CSNK2A2 (casein kinase 2 alpha 2) - Rat Genome Database

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Gene: CSNK2A2 (casein kinase 2 alpha 2) Pan paniscus
Analyze
Symbol: CSNK2A2
Name: casein kinase 2 alpha 2
RGD ID: 11915389
Description: ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN cerebral cortex development (ortholog); liver regeneration (ortholog); positive regulation of protein targeting to mitochondrion (ortholog); PARTICIPATES IN E-cadherin signaling pathway; mitochondrial autophagy pathway; nuclear factor kappa B signaling pathway; ASSOCIATED WITH Bardet-Biedl syndrome (ortholog); Chromosome 16q12 Duplication Syndrome (ortholog); developmental and epileptic encephalopathy (ortholog); FOUND IN acrosomal vesicle (ortholog); chromatin (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: casein kinase II subunit alpha'
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21867,620,768 - 67,660,961 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11673,541,651 - 73,581,859 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01638,426,399 - 38,466,575 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11657,557,262 - 57,596,218 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1657,557,270 - 57,596,218 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CSNK2A2BonoboOxygen-Induced Retinopathy  ISORGD:13157529068941 RGDPMID:16651637|REF_RGD_ID:11565123
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CSNK2A2BonoboBardet-Biedl syndrome  ISORGD:13157518554872ClinVar Annotator: match by term: Bardet-Biedl syndromeClinVarPMID:11285252|PMID:20177705|PMID:24608809|PMID:26518167|PMID:28492532|PMID:28747448|PMID:30866059
CSNK2A2BonoboChromosome 16q12 Duplication Syndrome  ISORGD:13157518554872ClinVar Annotator: match by term: Chromosome 16q12 duplication syndromeClinVarPMID:25741868
CSNK2A2Bonobodevelopmental and epileptic encephalopathy  ISORGD:13157518554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathyClinVarPMID:11285252|PMID:20177705|PMID:24608809|PMID:26518167|PMID:28492532|PMID:28747448|PMID:30866059
CSNK2A2Bonoboearly infantile epileptic encephalopathy  ISORGD:13157518554872ClinVar Annotator: match by term: Early infantile epileptic encephalopathyClinVarPMID:11285252|PMID:20177705|PMID:24608809|PMID:26518167|PMID:28492532|PMID:28747448|PMID:30866059
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CSNK2A2BonoboSkin Neoplasms  ISORGD:13157519068941CTD Direct Evidence: marker/mechanismCTDPMID:18572023
CSNK2A2Bonobosquamous cell carcinoma  ISORGD:13157519068941CTD Direct Evidence: marker/mechanismCTDPMID:18572023
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CSNK2A2Bonobomale infertility  ISORGD:13157529068941 MouseDO 


Biological Process
1 to 14 of 14 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CSNK2A2Bonobocerebral cortex development  ISORGD:13068829068941 RGDPMID:7735332|REF_RGD_ID:11565823
CSNK2A2Bonobodouble-strand break repair involved_inIEAUniProtKB:P19784|ensembl:ENSP00000262506150520179 EnsemblGO_REF:0000107
CSNK2A2Bonoboliver regeneration  ISORGD:13068829068941 RGDPMID:8573159|REF_RGD_ID:11565141
CSNK2A2Bonobonegative regulation of proteasomal ubiquitin-dependent protein catabolic process involved_inIEAUniProtKB:P19784|ensembl:ENSP00000262506150520179 EnsemblGO_REF:0000107
CSNK2A2Bonobopositive regulation of protein targeting to mitochondrion involved_inISORGD:13157519068941 PMID:24912190ParkinsonsUK-UCLPMID:24912190
CSNK2A2Bonoboprotein phosphorylation acts_upstream_of_or_withinISORGD:13157529068941 PMID:18496528MGIPMID:18496528
CSNK2A2Bonoboprotein phosphorylation acts_upstream_of_or_withinISORGD:13157529068941 PMID:14644449, PMID:27998980MGIPMID:14644449|PMID:27998980
CSNK2A2Bonoboregulation of cell cycle involved_inIEAPANTHER:PTN000621963150520179 TreeGrafterGO_REF:0000118
CSNK2A2Bonoboregulation of cell cycle acts_upstream_of_or_withinIEAUniProtKB:O54833|ensembl:ENSMUSP00000148404150520179 EnsemblGO_REF:0000107
CSNK2A2Bonoboregulation of chromosome separation involved_inIEAPANTHER:PTN000621963150520179 TreeGrafterGO_REF:0000118
CSNK2A2Bonoboregulation of chromosome separation involved_inIEAUniProtKB:P19784|ensembl:ENSP00000262506150520179 EnsemblGO_REF:0000107
CSNK2A2Bonoboregulation of mitophagy involved_inISORGD:13157519068941 PMID:24912190ParkinsonsUK-UCLPMID:24912190
CSNK2A2Bonobospermatogenesis  ISORGD:13068829068941 RGDPMID:19711102|REF_RGD_ID:11565138
CSNK2A2Bonobospermatogenesis acts_upstream_of_or_withinIEAUniProtKB:O54833|ensembl:ENSMUSP00000148404150520179 EnsemblGO_REF:0000107
1 to 14 of 14 rows

Cellular Component
1 to 10 of 10 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CSNK2A2Bonoboacrosomal vesicle  ISORGD:13068829068941 RGDPMID:19711102|REF_RGD_ID:11565138
CSNK2A2Bonobochromatin  ISORGD:13068829068941 RGDPMID:9916157|REF_RGD_ID:11565845
CSNK2A2Bonobocytosol located_inIEAPANTHER:PTN000621963150520179 TreeGrafterGO_REF:0000118
CSNK2A2Bonobonucleus located_inIEAUniProtKB-KW:KW-0539150520179 UniProtGO_REF:0000043
CSNK2A2Bonobonucleus located_inIEAPANTHER:PTN000621963150520179 TreeGrafterGO_REF:0000118
CSNK2A2Bonobonucleus located_inIEAUniProtKB:P19784|ensembl:ENSP00000262506150520179 EnsemblGO_REF:0000107
CSNK2A2Bonobonucleus located_inIEAUniProtKB-SubCell:SL-0191150520179 UniProtGO_REF:0000044
CSNK2A2Bonobonucleus located_inIEAUniRule:UR001903793150520179 UniProtGO_REF:0000104
CSNK2A2BonoboPcG protein complex located_inIEAUniProtKB:P19784|ensembl:ENSP00000262506150520179 EnsemblGO_REF:0000107
CSNK2A2Bonoboprotein kinase CK2 complex part_ofIEAPANTHER:PTN000621963150520179 TreeGrafterGO_REF:0000118
1 to 10 of 10 rows

Molecular Function
1 to 20 of 26 rows

  
Object Symbol
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Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CSNK2A2BonoboATP binding enablesIEAUniRule:UR001503341|UniRule:UR001903793150520179 UniProtGO_REF:0000104
CSNK2A2BonoboATP binding enablesIEAUniProtKB-KW:KW-0067150520179 UniProtGO_REF:0000043
CSNK2A2BonoboATP binding enablesIEAInterPro:IPR000719|InterPro:IPR017441150520179 InterProGO_REF:0000002
CSNK2A2Bonobokinase activity enablesIEAUniProtKB-KW:KW-0418150520179 UniProtGO_REF:0000043
CSNK2A2Bonobonucleotide binding enablesIEAUniProtKB-KW:KW-0547150520179 UniProtGO_REF:0000043
CSNK2A2Bonobonucleotide binding enablesIEAUniRule:UR001503341150520179 UniProtGO_REF:0000104
CSNK2A2Bonoboprotein binding enablesISOUniProtKB:P25686|UniProtKB:P25686-1|UniProtKB:P25686-29068941 PMID:28031292ARUK-UCLPMID:28031292
CSNK2A2Bonoboprotein binding enablesISOPR:Q8CH199068941 PMID:19273531MGIPMID:19273531
CSNK2A2Bonoboprotein binding enablesISOUniProtKB:P684009068941 PMID:25519132, PMID:25852190, PMID:28514442IntActPMID:25519132|PMID:25852190|PMID:28514442
CSNK2A2Bonoboprotein binding enablesISOUniProtKB:O60282|UniProtKB:P67870|UniProtKB:P684009068941 PMID:19011756IntActPMID:19011756
CSNK2A2Bonoboprotein binding enablesISOUniProtKB:P67870|UniProtKB:Q9BS349068941 PMID:21988832IntActPMID:21988832
CSNK2A2Bonoboprotein binding enablesISOUniProtKB:P67870|UniProtKB:Q8WV44|UniProtKB:Q9BS34|UniProtKB:Q9NRD59068941 PMID:32296183IntActPMID:32296183
CSNK2A2Bonoboprotein binding enablesISOUniProtKB:Q8WV449068941 PMID:25416956, PMID:31515488IntActPMID:25416956|PMID:31515488
CSNK2A2Bonoboprotein binding enablesISOUniProtKB:P678709068941 PMID:10094392, PMID:14667819, PMID:23555304, PMID:26496610IntActPMID:10094392|PMID:14667819|PMID:23555304|PMID:26496610
CSNK2A2Bonoboprotein binding enablesISOUniProtKB:P250549068941 PMID:11972058UniProtPMID:11972058
CSNK2A2Bonoboprotein binding enablesISOUniProtKB:P67870|UniProtKB:P684009068941 PMID:23455922, PMID:27705803, PMID:32707033, PMID:35271311IntActPMID:23455922|PMID:27705803|PMID:32707033|PMID:35271311
CSNK2A2Bonoboprotein binding enablesISOUniProtKB:P67870|UniProtKB:P68400|UniProtKB:Q8NDY69068941 PMID:33961781IntActPMID:33961781
CSNK2A2Bonoboprotein kinase activity enablesIEAInterPro:IPR000719|InterPro:IPR008271150520179 InterProGO_REF:0000002
CSNK2A2Bonoboprotein kinase activity enablesIEAUniProtKB:O54833|ensembl:ENSMUSP00000148404150520179 EnsemblGO_REF:0000107
CSNK2A2Bonoboprotein serine kinase activity enablesIEAUniRule:UR001903793150520179 UniProtGO_REF:0000104
1 to 20 of 26 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CSNK2A2Bonobomitochondrial autophagy pathway   ISORGD:13157519068941 RGDPMID:25840011|REF_RGD_ID:10400888

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CSNK2A2BonoboE-cadherin signaling pathway  ISORGD:13157519068941 PIDPID:200124
CSNK2A2Bonobonuclear factor kappa B signaling pathway   ISORGD:13157519068941 PIDPID:200021
PMID:22301074   PMID:30032202  



CSNK2A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21867,620,768 - 67,660,961 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11673,541,651 - 73,581,859 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01638,426,399 - 38,466,575 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11657,557,262 - 57,596,218 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1657,557,270 - 57,596,218 (-)Ensemblpanpan1.1panPan2
CSNK2A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381658,157,907 - 58,198,106 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1658,157,907 - 58,198,106 (-)EnsemblGRCh38hg38GRCh38
GRCh371658,191,811 - 58,232,010 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361656,749,312 - 56,789,283 (-)NCBINCBI36Build 36hg18NCBI36
Build 341656,749,314 - 56,789,283NCBI
Celera1642,691,263 - 42,731,230 (-)NCBICelera
Cytogenetic Map16q21NCBI
HuRef1644,059,729 - 44,099,930 (-)NCBIHuRef
CHM1_11659,598,846 - 59,638,724 (-)NCBICHM1_1
T2T-CHM13v2.01663,953,540 - 63,993,732 (-)NCBIT2T-CHM13v2.0
Csnk2a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39896,172,724 - 96,215,505 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl896,172,724 - 96,216,667 (-)EnsemblGRCm39 Ensembl
GRCm38895,446,096 - 95,488,868 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl895,446,096 - 95,490,039 (-)EnsemblGRCm38mm10GRCm38
MGSCv37897,969,996 - 98,012,720 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36898,337,101 - 98,377,919 (-)NCBIMGSCv36mm8
Celera899,760,768 - 99,802,427 (-)NCBICelera
Cytogenetic Map8C5- D1NCBI
cM Map847.12NCBI
Csnk2a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8199,562,340 - 9,602,136 (+)NCBIGRCr8
mRatBN7.2199,556,443 - 9,596,080 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl199,556,260 - 9,596,080 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx199,521,860 - 9,561,150 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01910,288,686 - 10,327,976 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0199,575,016 - 9,614,306 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0199,972,537 - 10,012,043 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl199,972,537 - 10,012,043 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0199,956,494 - 9,996,397 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41910,015,369 - 10,054,662 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11910,020,174 - 10,054,722 (+)NCBI
Celera199,448,494 - 9,487,786 (+)NCBICelera
Cytogenetic Map19p13NCBI
Csnk2a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543315,674,116 - 15,718,894 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543315,677,788 - 15,718,894 (-)NCBIChiLan1.0ChiLan1.0
CSNK2A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1258,361,328 - 58,441,701 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl258,360,838 - 58,432,371 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha254,991,254 - 55,071,046 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0258,899,781 - 58,979,588 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl258,899,298 - 58,971,571 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1255,731,413 - 55,811,164 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0256,739,015 - 56,818,751 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0257,631,725 - 57,711,511 (+)NCBIUU_Cfam_GSD_1.0
Csnk2a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934949,513,855 - 49,558,667 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647510,033,717 - 10,075,511 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647510,030,408 - 10,073,576 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CSNK2A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl619,976,930 - 20,016,923 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1619,975,030 - 20,016,768 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2617,998,939 - 18,074,082 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CSNK2A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1544,093,320 - 44,133,352 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl544,093,215 - 44,133,335 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604732,045,388 - 32,085,772 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Csnk2a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474628,012,556 - 28,060,413 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474628,012,543 - 28,064,610 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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RefSeq Transcripts XM_034940298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055099161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSPPAT00000056667   ⟹   ENSPPAP00000033790
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1657,557,270 - 57,596,218 (-)Ensembl
RefSeq Acc Id: XM_034940298   ⟹   XP_034796189
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21867,620,768 - 67,660,961 (-)NCBI
NHGRI_mPanPan11673,541,651 - 73,581,859 (-)NCBI
Mhudiblu_PPA_v01638,426,399 - 38,466,575 (-)NCBI
RefSeq Acc Id: XM_055099161   ⟹   XP_054955136
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21867,622,417 - 67,660,603 (-)NCBI
NHGRI_mPanPan11673,543,632 - 73,581,498 (-)NCBI
Protein RefSeqs XP_034796189 (Get FASTA)   NCBI Sequence Viewer  
  XP_054955136 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000033790.1
RefSeq Acc Id: XP_034796189   ⟸   XM_034940298
Ensembl Acc Id: ENSPPAP00000033790   ⟸   ENSPPAT00000056667
RefSeq Acc Id: XP_054955136   ⟸   XM_055099161
Protein kinase



1 to 19 of 19 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSPPAG00000039756 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000056667.1 UniProtKB/TrEMBL
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro CK2_alpha UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene CSNK2A2 ENTREZGENE
PANTHER CASEIN KINASE II SUBUNIT ALPHA UniProtKB/TrEMBL
  PTHR24054 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A2R9BZ77_PANPA UniProtKB/TrEMBL
1 to 19 of 19 rows