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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (R)-noradrenaline | affects response to substance | ISO | RGD:10126 | 6480464 | AGTR2 protein affects the susceptibility to Norepinephrine | CTD | PMID:11714657 | (S)-nicotine | decreases expression | ISO | RGD:2072 | 6480464 | Nicotine results in decreased expression of AGTR2 protein; more ... | CTD | PMID:19429393 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:10126 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AGTR2 mRNA | CTD | PMID:17942748 | 17beta-estradiol | increases expression | ISO | RGD:2072 | 6480464 | Estradiol results in increased expression of AGTR2 mRNA; more ... | CTD | PMID:18388195 | 17beta-estradiol | multiple interactions | ISO | RGD:2072 | 6480464 | [PD 123319 results in decreased activity of AGTR2 protein] which results in decreased susceptibility to Estradiol | CTD | PMID:18388195 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:10126 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AGTR2 mRNA | CTD | PMID:17942748 | 3',5'-cyclic GMP | multiple interactions | ISO | RGD:2072 | 6480464 | [PD 123319 results in decreased activity of AGTR2 protein] inhibits the reaction [valsartan results in increased abundance of Cyclic GMP] | CTD | PMID:16982965 | 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine | multiple interactions | ISO | RGD:2072 | 6480464 | [Puromycin Aminonucleoside co-treated with Cholesterol] results in increased expression of AGTR2 mRNA | CTD | PMID:12495295 | 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine | increases expression | ISO | RGD:2072 | 6480464 | Puromycin Aminonucleoside results in increased expression of AGTR2 mRNA | CTD | PMID:12495295 | aldosterone | increases expression | ISO | RGD:2072 | 6480464 | Aldosterone results in increased expression of AGTR2 mRNA | CTD | PMID:15809360 | amlodipine | decreases expression | ISO | RGD:2072 | 6480464 | Amlodipine results in decreased expression of AGTR2 mRNA | CTD | PMID:18403896 | ammonium chloride | affects expression | ISO | RGD:2072 | 6480464 | Ammonium Chloride affects the expression of AGTR2 mRNA | CTD | PMID:16483693 | angiotensin II | increases expression | ISO | RGD:2072 | 6480464 | Angiotensin II results in increased expression of AGTR2 mRNA; more ... | CTD | PMID:12969123 | candesartan | multiple interactions | EXP | | 6480464 | [PD 123319 binds to and results in decreased activity of AGTR2 protein] inhibits the reaction [candesartan results in increased expression of NOS3 protein] | CTD | PMID:18551021 | candesartan | decreases expression | ISO | RGD:2072 | 6480464 | candesartan results in decreased expression of AGTR2 mRNA | CTD | PMID:18796534 | cholesterol | multiple interactions | ISO | RGD:2072 | 6480464 | [Puromycin Aminonucleoside co-treated with Cholesterol] results in increased expression of AGTR2 mRNA | CTD | PMID:12495295 | cholesterol | multiple interactions | ISO | RGD:2072 | 6480464 | [Cholesterol co-treated with Methylthiouracil] results in increased expression of AGTR2 mRNA; more ... | CTD | PMID:21269478 | clofibrate | increases expression | ISO | RGD:10126 | 6480464 | Clofibrate results in increased expression of AGTR2 mRNA | CTD | PMID:17585979 | copper(2+) sulfate | affects expression | EXP | | 6480464 | Copper Sulfate affects the expression of AGTR2 mRNA | CTD | PMID:19549813 | diethylstilbestrol | increases expression | ISO | RGD:2072 | 6480464 | Diethylstilbestrol results in increased expression of AGTR2 mRNA; more ... | CTD | PMID:14722030 | dioxygen | increases expression | ISO | RGD:10126 | 6480464 | Oxygen deficiency results in increased expression of AGTR2 mRNA | CTD | PMID:16769992 | dioxygen | increases expression | ISO | RGD:2072 | 6480464 | Oxygen deficiency results in increased expression of AGTR2 mRNA; more ... | CTD | PMID:19118600 | doxorubicin | multiple interactions | ISO | RGD:2072 | 6480464 | Cilazapril inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA]; more ... | CTD | PMID:15331931 | doxorubicin | decreases expression | ISO | RGD:2072 | 6480464 | Doxorubicin results in decreased expression of AGTR2 mRNA | CTD | PMID:15331931 | edaravone | multiple interactions | ISO | RGD:2072 | 6480464 | phenylmethylpyrazolone inhibits the reaction [Lipopolysaccharides results in increased expression of AGTR2 mRNA] | CTD | PMID:19118600 | enalapril | decreases expression | ISO | RGD:2072 | 6480464 | Enalapril results in decreased expression of AGTR2 mRNA | CTD | PMID:9740612 | enalapril | decreases expression | ISO | RGD:2072 | 6480464 | Enalapril results in decreased expression of AGTR2 mRNA | CTD | PMID:18403896 PMID:9740612 | enalapril | decreases expression | ISO | RGD:2072 | 6480464 | Enalapril results in decreased expression of AGTR2 mRNA | CTD | PMID:9740612 PMID:18403896 | enalapril | increases expression | ISO | RGD:2072 | 6480464 | Enalapril results in increased expression of AGTR2 mRNA | CTD | PMID:18765277 | folic acid | increases expression | ISO | RGD:10126 | 6480464 | Folic Acid results in increased expression of AGTR2 mRNA; more ... | CTD | PMID:12969123 | Ile(5)-angiotensin II | increases expression | ISO | RGD:2072 | 6480464 | Angiotensin II results in increased expression of AGTR2 mRNA; more ... | CTD | PMID:12969123 | losartan | multiple interactions | ISO | RGD:2072 | 6480464 | [Losartan co-treated with Cilazapril] inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA]; more ... | CTD | PMID:15331931 | losartan | increases expression | ISO | RGD:2072 | 6480464 | Losartan results in increased expression of AGTR2 protein | CTD | PMID:18300857 | losartan | decreases expression | ISO | RGD:2072 | 6480464 | Losartan results in decreased expression of AGTR2 mRNA | CTD | PMID:9336375 | losartan | multiple interactions | ISO | RGD:2072 | 6480464 | Losartan promotes the reaction [AGTR2 protein binds to AGT protein] | CTD | PMID:11967826 | nitric oxide | affects response to substance | ISO | RGD:2072 | 6480464 | AGTR2 protein affects the susceptibility to Nitric Oxide | CTD | PMID:9374809 | paraquat | decreases expression | EXP | | 6480464 | Paraquat results in decreased expression of AGTR2 mRNA | CTD | PMID:20035857 | PD123319 | multiple interactions | EXP | | 6480464 | [PD 123319 binds to and results in decreased activity of AGTR2 protein] inhibits the reaction [candesartan results in increased expression of NOS3 protein] | CTD | PMID:18551021 | PD123319 | decreases activity | ISO | RGD:2072 | 6480464 | PD 123319 results in decreased activity of AGTR2 protein | CTD | PMID:11509473 PMID:18388195 | PD123319 | multiple interactions | ISO | RGD:2072 | 6480464 | [PD 123319 results in decreased activity of AGTR2 protein] inhibits the reaction [valsartan results in increased abundance of Cyclic GMP]; more ... | CTD | PMID:16982965 | PD123319 | decreases expression | ISO | RGD:2072 | 6480464 | PD 123319 results in decreased expression of AGTR2 mRNA | CTD | PMID:9740612 PMID:9336375 | PD123319 | increases expression | ISO | RGD:2072 | 6480464 | PD 123319 results in increased expression of AGTR2 mRNA; more ... | CTD | PMID:11893553 | PD123319 | multiple interactions | ISO | RGD:2072 | 6480464 | [PD 123319 results in decreased activity of AGTR2 protein] which results in decreased susceptibility to Estradiol | CTD | PMID:18388195 | PD123319 | decreases activity | ISO | RGD:2072 | 6480464 | PD 123319 results in decreased activity of AGTR2 protein | CTD | PMID:18388195 | PD123319 | decreases expression | ISO | RGD:2072 | 6480464 | PD 123319 results in decreased expression of AGTR2 mRNA | CTD | PMID:9336375 PMID:9740612 | PD123319 | multiple interactions | ISO | RGD:2072 | 6480464 | [PD 123319 binds to and results in decreased activity of AGTR2 protein] which affects the susceptibility to Phenylephrine | CTD | PMID:19151255 | PD123319 | multiple interactions | ISO | RGD:2072 | 6480464 | PD 123319 binds to and results in decreased activity of AGTR2 protein | CTD | PMID:18300857 PMID:19151255 | PD123319 | multiple interactions | EXP | | 6480464 | PD 123319 binds to and results in decreased activity of AGTR2 protein | CTD | PMID:15807884 | phenylephrine | multiple interactions | ISO | RGD:2072 | 6480464 | [CGP 42112A binds to and results in increased activity of AGTR2 protein] which affects the susceptibility to Phenylephrine; more ... | CTD | PMID:19151255 | phenylephrine | affects response to substance | ISO | RGD:10126 | 6480464 | AGTR2 protein affects the susceptibility to Phenylephrine | CTD | PMID:11714657 | pioglitazone | multiple interactions | ISO | RGD:10126 | 6480464 | [ANGPT2 protein binds to and results in increased activity of AGTR2 protein] promotes the reaction [pioglitazone binds to and results in increased activity of PPARG protein] | CTD | PMID:15992368 | pirinixic acid | increases expression | ISO | RGD:2072 | 6480464 | pirinixic acid results in increased expression of AGTR2 mRNA | CTD | PMID:12832660 | pirinixic acid | increases expression | ISO | RGD:2072 | 6480464 | pirinixic acid results in increased expression of AGTR2 protein | CTD | PMID:18300857 | reserpine | increases expression | ISO | RGD:2072 | 6480464 | Reserpine results in increased expression of AGTR2 mRNA; more ... | CTD | PMID:20964730 | rosiglitazone | multiple interactions | ISO | RGD:2072 | 6480464 | rosiglitazone promotes the reaction [[Cholesterol co-treated with Methylthiouracil] results in increased expression of AGTR2 protein]; more ... | CTD | PMID:21269478 | sodium chloride | multiple interactions | ISO | RGD:2072 | 6480464 | AGTR2 protein inhibits the reaction [Sodium Chloride results in increased activity of AGT protein] | CTD | PMID:15809360 | sodium chloride | decreases expression | ISO | RGD:2072 | 6480464 | Sodium Chloride results in decreased expression of AGTR2 mRNA; more ... | CTD | PMID:15809360 | spironolactone | increases expression | ISO | RGD:2072 | 6480464 | Spironolactone results in increased expression of AGTR2 protein | CTD | PMID:18586661 | streptozocin | increases expression | ISO | RGD:10126 | 6480464 | Streptozocin results in increased expression of AGTR2 mRNA; more ... | CTD | PMID:17724226 | streptozocin | increases expression | ISO | RGD:2072 | 6480464 | Streptozocin results in increased expression of AGTR2 mRNA; more ... | CTD | PMID:15587404 | streptozocin | multiple interactions | ISO | RGD:2072 | 6480464 | Drugs, Chinese Herbal inhibits the reaction [Streptozocin results in increased expression of AGTR2 mRNA]; more ... | CTD | PMID:15587404 | taurine | decreases expression | ISO | RGD:2072 | 6480464 | Taurine results in decreased expression of AGTR2 protein | CTD | PMID:16025228 | testosterone | affects expression | ISO | RGD:2072 | 6480464 | Testosterone affects the expression of AGTR2 mRNA | CTD | PMID:17237611 | tetrachloromethane | multiple interactions | ISO | RGD:10126 | 6480464 | AGTR2 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; more ... | CTD | PMID:16774739 | tetrachloromethane | increases response to substance | ISO | RGD:10126 | 6480464 | AGTR2 gene mutant form results in increased susceptibility to Carbon Tetrachloride | CTD | PMID:16774739 | tetrachloromethane | increases expression | ISO | RGD:2072 | 6480464 | Carbon Tetrachloride results in increased expression of AGTR2 mRNA | CTD | PMID:12832660 | tetrathiomolybdate(2-) | decreases expression | EXP | | 6480464 | tetrathiomolybdate analog results in decreased expression of AGTR2 mRNA | CTD | PMID:19323979 | trichloroethene | decreases expression | ISO | RGD:10126 | 6480464 | Trichloroethylene results in decreased expression of AGTR2 mRNA | CTD | PMID:15363585 | valsartan | multiple interactions | ISO | RGD:2072 | 6480464 | valsartan inhibits the reaction [AGT protein results in increased expression of AGTR2 mRNA]; more ... | CTD | PMID:11403356 | valsartan | increases expression | ISO | RGD:2072 | 6480464 | valsartan results in increased expression of AGTR2 protein | CTD | PMID:16982965 | valsartan | multiple interactions | ISO | RGD:2072 | 6480464 | [PD 123319 results in decreased activity of AGTR2 protein] which results in decreased susceptibility to valsartan; more ... | CTD | PMID:16982965 | valsartan | decreases expression | ISO | RGD:2072 | 6480464 | valsartan results in decreased expression of AGTR2 mRNA | CTD | PMID:18403896 | valsartan | affects response to substance | ISO | RGD:10126 | 6480464 | AGTR2 affects the susceptibility to valsartan | CTD | PMID:12215461 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Neuroactive ligand-receptor interaction |
| Renin-angiotensin system | |
Phenotype AnnotationsDisease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Neuroactive ligand-receptor interaction |
| Renin-angiotensin system | |
Phenotype AnnotationsReferences - curated| 1. |
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| 38. |
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| 39. |
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| 40. |
RGD automated import pipeline for gene-chemical interactions |
| 41. |
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| 42. |
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RGD Disease Portals| AGTR2 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| AGTR2 (Homo sapiens) |
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| Agtr2 (Rattus norvegicus) |
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Position Markers| GDB:360300 |
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| PMC153509P1 |
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| AGTR2__4208 |
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| AGTR2 |
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QTLs in Region (Human Genome Assembly GRCh37)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NG_016326 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_000686 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | ABBA01049276 | (Get FASTA) | Search GEO for Microarray Profiles |
| ABBA01049277 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AI911273 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK313927 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AL732602 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AMYH01022870 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AY322542 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AY324607 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AY536522 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC095504 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH471234 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CR541969 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CR738498 | (Get FASTA) | Search GEO for Microarray Profiles | |
| DA538369 | (Get FASTA) | Search GEO for Microarray Profiles | |
| L34579 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U10273 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U15592 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U16957 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U20860 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U27478 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X87722 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X87723 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_000686 | |||||||||||||||||||||||||
| RefSeq Status: | REVIEWED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_000677 | |||||||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_000677 | (Get FASTA) |
| GenBank Protein | AAA50762 | (Get FASTA) |
| AAA61794 | (Get FASTA) | |
| AAA67753 | (Get FASTA) | |
| AAA84900 | (Get FASTA) | |
| AAA85851 | (Get FASTA) | |
| AAA98990 | (Get FASTA) | |
| AAB34100 | (Get FASTA) | |
| AAH95504 | (Get FASTA) | |
| AAP72969 | (Get FASTA) | |
| AAP84355 | (Get FASTA) | |
| AAS45437 | (Get FASTA) | |
| BAG36648 | (Get FASTA) | |
| CAA61022 | (Get FASTA) | |
| CAG46767 | (Get FASTA) | |
| EAW51502 | (Get FASTA) | |
| P50052 | (Get FASTA) |
Promoters| RGD ID: | 6872862 | ||||||||||
| Promoter ID: | EPDNEW_H9596 | ||||||||||
| Type: | initiation region | ||||||||||
| Name: | AKAP12_1 | ||||||||||
| Description: | A kinase anchor protein 12 | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||||
| Position: |
|
External Database Links| Database | Acc Id | Source(s) |
| COSMIC | AGTR2 | COSMIC |
| Ensembl Genes | ENSG00000180772 | ENTREZGENE |
| Ensembl Protein | ENSP00000360973 | ENTREZGENE |
| Ensembl Transcript | ENST00000371906 | ENTREZGENE |
| Entrez Gene | 186 | ENTREZGENE |
| Germonline | ENSG00000180772 | |
| HGNC ID | 338 | ENTREZGENE |
| HomoloGene Group ID | 20172 | ENTREZGENE |
| HPRD ID | 02071 | ENTREZGENE |
| InterPro | 7TM_GPCR_Rhodpsn | UniProtKB/Swiss-Prot |
| ATII_AT2_rcpt | UniProtKB/Swiss-Prot | |
| ATII_rcpt | UniProtKB/Swiss-Prot | |
| GPCR_Rhodpsn_supfam | UniProtKB/Swiss-Prot | |
| IPI | IPI00029486 | UniProtKB/Swiss-Prot |
| KEGG Report | hsa:186 | ENTREZGENE, UniProtKB/Swiss-Prot |
| OMIM | 300034 | OMIM |
| 300852 | OMIM | |
| Pfam | 7tm_1 | UniProtKB/Swiss-Prot |
| PharmGKB | AGTR2 | RGD, PharmGKB |
| PRINTS | ANGIOTENSINR | UniProtKB/Swiss-Prot |
| ANGIOTENSN2R | UniProtKB/Swiss-Prot | |
| GPCRRHODOPSN | UniProtKB/Swiss-Prot | |
| PROSITE | G_PROTEIN_RECEP_F1_1 | UniProtKB/Swiss-Prot |
| G_PROTEIN_RECEP_F1_2 | UniProtKB/Swiss-Prot | |
| UniGene | Hs.405348 | ENTREZGENE |
| UniProt | AAB34100 | ENTREZGENE |
| AGTR2_HUMAN | UniProtKB/Swiss-Prot | |
| Q6UVH2_HUMAN | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2011-08-16 | AGTR2 | angiotensin II receptor, type 2 | AGTR2 | angiotensin II receptor, type 2 | Symbol and/or name change | 39860 | APPROVED |
| 2011-07-27 | AGTR2 | angiotensin II receptor, type 2 | AGTR2 | angiotensin II receptor, type 2 | Symbol and/or name change | 39860 | APPROVED |
| More on AGTR2 | |||
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Entrez Gene | ||
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Ensembl Gene | ||
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HGNC Report | ||
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NCBI Map Viewer | ||
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Vista | ||
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Vista + UCSC | ||
| RGD Object Information | |
| RGD ID: | 619558 |
| Created: | 2002-07-23 |
| Species: | Homo sapiens |
| Last Modified: | 2013-03-06 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.