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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735621 Species: Homo sapiens RGD Object: Gene Symbol: CXCL2 Name: chemokine (C-X-C motif) ligand 2

Acc ID: CHEBI:31530 Term: edaravone Definition: A ring assembly that has formula C10H10N2O. CasRN: 89-25-8 Chemical ID: MESH:C005435

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:70069	6480464	CTD	phenylmethylpyrazolone inhibits the reaction [lipopolysaccharide, Escherichia coli 0111 B4 results in increased expression of CXCL2 mRNA]	PMID:12954792
decreases expression	ISO	RGD:70069	6480464	CTD	phenylmethylpyrazolone results in decreased expression of CXCL2 mRNA	PMID:15948865