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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 728890
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ace2
Name: angiotensin converting enzyme 2
Acc ID: CHEBI:3011
Term: benazepril
Definition: A benzazepine that is benazeprilat in which the carboxy group of the 2-amino-4-phenylbutanoic acid moiety has been converted to the corresponding ethyl ester. It is used (generally as its hydrochloride salt) as a prodrug for the angiotensin-converting enzyme inhibitor benazeprilat in the treatment of hypertension and heart failure.
Chemical ID: MESH:C044946
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ace2affects response to substanceISOACE2 (Homo sapiens)6480464CTDACE2 gene SNP affects the susceptibility to benazeprilPMID:20559404
Ace2increases response to substanceISOACE2 (Homo sapiens)6480464CTDACE2 gene SNP results in increased susceptibility to benazeprilPMID:27121444
Ace2multiple interactionsISOACE2 (Homo sapiens)6480464CTD[AGT gene polymorphism co-treated with ACE2 gene polymorphism] affects the susceptibility to benazeprilPMID:21449848
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