Gene: PRNP (prion protein)  Homo sapiens Symbol: PRNP Name: prion protein Description: The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012] Type: protein-coding RefSeq Status: REVIEWED Also known as: alternative prion protein; major prion protein; AltPrP; ASCR; CD230; CD230 antigen; CJD; GSS; KURU; major prion protein; MGC26679; OTTHUMP00000030161; OTTHUMP00000030162; OTTHUMP00000030163; OTTHUMP00000161139; p27-30; p27-30; prion; prion protein; prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia); prion protein PrP; prion-related protein; PRIP; PrP; PrP27-30; PrP33-35C; PrPc Orthologs: Mus musculus : Prnp (prion protein)  MGI Rattus norvegicus : Prnp (prion protein) Latest Assembly: Human Genome Assembly GRCh37 Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 20 4,613,933 - 4,629,372 + NCBI Human Genome Assembly HuRef 20 4,620,194 - 4,635,632 + NCBI Human Genome Assembly GRCh37 20 4,666,797 - 4,682,234 + NCBI Human Genome Assembly Build 36 20 4,614,797 - 4,630,234 + NCBI Human Cytogenetic Map 20 p13   NCBI Human Genome Assembly 20 4,615,068 - 4,630,233   NCBI Model Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19) Annotation    (Toggle Detail/Summary View) Disease Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Creutzfeldt-Jakob Syndrome   IAGP   1599946 DNA:mutation RGD   Creutzfeldt-Jakob Syndrome   IEA   7240710   OMIM   Gerstmann-Straussler-Scheinker Disease   IEA   7240710   OMIM   Huntington Disease-Like 1   IEA   7240710   OMIM   Hyperglycemia   ISS RGD:3410 1599950   RGD   Insomnia, Fatal Familial   IEA   7240710   OMIM   Spongiform Encephalopathy with Neuropsychiatric Features   IEA   7240710   OMIM   Gene-Chemical Interaction Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) 17alpha-ethynylestradiol multiple interactions ISO RGD:11160 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRNP mRNA CTD PMID:17942748 17alpha-ethynylestradiol increases expression ISO RGD:3410 6480464 Ethinyl Estradiol results in increased expression of PRNP mRNA CTD PMID:12075121 17beta-estradiol affects expression EXP   6480464 Estradiol affects the expression of PRNP mRNA CTD PMID:22574217 17beta-hydroxy-5alpha-androstan-3-one decreases expression ISO RGD:11160 6480464 Dihydrotestosterone results in decreased expression of PRNP mRNA CTD PMID:17023530 2,2,2-tetramine increases expression ISO RGD:3410 6480464 Trientine results in increased expression of PRNP mRNA; more ... CTD PMID:22362149 2,2,2-tetramine affects response to substance ISO RGD:3410 6480464 PRNP protein affects the susceptibility to Trientine CTD PMID:22362149 2,2,2-trifluoroethanol affects folding EXP   6480464 Trifluoroethanol affects the folding of PRNP protein modified form CTD PMID:20936829 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:11160 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRNP mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:11160 6480464 Tetrachlorodibenzodioxin affects the expression of PRNP mRNA CTD PMID:21570461 2-methoxyethanol increases expression ISO RGD:3410 6480464 methyl cellosolve results in increased expression of PRNP mRNA CTD PMID:21061450 4,4'-diaminodiphenylmethane decreases expression ISO RGD:11160 6480464 4,4'-diaminodiphenylmethane results in decreased expression of PRNP mRNA CTD PMID:18648102 5-fluorouracil decreases response to substance EXP   6480464 PRNP protein results in decreased susceptibility to Fluorouracil CTD PMID:15386405 acetylsalicylic acid increases expression ISO RGD:3410 6480464 Aspirin results in increased expression of PRNP mRNA CTD PMID:12800193 aflatoxin B1 decreases expression ISO RGD:11160 6480464 Aflatoxin B1 results in decreased expression of PRNP mRNA CTD PMID:19770486 aflatoxin B1 increases expression EXP   6480464 Aflatoxin B1 results in increased expression of PRNP mRNA CTD PMID:22100608 all-trans-retinoic acid increases expression EXP   6480464 Tretinoin results in increased expression of PRNP mRNA CTD PMID:21934132 all-trans-retinoic acid decreases expression ISO RGD:3410 6480464 Tretinoin results in decreased expression of PRNP mRNA CTD PMID:20488242 all-trans-retinoic acid decreases expression EXP   6480464 Tretinoin results in decreased expression of PRNP mRNA CTD PMID:15498508 ammonium chloride affects expression ISO RGD:3410 6480464 Ammonium Chloride affects the expression of PRNP mRNA CTD PMID:16483693 bathocuproine disulfonic acid multiple interactions ISO RGD:3410 6480464 bathocuproine sulfonate inhibits the reaction [cupric chloride results in increased expression of PRNP protein] CTD PMID:16148034 benzene increases expression EXP   6480464 Benzene results in increased expression of PRNP mRNA CTD PMID:20359517 benzo[a]pyrene multiple interactions ISO RGD:11160 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to PRNP promoter] CTD PMID:19654925 benzo[a]pyrene increases expression ISO RGD:3410 6480464 Benzo(a)pyrene results in increased expression of PRNP mRNA CTD PMID:21839799 benzo[a]pyrene multiple interactions ISO RGD:11160 6480464 [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in increased expression of PRNP mRNA CTD PMID:21715664 bisphenol A decreases expression EXP   6480464 bisphenol A results in decreased expression of PRNP mRNA CTD PMID:20678512 bisphenol A increases expression ISO RGD:3410 6480464 bisphenol A results in increased expression of PRNP mRNA CTD PMID:12075121 butyric acid increases expression ISO RGD:3410 6480464 Butyric Acid results in increased expression of PRNP mRNA CTD PMID:12800193 cadmium dichloride increases expression EXP   6480464 Cadmium Chloride results in increased expression of PRNP mRNA CTD PMID:12760830 cadmium dichloride increases expression ISO RGD:3410 6480464 Cadmium Chloride results in increased expression of PRNP mRNA CTD PMID:16148034 caffeine decreases expression EXP   6480464 Caffeine results in decreased expression of PRNP mRNA CTD PMID:18444173 calcitriol increases expression EXP   6480464 Calcitriol results in increased expression of PRNP mRNA CTD PMID:16002434 cisplatin decreases response to substance EXP   6480464 PRNP protein results in decreased susceptibility to Cisplatin CTD PMID:15386405 Congo Red decreases expression ISO RGD:11160 6480464 Congo Red results in decreased expression of PRNP protein alternative form CTD PMID:11994310 copper atom affects binding EXP   6480464 PRNP protein binds to Copper CTD PMID:16847141 PMID:17112476 copper atom decreases response to substance ISO RGD:11160 6480464 PRNP protein results in decreased susceptibility to Copper CTD PMID:12500977 PMID:16787422 copper atom affects binding ISO RGD:11160 6480464 PRNP protein binds to Copper CTD PMID:12500977 more ... copper atom affects binding EXP   6480464 Copper binds to PRNP protein CTD PMID:16824036 more ... copper atom increases uptake ISO RGD:3410 6480464 PRNP protein results in increased uptake of Copper CTD PMID:22362149 PMID:19957168 copper atom multiple interactions ISO RGD:11160 6480464 PRNP protein affects the reaction [Copper results in increased nitrosation of GPC1 protein] CTD PMID:18717736 copper atom affects binding ISO RGD:11160 6480464 PRNP protein binds to Copper CTD PMID:16787422 more ... copper atom multiple interactions ISO RGD:11160 6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of PRNP mRNA CTD PMID:15467011 copper atom multiple interactions ISO RGD:11160 6480464 CAT protein inhibits the reaction [[Hydrogen Peroxide co-treated with Copper] results in increased cleavage of PRNP protein]; more ... CTD PMID:16595185 copper atom increases reduction EXP   6480464 PRNP protein results in increased reduction of Copper CTD PMID:12572668 copper atom decreases response to substance ISO RGD:11160 6480464 PRNP protein results in decreased susceptibility to Copper CTD PMID:16787422 PMID:12500977 copper atom multiple interactions ISO RGD:11160 6480464 [Copper co-treated with Filipin] results in increased cleavage of PRNP protein CTD PMID:19597535 copper atom increases cleavage EXP   6480464 Copper results in increased cleavage of PRNP protein CTD PMID:19597535 copper atom multiple interactions EXP   6480464 [Copper co-treated with NADP] promotes the reaction [PRNP protein binds to PRNP protein]; more ... CTD PMID:19149680 copper atom affects binding EXP   6480464 Copper binds to PRNP protein CTD PMID:19697239 more ... copper atom increases transport ISO RGD:11160 6480464 Copper results in increased transport of PRNP protein CTD PMID:21172064 copper atom multiple interactions EXP   6480464 Copper affects the reaction [1,2-Dipalmitoylphosphatidylcholine affects the folding of PRNP protein modified form] CTD PMID:20936829 copper atom multiple interactions EXP   6480464 [Copper binds to PRNP protein] which results in increased reduction of Copper; more ... CTD PMID:19697239 copper atom affects binding EXP   6480464 Copper binds to PRNP protein CTD PMID:17126907 more ... copper atom affects folding EXP   6480464 Copper affects the folding of PRNP protein modified form CTD PMID:20936829 copper atom increases uptake ISO RGD:3410 6480464 PRNP protein results in increased uptake of Copper CTD PMID:19957168 PMID:22362149 copper atom increases expression ISO RGD:3410 6480464 Copper results in increased expression of PRNP mRNA CTD PMID:22465980 copper atom increases expression ISO RGD:3410 6480464 Copper deficiency results in increased expression of PRNP mRNA; more ... CTD PMID:22362149 copper atom multiple interactions ISO RGD:11160 6480464 Copper promotes the reaction [PRNP protein binds to GRIN1 protein] CTD PMID:22307640 copper atom multiple interactions ISO RGD:3410 6480464 [PRNP protein results in increased uptake of Copper] which results in increased activity of SOD1 protein CTD PMID:22362149 copper atom affects binding EXP   6480464 Copper binds to PRNP protein CTD PMID:17126907 more ... copper atom affects binding ISO RGD:11160 6480464 Copper binds to PRNP protein CTD PMID:16990274 PMID:16698781 copper atom affects binding EXP   6480464 Copper binds to PRNP protein CTD PMID:16831968 more ... copper atom affects binding ISO RGD:11160 6480464 PRNP protein binds to Copper CTD PMID:17112476 PMID:16787422 copper atom affects binding EXP   6480464 Copper binds to PRNP protein CTD PMID:16824036 more ... copper atom affects binding ISO RGD:11160 6480464 PRNP protein binds to Copper CTD PMID:16787422 PMID:17112476 copper atom decreases response to substance ISO RGD:11160 6480464 PRNP protein results in decreased susceptibility to Copper CTD PMID:16787422 copper atom increases uptake ISO RGD:11160 6480464 Copper results in increased uptake of PRNP protein CTD PMID:17155929 copper atom affects binding ISO RGD:11160 6480464 Copper binds to PRNP protein CTD PMID:16698781 PMID:16990274 copper atom multiple interactions ISO RGD:11160 6480464 Copper affects the reaction [LRP1 protein results in increased uptake of PRNP protein] CTD PMID:17155929 copper atom multiple interactions EXP   6480464 [PRNP protein binds to Copper] which results in increased activity of SOD1 protein CTD PMID:17112476 copper atom affects binding EXP   6480464 PRNP protein polymorphism binds to Copper CTD PMID:16847141 copper atom multiple interactions ISO RGD:11160 6480464 Copper affects the localization of [GPC1 protein co-treated with PRNP protein] CTD PMID:16923158 copper atom affects binding EXP   6480464 Copper binds to PRNP protein CTD PMID:16824036 more ... copper(0) affects binding EXP   6480464 PRNP protein binds to Copper CTD PMID:16847141 PMID:17112476 copper(0) decreases response to substance ISO RGD:11160 6480464 PRNP protein results in decreased susceptibility to Copper CTD PMID:12500977 PMID:16787422 copper(0) affects binding ISO RGD:11160 6480464 PRNP protein binds to Copper CTD PMID:12500977 more ... copper(0) affects binding EXP   6480464 Copper binds to PRNP protein CTD PMID:16824036 more ... copper(0) increases uptake ISO RGD:3410 6480464 PRNP protein results in increased uptake of Copper CTD PMID:22362149 PMID:19957168 copper(0) multiple interactions ISO RGD:11160 6480464 PRNP protein affects the reaction [Copper results in increased nitrosation of GPC1 protein] CTD PMID:18717736 copper(0) affects binding ISO RGD:11160 6480464 PRNP protein binds to Copper CTD PMID:16787422 more ... copper(0) multiple interactions ISO RGD:11160 6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of PRNP mRNA CTD PMID:15467011 copper(0) multiple interactions ISO RGD:11160 6480464 CAT protein inhibits the reaction [[Hydrogen Peroxide co-treated with Copper] results in increased cleavage of PRNP protein]; more ... CTD PMID:16595185 copper(0) increases reduction EXP   6480464 PRNP protein results in increased reduction of Copper CTD PMID:12572668 copper(0) decreases response to substance ISO RGD:11160 6480464 PRNP protein results in decreased susceptibility to Copper CTD PMID:16787422 PMID:12500977 copper(0) multiple interactions ISO RGD:11160 6480464 [Copper co-treated with Filipin] results in increased cleavage of PRNP protein CTD PMID:19597535 copper(0) increases cleavage EXP   6480464 Copper results in increased cleavage of PRNP protein CTD PMID:19597535 copper(0) multiple interactions EXP   6480464 [Copper co-treated with NADP] promotes the reaction [PRNP protein binds to PRNP protein]; more ... CTD PMID:19149680 copper(0) affects binding EXP   6480464 Copper binds to PRNP protein CTD PMID:19697239 more ... copper(0) increases transport ISO RGD:11160 6480464 Copper results in increased transport of PRNP protein CTD PMID:21172064 copper(0) multiple interactions EXP   6480464 Copper affects the reaction [1,2-Dipalmitoylphosphatidylcholine affects the folding of PRNP protein modified form] CTD PMID:20936829 copper(0) multiple interactions EXP   6480464 [Copper binds to PRNP protein] which results in increased reduction of Copper; more ... CTD PMID:19697239 copper(0) affects binding EXP   6480464 Copper binds to PRNP protein CTD PMID:17126907 more ... copper(0) affects folding EXP   6480464 Copper affects the folding of PRNP protein modified form CTD PMID:20936829 copper(0) increases uptake ISO RGD:3410 6480464 PRNP protein results in increased uptake of Copper CTD PMID:19957168 PMID:22362149 copper(0) increases expression ISO RGD:3410 6480464 Copper results in increased expression of PRNP mRNA CTD PMID:22465980 copper(0) increases expression ISO RGD:3410 6480464 Copper deficiency results in increased expression of PRNP mRNA; more ... CTD PMID:22362149 copper(0) multiple interactions ISO RGD:11160 6480464 Copper promotes the reaction [PRNP protein binds to GRIN1 protein] CTD PMID:22307640 copper(0) multiple interactions ISO RGD:3410 6480464 [PRNP protein results in increased uptake of Copper] which results in increased activity of SOD1 protein CTD PMID:22362149 copper(0) affects binding EXP   6480464 Copper binds to PRNP protein CTD PMID:17126907 more ... copper(0) affects binding ISO RGD:11160 6480464 Copper binds to PRNP protein CTD PMID:16990274 PMID:16698781 copper(0) affects binding EXP   6480464 Copper binds to PRNP protein CTD PMID:16831968 more ... copper(0) affects binding ISO RGD:11160 6480464 PRNP protein binds to Copper CTD PMID:17112476 PMID:16787422 copper(0) affects binding EXP   6480464 Copper binds to PRNP protein CTD PMID:16824036 more ... copper(0) affects binding ISO RGD:11160 6480464 PRNP protein binds to Copper CTD PMID:16787422 PMID:17112476 copper(0) decreases response to substance ISO RGD:11160 6480464 PRNP protein results in decreased susceptibility to Copper CTD PMID:16787422 copper(0) increases uptake ISO RGD:11160 6480464 Copper results in increased uptake of PRNP protein CTD PMID:17155929 copper(0) affects binding ISO RGD:11160 6480464 Copper binds to PRNP protein CTD PMID:16698781 PMID:16990274 copper(0) multiple interactions ISO RGD:11160 6480464 Copper affects the reaction [LRP1 protein results in increased uptake of PRNP protein] CTD PMID:17155929 copper(0) multiple interactions EXP   6480464 [PRNP protein binds to Copper] which results in increased activity of SOD1 protein CTD PMID:17112476 copper(0) affects binding EXP   6480464 PRNP protein polymorphism binds to Copper CTD PMID:16847141 copper(0) multiple interactions ISO RGD:11160 6480464 Copper affects the localization of [GPC1 protein co-treated with PRNP protein] CTD PMID:16923158 copper(0) affects binding EXP   6480464 Copper binds to PRNP protein CTD PMID:16824036 more ... copper(2+) sulfate affects binding EXP   6480464 PRNP protein binds to Copper Sulfate; more ... CTD PMID:16847141 copper(2+) sulfate multiple interactions ISO RGD:11160 6480464 Copper Sulfate results in increased uptake of and affects the localization of PRNP protein; more ... CTD PMID:11994310 copper(2+) sulfate multiple interactions EXP   6480464 Filipin inhibits the reaction [Copper Sulfate results in increased uptake of and affects the localization of PRNP protein]; more ... CTD PMID:11994310 copper(2+) sulfate increases expression EXP   6480464 Copper Sulfate results in increased expression of PRNP mRNA CTD PMID:19549813 copper(2+) sulfate affects binding ISO RGD:11160 6480464 PRNP protein binds to Copper Sulfate CTD PMID:16787422 copper(2+) sulfate decreases response to substance ISO RGD:11160 6480464 PRNP protein results in decreased susceptibility to Copper Sulfate CTD PMID:16787422 copper(II) chloride multiple interactions ISO RGD:11160 6480464 [NADP co-treated with cupric chloride] promotes the reaction [PRNP protein binds to PRNP protein] CTD PMID:16990274 copper(II) chloride multiple interactions ISO RGD:3410 6480464 bathocuproine sulfonate inhibits the reaction [cupric chloride results in increased expression of PRNP protein] CTD PMID:16148034 copper(II) chloride increases expression ISO RGD:3410 6480464 cupric chloride results in increased expression of PRNP mRNA; more ... CTD PMID:16148034 cyclosporin A increases expression EXP   6480464 Cyclosporine results in increased expression of PRNP mRNA CTD PMID:20106945 cyclosporin A increases expression ISO RGD:11160 6480464 Cyclosporine results in increased expression of PRNP mRNA CTD PMID:19770486 cytarabine decreases expression EXP   6480464 Cytarabine results in decreased expression of PRNP mRNA CTD PMID:21198554 D-glucose multiple interactions EXP   6480464 [PRNP protein results in increased expression of SLC2A1 protein] which results in increased uptake of Glucose CTD PMID:21265952 dichloromethane increases expression EXP   6480464 Methylene Chloride results in increased expression of PRNP mRNA CTD PMID:20359517 dioxygen increases expression EXP   6480464 Oxygen deficiency results in increased expression of PRNP mRNA; more ... CTD PMID:17387271 dioxygen multiple interactions ISO RGD:11160 6480464 Oxygen inhibits the reaction [Oxygen deficiency results in increased expression of PRNP mRNA] CTD PMID:22629407 dioxygen increases expression ISO RGD:11160 6480464 Oxygen deficiency results in increased expression of PRNP mRNA CTD PMID:22629407 dioxygen multiple interactions EXP   6480464 PD 98059 inhibits the reaction [Oxygen deficiency results in increased expression of PRNP mRNA] CTD PMID:17387271 doxorubicin decreases response to substance EXP   6480464 PRNP protein results in decreased susceptibility to Doxorubicin CTD PMID:15386405 edaravone multiple interactions ISO RGD:3410 6480464 phenylmethylpyrazolone inhibits the reaction [PRNP protein alternative form results in decreased activity of SOD1 protein]; more ... CTD PMID:20806394 ethylbenzene increases expression EXP   6480464 ethylbenzene results in increased expression of PRNP mRNA CTD PMID:20359517 ethylenediaminetetraacetic acid multiple interactions ISO RGD:11160 6480464 Edetic Acid inhibits the reaction [[Hydrogen Peroxide co-treated with Iron] results in increased cleavage of PRNP protein]; more ... CTD PMID:16595185 etoposide decreases response to substance EXP   6480464 PRNP protein results in decreased susceptibility to Etoposide CTD PMID:15386405 genistein increases expression ISO RGD:3410 6480464 Genistein results in increased expression of PRNP mRNA CTD PMID:12075121 genistein increases expression EXP   6480464 Genistein results in increased expression of PRNP mRNA CTD PMID:18444173 glucose multiple interactions EXP   6480464 [PRNP protein results in increased expression of SLC2A1 protein] which results in increased uptake of Glucose CTD PMID:21265952 glutathione multiple interactions ISO RGD:11160 6480464 PRNP protein inhibits the reaction [manganese chloride results in decreased abundance of Glutathione] CTD PMID:17483122 heparan sulfate affects binding ISO RGD:11160 6480464 PRNP protein modified form binds to Heparitin Sulfate metabolite CTD PMID:18717736 hydrogen peroxide increases expression EXP   6480464 Hydrogen Peroxide results in increased expression of PRNP mRNA CTD PMID:12419474 hydrogen peroxide decreases response to substance ISO RGD:11160 6480464 PRNP protein results in decreased susceptibility to Hydrogen Peroxide CTD PMID:17483122 hydrogen peroxide increases response to substance ISO RGD:11160 6480464 PRNP protein results in increased susceptibility to Hydrogen Peroxide CTD PMID:12500977 hydrogen peroxide multiple interactions ISO RGD:11160 6480464 CAT protein inhibits the reaction [[Hydrogen Peroxide co-treated with Copper] results in increased cleavage of PRNP protein]; more ... CTD PMID:16595185 iron atom multiple interactions ISO RGD:11160 6480464 Edetic Acid inhibits the reaction [[Hydrogen Peroxide co-treated with Iron] results in increased cleavage of PRNP protein] CTD PMID:16595185 manganese atom increases stability ISO RGD:11160 6480464 Manganese results in increased stability of PRNP protein CTD PMID:20176619 manganese atom affects binding ISO RGD:11160 6480464 PRNP protein binds to Manganese CTD PMID:16595185 manganese atom multiple interactions ISO RGD:11160 6480464 CAT protein inhibits the reaction [[[PRNP protein binds to Manganese] which co-treated with Hydrogen Peroxide] results in increased cleavage of [PRNP protein binds to PRNP protein]]; more ... CTD PMID:16595185 manganese(0) increases stability ISO RGD:11160 6480464 Manganese results in increased stability of PRNP protein CTD PMID:20176619 manganese(0) affects binding ISO RGD:11160 6480464 PRNP protein binds to Manganese CTD PMID:16595185 manganese(0) multiple interactions ISO RGD:11160 6480464 CAT protein inhibits the reaction [[[PRNP protein binds to Manganese] which co-treated with Hydrogen Peroxide] results in increased cleavage of [PRNP protein binds to PRNP protein]]; more ... CTD PMID:16595185 manganese(II) chloride multiple interactions ISO RGD:11160 6480464 PRNP protein inhibits the reaction [manganese chloride results in decreased abundance of Glutathione]; more ... CTD PMID:17483122 manganese(II) chloride decreases response to substance ISO RGD:11160 6480464 PRNP protein results in decreased susceptibility to manganese chloride CTD PMID:17483122 methotrexate decreases expression EXP   6480464 Methotrexate results in decreased expression of PRNP mRNA CTD PMID:17400583 mitomycin C increases expression EXP   6480464 Mitomycin results in increased expression of PRNP mRNA CTD PMID:12760830 mono(2-ethylhexyl) phthalate increases expression EXP   6480464 mono-(2-ethylhexyl)phthalate results in increased expression of PRNP mRNA CTD PMID:23360888 N-nitrosodiethylamine increases expression ISO RGD:3410 6480464 Diethylnitrosamine results in increased expression of PRNP mRNA CTD PMID:19638242 NADP zwitterion multiple interactions ISO RGD:11160 6480464 [NADP co-treated with cupric chloride] promotes the reaction [PRNP protein binds to PRNP protein] CTD PMID:16990274 NADP zwitterion multiple interactions EXP   6480464 [Copper co-treated with NADP] promotes the reaction [PRNP protein binds to PRNP protein]; more ... CTD PMID:19149680 NADP(+) multiple interactions ISO RGD:11160 6480464 [NADP co-treated with cupric chloride] promotes the reaction [PRNP protein binds to PRNP protein] CTD PMID:16990274 NADP(+) multiple interactions EXP   6480464 [Copper co-treated with NADP] promotes the reaction [PRNP protein binds to PRNP protein]; more ... CTD PMID:19149680 nickel atom affects binding EXP   6480464 Nickel binds to PRNP protein CTD PMID:17126907 nickel atom multiple interactions ISO RGD:11160 6480464 Nickel inhibits the reaction [PRNP protein binds to PRNP protein] CTD PMID:16595185 nitroprusside multiple interactions EXP   6480464 [Nitroprusside results in increased abundance of nitrosonium ion] which results in increased expression of PRNP mRNA CTD PMID:12393473 o-xylene increases expression EXP   6480464 2-xylene results in increased expression of PRNP mRNA CTD PMID:20359517 paracetamol increases expression EXP   6480464 Acetaminophen results in increased expression of PRNP mRNA CTD PMID:21420995 paracetamol increases expression EXP   6480464 Acetaminophen results in increased expression of PRNP mRNA CTD PMID:21420995 PMID:22230336 paraquat decreases response to substance ISO RGD:11160 6480464 PRNP protein results in decreased susceptibility to Paraquat CTD PMID:17896796 PMID:15451062 paraquat decreases response to substance ISO RGD:11160 6480464 PRNP protein results in decreased susceptibility to Paraquat CTD PMID:15451062 PMID:17896796 pirinixic acid decreases expression ISO RGD:11160 6480464 pirinixic acid results in decreased expression of PRNP mRNA CTD PMID:17426115 progesterone increases expression EXP   6480464 Progesterone results in increased expression of PRNP mRNA CTD PMID:18037150 silver atom affects expression ISO RGD:11160 6480464 Silver affects the expression of PRNP mRNA CTD PMID:19429238 silver(0) affects expression ISO RGD:11160 6480464 Silver affects the expression of PRNP mRNA CTD PMID:19429238 tamibarotene affects expression EXP   6480464 Am 80 affects the expression of PRNP mRNA; more ... CTD PMID:15498508 tert-butyl hydroperoxide increases expression EXP   6480464 tert-Butylhydroperoxide results in increased expression of PRNP mRNA CTD PMID:15336504 tetracycline affects binding EXP   6480464 Tetracycline binds to PRNP protein CTD PMID:10903871 tetracycline multiple interactions EXP   6480464 Tetracycline inhibits the reaction [PRNP protein binds to PRNP protein] CTD PMID:10903871 toluene increases expression EXP   6480464 Toluene results in increased expression of PRNP mRNA CTD PMID:20359517 trichloroethene decreases expression ISO RGD:11160 6480464 Trichloroethylene results in decreased expression of PRNP mRNA CTD PMID:19448997 trichloroethene increases expression EXP   6480464 Trichloroethylene results in increased expression of PRNP mRNA CTD PMID:20359517 ursodeoxycholic acid decreases expression ISO RGD:3410 6480464 Ursodeoxycholic Acid results in decreased expression of PRNP mRNA CTD PMID:15885361 valproic acid increases expression EXP   6480464 Valproic Acid results in increased expression of PRNP mRNA CTD PMID:19101580 vincristine decreases response to substance EXP   6480464 PRNP protein results in decreased susceptibility to Vincristine CTD PMID:15386405 zinc atom affects localization ISO RGD:11160 6480464 PRNP protein affects the localization of Zinc CTD PMID:19486831 zinc atom decreases response to substance ISO RGD:11160 6480464 PRNP protein results in decreased susceptibility to Zinc CTD PMID:19486831 zinc oxide increases expression EXP   6480464 Zinc Oxide results in increased expression of PRNP mRNA CTD PMID:19755143 zinc(0) affects localization ISO RGD:11160 6480464 PRNP protein affects the localization of Zinc CTD PMID:19486831 zinc(0) decreases response to substance ISO RGD:11160 6480464 PRNP protein results in decreased susceptibility to Zinc CTD PMID:19486831 Gene Ontology Annotations Biological Process Term Qualifier Evidence With Reference Notes Source Original Reference(s) axon guidance   TAS   2290271 Reactome:REACT_18266 Reactome Reactome:REACT_18266 cell cycle arrest   IEA UniProtKB-KW:KW-0338 2290271 GO_REF:0000037 UniProtKB GO_REF:0000037 cellular copper ion homeostasis   NAS   2290271 PMID:16004966 UniProtKB PMID:16004966 learning or memory   IEA Ensembl:ENSRNOP00000028881 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 metabolic process   TAS   2290271 PMID:3755672 PINC PMID:3755672 negative regulation of activated T cell proliferation   ISS UniProtKB:P04925 2290271 GO_REF:0000024 BHF-UCL GO_REF:0000024 negative regulation of activated T cell proliferation   IEA Ensembl:ENSMUSP00000088833 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of apoptotic process   IEA Ensembl:ENSMUSP00000088833 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of apoptotic process   IEA Ensembl:ENSRNOP00000028881 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of calcineurin-NFAT signaling cascade   ISS UniProtKB:P04925 2290271 GO_REF:0000024 BHF-UCL GO_REF:0000024 negative regulation of calcineurin-NFAT signaling cascade   IEA Ensembl:ENSMUSP00000088833 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of interferon-gamma production   ISS UniProtKB:P04925 2290271 GO_REF:0000024 BHF-UCL GO_REF:0000024 negative regulation of interferon-gamma production   IEA Ensembl:ENSMUSP00000088833 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of interleukin-17 production   ISS UniProtKB:P04925 2290271 GO_REF:0000024 BHF-UCL GO_REF:0000024 negative regulation of interleukin-17 production   IEA Ensembl:ENSMUSP00000088833 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of interleukin-2 production   ISS UniProtKB:P04925 2290271 GO_REF:0000024 BHF-UCL GO_REF:0000024 negative regulation of interleukin-2 production   IEA Ensembl:ENSMUSP00000088833 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of protein phosphorylation   ISS UniProtKB:P04925 2290271 GO_REF:0000024 BHF-UCL GO_REF:0000024 negative regulation of protein phosphorylation   IEA Ensembl:ENSMUSP00000088833 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of sequence-specific DNA binding transcription factor activity   ISS UniProtKB:P04925 2290271 GO_REF:0000024 BHF-UCL GO_REF:0000024 negative regulation of sequence-specific DNA binding transcription factor activity   IEA Ensembl:ENSMUSP00000088833 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of T cell receptor signaling pathway   ISS UniProtKB:P04925 2290271 GO_REF:0000024 BHF-UCL GO_REF:0000024 negative regulation of T cell receptor signaling pathway   IEA Ensembl:ENSMUSP00000088833 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 protein homooligomerization   IEA InterPro:IPR000817|InterPro:IPR022416 2290271 GO_REF:0000002 InterPro GO_REF:0000002 response to cadmium ion   IEA Ensembl:ENSRNOP00000028881 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 response to copper ion   IEA Ensembl:ENSRNOP00000028881 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 response to oxidative stress   ISS UniProtKB:P04925 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 response to oxidative stress   IEA Ensembl:ENSMUSP00000088833 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 Cellular Component Term Qualifier Evidence With Reference Notes Source Original Reference(s) anchored to membrane   IEA UniProtKB-KW:KW-0336 2290271 GO_REF:0000037 UniProtKB GO_REF:0000037 cytoplasm   TAS   2290271 PMID:16004966 UniProtKB PMID:16004966 endoplasmic reticulum   ISS UniProtKB:P04925 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 endoplasmic reticulum   IEA Ensembl:ENSMUSP00000088833 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 extrinsic to membrane   TAS   2290271 PMID:16004966 UniProtKB PMID:16004966 Golgi apparatus   ISS UniProtKB:P04925 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 Golgi apparatus   IEA Ensembl:ENSMUSP00000088833 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 integral to membrane   IEA UniProtKB-KW:KW-0812 2290271 GO_REF:0000037 UniProtKB GO_REF:0000037 intracellular membrane-bounded organelle   IDA   2290271 GO_REF:0000052 HPA GO_REF:0000052 membrane raft   ISS UniProtKB:P04925 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 mitochondrial outer membrane   IDA   2290271 PMID:21478263 UniProtKB PMID:21478263 nucleolus   IDA   2290271 GO_REF:0000052 HPA GO_REF:0000052 nucleus   IDA   2290271 GO_REF:0000052 HPA GO_REF:0000052 plasma membrane   ISS UniProtKB:P04925 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 plasma membrane   IEA Ensembl:ENSMUSP00000088833 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 plasma membrane   IEA Ensembl:ENSRNOP00000028881 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 Molecular Function Term Qualifier Evidence With Reference Notes Source Original Reference(s) ATP-dependent protein binding   IEA Ensembl:ENSRNOP00000028881 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 chaperone binding   IEA Ensembl:ENSRNOP00000028881 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 copper ion binding   IDA   2290271 PMID:11900542 UniProtKB PMID:11900542 copper ion binding   TAS   2290271 PMID:16294306 UniProtKB PMID:16294306 identical protein binding   IPI UniProtKB:P04156 2290271 PMID:16286452 IntAct PMID:16286452 microtubule binding   IDA   2290271 PMID:16004966 UniProtKB PMID:16004966 protein binding   IPI UniProtKB:P29372 2290271 PMID:18482256 IntAct PMID:18482256 protein binding   IPI UniProtKB:Q9H4B4 2290271 PMID:18482256 IntAct PMID:18482256 protein binding   IPI UniProtKB:Q9BSJ6 2290271 PMID:18482256 IntAct PMID:18482256 protein binding   IPI UniProtKB:P49639 2290271 PMID:18482256 IntAct PMID:18482256 tubulin binding   IDA   2290271 PMID:16004966 UniProtKB PMID:16004966 Molecular Pathway Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) glypican signaling pathway   EXP   6484113   PID PID:200026 prion diseases pathway   IEA RGD:737306 6907045   KEGG hsa:05020 External Database Links KEGG Pathway Prion diseases Pathway Interaction Database Glypican 1 network (PID:200026) Disease Annotations Creutzfeldt-Jakob Syndrome  (IAGP,IEA) Gerstmann-Straussler-Scheinker Disease  (IEA) Huntington Disease-Like 1  (IEA) Hyperglycemia  (ISS) Insomnia, Fatal Familial  (IEA) Spongiform Encephalopathy with Neuropsychiatric Features  (IEA) Gene-Chemical Interaction Annotations 17alpha-ethynylestradiol  (ISO) 17beta-estradiol  (EXP) 17beta-hydroxy-5alpha-androstan-3-one  (ISO) 2,2,2-tetramine  (ISO) 2,2,2-trifluoroethanol  (EXP) 2,3,7,8-tetrachlorodibenzodioxine  (ISO) 2-methoxyethanol  (ISO) 4,4'-diaminodiphenylmethane  (ISO) 5-fluorouracil  (EXP) acetylsalicylic acid  (ISO) aflatoxin B1  (EXP,ISO) all-trans-retinoic acid  (EXP,ISO) ammonium chloride  (ISO) bathocuproine disulfonic acid  (ISO) benzene  (EXP) benzo[a]pyrene  (ISO) bisphenol A  (EXP,ISO) butyric acid  (ISO) cadmium dichloride  (EXP,ISO) caffeine  (EXP) calcitriol  (EXP) cisplatin  (EXP) Congo Red  (ISO) copper atom  (EXP,ISO) copper(0)  (EXP,ISO) copper(2+) sulfate  (EXP,ISO) copper(II) chloride  (ISO) cyclosporin A  (EXP,ISO) cytarabine  (EXP) D-glucose  (EXP) dichloromethane  (EXP) dioxygen  (EXP,ISO) doxorubicin  (EXP) edaravone  (ISO) ethylbenzene  (EXP) ethylenediaminetetraacetic acid  (ISO) etoposide  (EXP) genistein  (EXP,ISO) glucose  (EXP) glutathione  (ISO) heparan sulfate  (ISO) hydrogen peroxide  (EXP,ISO) iron atom  (ISO) manganese atom  (ISO) manganese(0)  (ISO) manganese(II) chloride  (ISO) methotrexate  (EXP) mitomycin C  (EXP) mono(2-ethylhexyl) phthalate  (EXP) N-nitrosodiethylamine  (ISO) NADP zwitterion  (EXP,ISO) NADP(+)  (EXP,ISO) nickel atom  (EXP,ISO) nitroprusside  (EXP) o-xylene  (EXP) paracetamol  (EXP) paraquat  (ISO) pirinixic acid  (ISO) progesterone  (EXP) silver atom  (ISO) silver(0)  (ISO) tamibarotene  (EXP) tert-butyl hydroperoxide  (EXP) tetracycline  (EXP) toluene  (EXP) trichloroethene  (EXP,ISO) ursodeoxycholic acid  (ISO) valproic acid  (EXP) vincristine  (EXP) zinc atom  (ISO) zinc oxide  (EXP) zinc(0)  (ISO) Gene Ontology Annotations Biological Process axon guidance  (TAS) cell cycle arrest  (IEA) cellular copper ion homeostasis  (NAS) learning or memory  (IEA) metabolic process  (TAS) negative regulation of activated T cell proliferation  (IEA,ISS) negative regulation of apoptotic process  (IEA) negative regulation of calcineurin-NFAT signaling cascade  (IEA,ISS) negative regulation of interferon-gamma production  (IEA,ISS) negative regulation of interleukin-17 production  (IEA,ISS) negative regulation of interleukin-2 production  (IEA,ISS) negative regulation of protein phosphorylation  (IEA,ISS) negative regulation of sequence-specific DNA binding transcription factor activity  (IEA,ISS) negative regulation of T cell receptor signaling pathway  (IEA,ISS) protein homooligomerization  (IEA) response to cadmium ion  (IEA) response to copper ion  (IEA) response to oxidative stress  (IEA,ISS) Cellular Component anchored to membrane  (IEA) cytoplasm  (TAS) endoplasmic reticulum  (IEA,ISS) extrinsic to membrane  (TAS) Golgi apparatus  (IEA,ISS) integral to membrane  (IEA) intracellular membrane-bounded organelle  (IDA) membrane raft  (ISS) mitochondrial outer membrane  (IDA) nucleolus  (IDA) nucleus  (IDA) plasma membrane  (IEA,ISS) Molecular Function ATP-dependent protein binding  (IEA) chaperone binding  (IEA) copper ion binding  (IDA,TAS) identical protein binding  (IPI) microtubule binding  (IDA) protein binding  (IPI) tubulin binding  (IDA) Molecular Pathway Annotations glypican signaling pathway  (EXP) prion diseases pathway  (IEA) External Database Links KEGG Pathway Prion diseases Pathway Interaction Database Glypican 1 network (PID:200026) References - curated 1. GOA_HUMAN data from the GO Consortium 2. Goldfarb LG, etal., Eur J Epidemiol. 1991 Sep;7(5):477-86. 3. Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology 4. Pipeline to import Pathway Interaction Database annotations from NCI into RGD 5. RGD automated import pipeline for gene-chemical interactions 6. RGD Automated Pipelines 7. Strom A, etal., Lab Invest. 2006 Dec 4;. References - uncurated PubMed 10090891   10581485   10618385   10631141   10790216   10900000   10954699   10970892   10987652   10988071   11032800   11060296   11062072   11100730   11120925   11161453   11220690   11244488   11278562   11283320   11438139   11559357   11571277   11584448   11593450   11684342   11704923   11709001   11756421   11775001   11780052   11787070   11833672   11840201   11882649   11900542   11961239   11986958   12034503   12070046   12084159   12093732   12161431   12186633   12205650   12356762   12356908   12359724   12392052   12399017   12459456   12464104   12477932   12514748   12543108   12547204   12568340   12590162   12601712   12621436   12645301   12659837   12679034   12679875   12682740   12684540   12690204   12692258   12694397   12719777   12778138   12796830   12805563   12867116   12917418   12917444   12946346   12952977   12970341   1346338   1347910   1351748   1352724   1357663   1363802   1363810   1439789   14519851   14576159   14593432   14610121   14616310   14623188   14645231   14668351   14702039   14744790   14745079   14761942   14970845   14983221   15050367   15123682   15131108   15140132   15145944   15146195   15148589   15203115   15208260   15215178   15247220   15258222   15266305   15277640   15304595   15342556   15469448   15488240   15489334   15539564   15555583   15557533   15583862   15591591   15609351   15639746   15684434   15748158   15775715   15837581   15846375   15850959   15862295   15946217   15987701   15997418   16004966   16009550   16025285   16051190   16099550   16099923   16119432   16120605   16156720   16159877   16169070   16175355   16187142   16192387   16215457   16215462   16217673   16263114   16286452   16287045   16294306   16298483   16314483   16315279   16324095   16342955   16344560   16432880   16434486   16443601   16460908   16478730   16519692   16533975   16537913   16543824   16545382   16547836   16580884   16582585   16672189   16674609   16704797   16713569   1671440   1672107   16750169   16764594   1677164   1678248   16824036   16825951   16825956   16831968   1683708   16847141   16847689   16858508   16889908   16897605   16908519   16914329   16921242   16925523   16934224   16950206   16987816   17023178   17029361   17047093   17092648   17121821   17134829   17149767   17156017   17192785   17202849   17242357   17260961   17276393   17313881   17334659   1736177   17385076   17409275   17410475   17414209   17449139   17472702   17497959   17500595   17519231   17539938   17559305   17560545   17570906   17709704   17822808   17827389   17873292   17965961   17987393   17996224   18006836   18025469   18029348   18038270   18051367   18188498   18191917   18204788   18217885   18218718   18236005   18236081   18247504   18275852   18325785   18332630   18347820   18349519   18372408   18406463   18413481   18419754   18423780   18425766   18436646   18443555   18445040   18478114   18482256   18505059   18508914   18539633   18549395   18549399   18563793   18597782   18619462   18638557   18665216   18691383   18706660   18720902   18722532   18786636   18810471   18830724   18930924   18955686   18959744   18990686   19008948   19010951   19030774   19035579   19051123   19056496   19064990   19074151   19077115   19081515   19099191   19129193   19140013   19156168   19158507   19164910   19172188   19196429   19204171   19210573   19212444   19218199   19226372   19228673   19249347   19278656   19321423   19327369   19351416   19363267   19369250   19416900   19476383   19477226   19495414   19524515   19534429   19542614   19556894   19558790   19583442   19587281   19597535   19601795   19602567   19606064   19607920   19643043   19675240   19690385   19696976   19697238   19698114   19709627   19710507   19725833   19728151   19734292   19786843   19807656   19822779   19882604   19889475   19910028   19911184   19917818   19923577   19927125   19996123   20004419   20005032   20028338   20035629   20036811   20036833   20049591   20077484   20105449   20109837   20145049   20175205   20195363   20198483   20301407   20392961   20413850   20422111   20453509   20465257   20473510   20487506   20506117   20515742   20515743   20515747   20526338   20526696   20529115   20541558   20547212   20547859   20552563   20562404   20564047   20564346   20573963   20574532   20576610   20583301   20583902   20592456   20593190   20613639   20625387   20650901   20661422   20685658   20694796   20711061   20718410   20724601   20799315   20804519   20816195   20838930   20861579   20870462   20880607   20919751   20923664   20930299   20932979   20949975   20964628   20970434   21029243   21058033   21062360   21071944   21094273   21107135   21107851   21116546   21119307   21193246   21209079   21212268   21232818   21257747   21265952   21293298   21296677   21297264   21298055   21301993   21320996   21323366   21338080   21356381   21385869   21439722   21445238   21451573   21453198   21478263   21478678   21508834   21552571   21559407   21593310   2159587   21597335   21600043   21616973   21631281   21654203   21689534   21743439   21763357   21795680   21799773   2180366   21804240   21827207   21833705   21839748   21841253   21857997   21875156   21900252   21911696   21920025   21943430   21957246   21957261   21980292   21980981   21983261   22002245   22028931   22031292   22032174   22036844   22046086   22076653   22128151   22129783   22137330   22155634   22184125   22210626   22252492   22318125   22318606   22356913   22363722   22384235   22411239   22484317   22505365   22511770   22558368   22561193   22615124   22658899   22669942   22675855   22676969   22685557   22788868   22791135   22820080   22842913   22860629   22874673   22876179   22895088   22895089   22915585   22930754   22936677   22972305   22978166   23022479   23090399   23115236   23131565   23175838   23209282   23225390   23256626   23319218   23392670   2564168   2567794   2572450   2783132   3014653   3755672   7485229   7572084   7592679   7630420   7642585   7699395   7783876   7902693   7902972   7906019   7913755   8105771   8364585   8461023   8676499   8797471   8797472   8909447   8962161   9266722   9384372   9473220   9482303   9786248   9799790 RGD Disease Portals PRNP has been annotated in the following RGD Disease Portals. Biological Process Cancer Pathways Cardiovascular Pathways Diabetes Diseases Diabetes Pathways Biological Process Immune and Inflammatory Pathways Biological Process Neurological Diseases Neurological Pathways Obesity Diseases Obesity Pathways Biological Process Respiratory Pathways Genomics Comparative Map Data PRNP   (Homo sapiens) Map Chr Position Strand Source Human Alternate Assembly CHM1_1 20 4,613,933 - 4,629,372 + NCBI Human Genome Assembly HuRef 20 4,620,194 - 4,635,632 + NCBI Human Genome Assembly GRCh37 20 4,666,797 - 4,682,234 + NCBI Human Genome Assembly Build 36 20 4,614,797 - 4,630,234 + NCBI Human Cytogenetic Map 20 p13   NCBI Human Genome Assembly 20 4,615,068 - 4,630,233   NCBI Prnp   (Mus musculus) Map Chr Position Strand Source Mouse Genome Assembly GRCm38 2 131,909,928 - 131,938,431 + NCBI Mouse cM Map 2 64.07   NCBI Mouse Celera Assembly 2 133,143,177 - 133,164,079 + NCBI Mouse Genome Assembly Build 37 2 131,735,664 - 131,764,167 + NCBI Mouse Genome Assembly Build 36.1 2 131,735,693 - 131,764,163 + NCBI Mouse Cytogenetic Map 2 F2   NCBI Prnp   (Rattus norvegicus) Map Chr Position Strand Source Rat Cytogenetic Map 3 q36   NCBI RGSC Genome Assembly v5.0 3 131,010,028 - 131,025,366 + NCBI RGSC Genome Assembly v3.4 3 119,676,137 - 119,691,507 + NCBI Rat Celera Assembly 3 117,986,209 - 118,001,394 + NCBI Genome Assembly 3.1 3 119,581,709 - 119,597,080 + NCBI Position Markers WI-18738   Map Chr Position Strand Source Human NCBI RH Map 20 44.2   UniSTS Human Whitehead-RH Map 20 31.5   UniSTS Human GeneMap99-GB4 RH Map 20 21.57   UniSTS Human Genome Assembly HuRef 20 4,634,468 - 4,634,611   UniSTS Human Genome Assembly GRCh37 20 4,681,070 - 4,681,213   UniSTS Human Celera Assembly 20 4,750,784 - 4,750,927   RGD Human Genome Assembly Build 36 20 4,629,070 - 4,629,213   RGD Human Cytogenetic Map 20 p13   UniSTS SGC44304   Map Chr Position Strand Source Human NCBI RH Map 20 74.7   UniSTS Human Whitehead-RH Map 20 29.6   UniSTS Human GeneMap99-GB4 RH Map 20 20.93   UniSTS Human Genome Assembly HuRef 20 4,635,435 - 4,635,570   UniSTS Human Genome Assembly GRCh37 20 4,682,037 - 4,682,172   UniSTS Human Celera Assembly 20 4,751,751 - 4,751,886   RGD Human Genome Assembly Build 36 20 4,630,037 - 4,630,172   RGD Human Cytogenetic Map 20 p13   UniSTS GDB:181561   Map Chr Position Strand Source Human Genome Assembly HuRef 20 4,634,663 - 4,635,076   UniSTS Human Genome Assembly GRCh37 20 4,681,265 - 4,681,678   UniSTS Human Celera Assembly 20 4,750,979 - 4,751,392   RGD Human Genome Assembly Build 36 20 4,629,265 - 4,629,678   RGD Human Cytogenetic Map 20 p13   UniSTS GDB:607655   Map Chr Position Strand Source Human Genome Assembly HuRef 20 4,633,285 - 4,633,678   UniSTS Human Genome Assembly GRCh37 20 4,679,887 - 4,680,280   UniSTS Human Celera Assembly 20 4,749,601 - 4,749,994   RGD Human Genome Assembly Build 36 20 4,627,887 - 4,628,280   RGD Human Cytogenetic Map 20 p13   UniSTS PRNP-2   Map Chr Position Strand Source Human Genome Assembly HuRef 20 4,633,360 - 4,633,747   UniSTS Human Genome Assembly GRCh37 20 4,679,962 - 4,680,349   UniSTS Human Celera Assembly 20 4,749,676 - 4,750,063   RGD Human Genome Assembly Build 36 20 4,627,962 - 4,628,349   RGD PMC136957P1   Map Chr Position Strand Source Human Genome Assembly HuRef 20 4,633,257 - 4,634,036   UniSTS Human Genome Assembly GRCh37 20 4,679,859 - 4,680,638   UniSTS Human Celera Assembly 20 4,749,573 - 4,750,352   RGD Human Genome Assembly Build 36 20 4,627,859 - 4,628,638   RGD Human Cytogenetic Map 20 p13   UniSTS D20S1014   Map Chr Position Strand Source Human GeneMap99-G3 RH Map 20 224.0   UniSTS Human NCBI RH Map 20 36.6   UniSTS Human Whitehead-YAC Contig Map 20     UniSTS Human GeneMap99-GB4 RH Map 20 12.19   UniSTS Human Stanford-G3 RH Map 20 224.0   UniSTS Human Genome Assembly HuRef 20 4,635,159 - 4,635,491   UniSTS Human Genome Assembly GRCh37 20 4,681,761 - 4,682,093   UniSTS Human Celera Assembly 20 4,751,475 - 4,751,807   RGD Human Genome Assembly Build 36 20 4,629,761 - 4,630,093   RGD Human Cytogenetic Map 20 p13   UniSTS PRNP   Map Chr Position Strand Source Human Genome Assembly HuRef 20 4,633,948 - 4,634,022   UniSTS Human Genome Assembly GRCh37 20 4,680,550 - 4,680,624   UniSTS Human Celera Assembly 20 4,750,264 - 4,750,338   RGD Human Genome Assembly Build 36 20 4,628,550 - 4,628,624   RGD RH71030   Map Chr Position Strand Source Human NCBI RH Map 20 40.2   UniSTS Human GeneMap99-GB4 RH Map 20 24.46   UniSTS Human Genome Assembly HuRef 20 4,633,406 - 4,633,678   UniSTS Human Genome Assembly GRCh37 20 4,680,008 - 4,680,280   UniSTS Human Celera Assembly 20 4,749,722 - 4,749,994   RGD Human Genome Assembly Build 36 20 4,628,008 - 4,628,280   RGD Human Cytogenetic Map 20 p13   UniSTS RH47809   Map Chr Position Strand Source Human NCBI RH Map 8 771.3   UniSTS Human GeneMap99-GB4 RH Map 8 299.46   UniSTS Human Genome Assembly HuRef 8 49,895,179 - 49,895,357   UniSTS Human Genome Assembly GRCh37 8 54,427,760 - 54,427,938   UniSTS Human Celera Assembly 8 50,418,526 - 50,418,704   RGD Human Genome Assembly Build 36 8 54,590,313 - 54,590,491   RGD RH70248   Map Chr Position Strand Source Human NCBI RH Map 20 77.8   UniSTS Human GeneMap99-GB4 RH Map 20 24.77   UniSTS Human Genome Assembly HuRef 20 4,635,269 - 4,635,508   UniSTS Human Genome Assembly GRCh37 20 4,681,871 - 4,682,110   UniSTS Human Celera Assembly 20 4,751,585 - 4,751,824   RGD Human Genome Assembly Build 36 20 4,629,871 - 4,630,110   RGD Human Cytogenetic Map 20 p13   UniSTS RH71032   Map Chr Position Strand Source Human NCBI RH Map 20 39.5   UniSTS Human GeneMap99-GB4 RH Map 20 21.14   UniSTS Human Genome Assembly HuRef 20 4,633,301 - 4,633,663   UniSTS Human Genome Assembly GRCh37 20 4,679,903 - 4,680,265   UniSTS Human Celera Assembly 20 4,749,617 - 4,749,979   RGD Human Genome Assembly Build 36 20 4,627,903 - 4,628,265   RGD Human Cytogenetic Map 20 p13   UniSTS QTLs in Region (Human Genome Assembly GRCh37) The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer RGD ID Symbol Name LOD P Value Trait Sub Trait Chr Start Stop Species 1643060 BW123_H Body Weight QTL 123 (human) 2.46 .00038 Body weight 20 1 25584381 Human 1357298 AASTH25_H Allergic/atopic asthma related QTL 25 (human) 1.07 Reversible airflow obstruction post-bronchodilator FEV1 20 1 16465530 Human 1559361 BW40_H Body weight QTL 40 (human) 4.08 .000046 Body weight body mass index 20 1 21862009 Human 1559359 BW39_H Body weight QTL 39 (human) 3.55 .00016 Body weight body mass index 20 1 17506357 Human 1578598 SCL126_H Serum cholesterol level QTL 126 (human) 1.7 Lipid level triglyceride-HDL ratio 20 559258 49561921 Human 2289218 BW368_H Body weight QTL 368 (human) .0185 Body fat amount percent fat 20 1 13559334 Human 2289553 BP95_H Blood pressure QTL 95 (human) Blood pressure systolic 20 1 25584381 Human 2289599 BW479_H Body weight QTL 479 (human) 1 Body fat amount none 20 1 24173953 Human 2289620 BW488_H Body weight QTL 488 (human) 1.51 Body fat amount none 20 1 21862009 Human 2292964 PRSTS150_H Prostate tumor susceptibility QTL 150 (human) 5.13 .000055 Prostate tumor susceptibility 20 1 13655267 Human 2293434 PRSTS208_H Prostate tumor susceptibility QTL 208 (human) 1.02 Prostate tumor susceptibility 20 1 16947114 Human 2292814 MYI36_H Myocardial infarction susceptibility QTL 36 (human) Myocardial infarction susceptibility early-onset 20 1 17506357 Human 2292801 MYI35_H Myocardial infarction susceptibility QTL 35 (human) Myocardial infarction susceptibility early-onset 20 1 17506357 Human 2301810 PRSTS434_H Prostate tumor susceptibility QTL 434 (human) .029 Prostate tumor susceptibility 20 1 24523882 Human 2301806 PRSTS437_H Prostate tumor susceptibility QTL 437 (human) .13 Prostate tumor susceptibility 20 1 24523882 Human 2301808 PRSTS435_H Prostate tumor susceptibility QTL 435 (human) .037 Prostate tumor susceptibility 20 1 16947114 Human 2301809 PRSTS436_H Prostate tumor susceptibility QTL 436 (human) .15 Prostate tumor susceptibility 20 1 13655267 Human 2314748 GLUCO93_H Glucose level QTL 93 (human) .59 .015 Glucose level non-insulin dependent 20 2276302 28276302 Human 2316872 GLUCO305_H Glucose level QTL 305 (human) 1.742 .0073 Glucose level 20 4029415 30029415 Human 2316328 GLUCO237_H Glucose level QTL 237 (human) Glucose level 20 1 13559334 Human 2316725 GLUCO287_H Glucose level QTL 287 (human) 1.86 .00312 Glucose level 20 1 24523882 Human 2316060 GLUCO212_H Glucose level QTL 212 (human) .013 Glucose level 20 1 16947114 Human 2316059 GLUCO213_H Glucose level QTL 213 (human) .04 Glucose level 20 1 16947114 Human Sequence Nucleotide Sequences Nucleotide RefSeqs NG_009087 (Get FASTA) Search GEO for Microarray Profiles   NM_000311 (Get FASTA) Search GEO for Microarray Profiles   NM_001080121 (Get FASTA) Search GEO for Microarray Profiles   NM_001080122 (Get FASTA) Search GEO for Microarray Profiles   NM_001080123 (Get FASTA) Search GEO for Microarray Profiles   NM_001271561 (Get FASTA) Search GEO for Microarray Profiles   NM_183079 (Get FASTA) Search GEO for Microarray Profiles GenBank Nucleotide AB300823 (Get FASTA) Search GEO for Microarray Profiles   AB300825 (Get FASTA) Search GEO for Microarray Profiles   ABBA01053856 (Get FASTA) Search GEO for Microarray Profiles   AF030575 (Get FASTA) Search GEO for Microarray Profiles   AF076976 (Get FASTA) Search GEO for Microarray Profiles   AF085477 (Get FASTA) Search GEO for Microarray Profiles   AF315723 (Get FASTA) Search GEO for Microarray Profiles   AK090575 (Get FASTA) Search GEO for Microarray Profiles   AK293312 (Get FASTA) Search GEO for Microarray Profiles   AK295415 (Get FASTA) Search GEO for Microarray Profiles   AK295943 (Get FASTA) Search GEO for Microarray Profiles   AK312276 (Get FASTA) Search GEO for Microarray Profiles   AL133396 (Get FASTA) Search GEO for Microarray Profiles   AMYH01011686 (Get FASTA) Search GEO for Microarray Profiles   AW452130 (Get FASTA) Search GEO for Microarray Profiles   AY008282 (Get FASTA) Search GEO for Microarray Profiles   AY219882 (Get FASTA) Search GEO for Microarray Profiles   AY219883 (Get FASTA) Search GEO for Microarray Profiles   AY458651 (Get FASTA) Search GEO for Microarray Profiles   AY569456 (Get FASTA) Search GEO for Microarray Profiles   BC012844 (Get FASTA) Search GEO for Microarray Profiles   BC016809 (Get FASTA) Search GEO for Microarray Profiles   BC022532 (Get FASTA) Search GEO for Microarray Profiles   BG397054 (Get FASTA) Search GEO for Microarray Profiles   BI669189 (Get FASTA) Search GEO for Microarray Profiles   BK007887 (Get FASTA) Search GEO for Microarray Profiles   BP251427 (Get FASTA) Search GEO for Microarray Profiles   BT019496 (Get FASTA) Search GEO for Microarray Profiles   CH471133 (Get FASTA) Search GEO for Microarray Profiles   CR542039 (Get FASTA) Search GEO for Microarray Profiles   CR542072 (Get FASTA) Search GEO for Microarray Profiles   D00015 (Get FASTA) Search GEO for Microarray Profiles   DA122620 (Get FASTA) Search GEO for Microarray Profiles   DA297032 (Get FASTA) Search GEO for Microarray Profiles   DB461478 (Get FASTA) Search GEO for Microarray Profiles   DQ408531 (Get FASTA) Search GEO for Microarray Profiles   HM459606 (Get FASTA) Search GEO for Microarray Profiles   M13667 (Get FASTA) Search GEO for Microarray Profiles   M13899 (Get FASTA) Search GEO for Microarray Profiles   M81929 (Get FASTA) Search GEO for Microarray Profiles   M81930 (Get FASTA) Search GEO for Microarray Profiles   S71208 (Get FASTA) Search GEO for Microarray Profiles   S71210 (Get FASTA) Search GEO for Microarray Profiles   S71212 (Get FASTA) Search GEO for Microarray Profiles   S79978 (Get FASTA) Search GEO for Microarray Profiles   S80539 (Get FASTA) Search GEO for Microarray Profiles   S80732 (Get FASTA) Search GEO for Microarray Profiles   S80743 (Get FASTA) Search GEO for Microarray Profiles   S83341 (Get FASTA) Search GEO for Microarray Profiles   U29185 (Get FASTA) Search GEO for Microarray Profiles   X83416 (Get FASTA) Search GEO for Microarray Profiles Reference Sequences RefSeq Acc Id: NM_000311 RefSeq Status: REVIEWED Type: CODING Protein Acc Id: NP_000302 Peptide Label: preproprotein Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 20 4,613,933 - 4,629,372 + NCBI Human Genome Assembly HuRef 20 4,620,194 - 4,635,632 + ENTREZGENE Human Genome Assembly GRCh37 20 4,666,797 - 4,682,234 + ENTREZGENE Human Genome Assembly Build 36 20 4,614,797 - 4,630,234 + NCBI Archive RefSeq Acc Id: NM_001080121 RefSeq Status: REVIEWED Type: CODING Protein Acc Id: NP_001073590 Peptide Label: preproprotein Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 20 4,613,933 - 4,629,372 + NCBI Human Genome Assembly HuRef 20 4,620,194 - 4,635,632 + ENTREZGENE Human Genome Assembly GRCh37 20 4,666,797 - 4,682,234 + ENTREZGENE Human Genome Assembly Build 36 20 4,614,797 - 4,630,234 + NCBI Archive RefSeq Acc Id: NM_183079 RefSeq Status: REVIEWED Type: CODING Protein Acc Id: NP_898902 Peptide Label: preproprotein Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 20 4,613,933 - 4,629,372 + NCBI Human Genome Assembly HuRef 20 4,620,194 - 4,635,632 + ENTREZGENE Human Genome Assembly GRCh37 20 4,666,797 - 4,682,234 + ENTREZGENE Human Genome Assembly Build 36 20 4,614,797 - 4,630,234 + NCBI Archive RefSeq Acc Id: NM_001080122 RefSeq Status: REVIEWED Type: CODING Protein Acc Id: NP_001073591 Peptide Label: preproprotein Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 20 4,613,933 - 4,629,372 + NCBI Human Genome Assembly HuRef 20 4,620,194 - 4,635,632 + ENTREZGENE Human Genome Assembly GRCh37 20 4,666,797 - 4,682,234 + ENTREZGENE Human Genome Assembly Build 36 20 4,614,797 - 4,630,234 + NCBI Archive RefSeq Acc Id: NM_001080123 RefSeq Status: REVIEWED Type: CODING Protein Acc Id: NP_001073592 Peptide Label: preproprotein Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 20 4,613,933 - 4,629,372 + NCBI Human Genome Assembly HuRef 20 4,620,194 - 4,635,632 + ENTREZGENE Human Genome Assembly GRCh37 20 4,666,797 - 4,682,234 + ENTREZGENE Human Genome Assembly Build 36 20 4,615,157 - 4,630,234 + NCBI Archive RefSeq Acc Id: NM_001271561 RefSeq Status: REVIEWED Type: CODING Protein Acc Id: NP_001258490 Peptide Label: AltPrp Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 20 4,613,933 - 4,629,372 + NCBI Human Genome Assembly HuRef 20 4,620,194 - 4,635,632 + NCBI Human Genome Assembly GRCh37 20 4,666,797 - 4,682,234 + NCBI Protein Sequences Protein RefSeqs NP_000302 (Get FASTA)   NP_001073590 (Get FASTA)   NP_001073591 (Get FASTA)   NP_001073592 (Get FASTA)   NP_001258490 (Get FASTA)   NP_898902 (Get FASTA) GenBank Protein AAA19664 (Get FASTA)   AAA60182 (Get FASTA)   AAB20521 (Get FASTA)   AAB20522 (Get FASTA)   AAB20523 (Get FASTA)   AAB21334 (Get FASTA)   AAB35416 (Get FASTA)   AAB50648 (Get FASTA)   AAB50649 (Get FASTA)   AAB50777 (Get FASTA)   AAB59442 (Get FASTA)   AAB59443 (Get FASTA)   AAC05365 (Get FASTA)   AAC62750 (Get FASTA)   AAC78725 (Get FASTA)   AAD46098 (Get FASTA)   AAG21693 (Get FASTA)   AAH12844 (Get FASTA)   AAH22532 (Get FASTA)   AAO83635 (Get FASTA)   AAO83636 (Get FASTA)   AAR21603 (Get FASTA)   AAS80162 (Get FASTA)   AAV38303 (Get FASTA)   ABD63004 (Get FASTA)   ABM82244 (Get FASTA)   ABM85428 (Get FASTA)   ADO16981 (Get FASTA)   BAA00011 (Get FASTA)   BAG32276 (Get FASTA)   BAG32278 (Get FASTA)   BAG35206 (Get FASTA)   BAG52189 (Get FASTA)   BAG56832 (Get FASTA)   BAG58365 (Get FASTA)   BAG58727 (Get FASTA)   CAA58442 (Get FASTA)   CAG46836 (Get FASTA)   CAG46869 (Get FASTA)   DAA34790 (Get FASTA)   EAX10449 (Get FASTA)   EAX10450 (Get FASTA)   P04156 (Get FASTA) Promoters RGD ID: 6798912 Promoter ID: HG_KWN:38471 Type: CpG-Island SO ACC ID: SO:0000170 Source: MPROMDB Tissues & Cell Lines: CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4 Transcripts: NM_001080121,   NM_001080122,   NM_001080123,   OTTHUMT00000077820,   OTTHUMT00000077821,   UC002WKT.1 Position: Map Chr Position Strand Source Human Genome Assembly Build 36 20 4,614,844 - 4,615,344 + MPROMDB RGD ID: 6850760 Promoter ID: EP73174 Type: multiple initiation site Name: HS_PRNP Description: Prion protein (p27-30) (Creutzfeld-Jakob disease,Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia). SO ACC ID: SO:0000170 Source: EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/) Experiment Methods: NEDO full length human cDNA sequencing project.; Oligo-capping Position: Map Chr Position Strand Source Human Genome Assembly Build 36 20 4,615,105 - 4,615,165   EPD RGD ID: 6871188 Promoter ID: EPDNEW_H8759 Type: initiation region Name: MSH5-SAPCD1_2 Description: MSH5-SAPCD1 readthrough (non-protein coding) SO ACC ID: SO:0000170 Source: EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) Position: Map Chr Position Strand Source Human Genome Assembly Build 36 6 31,730,195 - 31,730,255   EPDNEW Additional Information External Database Links Database Acc Id Source(s) COSMIC PRNP COSMIC Ensembl Genes ENSG00000171867 ENTREZGENE Ensembl Protein ENSP00000368752 ENTREZGENE   ENSP00000399376 ENTREZGENE Ensembl Transcript ENST00000379440 ENTREZGENE   ENST00000430350 ENTREZGENE Entrez Gene 5621 ENTREZGENE Gene3D-CATH 90.10 UniProtKB/Swiss-Prot Germonline ENSG00000171867 HGNC ID 9449 ENTREZGENE HomoloGene Group ID 7904 ENTREZGENE HPRD ID 01453 ENTREZGENE InterPro Prion UniProtKB/Swiss-Prot   Prion/Doppel_prot_b-ribbon_dom UniProtKB/Swiss-Prot   Prion_N_dom UniProtKB/Swiss-Prot IPI IPI00022284 UniProtKB/Swiss-Prot   IPI00956325 UniProtKB/Swiss-Prot   IPI01026282 UniProtKB/Swiss-Prot KEGG Report hsa:5621 ENTREZGENE, UniProtKB/Swiss-Prot OMIM 123400 OMIM   137440 OMIM   176640 OMIM   245300 OMIM   600072 OMIM   603218 OMIM   606688 OMIM PANTHER PTHR11522 UniProtKB/Swiss-Prot Pfam Prion UniProtKB/Swiss-Prot   Prion_bPrPp UniProtKB/Swiss-Prot PharmGKB PA33796 PharmGKB PRINTS PRION UniProtKB/Swiss-Prot PROSITE PRION_1 UniProtKB/Swiss-Prot   PRION_2 UniProtKB/Swiss-Prot SMART PRP UniProtKB/Swiss-Prot Superfamily-SCOP Prion UniProtKB/Swiss-Prot UniGene Hs.472010 ENTREZGENE   Hs.610285 ENTREZGENE   Hs.721670 ENTREZGENE UniProt A2A2V1_HUMAN UniProtKB/TrEMBL   APRIO_HUMAN UniProtKB/Swiss-Prot   PRIO_HUMAN UniProtKB/Swiss-Prot   Q53YK7_HUMAN UniProtKB/TrEMBL Nomenclature History Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status 2011-08-16 PRNP  prion protein  PRNP  prion protein  Symbol and/or name change 39860 APPROVED

More on PRNP Entrez Gene Ensembl Gene Genome Browser: (hg18) (hg19) HGNC Report NCBI Map Viewer Vista Vista + UCSC RGD Object Information RGD ID: 737306 Created: 2004-02-06 Species: Homo sapiens Last Modified: 2013-04-23 Status: ACTIVE