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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal eosinophil physiology
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Accession:MP:0002465 term browser browse the term
Definition:any functional anomaly of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin and is involved in clearance of parasitic infections and in allergic reactions
Synonyms:exact_synonym: abnormal eosinocyte physiology;   abnormal eosinophilic leucocyte physiology;   abnormal eosinophilic leukocyte physiology;   eosinophil dysfunction
 broad_synonym: abnormal polymorphonuclear leucocyte physiology;   abnormal polymorphonuclear leukocyte physiology


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abnormal eosinophil physiology term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3ar1 complement component 3a receptor 1 IAGP MGI PMID:12421977 NCBI chr 6:122,824,099...122,833,116
Ensembl chr 6:122,824,097...122,833,120 		JBrowse link
G Ccr3 C-C motif chemokine receptor 3 IAGP MGI PMID:11830666 PMID:11877470 NCBI chr 9:123,817,799...123,831,729
Ensembl chr 9:123,822,009...123,831,726 		JBrowse link
G Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) IAGP MGI PMID:7697542 PMID:8839836 NCBI chr15:78,210,000...78,235,201
Ensembl chr15:78,209,952...78,238,047 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 IAGP MGI PMID:11801688 NCBI chr 1:74,193,153...74,200,405
Ensembl chr 1:74,193,150...74,200,405 		JBrowse link
G Dusp5 dual specificity phosphatase 5 IAGP MGI PMID:25398911 NCBI chr19:53,517,576...53,530,240
Ensembl chr19:53,517,540...53,530,862 		JBrowse link
G Fyn Fyn proto-oncogene IAGP MGI PMID:11306441 NCBI chr10:39,245,735...39,441,377
Ensembl chr10:39,244,851...39,441,377 		JBrowse link
G Gnai2 G protein subunit alpha i2 IAGP MGI PMID:17360531 NCBI chr 9:107,491,324...107,512,542
Ensembl chr 9:107,491,324...107,512,566 		JBrowse link
G Icam2 intercellular adhesion molecule 2 IAGP MGI PMID:10023766 NCBI chr11:106,268,482...106,278,948
Ensembl chr11:106,268,482...106,278,901 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 IAGP MGI PMID:10727469 NCBI chr 1:40,444,105...40,504,575
Ensembl chr 1:40,468,730...40,504,575 		JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D IEA MGI NCBI chr 1:87,548,034...87,648,232
Ensembl chr 1:87,548,034...87,648,229 		JBrowse link
G Morrbid myeloid RNA regulator of BCL2L11 induced cell death IAGP MGI PMID:27525555 NCBI chr 2:128,140,583...128,271,271
Ensembl chr 2:128,020,239...128,344,685 		JBrowse link
G Rag2 recombination activating gene 2 IAGP MGI PMID:25398911 NCBI chr 2:101,455,057...101,462,873
Ensembl chr 2:101,455,063...101,462,874 		JBrowse link
G S100a4 S100 calcium binding protein A4 IAGP MGI PMID:20519440 NCBI chr 3:90,511,077...90,513,349
Ensembl chr 3:90,511,078...90,513,352 		JBrowse link
G Siglecf sialic acid binding Ig-like lectin F IAGP MGI PMID:17272508 NCBI chr 7:43,000,496...43,008,899
Ensembl chr 7:43,000,765...43,008,955 		JBrowse link
G Spred1 sprouty protein with EVH-1 domain 1, related sequence IAGP MGI PMID:15630138 NCBI chr 2:116,951,576...117,012,760
Ensembl chr 2:116,951,855...117,012,760 		JBrowse link
impaired eosinophil chemotaxis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr3 C-C motif chemokine receptor 3 IAGP MGI PMID:11830666 NCBI chr 9:123,817,799...123,831,729
Ensembl chr 9:123,822,009...123,831,726 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 IAGP MGI PMID:12960353 NCBI chr10:127,478,855...127,496,856
Ensembl chr10:127,478,855...127,496,826 		JBrowse link
impaired eosinophil recruitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl11 C-C motif chemokine ligand 11 IAGP MGI PMID:9034156 NCBI chr11:81,948,658...81,953,781
Ensembl chr11:81,948,649...81,953,781 		JBrowse link
G Ccr3 C-C motif chemokine receptor 3 IAGP MGI PMID:11830666 PMID:11877470 NCBI chr 9:123,817,799...123,831,729
Ensembl chr 9:123,822,009...123,831,726 		JBrowse link
G Ccr6 C-C motif chemokine receptor 6 IAGP MGI PMID:11514610 NCBI chr17:8,454,875...8,477,353
Ensembl chr17:8,454,875...8,475,973 		JBrowse link
G Chi3l1 chitinase 3 like 1 IAGP MGI PMID:19414556 NCBI chr 1:134,109,894...134,117,769
Ensembl chr 1:134,109,914...134,117,919 		JBrowse link
G Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) IAGP MGI PMID:18178860 NCBI chr15:78,210,000...78,235,201
Ensembl chr15:78,209,952...78,238,047 		JBrowse link
G Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) IAGP MGI PMID:18178860 NCBI chr15:78,166,707...78,189,921
Ensembl chr15:78,166,707...78,189,921 		JBrowse link
G Fcer2a Fc receptor, IgE, low affinity II, alpha polypeptide IAGP MGI PMID:10508270 NCBI chr 8:3,730,280...3,744,174
Ensembl chr 8:3,731,737...3,744,175 		JBrowse link
G Hpse heparanase IAGP MGI PMID:24532362 NCBI chr 5:100,827,350...100,867,582
Ensembl chr 5:100,827,350...100,867,582 		JBrowse link
G Igh-7 immunoglobulin heavy chain 7 (heavy chain of IgE) IAGP MGI PMID:18354212
G Il13 interleukin 13 IAGP MGI PMID:11950906 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529 		JBrowse link
G Il21r interleukin 21 receptor IAGP MGI PMID:17077330 NCBI chr 7:125,202,424...125,232,742
Ensembl chr 7:125,202,601...125,232,742 		JBrowse link
G Il4 interleukin 4 IAGP MGI PMID:18719110 PMID:21131966 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Kdm6b KDM1 lysine (K)-specific demethylase 6B IAGP MGI PMID:20729857 NCBI chr11:69,289,334...69,311,188
Ensembl chr11:69,289,334...69,304,501 		JBrowse link
G Ltb4r1 leukotriene B4 receptor 1 IAGP MGI PMID:10934232 NCBI chr14:56,002,154...56,005,951
Ensembl chr14:56,003,419...56,005,951 		JBrowse link
G Ms4a4a membrane-spanning 4-domains, subfamily A, member 4A IAGP MGI PMID:32589266 NCBI chr19:11,352,827...11,370,682
Ensembl chr19:11,352,887...11,370,154 		JBrowse link
G Ptgdr2 prostaglandin D2 receptor 2 IAGP MGI PMID:18097056 NCBI chr19:10,901,883...10,919,875
Ensembl chr19:10,914,524...10,919,875 		JBrowse link
G Retnla resistin like alpha IAGP MGI PMID:19201890 NCBI chr16:48,662,972...48,664,824
Ensembl chr16:48,662,914...48,664,824 		JBrowse link
G Sele selectin, endothelial cell IAGP MGI PMID:10500197 NCBI chr 1:163,867,200...163,886,056
Ensembl chr 1:163,875,773...163,885,246 		JBrowse link
G Sell selectin, lymphocyte IAGP MGI PMID:10500197 NCBI chr 1:163,889,556...163,908,354
Ensembl chr 1:163,889,551...163,911,750 		JBrowse link
G Selp selectin, platelet IAGP MGI PMID:10500197 NCBI chr 1:163,942,833...163,977,595
Ensembl chr 1:163,942,833...163,977,595 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 IAGP MGI PMID:9500796 PMID:18719110 NCBI chr10:127,478,855...127,496,856
Ensembl chr10:127,478,855...127,496,826 		JBrowse link
G Tpsb2 tryptase beta 2 IAGP MGI PMID:18354212 NCBI chr17:25,585,282...25,587,070
Ensembl chr17:25,585,170...25,588,079 		JBrowse link
G Traf3ip2 TRAF3 interacting protein 2 IAGP MGI PMID:19155511 NCBI chr10:39,488,930...39,531,303
Ensembl chr10:39,488,930...39,531,303 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 16734
    immune system phenotype 5613
      abnormal immune system physiology 3422
        abnormal immune cell physiology 1788
          abnormal leukocyte physiology 1753
            abnormal granulocyte physiology 289
              abnormal eosinophil physiology 36
                impaired eosinophil chemotaxis 2
                impaired eosinophil recruitment 23
paths to the root