protein]
AGT gene SNP affects the susceptibility to benazepril
benazepril inhibits the reaction [Doxorubicin results in increased expression of AGT protein modified form]; benazepril inhibits the reaction [Particulate Matter results in increased expression of AGT protein modified form]; benazepril inhibits the reaction [Streptozocin results in increased expression of AGT protein modified form]		 CTD PMID:10515446 PMID:11501062 PMID:11798627 PMID:12676074 PMID:17177138 More... NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions
decreases expression		 EXP
ISO		 benazepril inhibits the reaction [Doxorubicin results in increased expression of AGTR1 protein]
[AGT gene polymorphism co-treated with AGTR1 gene polymorphism] affects the susceptibility to benazepril
benazepril results in decreased expression of AGTR1A mRNA; benazepril results in decreased expression of AGTR1A protein		 CTD PMID:9596920 PMID:15157388 PMID:21449848 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor decreases expression
multiple interactions		 ISO benazepril results in decreased expression of AMBP protein
benazepril promotes the reaction [Losartan results in decreased expression of AMBP protein]; Losartan promotes the reaction [benazepril results in decreased expression of AMBP protein]		 CTD PMID:16303729 NCBI chr 5:76,568,094...76,578,416
Ensembl chr 5:76,568,094...76,578,331 		JBrowse link
G Apob apolipoprotein B multiple interactions ISO [Valsartan co-treated with benazepril] results in decreased expression of APOB protein; fluvastatin promotes the reaction [[Valsartan co-treated with benazepril] results in decreased expression of APOB protein] CTD PMID:20671225 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497 		JBrowse link
G Aqp1 aquaporin 1 multiple interactions EXP benazepril inhibits the reaction [Glucose results in increased expression of AQP1 mRNA] CTD PMID:11510275 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690 		JBrowse link
G Aqp4 aquaporin 4 multiple interactions EXP benazepril inhibits the reaction [Glucose results in increased expression of AQP4 mRNA] CTD PMID:11510275 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression EXP benazepril results in decreased expression of BAX protein CTD PMID:20026869 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP benazepril results in increased expression of BCL2 protein CTD PMID:20026869 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdkrb2 bradykinin receptor B2 increases activity
multiple interactions		 ISO
EXP		 benazepril results in increased activity of BDKRB2 protein
[icatibant results in decreased activity of BDKRB2 protein] which results in decreased susceptibility to benazepril		 CTD PMID:15339989 PMID:16982965 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP benazepril inhibits the reaction [Estrogens deficiency results in increased expression of CCL2 protein]; benazepril inhibits the reaction [Ethylene Glycol results in increased expression of CCL2 protein] CTD PMID:16284884 PMID:19553526 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions EXP benazepril inhibits the reaction [Estrogens deficiency results in increased expression of CCL3 protein] CTD PMID:19553526 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions EXP benazepril inhibits the reaction [Ethylene Glycol results in increased expression of CCL5 protein] CTD PMID:16284884 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression EXP benazepril results in decreased expression of CCN2 mRNA CTD PMID:17121042 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Cd36 CD36 molecule increases expression EXP benazepril results in increased expression of CD36 mRNA CTD PMID:14871019 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Col4a1 collagen type IV alpha 1 chain decreases expression
multiple interactions		 EXP benazepril results in decreased expression of COL4A1 mRNA
benazepril inhibits the reaction [Streptozocin results in increased expression of COL4A1 mRNA]		 CTD PMID:11798618 PMID:16191423 NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP benazepril inhibits the reaction [Estrogens deficiency results in increased expression of CXCL1 protein] CTD PMID:19553526 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 affects response to substance ISO CYP11B2 gene polymorphism affects the susceptibility to benazepril CTD PMID:16765146 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
G Edn1 endothelin 1 decreases expression
increases activity
multiple interactions		 EXP benazepril results in decreased expression of EDN1 mRNA; benazepril results in decreased expression of EDN1 protein
benazepril results in increased activity of EDN1 protein
[Valsartan co-treated with benazepril] results in decreased expression of EDN1 protein		 CTD PMID:7528292 PMID:11136700 PMID:16191423 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 increases expression EXP benazepril results in increased expression of EGLN3 mRNA CTD PMID:14871019 NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP benazepril inhibits the reaction [Doxorubicin results in increased expression of FAS protein]; benazepril promotes the reaction [Valsartan inhibits the reaction [Doxorubicin results in increased expression of FAS protein]]; Valsartan promotes the reaction [benazepril inhibits the reaction [Doxorubicin results in increased expression of FAS protein]] CTD PMID:15315341 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand multiple interactions EXP benazepril inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]; benazepril promotes the reaction [Valsartan inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]]; Valsartan promotes the reaction [benazepril inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]] CTD PMID:15315341 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fn1 fibronectin 1 decreases expression
multiple interactions		 EXP benazepril results in decreased expression of FN1 mRNA; benazepril results in decreased expression of FN1 protein
benazepril inhibits the reaction [Doxorubicin results in increased expression of FN1 protein]; benazepril inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]		 CTD PMID:10515446 PMID:11798618 PMID:16191423 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP benazepril results in increased expression of FOS mRNA CTD PMID:8539265 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 increases expression EXP benazepril results in increased expression of GOT2 mRNA CTD PMID:14871019 NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994 		JBrowse link
G Hgf hepatocyte growth factor increases expression EXP benazepril results in increased expression of HGF mRNA CTD PMID:16696918 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 increases expression EXP benazepril results in increased expression of HSPE1 mRNA CTD PMID:14871019 NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP benazepril inhibits the reaction [Ethylene Glycol results in increased expression of IL6 protein] CTD PMID:16284884 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP benazepril inhibits the reaction [Glucose results in increased secretion of INS1 protein]; benazepril promotes the reaction [INS1 protein results in increased metabolism of Glucose] CTD PMID:7498292 PMID:9030901 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Kng1 kininogen 1 increases expression
multiple interactions		 EXP benazepril results in increased expression of KNG1 protein modified form
benazepril promotes the reaction [Valsartan results in increased expression of KNG1 protein modified form]; PD 123319 inhibits the reaction [benazepril promotes the reaction [Valsartan results in increased expression of KNG1 protein modified form]]; PD 123319 inhibits the reaction [Valsartan promotes the reaction [benazepril results in increased expression of KNG1 protein modified form]]; Valsartan promotes the reaction [benazepril results in increased expression of KNG1 protein modified form]		 CTD PMID:11509473 NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression EXP benazepril results in increased expression of MAPK1 mRNA CTD PMID:14871019 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Me1 malic enzyme 1 increases expression EXP benazepril results in increased expression of ME1 mRNA CTD PMID:14871019 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP benazepril inhibits the reaction [Doxorubicin results in decreased expression of MMP2 mRNA]; benazepril inhibits the reaction [Doxorubicin results in decreased expression of MMP2 protein]; benazepril inhibits the reaction [Streptozocin results in decreased expression of MMP2 mRNA]; benazepril inhibits the reaction [Streptozocin results in decreased expression of MMP2 protein] CTD PMID:16732983 PMID:19357873 PMID:20821936 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions
increases activity		 ISO
EXP		 benazepril results in decreased expression of MMP9 protein
benazepril inhibits the reaction [Doxorubicin results in decreased expression of MMP9 mRNA]; benazepril inhibits the reaction [Doxorubicin results in decreased expression of MMP9 protein]
benazepril results in increased activity of MMP9 protein		 CTD PMID:15339989 PMID:19357873 PMID:20981132 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase affects response to substance ISO MTHFR gene polymorphism affects the susceptibility to benazepril; MTHFR gene SNP affects the susceptibility to benazepril CTD PMID:16081343 PMID:20445573 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase affects response to substance ISO MTR gene SNP affects the susceptibility to benazepril; MTR protein polymorphism affects the susceptibility to benazepril CTD PMID:15148588 PMID:20445573 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP benazepril results in increased expression of MYC mRNA CTD PMID:8539265 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Myh6 myosin heavy chain 6 multiple interactions EXP [Valsartan co-treated with benazepril] results in increased expression of MYH6 mRNA CTD PMID:11136700 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 decreases expression EXP benazepril results in decreased expression of NCF1 mRNA CTD PMID:19018797 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP benazepril inhibits the reaction [Ethylene Glycol results in increased expression of NFKB1 protein] CTD PMID:16284884 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP benazepril inhibits the reaction [Streptozocin results in decreased expression of NFKBIA mRNA] CTD PMID:17900838 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression EXP benazepril results in decreased expression of NOS2 mRNA; benazepril results in decreased expression of NOS2 protein CTD PMID:16191423 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nppa natriuretic peptide A multiple interactions
decreases expression		 EXP [Valsartan co-treated with benazepril] results in decreased expression of NPPA mRNA
benazepril results in decreased expression of NPPA mRNA		 CTD PMID:8763405 PMID:11136700 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B multiple interactions
decreases expression		 EXP [Valsartan co-treated with benazepril] results in decreased expression of NPPB mRNA
benazepril results in decreased expression of NPPB mRNA		 CTD PMID:11136700 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO benazepril inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression EXP benazepril results in decreased expression of PCNA protein CTD PMID:17121042 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression EXP benazepril results in increased expression of PDK4 mRNA CTD PMID:14871019 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850 		JBrowse link
G Pla2g5 phospholipase A2, group V decreases expression EXP benazepril results in decreased expression of PLA2G5 mRNA CTD PMID:14871019 NCBI chr 5:151,041,339...151,109,433
Ensembl chr 5:151,041,340...151,062,658 		JBrowse link
G Plau plasminogen activator, urokinase multiple interactions EXP benazepril inhibits the reaction [Streptozocin results in increased expression of PLAU mRNA] CTD PMID:15322501 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Plaur plasminogen activator, urokinase receptor multiple interactions EXP benazepril inhibits the reaction [Streptozocin results in increased expression of PLAUR mRNA] CTD PMID:15322501 NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595 		JBrowse link
G Plg plasminogen increases activity
multiple interactions		 ISO benazepril results in increased activity of PLG protein
FR 173657 inhibits the reaction [benazepril results in increased activity of PLG protein]		 CTD PMID:15339989 NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786 		JBrowse link
G Prcp prolylcarboxypeptidase affects response to substance ISO PRCP gene SNP affects the susceptibility to benazepril CTD PMID:20079160 NCBI chr 1:146,931,487...146,983,891
Ensembl chr 1:146,930,561...146,984,530 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases phosphorylation
decreases expression		 EXP benazepril inhibits the reaction [Doxorubicin results in increased expression of RELA mRNA]; benazepril inhibits the reaction [Streptozocin results in increased expression of RELA mRNA]
benazepril results in decreased phosphorylation of RELA protein
benazepril results in decreased expression of RELA mRNA; benazepril results in decreased expression of RELA protein		 CTD PMID:15157388 PMID:17900838 PMID:19018797 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ren renin increases expression
multiple interactions
increases activity		 ISO
EXP		 benazepril results in increased expression of REN protein
[benazepril co-treated with Valsartan] results in increased activity of REN protein
benazepril results in increased activity of REN protein		 CTD PMID:1316404 PMID:10836730 PMID:11501062 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 decreases expression EXP benazepril results in decreased expression of RSAD2 mRNA CTD PMID:14871019 NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699 		JBrowse link
G Serpine1 serpin family E member 1 decreases expression
multiple interactions		 ISO
EXP		 benazepril results in decreased expression of SERPINE1 mRNA; benazepril results in decreased expression of SERPINE1 protein
benazepril inhibits the reaction [Streptozocin results in increased expression of SERPINE1 mRNA]
FR 173657 inhibits the reaction [benazepril results in decreased expression of SERPINE1 mRNA]		 CTD PMID:15322501 PMID:15339989 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Serpinh1 serpin family H member 1 increases expression EXP benazepril results in increased expression of SERPINH1 mRNA CTD PMID:14871019 NCBI chr 1:153,643,500...153,650,853
Ensembl chr 1:153,643,510...153,650,801 		JBrowse link
G Slc15a1 solute carrier family 15 member 1 multiple interactions ISO benazepril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545 		JBrowse link
G Slc15a2 solute carrier family 15 member 2 multiple interactions ISO
EXP		 benazepril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225 		JBrowse link
G Smad2 SMAD family member 2 affects expression
multiple interactions		 EXP benazepril affects the expression of SMAD2 mRNA; benazepril affects the expression of SMAD2 protein
[benazepril co-treated with irbesartan] affects the expression of SMAD2 mRNA; [benazepril co-treated with irbesartan] affects the expression of SMAD2 protein		 CTD PMID:16635409 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Smad3 SMAD family member 3 affects expression
multiple interactions		 EXP benazepril affects the expression of SMAD3 mRNA; benazepril affects the expression of SMAD3 protein
[benazepril co-treated with candesartan] results in decreased expression of SMAD3 protein; [benazepril co-treated with irbesartan] affects the expression of SMAD3 mRNA; [benazepril co-treated with irbesartan] affects the expression of SMAD3 protein		 CTD PMID:16635409 PMID:19487956 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Snrpn small nuclear ribonucleoprotein polypeptide N decreases expression EXP benazepril results in decreased expression of SNRPN mRNA CTD PMID:14871019 NCBI chr 1:111,101,327...111,123,400
Ensembl chr 1:111,101,329...111,123,634 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO [benazepril co-treated with Valsartan] results in increased expression of SOD1 protein CTD PMID:20445533 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression EXP benazepril results in decreased expression of SPP1 mRNA CTD PMID:11867951 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions
affects expression		 ISO
EXP		 benazepril results in decreased expression of TGFB1 protein
[benazepril co-treated with Valsartan] results in decreased expression of TGFB1 protein
benazepril affects the expression of TGFB1 mRNA
[benazepril co-treated with candesartan] results in decreased expression of TGFB1 protein; [benazepril co-treated with Irbesartan] affects the expression of TGFB1 mRNA; benazepril inhibits the reaction [Doxorubicin results in increased expression of TGFB1 mRNA]; benazepril inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; benazepril inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; benazepril inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]
benazepril results in decreased expression of TGFB1 mRNA; benazepril results in decreased expression of TGFB1 protein		 CTD PMID:10515446 PMID:11798627 PMID:11867951 PMID:16191423 PMID:16409969 More... NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 multiple interactions EXP benazepril inhibits the reaction [Streptozocin results in increased expression of TGFBR1 mRNA]; benazepril inhibits the reaction [Streptozocin results in increased expression of TGFBR1 protein] CTD PMID:11798618 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 decreases expression
multiple interactions		 EXP benazepril results in decreased expression of TIMP1 mRNA; benazepril results in decreased expression of TIMP1 protein
benazepril inhibits the reaction [Doxorubicin results in increased expression of TIMP1 mRNA]; benazepril inhibits the reaction [Doxorubicin results in increased expression of TIMP1 protein]		 CTD PMID:11867951 PMID:18471418 PMID:19357873 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP benazepril inhibits the reaction [Streptozocin results in increased expression of TIMP2 mRNA]; benazepril inhibits the reaction [Streptozocin results in increased expression of TIMP2 protein] CTD PMID:16732983 PMID:20821936 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Tlr4 toll-like receptor 4 decreases expression ISO benazepril results in decreased expression of TLR4 protein CTD PMID:20981132 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions		 ISO
EXP		 benazepril results in decreased expression of TNF protein
[benazepril co-treated with Amlodipine] results in decreased expression of TNF protein		 CTD PMID:16775501 PMID:20981132 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression EXP benazepril results in decreased expression of VCAM1 mRNA; benazepril results in decreased expression of VCAM1 protein CTD PMID:19018797 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP benazepril inhibits the reaction [Streptozocin results in increased expression of VEGFA protein] CTD PMID:20844835 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19834
    role 19810
      application 19653
        pro-agent 11548
          prodrug 11309
            benazepril 76
Path 2
Term Annotations click to browse term
  CHEBI ontology 19834
    subatomic particle 19832
      composite particle 19832
        hadron 19832
          baryon 19832
            nucleon 19832
              atomic nucleus 19832
                atom 19832
                  main group element atom 19782
                    p-block element atom 19782
                      carbon group element atom 19731
                        carbon atom 19727
                          organic molecular entity 19727
                            heteroorganic entity 19484
                              organochalcogen compound 19248
                                organooxygen compound 19165
                                  carbon oxoacid 18633
                                    carboxylic acid 18630
                                      carboacyl group 17703
                                        univalent carboacyl group 17703
                                          carbamoyl group 17553
                                            carboxamide 17553
                                              lactam 8387
                                                benazeprilat 76
                                                  benazepril 76
paths to the root