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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:nuclear factor kappa B signaling pathway
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Accession:PW:0000499 term browser browse the term
Definition:NF-kB signaling plays an essential role in the mammalian immune system. The classical/canonical pathway, downstream but not exclusively of tumor necrosis factor/receptor 1 signaling, is regarded as a paradigm of NF-kB signaling. The classical and the non-classical pathway downstream of a subset of Tnf receptor superfamily, share similar sets of core components, albeit in distinct ways. Collectively they regulate the expression of a vast array of genes.
Synonyms:related_synonym: KEGG:04064;   NF-kB signaling pathway;   NF-kappaB signaling pathway;   PID:200021;   PID:200031;   PID:200048
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nuclear factor kappa B signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARRB2 arrestin beta 2 ISO PID PID:200021 NCBI chr17:4,766,616...4,777,253
Ensembl chr17:4,757,048...4,767,517 		JBrowse link
G ATM ATM serine/threonine kinase ISO PID PID:200031 NCBI chr11:103,109,979...103,256,405
Ensembl chr11:106,584,228...106,727,041 		JBrowse link
G BCL10 BCL10 immune signaling adaptor ISO PID PID:200031 NCBI chr 1:117,823,388...117,834,314 JBrowse link
G BCL3 BCL3 transcription coactivator ISO PID PID:200021 NCBI chr19:41,696,162...41,708,485
Ensembl chr19:50,304,171...50,313,005 		JBrowse link
G BIRC2 baculoviral IAP repeat containing 2 ISO PID PID:200031 NCBI chr11:97,298,736...97,324,966
Ensembl chr11:100,793,036...100,822,421 		JBrowse link
G BTRC beta-transducin repeat containing E3 ubiquitin protein ligase ISO RGD PMID:21135871 RGD:5490225 NCBI chr10:97,958,527...98,159,550
Ensembl chr10:101,431,318...101,632,496 		JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex ISO PID
RGD		 PMID:18267068 PID:200031 PID:200048 RGD:2292172 NCBI chr10:96,794,228...96,835,449
Ensembl chr10:100,280,490...100,316,918 		JBrowse link
G CSNK2A1 casein kinase 2 alpha 1 ISO PID PID:200021 NCBI chr20:689,494...752,092
Ensembl chr20:456,629...521,126 		JBrowse link
G CSNK2A2 casein kinase 2 alpha 2 ISO PID PID:200021 NCBI chr16:38,426,399...38,466,575
Ensembl chr16:57,557,270...57,596,218 		JBrowse link
G CSNK2B casein kinase 2 beta ISO PID PID:200021 NCBI chr 6:31,327,250...31,331,250 JBrowse link
G CUL1 cullin 1 ISO RGD PMID:21135871 RGD:5490225 NCBI chr 7:140,428,442...140,531,136
Ensembl chr 7:152,908,303...153,011,254 		JBrowse link
G CYLD CYLD lysine 63 deubiquitinase ISO PID
RGD		 PMID:21119682 PMID:23312890 PID:200031 RGD:7800734 RGD:7800735 NCBI chr16:31,004,393...31,064,546
Ensembl chr16:49,882,751...49,942,629 		JBrowse link
G ERC1 ELKS/RAB6-interacting/CAST family member 1 ISO PID PID:200031 NCBI chr12:1,066,034...1,597,562
Ensembl chr12:1,027,967...1,545,431 		JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta ISO PID
RGD		 PMID:18267068 PID:200021 PID:200031 RGD:2292172 NCBI chr 8:41,515,613...41,576,229
Ensembl chr 8:38,960,594...39,020,971 		JBrowse link
G IKBKG inhibitor of nuclear factor kappa B kinase regulatory subunit gamma ISO PID
RGD		 PMID:18267068 PID:200031 RGD:2292172 NCBI chr  X:143,988,720...144,010,078
Ensembl chr  X:153,854,493...153,876,092 		JBrowse link
G IRF1 interferon regulatory factor 1 ISO RGD PMID:15141302 RGD:5128786 NCBI chr 5:127,903,887...127,913,843
Ensembl chr 5:134,067,441...134,075,035 		JBrowse link
G LCK LCK proto-oncogene, Src family tyrosine kinase ISO PID PID:200021 NCBI chr 1:31,560,229...31,572,391
Ensembl chr 1:32,565,739...32,579,923 		JBrowse link
G MALT1 MALT1 paracaspase ISO PID PID:200031 NCBI chr18:52,060,878...52,141,985
Ensembl chr18:55,395,462...55,473,574 		JBrowse link
G MAP3K14 mitogen-activated protein kinase kinase kinase 14 ISO PID
RGD		 PMID:18267068 PID:200048 RGD:2292172 NCBI chr17:12,011,037...12,064,978
Ensembl chr17:12,183,243...12,237,131 		JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 ISO RGD PMID:21135871 PMID:30854566 RGD:155791647 RGD:5490225 NCBI chr 6:88,398,329...88,470,926
Ensembl chr 6:91,664,263...91,737,468 		JBrowse link
G MAPK14 mitogen-activated protein kinase 14 ISO PID PID:200021 NCBI chr 6:35,586,847...35,683,041
Ensembl chr 6:36,788,233...36,871,114 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 ISO PID
RGD		 PMID:18267068 PMID:23975431 PID:200021 PID:200031 PID:200048 RGD:2292172 RGD:40902973 NCBI chr 4:94,925,048...95,040,849
Ensembl chr 4:105,589,062...105,704,098 		JBrowse link
G NFKB2 nuclear factor kappa B subunit 2 ISO PID
RGD		 PMID:18267068 PID:200048 RGD:2292172 NCBI chr10:98,997,604...99,006,407
Ensembl chr10:102,463,503...102,471,907 		JBrowse link
G NFKBIA NFKB inhibitor alpha ISO PID
RGD		 PMID:18267068 PID:200021 PID:200031 RGD:2292172 NCBI chr14:16,155,331...16,158,588 JBrowse link
G NFKBIB NFKB inhibitor beta ISO RGD PMID:18267068 RGD:2292172 NCBI chr19:36,005,797...36,015,897 JBrowse link
G NFKBIE NFKB inhibitor epsilon ISO RGD PMID:18267068 RGD:2292172 NCBI chr 6:43,853,921...43,861,686
Ensembl chr 6:45,138,209...45,144,680 		JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 ISO PID PID:200031 NCBI chr16:30,955,976...30,995,451
Ensembl chr16:49,837,891...49,873,773 		JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISO PID PID:200021 NCBI chr 3:176,182,765...176,272,024
Ensembl chr 3:184,355,785...184,441,977 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PID:200021 NCBI chr 5:45,701,219...45,786,652
Ensembl chr 5:47,267,286...47,350,960 		JBrowse link
G PRKCA protein kinase C alpha ISO PID PID:200031 NCBI chr17:60,246,485...60,747,158
Ensembl chr17:65,454,907...65,947,903 		JBrowse link
G RAN RAN, member RAS oncogene family ISO PID PID:200031 NCBI chr12:128,497,407...128,503,049
Ensembl chr12:132,694,498...132,699,668 		JBrowse link
G RBCK1 RANBP2-type and C3HC4-type zinc finger containing 1 ISO RGD PMID:23085193 RGD:7800730 NCBI chr20:615,987...639,366
Ensembl chr20:386,569...409,580 		JBrowse link
G RBX1 ring-box 1 ISO RGD PMID:21135871 RGD:5490225 NCBI chr22:21,845,351...21,866,627
Ensembl chr22:39,941,405...39,962,175 		JBrowse link
G REL REL proto-oncogene, NF-kB subunit ISO PID
RGD		 PMID:18267068 PID:200021 RGD:2292172 NCBI chr2A:60,972,022...61,013,562
Ensembl chr2A:62,113,581...62,155,241 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit ISO PID
RGD		 PMID:18267068 PID:200021 PID:200031 RGD:2292172 NCBI chr11:61,012,839...61,022,225
Ensembl chr11:64,347,859...64,356,868 		JBrowse link
G RELB RELB proto-oncogene, NF-kB subunit ISO PID
RGD		 PMID:18267068 PID:200048 RGD:2292172 NCBI chr19:41,948,559...41,987,121
Ensembl chr19:50,554,864...50,590,223 		JBrowse link
G RIPK2 receptor interacting serine/threonine kinase 2 ISO PID PID:200031 NCBI chr 8:86,447,216...86,480,511
Ensembl chr 8:88,398,468...88,456,268 		JBrowse link
G RNF31 ring finger protein 31 ISO RGD PMID:23085193 RGD:7800730 NCBI chr14:4,923,391...4,936,959
Ensembl chr14:23,047,893...23,061,923 		JBrowse link
G SHARPIN SHANK associated RH domain interactor ISO RGD PMID:23085193 RGD:7800730 NCBI chr 8:140,865,009...140,870,580
Ensembl chr 8:143,854,902...143,862,888 		JBrowse link
G SKP1 S-phase kinase associated protein 1 ISO RGD PMID:21135871 RGD:5490225 NCBI chr 5:129,560,086...129,580,188
Ensembl chr 5:135,713,085...135,729,653 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase ISO PID PID:200021 NCBI chr20:33,667,614...33,727,126
Ensembl chr20:34,822,271...34,839,634 		JBrowse link
G SSPOP SCO-spondin, pseudogene ISO PID PID:200021 PID:200031 PID:200048 NCBI chr 7:141,477,578...141,537,109 JBrowse link
G SYK spleen associated tyrosine kinase ISO PID PID:200021 NCBI chr 9:61,859,767...61,956,619
Ensembl chr 9:89,959,599...90,056,101 		JBrowse link
G TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 ISO RGD PMID:21135871 RGD:5490225 NCBI chr22:20,303,547...20,343,314
Ensembl chr22:38,122,835...38,162,705 		JBrowse link
G TAB2 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 ISO RGD PMID:21135871 RGD:5490225 NCBI chr 6:147,138,553...147,231,559
Ensembl chr 6:151,868,513...151,936,841 		JBrowse link
G TAB3 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 ISO RGD PMID:21135871 RGD:5490225 NCBI chr  X:23,428,343...23,489,688
Ensembl chr  X:30,980,841...31,012,994 		JBrowse link
G TNF tumor necrosis factor ISO PID PID:200031 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
G TNFAIP3 TNF alpha induced protein 3 ISO PID PID:200031 NCBI chr 6:135,617,465...135,634,085
Ensembl chr 6:139,705,255...139,720,819 		JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A ISO PID PID:200031 NCBI chr12:6,457,617...6,470,969
Ensembl chr12:6,374,257...6,387,613 		JBrowse link
G TRAF6 TNF receptor associated factor 6 ISO PID PID:200031 NCBI chr11:36,457,633...36,483,616
Ensembl chr11:36,335,609...36,356,334 		JBrowse link
G UBE2D3 ubiquitin conjugating enzyme E2 D3 ISO PID PID:200031 NCBI chr 4:95,218,319...95,293,053
Ensembl chr 4:105,883,133...105,900,546 		JBrowse link
G XPO1 exportin 1 ISO PID PID:200031 NCBI chr2A:61,562,372...61,622,841
Ensembl chr2A:62,698,935...62,757,793 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4063
    signaling pathway 1929
      transcription factor mediated signaling pathway 360
        nuclear factor kappa B signaling pathway 52
          altered nuclear factor kappa B signaling pathway 0
Path 2
Term Annotations click to browse term
  pathway 4063
    regulatory pathway 2507
      pathway pertinent to DNA replication and repair, cell cycle, maintenance of genomic integrity, RNA and protein biosynthesis 1338
        transcription pathway 927
          transcription pathway via transcription factor mediated signaling 360
            nuclear factor kappa B signaling pathway 52
              altered nuclear factor kappa B signaling pathway 0
paths to the root