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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:edaravone
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Accession:CHEBI:31530 term browser browse the term
Definition:A pyrazolone that is 2,4-dihydro-3H-pyrazol-3-one which is substituted at positions 2 and 5 by phenyl and methyl groups, respectively.
Synonyms:related_synonym: 1-phenyl-3-methyl-5-oxo-2-pyrazoline;   2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one;   3-methyl-1-phenyl-2-pyrazolin-5-one;   3-methyl-1-phenyl-5-pyrazolone;   3-methyl-1-phenylpyrazol-5-one;   C.I. developer 1;   Formula=C10H10N2O;   InChI=1S/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3;   InChIKey=QELUYTUMUWHWMC-UHFFFAOYSA-N;   Radicut;   SMILES=CC1=NN(C(=O)C1)c1ccccc1;   developer Z;   methylphenylpyrazolone;   norphenazone;   phenyl methyl pyrazolone;   phenylmethylpyrazolone
 xref: Beilstein:609575;   CAS:89-25-8;   Drug_Central:4156;   Gmelin:241147;   HMDB:HMDB0006240;   KEGG:C13008;   KEGG:D01552;   LINCS:LSM-5486
 xref_mesh: MESH:C005435
 xref: PMID:12935312;   PMID:14758002;   PMID:15304976;   PMID:16545576;   PMID:17280782;   PMID:17997244;   PMID:18485133;   PMID:25348283;   PMID:26196041;   PMID:26778341;   PMID:27018216;   PMID:27037019;   PMID:27056755;   PMID:27116382;   PMID:27128210


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edaravone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTA2 actin alpha 2, smooth muscle multiple interactions ISO Edaravone inhibits the reaction [Thioacetamide results in increased expression of ACTA2 mRNA] CTD PMID:36343683 NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,934,822...88,991,339 		JBrowse link
G ADORA1 adenosine A1 receptor multiple interactions ISO Edaravone inhibits the reaction [Corticosterone results in decreased expression of ADORA1 mRNA] CTD PMID:31344373 NCBI chr 1:203,127,726...203,167,405
Ensembl chr 1:203,090,654...203,167,405 		JBrowse link
G AGTR1 angiotensin II receptor type 1 multiple interactions ISO Edaravone inhibits the reaction [Lipopolysaccharides results in decreased expression of AGTR1A mRNA] CTD PMID:19118600 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008 		JBrowse link
G AGTR2 angiotensin II receptor type 2 multiple interactions ISO Edaravone inhibits the reaction [Lipopolysaccharides results in increased expression of AGTR2 mRNA] CTD PMID:19118600 NCBI chr  X:116,170,744...116,174,974
Ensembl chr  X:116,170,744...116,174,974 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions ISO Edaravone inhibits the reaction [[IL1B protein results in increased phosphorylation of AKT1 protein] which results in increased expression of IL1R1 mRNA]; Edaravone inhibits the reaction [[IL1B protein results in increased phosphorylation of AKT1 protein] which results in increased expression of IL1R1 protein] CTD PMID:18078833 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759 		JBrowse link
G ALOX5 arachidonate 5-lipoxygenase multiple interactions ISO Edaravone inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of ALOX5 protein]; Edaravone inhibits the reaction [Hydrogen Peroxide affects the localization of ALOX5 protein] CTD PMID:18951527 NCBI chr10:45,374,216...45,446,117
Ensembl chr10:45,374,176...45,446,119 		JBrowse link
G APP amyloid beta precursor protein multiple interactions ISO Edaravone inhibits the reaction [APP protein modified form results in decreased expression of BCL2 mRNA]; Edaravone inhibits the reaction [APP protein modified form results in increased expression of BAX mRNA]; Edaravone inhibits the reaction [APP protein modified form results in increased expression of CYCS mRNA] CTD PMID:26111763 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO Edaravone inhibits the reaction [APP protein modified form results in increased expression of BAX mRNA] CTD PMID:26111763 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO Edaravone inhibits the reaction [APP protein modified form results in decreased expression of BCL2 mRNA] CTD PMID:26111763 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G CASP12 caspase 12 (gene/pseudogene) multiple interactions ISO Edaravone inhibits the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of CASP12 protein] CTD PMID:21429313 NCBI chr11:104,883,286...104,898,460
Ensembl chr11:104,885,718...104,898,670 		JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity		 ISO
EXP		 Edaravone inhibits the reaction [Paraquat results in increased cleavage of CASP3 protein]; Edaravone inhibits the reaction [PRNP protein alternative form results in increased activity of CASP3 protein]
Edaravone analog results in increased activity of CASP3 protein		 CTD PMID:20806394 PMID:25684395 PMID:25947082 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP7 caspase 7 increases activity EXP Edaravone analog results in increased activity of CASP7 protein CTD PMID:25684395 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907 		JBrowse link
G CASP8 caspase 8 decreases expression ISO Edaravone results in decreased expression of CASP8 protein CTD PMID:17967739 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CASP9 caspase 9 increases activity EXP Edaravone analog results in increased activity of CASP9 protein CTD PMID:25684395 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CAT catalase multiple interactions EXP Edaravone inhibits the reaction [Iron-Dextran Complex results in decreased activity of CAT protein] CTD PMID:32135237 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CCL13 C-C motif chemokine ligand 13 multiple interactions ISO Edaravone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL12 mRNA] CTD PMID:12954792 NCBI chr17:34,356,480...34,358,610
Ensembl chr17:34,356,480...34,358,610 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions
decreases expression		 ISO Edaravone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL2 mRNA]; Edaravone inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased secretion of CCL2 protein]; Edaravone inhibits the reaction [SDC2 protein results in increased expression of and results in increased secretion of CCL2 protein]
Edaravone inhibits the reaction [Thioacetamide results in increased expression of CCL2 mRNA]
Edaravone results in decreased expression of CCL2 mRNA; Edaravone results in decreased expression of CCL2 protein		 CTD PMID:12954792 PMID:15948865 PMID:18803305 PMID:19381132 PMID:36343683 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCL3 C-C motif chemokine ligand 3 decreases expression ISO Edaravone results in decreased expression of CCL3 mRNA CTD PMID:15948865 NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 multiple interactions ISO Edaravone inhibits the reaction [Thioacetamide results in increased expression of CCR2 mRNA] CTD PMID:36343683 NCBI chr 3:46,354,111...46,360,940
Ensembl chr 3:46,353,864...46,360,940 		JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions ISO Edaravone inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA] CTD PMID:36343683 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632 		JBrowse link
G COMT catechol-O-methyltransferase multiple interactions ISO Edaravone inhibits the reaction [Corticosterone results in decreased expression of COMT mRNA] CTD PMID:31344373 NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,371...19,969,975 		JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 decreases expression
multiple interactions		 ISO Edaravone results in decreased expression of CXCL1 mRNA; Edaravone results in decreased expression of CXCL1 protein
Edaravone results in decreased expression of CXCL3 mRNA
Edaravone inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein]		 CTD PMID:14654979 PMID:15629513 PMID:15948865 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308 		JBrowse link
G CXCL12 C-X-C motif chemokine ligand 12 multiple interactions ISO Edaravone inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased secretion of CXCL12 protein]; Edaravone inhibits the reaction [SDC2 protein results in increased expression of and results in increased secretion of CXCL12 protein] CTD PMID:18803305 NCBI chr10:44,370,165...44,385,097
Ensembl chr10:44,370,165...44,386,493 		JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 decreases expression
multiple interactions		 ISO Edaravone results in decreased expression of CXCL2 mRNA
Edaravone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CXCL2 mRNA]		 CTD PMID:12954792 PMID:15948865 NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196 		JBrowse link
G CYBB cytochrome b-245 beta chain multiple interactions ISO Edaravone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB mRNA] CTD PMID:18643790 NCBI chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,018...37,813,461 		JBrowse link
G CYCS cytochrome c, somatic multiple interactions ISO Edaravone inhibits the reaction [APP protein modified form results in increased expression of CYCS mRNA] CTD PMID:26111763 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260 		JBrowse link
G DAXX death domain associated protein decreases expression ISO Edaravone results in decreased expression of DAXX mRNA; Edaravone results in decreased expression of DAXX protein CTD PMID:17967739 NCBI chr 6:33,318,558...33,322,959
Ensembl chr 6:33,318,558...33,323,016 		JBrowse link
G EPHX2 epoxide hydrolase 2 multiple interactions ISO Edaravone inhibits the reaction [Cisplatin results in decreased expression of EPHX2 protein] CTD PMID:26165641 NCBI chr 8:27,491,143...27,548,626
Ensembl chr 8:27,490,781...27,545,564 		JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 increases expression ISO Edaravone results in increased expression of ERN1 mRNA CTD PMID:19558813 NCBI chr17:64,039,142...64,130,144
Ensembl chr17:64,039,080...64,130,819 		JBrowse link
G FADD Fas associated via death domain decreases expression ISO Edaravone results in decreased expression of FADD mRNA; Edaravone results in decreased expression of FADD protein CTD PMID:17967739 NCBI chr11:70,203,296...70,207,390
Ensembl chr11:70,203,296...70,207,390 		JBrowse link
G FKBP5 FKBP prolyl isomerase 5 multiple interactions ISO Edaravone inhibits the reaction [Corticosterone results in decreased expression of FKBP5 mRNA] CTD PMID:31344373 NCBI chr 6:35,573,590...35,728,583
Ensembl chr 6:35,573,585...35,728,583 		JBrowse link
G FLT1 fms related receptor tyrosine kinase 1 multiple interactions EXP Edaravone inhibits the reaction [cobaltous chloride results in increased expression of FLT1 mRNA]; Edaravone inhibits the reaction [cobaltous chloride results in increased expression of FLT1 protein] CTD PMID:24840734 NCBI chr13:28,300,346...28,495,128
Ensembl chr13:28,300,346...28,495,145 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions EXP [Edaravone inhibits the reaction [HIF1A protein binds to VEGFA promoter]] which affects the expression of VEGFA mRNA; Edaravone inhibits the reaction [HIF1A protein binds to VEGFA promoter]; Edaravone inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]; Edaravone inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein] CTD PMID:17889387 NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259 		JBrowse link
G HMOX1 heme oxygenase 1 increases expression
multiple interactions		 ISO Edaravone results in increased expression of HMOX1 mRNA; Edaravone results in increased expression of HMOX1 protein
Edaravone promotes the reaction [Carbon Monoxide results in increased expression of HMOX1 protein]		 CTD PMID:25348283 PMID:25422538 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G HSPA1A heat shock protein family A (Hsp70) member 1A decreases expression ISO Edaravone results in decreased expression of HSPA1A mRNA; Edaravone results in decreased expression of HSPA1A protein CTD PMID:19338546 PMID:19694712 NCBI chr 6:31,815,543...31,817,942
Ensembl chr 6:31,815,543...31,817,946 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Edaravone promotes the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of HSPA5 protein] CTD PMID:21429313 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 decreases expression ISO Edaravone results in decreased expression of ICAM1 mRNA; Edaravone results in decreased expression of ICAM1 protein alternative form CTD PMID:15948865 PMID:16301206 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G IFNG interferon gamma multiple interactions ISO Edaravone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IFNG mRNA]; Edaravone inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein] CTD PMID:12954792 PMID:15629513 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL10 interleukin 10 multiple interactions ISO Edaravone inhibits the reaction [Carbon Tetrachloride results in increased expression of IL10 mRNA]; Edaravone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL10 mRNA] CTD PMID:12954792 PMID:14567445 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL1A interleukin 1 alpha multiple interactions ISO Edaravone inhibits the reaction [Thioacetamide results in increased expression of IL1A mRNA] CTD PMID:36343683 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493 		JBrowse link
G IL1B interleukin 1 beta multiple interactions
decreases expression
decreases activity		 EXP
ISO		 Edaravone inhibits the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of IL1B mRNA]; Edaravone inhibits the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of IL1B protein]; Edaravone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Edaravone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
Edaravone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Edaravone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Edaravone inhibits the reaction [Thioacetamide results in increased expression of IL1B mRNA]
Edaravone results in decreased expression of IL1B mRNA
Edaravone inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Edaravone inhibits the reaction [[IL1B protein results in increased phosphorylation of AKT1 protein] which results in increased expression of IL1R1 mRNA]; Edaravone inhibits the reaction [[IL1B protein results in increased phosphorylation of AKT1 protein] which results in increased expression of IL1R1 protein]; Edaravone inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Edaravone inhibits the reaction [IL1B protein results in increased localization of and results in increased activity of RELA protein]; Edaravone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Edaravone inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased secretion of IL1B protein]; Edaravone inhibits the reaction [SDC2 protein results in increased expression of and results in increased secretion of IL1B protein]
Edaravone results in decreased activity of IL1B protein		 CTD PMID:15629513 PMID:15948865 PMID:16390820 PMID:18078833 PMID:18803305 More... NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL1R1 interleukin 1 receptor type 1 multiple interactions ISO Edaravone inhibits the reaction [[IL1B protein results in increased phosphorylation of AKT1 protein] which results in increased expression of IL1R1 mRNA]; Edaravone inhibits the reaction [[IL1B protein results in increased phosphorylation of AKT1 protein] which results in increased expression of IL1R1 protein] CTD PMID:18078833 NCBI chr 2:102,070,390...102,179,874
Ensembl chr 2:102,064,544...102,179,874 		JBrowse link
G IL4 interleukin 4 multiple interactions ISO Edaravone inhibits the reaction [Carbon Tetrachloride results in increased expression of IL4 mRNA] CTD PMID:14567445 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678 		JBrowse link
G IL6 interleukin 6 affects activity
decreases expression
multiple interactions		 ISO Edaravone affects the activity of IL6 protein
Edaravone results in decreased expression of IL6 mRNA
Edaravone inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; Edaravone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; Edaravone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]; Edaravone inhibits the reaction [Paraquat results in increased expression of IL6 protein]; Edaravone promotes the reaction [Taurocholic Acid results in increased expression of IL6 mRNA]		 CTD PMID:12954792 PMID:14567445 PMID:15629865 PMID:18031376 PMID:20035747 More... NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G INS-IGF2 INS-IGF2 readthrough multiple interactions ISO Edaravone inhibits the reaction [Streptozocin results in decreased secretion of INS1 protein] CTD PMID:18291360 NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209 		JBrowse link
G MAP3K5 mitogen-activated protein kinase kinase kinase 5 decreases activity ISO Edaravone results in decreased activity of MAP3K5 protein CTD PMID:15824197 NCBI chr 6:136,557,046...136,793,091
Ensembl chr 6:136,557,046...136,793,097 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases phosphorylation
decreases phosphorylation		 EXP
ISO		 Edaravone results in increased phosphorylation of MAPK8 protein
Edaravone results in decreased phosphorylation of MAPK8 protein		 CTD PMID:15824197 PMID:19954754 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G MMP2 matrix metallopeptidase 2 decreases expression
multiple interactions		 ISO Edaravone results in decreased expression of MMP2 protein
Edaravone inhibits the reaction [Paraquat results in increased expression of MMP2 mRNA]		 CTD PMID:19381132 PMID:21040696 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691 		JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions ISO Edaravone inhibits the reaction [PLAT protein results in increased expression of and results in increased activity of MMP9 protein]; Edaravone inhibits the reaction [PLAT protein results in increased expression of MMP9 mRNA] CTD PMID:19095969 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G MPO myeloperoxidase affects expression
decreases activity
multiple interactions
decreases expression		 ISO Edaravone affects the expression of MPO mRNA
Edaravone results in decreased activity of MPO protein
Edaravone inhibits the reaction [Taurocholic Acid results in increased activity of MPO protein]
Edaravone results in decreased expression of MPO protein		 CTD PMID:14654979 PMID:18031376 PMID:19694712 PMID:20035747 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935 		JBrowse link
G NCF1 neutrophil cytosolic factor 1 multiple interactions ISO Edaravone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NCF1 mRNA] CTD PMID:18643790 NCBI chr 7:74,774,011...74,789,315
Ensembl chr 7:74,774,011...74,789,315 		JBrowse link
G NDUFS1 NADH:ubiquinone oxidoreductase core subunit S1 multiple interactions ISO Edaravone inhibits the reaction [Rotenone results in decreased expression of NDUFS1 mRNA] CTD PMID:27108097 NCBI chr 2:206,114,817...206,159,444
Ensembl chr 2:206,114,817...206,159,509 		JBrowse link
G NDUFS4 NADH:ubiquinone oxidoreductase subunit S4 multiple interactions ISO Edaravone inhibits the reaction [Rotenone results in decreased expression of NDUFS4 mRNA] CTD PMID:27108097 NCBI chr 5:53,560,639...53,683,338
Ensembl chr 5:53,560,633...53,683,338 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 affects localization
multiple interactions		 ISO Edaravone affects the localization of NFE2L2 protein
[Edaravone co-treated with Chlorpyrifos] results in increased expression of NFE2L2 protein; Edaravone promotes the reaction [Carbon Monoxide results in increased expression of NFE2L2 protein]		 CTD PMID:25348283 PMID:25422538 PMID:30758894 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NFKBIA NFKB inhibitor alpha increases expression ISO Edaravone results in increased expression of NFKBIA mRNA CTD PMID:18078833 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NGF nerve growth factor increases expression
multiple interactions		 EXP Edaravone results in increased expression of NGF mRNA; Edaravone results in increased expression of NGF protein
pyrazolanthrone inhibits the reaction [Edaravone results in increased expression of NGF mRNA]; pyrazolanthrone inhibits the reaction [Edaravone results in increased expression of NGF protein]; U 0126 inhibits the reaction [Edaravone results in increased expression of NGF mRNA]; U 0126 inhibits the reaction [Edaravone results in increased expression of NGF protein]		 CTD PMID:19954754 NCBI chr 1:115,285,917...115,338,249
Ensembl chr 1:115,285,904...115,338,770 		JBrowse link
G NOS1 nitric oxide synthase 1 multiple interactions ISO Edaravone inhibits the reaction [Pilocarpine results in increased expression of NOS1 protein] CTD PMID:18672383 NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions
increases degradation
decreases expression		 ISO Edaravone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; Edaravone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]
Edaravone results in increased degradation of NOS2 mRNA
Edaravone results in decreased expression of NOS2 protein
Edaravone inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Edaravone inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Edaravone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Edaravone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Edaravone inhibits the reaction [Pilocarpine results in increased expression of NOS2 protein]		 CTD PMID:15629513 PMID:18078833 PMID:18496239 PMID:18672383 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NOS3 nitric oxide synthase 3 increases expression
decreases degradation		 ISO
EXP		 Edaravone results in increased expression of NOS3 mRNA; Edaravone results in increased expression of NOS3 protein
Edaravone results in decreased degradation of NOS3 mRNA		 CTD PMID:12969758 PMID:15721014 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588 		JBrowse link
G NPPA natriuretic peptide A decreases expression ISO Edaravone results in decreased expression of NPPA mRNA CTD PMID:15824197 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage EXP Edaravone analog results in increased cleavage of PARP1 protein CTD PMID:25684395 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PEPD peptidase D multiple interactions ISO Edaravone inhibits the reaction [Valproic Acid results in increased activity of PEPD protein] CTD PMID:34309930 NCBI chr19:33,386,950...33,521,791
Ensembl chr19:33,386,950...33,521,823 		JBrowse link
G PLAT plasminogen activator, tissue type multiple interactions ISO Edaravone inhibits the reaction [PLAT protein results in increased activity of RELA protein]; Edaravone inhibits the reaction [PLAT protein results in increased expression of and results in increased activity of MMP9 protein]; Edaravone inhibits the reaction [PLAT protein results in increased expression of MMP9 mRNA] CTD PMID:19095969 NCBI chr 8:42,174,718...42,207,565
Ensembl chr 8:42,174,718...42,207,709 		JBrowse link
G PON1 paraoxonase 1 multiple interactions ISO Edaravone inhibits the reaction [Valproic Acid results in decreased activity of PON1 protein] CTD PMID:34309930 NCBI chr 7:95,297,676...95,324,532
Ensembl chr 7:95,297,676...95,324,532 		JBrowse link
G PPARGC1A PPARG coactivator 1 alpha multiple interactions ISO Edaravone inhibits the reaction [Rotenone results in decreased expression of PPARGC1A mRNA] CTD PMID:30240821 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089 		JBrowse link
G PRNP prion protein (Kanno blood group) multiple interactions ISO Edaravone inhibits the reaction [PRNP protein alternative form results in decreased activity of SOD1 protein]; Edaravone inhibits the reaction [PRNP protein alternative form results in decreased activity of SOD2 protein]; Edaravone inhibits the reaction [PRNP protein alternative form results in increased activity of CASP3 protein] CTD PMID:20806394 NCBI chr20:4,686,456...4,701,588
Ensembl chr20:4,686,350...4,701,590 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression		 ISO Edaravone inhibits the reaction [IL1B protein results in increased localization of and results in increased activity of RELA protein]; Edaravone inhibits the reaction [PLAT protein results in increased activity of RELA protein]
Edaravone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]
Edaravone results in decreased expression of RELA protein		 CTD PMID:18078833 PMID:19095969 PMID:19381132 PMID:36343683 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G SDC2 syndecan 2 multiple interactions ISO Edaravone inhibits the reaction [SDC2 protein promotes the reaction [Oxygen deficiency results in increased abundance of Reactive Oxygen Species]]; Edaravone inhibits the reaction [SDC2 protein results in increased expression of and results in increased secretion of CCL2 protein]; Edaravone inhibits the reaction [SDC2 protein results in increased expression of and results in increased secretion of CXCL12 protein]; Edaravone inhibits the reaction [SDC2 protein results in increased expression of and results in increased secretion of IL1B protein]; Edaravone inhibits the reaction [SDC2 protein results in increased expression of and results in increased secretion of TNF protein] CTD PMID:18803305 NCBI chr 8:96,493,813...96,611,790
Ensembl chr 8:96,493,813...96,611,790 		JBrowse link
G SELE selectin E decreases expression ISO Edaravone results in decreased expression of SELE mRNA; Edaravone results in decreased expression of SELE protein CTD PMID:17064733 NCBI chr 1:169,722,640...169,734,079
Ensembl chr 1:169,722,640...169,764,705 		JBrowse link
G SLC6A15 solute carrier family 6 member 15 multiple interactions ISO Edaravone inhibits the reaction [Corticosterone results in decreased expression of SLC6A15 mRNA] CTD PMID:31344373 NCBI chr12:84,859,491...84,912,799
Ensembl chr12:84,859,491...84,913,629 		JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions ISO Edaravone inhibits the reaction [PRNP protein alternative form results in decreased activity of SOD1 protein] CTD PMID:20806394 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931 		JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions ISO Edaravone inhibits the reaction [PRNP protein alternative form results in decreased activity of SOD2 protein] CTD PMID:20806394 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO Edaravone inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA] CTD PMID:21040696 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TH tyrosine hydroxylase multiple interactions ISO Edaravone inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:27108097 NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815 		JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO Edaravone inhibits the reaction [Paraquat results in increased expression of TIMP1 mRNA] CTD PMID:21040696 NCBI chr  X:47,582,436...47,586,789
Ensembl chr  X:47,582,408...47,586,789 		JBrowse link
G TNF tumor necrosis factor multiple interactions
decreases expression		 ISO Edaravone inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; Edaravone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; Edaravone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; Edaravone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Edaravone inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased secretion of TNF protein]; Edaravone inhibits the reaction [Paraquat results in increased expression of TNF protein]; Edaravone inhibits the reaction [SDC2 protein results in increased expression of and results in increased secretion of TNF protein]; Edaravone promotes the reaction [Taurocholic Acid results in increased expression of TNF mRNA]
Edaravone inhibits the reaction [Thioacetamide results in increased expression of TNF mRNA]
Edaravone results in decreased expression of TNF mRNA; Edaravone results in decreased expression of TNF protein		 CTD PMID:12954792 PMID:14567445 PMID:15629513 PMID:15948865 PMID:17064733 More... NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G UCP2 uncoupling protein 2 multiple interactions ISO Edaravone inhibits the reaction [Isoproterenol results in increased expression of UCP2 mRNA]; Edaravone inhibits the reaction [Isoproterenol results in increased expression of UCP2 protein] CTD PMID:16580698 NCBI chr11:73,974,672...73,983,202
Ensembl chr11:73,974,672...73,982,843 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 decreases expression ISO Edaravone results in decreased expression of VCAM1 protein CTD PMID:19381132 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045 		JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions EXP [Edaravone inhibits the reaction [HIF1A protein binds to VEGFA promoter]] which affects the expression of VEGFA mRNA; Edaravone inhibits the reaction [HIF1A protein binds to VEGFA promoter]; Edaravone inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; Edaravone inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein] CTD PMID:17889387 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
G WDR35 WD repeat domain 35 multiple interactions ISO Edaravone inhibits the reaction [domoic acid results in increased expression of WDR35 protein] CTD PMID:23289926 NCBI chr 2:19,910,263...19,990,105
Ensembl chr 2:19,910,263...19,990,105 		JBrowse link
G XDH xanthine dehydrogenase multiple interactions ISO Edaravone inhibits the reaction [Valproic Acid results in increased activity of XDH protein] CTD PMID:34309930 NCBI chr 2:31,334,321...31,414,742
Ensembl chr 2:31,334,321...31,414,742 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26040
    role 25956
      chemical role 24245
        antioxidant 17490
          edaravone 81
Path 2
Term Annotations click to browse term
  CHEBI ontology 26040
    subatomic particle 26015
      composite particle 26015
        hadron 26015
          baryon 26015
            nucleon 26015
              atomic nucleus 26015
                atom 26015
                  main group element atom 25840
                    p-block element atom 25840
                      carbon group element atom 25437
                        carbon atom 25395
                          organic molecular entity 25395
                            organic molecule 25223
                              organic cyclic compound 24277
                                organic heterocyclic compound 22320
                                  heteroarene 18775
                                    monocyclic heteroarene 16136
                                      azole 15693
                                        diazole 11194
                                          pyrazoles 2626
                                            pyrazolone 85
                                              edaravone 81
paths to the root